Download final examination july 2011 examination 1/2011/2012 session

FINAL EXAMINATION
JULY 2011 EXAMINATION
1/2011/2012 SESSION
SUBJECT
SUBJECT CODE
DURATION
FACULTY
PROGRAMME
LECTURER
: PRINCIPLE OF PHARMACOLOGY
: MFD 1232
: 2 HOURS
: BIOMEDICAL AND HEALTH SCIENCES
: DIPLOMA OF PHYSIOTHERAPY
: MADAM HAMIDAH ABU BAKAR
INSTRUCTIONS TO CANDIDATES
This question paper consists of:
SECTION A: 30 objective questions
– Answer ALL questions.
SECTION B: 3 structured questions
– Answer ALL questions
SECTION C: 3 essay questions
– Answer TWO (2) questions
Part A must be answered in the OMR sheet provided.
Part B and Part C must be written in answer booklet provided
Answer to each question must start on a new page
Do Not Open The Question Paper Until Instructed
This Question Paper Consists of NINE (9) Printed Pages
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SECTION A – OBJECTIVE QUESTIONS
(20 MARKS)
Choose ONE best statement to answer the questions.
1.
The following pathological conditions are associated with the lung EXCEPT
(A)
(B)
(C)
(D)
2.
Which of the following is NOT an antacid?
(A)
(B)
(C)
(D)
3.
Aluminum hydroxide.
Calcium carbonate.
Magaldrate.
Lomotil.
Penicillin’s mode of action is that it
(A)
(B)
(C)
(D)
4.
emphysema.
asthma.
myocardium infarction.
chronic bronchitis.
inhibits bacterial cell wall formation by blocking cross-linking of it.
blocks DNA synthesis by inhibiting one of the enzymes.
inhibits protein synthesis by binding to bacterial ribosome (30S)
inhibits protein synthesis by binding to bacterial ribosome (50S).
Which of the following statement is NOT TRUE for antibiotic?
(A)
(B)
(C)
(D)
Antibiotic can also be called as chemotherapeutic agent.
The minimum inhibitory concentration is used to measure in vivo
antimicrobial activity.
At the highest level, bacteriostatic antimicrobial can prevent cell
division.
Bactericidal antimicrobials are more potent than bacteriostatic
antimicrobial.
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5.
Which of the following is the second line drug treatment for heart failure?
(A)
(B)
(C)
(D)
6.
Beta blockers.
Angiotensin-converting enzyme inhibitors.
Angiotensin II receptor blockers.
Vasodilators.
Which of the following pair is TRUE on the influence of cardiovascular drug
therapies on exercise?
Drugs
(A) Nitrates
(B) Beta blockers
(C) Alpha adrenergic blocker
(D) Calcium channel blocker
7.
Which of the following is NOT the role of aspirin?
(A)
(B)
(C)
(D)
8.
Anti pyretic
Anti rheumatic
Analgesic
Anti infective
Which of the following is NOT an arachidonic acid derivative?
(A)
(B)
(C)
(D)
9.
Exercise tolerance
Increase
Decrease
Constant
Decrease
Prostaglandin
Leukotrienes
Thromboxanes
Mitomycin
Bulk forming laxatives
(A)
(B)
(C)
(D)
are the first choice of therapy for constipation.
onset of action for oral is 6-8 hours when taken orally.
are anionic surfactants for softening the stool.
are systemically absorbed.
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10.
The anti diarrheal agent’s mode of action is that it
(A)
(B)
(C)
(D)
11.
Which of the following pair is compatible?
(A)
(B)
(C)
(D)
12.
Syrup of ipecac
Apomorphine
Digoxin
Estrogen
Parkinsonism is due to deficiency of dopamine in substantia nigra.
Levodopa is a precursor of dopamine.
Dopamine is the first line of drug therapy in Parkinsonism.
One of the common adverse effects is anorexia.
The following pairs are TRUE for the generation of cephalosporins EXCEPT
(A)
(B)
(C)
(D)
15.
Agent
Atenolol
Clonidone
Sodium nitroprusside
Carvedilol
The following statements are TRUE for Parkinson’s EXCEPT
(A)
(B)
(C)
(D)
14.
Group
Thiazide-like diuretics
Vasodilators
ACE inhibitors
Mixed adrenergic Alpha + Beta
blockers
Which of the following is a central emetic agent?
(A)
(B)
(C)
(D)
13.
blocks GABA receptor.
increases intracellular concentration of cGMP.
Coats the walls of the GI tract and bind to the causative bacteria or
toxin.
binds to the hydrochloric acid in the stomach and acts like an acid
buffer with cytoprotective properties.
1st Generation
2nd Generation
3rd Generation
4th Generation
Gram (+)
Gram (-)
Gram (-), but also some Gram (+)
Gram (+) and Gram (-)
Which of the following is NOT TRUE for indole derivatives?
(A)
(B)
(C)
(D)
Weak cyclooxygenase inhibitors.
Often used as standard for comparison.
Well absorbed, variable half life.
Can act as antipyretic and analgesic.
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16.
Which of the following pair is NOT TRUE for chemotherapy treatment?
(A)
(B)
(C)
(D)
17.
As anti arrhythmic agents, the aim of fast association natrium channel
blockers is the
(A)
(B)
(C)
(D)
18.
