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Endocrine Disorders Type I Diabetes Type I Diabetes • High blood sugar level (hyperglycemia) – >200 mg/dL – shaking, sweating, anxiety, hunger, difficulty concentrating, weight loss, fatigue, increased thirst, urinating often • Excess excreted in urine • Insulin dependent diabetes – Juvenile onset diabetes Type I Diabetes Causes • Insulin deficiency because body does not naturally produce insulin • Often caused by inherited immune disorder that destroys pancreatic cells Type I Diabetes Treatment • Insulin injections • Monitor blood glucose levels • Exercise & healthy diet Type 2 Diabetes Type II Diabetes Description • High blood sugar level (hyperglycemia) – >200 mg/dL – Shaking, sweating, anxiety, hunger, difficulty concentrating, fatigue, urinating often • Non-insulin dependent diabetes – Adult-onset diabetes Type II Diabetes Causes • Body does not use insulin properly (insulin resistance) • Pancreas makes extra insulin at first, but over time cannot keep up and cannot make enough insulin to keep blood glucose at normal levels Type II Diabetes Treatment • Insulin injections • Monitor blood glucose levels • Exercise & healthy diet Graves’ Disease Graves’ Disease Graves’ Disease Description • Enlarged thyroid, protrusion of eyes, lumpy reddish skin on lower legs, excessive reactions to stimuli, period of hyperactivity and fatigue, tremors • Symptoms usually develop slowly over a long period. Graves’ Disease Causes • Autoimmune disorder triggered by a bacterial infection leading to the overproduction of hormones in the thyroid. Graves’ Disease Treatments • Can only treat symptoms. Antithyroid drugs, partial or complete destruction of thyroid by radioactive iodine, partial or complete surgical removal of thyroid Dwarfism Dwarfism Dwarfism Dwarfism Description • A person who is shorter than 4’ 10” Dwarfism Causes • Two main causes: – Acondroplasia-a genetic condition that causes growth factors to not be registered by the bones. – Human growth hormone (HGH) deficiency-many reasons for this including genetics, stress and malnutrition. Dwarfism Treatment • Hormone therapy if growth hormone deficiency. • PT and braces if the condition causes pain. Hypothyroidism Hypothyroidism (goiter) Hypothyroidism Description • Poor muscle tone, fatigue, increased sensitivity to cold, constipation, depression, pale and dry skin, decreased sweating, weight gain • Goiters can develop • Later - slow speech, deep puffy face, low body temperature and abnormal menstrual cycles Hypothyroidism Causes • Iodine deficiency • Autoimmune disorder where antibodies attack thyroid Hypothyroidism Treatment • Hormone replacement pills for thyroid hormones • Iodine in diet Acromegaly Acromegaly Acromegaly Acromegaly Description • Enlargement of the hands, feet, nose, lips and ears, heart, kidney, skull • Protruding brow and lower jaw, gaps between lower teeth • Headaches and visual disturbances. Acromegaly Causes • Overproduction of growth hormones is caused by a benign tumor of the pituitary gland • Tumors produce excess growth hormones and, as they expand, compress surrounding brain tissues, such as the optic nerves Acromegaly Treatment • Surgery, drug therapy or radiation therapy to remove or destroy the tumor. Hirsutism Hirsutism Hirsutism Description • Excessive hair on the body (both men and women) Hirsutism Causes • Increased levels of male hormones in body (stimulating hair growth) or sensitivity of hair follicles to male hormones Hirsutism Treatment • Drugs to reduce hormone levels OR waxing/shaving/hair removal