Download 40364 Genetics

1. COURSE DECRIPTION – GENERAL INFORMATION
1.1. Course
Višnja Besendorfer
2nd
1.6. Year of study
teacher
1.2. Name of the
Genetics
1.7. Credit value
9
course
(ECTS)
1.8. Type of instruction
4+3+1+0
1.3. Associate
(number of hours
teachers
L+S+E+e-learning)
40
1.4. Study
undergraduate
programme
1.9. Expected
(undergraduat
enrolment in the
e, graduate,
course
integrated)
1.10. Level of use of e- 1
required
learning (1, 2, 3
1.5. Status of the
level), percentage
course
of instruction in the
course on line
(20% maximum)
2. COURSE DESCRIPTION
It is an introductory course where students get an integral knowledge on genetics
– principles of heredity and principles of molecular genetics, population genetics
2.1. Course
and genetic engineering. The special attention is given to practical course where
objectives
students get the basic skills in genetic crossing using various model organisms
like fruit fly, Arabidopsis, bacteria through small projects using classical and
molecular techniques.
2.2. Enrolment
Basic knowledge in cell biology.
requirements
and required
entry
competences
for the course
2.3. Learning
Students will learn how to solve the genetic problems using principles of heredity
outcomes at
at the individual and population level as well as on molecular level using modern
the level of the molecular techniques.
study
programme to
which the
course
contributes
2.4. Expected
Students will be able to perform crosses in order to: determine the genotype and
phenotype using different model organisms, establishment of genetic
learning
outcomes at
experiments; use of various molecular techniques in experiments and use of
the level of the mathematical models in quantitative and qualitative population genetics.
course (4-10
learning
outcomes)
Genetics – science of heredity. Brief overview of the Modern history of genetics.
Mendelian principles of heredity: Low of segregation and independent
segregation. Genes i chromosomes. Allelic interactions; modification of
2.5. Course
phenotype ratio in F2 generation. Epistasis. Multiple alleles. Probability and
content
broken down
statistics in genetics - χ2 - test. Linkage and gene mapping in eukaryotes. Sex
in detail by
determination. Sex linkage and pedigree analysis. Sex determination and
weekly class
dosage compensation. Chromosome aberrations; changes in chromosome
schedule
number and structure. Induced chromosome aberrations. Structure and
(syllabus)
replication of DNA, transcription and translation. Mutation of DNA, repair and
recombination. Genetics of bacteria. Mechanisms of genetic variation in bacteria:
transformation, conjugation, transduction. Regulation of gene expression in
2.6. Type of
instruction
2.8. Student
responsibilities
2.9. Screening of
student’s work
(specify the
proportion of
ECTS credits
for each
activity so that
the total
number of
CTS credits is
equal to the
credit value of
the course)):
2.1. Grading and
evaluation of
student work
over the
course of
instruction and
at a final exam
prokaryotes - Lac-operon (inducible system), Trp operon (represive system), and
in eukaryotes. Eukaryote chromosomes: nature of DNA sequences, chromatin
organization and epigenetics. Genetic basis of the cancer; oncogenes and
tumour suppressor genes. Cytoplasmic inheritance (mitochondria, chloroplasts,
infective molecules, bacterial plasmids). Population genetics – quantitative and
evolutionary genetics, the Hardy-Weinberg equilibrium and mating system,
processes that change allelic frequencies.
lectures
independent study
2.7. Comments:
seminars and
multimedia and the
workshops
internet
exercises
laboratory
online in entirety
work with the
mixed e-learning
mentor
(other)
field work
Active and regular attending of the courses
Active and regular attending of practicum and seminars
Fulfillment of student’s seminars and oral presentation.
Class
Practical
2
Research
attendance
training
Experimental
2
Report
work
Seminar
(Other-Essay
1
describe)
essay
Tests
Written exam
Oral exam
2
2
Project
2.12. Optional
literature (at
the time of
the
submission of
the study
programme
(Other—
describe)
Active and regular attending the courses
Evaluation of practical work
Evaluation of student seminars and oral presentation
Evaluation of written test
Evaluation of oral exam and discussion
Title
2.2. Required
literature
(available at
the library and
via other
media)
(Other—
describe)
L.H. Hartwell, L. Hood, M.L. Goldberg, A.E.
Reynolds, L.M. Silver, R.C. Veres: Genetics; from
genes to genomes. McGraw Hill 2008.
B. Lewin: Genes VIII. Oxford University Press
2004.
R. H. Tamarin: Principles of Genetics. Mc Graw
Hill, New York, 1999.
Internal scripta for practical work
Original scientific papers for seminars
Number
of
copies
at the
library
5
Availability via
other media
2
50
www.biol.pmf.hr
proposal)
2.13. Methods of
monitoring
quality that
ensure
acquisition of
exit
competences
Periodical exams
Laboratory notes after each practicum
Written seminars and oral presentation
Written and oral exams