Polymixins
Tetracyclins
Macrolides
Vancomycin
Which of the following statement is TRUE for anti gout agent?
(A)
(B)
(C)
(D)
20.
treatment or prevention during and immediately after myocardial
infarction.
prevention of paroxysmal atrial fibrillation.
treatment of ventricular arrhythmias.
prevention of recurrence of tachyarrhythmias.
Which of the following is a glycopeptide cell wall inhibitor?
(A)
(B)
(C)
(D)
19.
Tamoxifen - reduce the risk of breast cancer in high-risk women.
Raloxifen - more selective than tamoxifen against breast cancer.
Celexocib - selective against lung cancer.
Finasteride - effective against prostate cancer.
An additional proton pump inhibitor may be given for those at risk of
gastric irritation from NSAIDs.
Over-the-counter medication is restricted for gout patient.
Aspirin is a drug of choice to avoid secondary gout.
Acetazolamide, a diuretic, can be used to treat gout.
Which of the following pair is compatible?
(A)
Terminology
Potency
(B)
(C)
(D)
Ceiling dose
Drug tolerance
Side effects
Definition
Maximum intensity of effect or response that can be
obtained with a drug.
Strength of the medicine.
Predictable adverse drug effect.
Lack of specificity of action by the drug, therefore acts
not only on the tissues which intended.
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21.
Which of the following statement is NOT TRUE for the indication of
neuromuscular junction blocker?
(A)
(B)
(C)
(D)
22.
Which of the following pair is NOT a synonym?
(A)
(B)
(C)
(D)
23.
(B)
(C)
(D)
Parasympatholytic.
Cholinergic agonist.
Adrenergic agonist.
Sympatomimetic.
Cholinergic blocking agents are compounds which prevent
acetylcholine from stimulating the receptor site.
These compounds compete with acetylcholine for receptor sites.
They do not themselves produce an excitant effect but rather limit the
excitant effects of acetylcholine.
They have similar actions with acetylcholine, by direct or indirect
action.
Which of the following antibacterial agent kills bacteria by blocking the
pathway of folic acid synthesis?
(A)
(B)
(C)
(D)
25.
Cholinomimetics
Cholinergics
Adrenomimetics
Adrenergics
Which of the following statement is NOT TRUE for cholinergic antagonist
agents?
(A)
24.
Cause a pharmacologic restraint so patients do not harm themselves.
Relax the vocal cords and allow the passage of a tracheal tube.
Eliminate spontaneous breathing and promote mechanical ventilation.
Increase oxygen consumption.
Trimethoprim
Polymyxin
Chloramphenicol
Macrolides
Which of the following drug is used to treat ulcer?
(A)
(B)
(C)
(D)
Laxatives
Proton pump inhibitors
Intestinal flora modifiers
Estrogen
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26.
Monobactams are
(A)
(B)
(C)
(D)
27.
Long term administration of narcotic analgesic produces
(A)
(B)
(C)
(D)
28.
(B)
(C)
(D)
Prevent the increases in intracellular concentration of cyclic guanosine
monophosphate.
Stimulate the increases in intracellular concentration of cyclic
guanosine monophosphate.
Increase blood pressure and heart rate.
Inhibit inflammatory mediation.
Which of the following is a pyrimidine analog?
(A)
(B)
(C)
(D)
30.
respiratory depression.
nausea.
tolerance.
drowsiness.
Choose the statement that refers to anti cholinergic agent’s mode of action in
chronic obstructive pulmonary disease treatment.
(A)
29.
well distributed into on ‘inflamed tissues.
only effective against Gram positive aerobic bacteria.
excreted through defecation.
susceptible to P. aeruginosa.
Methotrexate
Mercaptoguanine
Fluorouracil
Mitomycin
Corticosteroids
(A)
(B)
(C)
(D)
selectively inhibit cyclooxygenase.
competitively inhibit cyclooxygenase.
inhibit phospholipase A2 production.
stimulate phospholipase A2 production.
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SECTION B – SHORT ANSWER QUESTIONS
(30 MARKS)
Answer ALL questions.
1.
a.
What is the difference between asthma and exercise-induced
bronchoconstriction?
b.
(2 Marks)
State all approaches used in asthma treatment, including drugs which
are used in the treatment.
(9 Marks)
a.
Define of psychomotor stimulants.
(2 Marks)
b.
State THREE (3) side effects of psychomotor stimulants.
(3 Marks)
c.
State THREE (3) objectives of schizophrenia management. (3 Marks)
d.
Define general anesthesia.
a.
b.
Outline principals of laxative therapy.
(5 Marks)
Discuss the role of anticholinergics and opiates for diarrhea treatments.
(5 Marks)
.
2.
3.
(2 Marks)
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SECTION C -ESSAY
(40 MARKS)
Answer TWO (2) questions only.
Question 1
Discuss on anti cancer drugs principals and differentiate between cell cycle specific and
cell cycle non specific agents. Briefly, explain on alkylating agents mode of action.
(20 Marks)
Question 2
Discuss on the various sources of drugs, dosage forms of drugs and factors that may
influence the effectiveness of a drug.
(20 Marks)
Question 3
Discuss on anti-angina drugs and relate their influence on exercise.
(20 Marks)
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