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Functional Medicine University’s Functional Diagnostic Medicine Training Program INSIDER’S GUIDE INTERPRETATION AND TREATMENT: VIRAL SCREENING By Ron Grisanti, D.C. & Dicken Weatherby, N.D. http://www.FunctionalMedicineUniversity.com Limits of Liability & Disclaimer of Warranty We have designed this book to provide information in regard to the subject matter covered. It is made available with the understanding that the authors are not liable for the misconception or misuse of information provided. The purpose of this book is to educate. It is not meant to be a comprehensive source for the topic covered, and is not intended as a substitute for medical diagnosis or treatment, or intended as a substitute for medical counseling. Information contained in this book should not be construed as a claim or representation that any treatment, process or interpretation mentioned constitutes a cure, palliative, or ameliorative. The information covered is intended to supplement the practitioner’s knowledge of their patient. It should be considered as adjunctive support to other diagnostic medical procedures. This material contains elements protected under International and Federal Copyright laws and treaties. Any unauthorized reprint or use of this material is prohibited Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 1 Copyright © 2008 Sequoia Education Systems, Inc WHAT IS A VIRUS? .................................................................................................................. 2 SOME NOMENCLATURE ............................................................................................................. 3 TREATMENT ............................................................................................................................. 4 Novel Natural Agent............................................................................................................ 4 PRACTICAL APPLICATION: CASE REVIEW .................................................................................... 5 What is a Virus? If you can imagine something thousands times smaller than a bacteria, in fact, so small that a traditional light microscope can not observe it. And if you can imagine that this pathogen has been in debate whether it is alive or not yet has been known to lead to many health challenges such as chronic fatigue syndrome, herpes, then you will know what a virus is. Remember bacteria are stand-alone living entities able to eat, grow and reproduce. On the other hand, viruses only become alive (so to speak) when they insert themselves into living tissues allowing them to reproduce. It is important to understand that viruses contain only DNA or RNA, but not both, which is why they are incapable of growth or reproduction apart from living cells. So they must seek out a host in order to grow and multiply. Once inside the cell, the viral enzymes literally take over the host’s functions and begin making copies of the viral genetic instructions and new viral proteins. The new copies of the viral genetic instructions are packaged inside the new protein coats to make new viruses. Outside of a host cell, viruses cannot function making it dormant and unable to reproduce. For this reason, viruses tread the fine line that separates living things from nonliving things. However, some viruses can remain dormant inside host cells for a long time. Often they are held in check by the immune system until the host is weakened, possibly by an infection, a toxic exposure, a drug. Once the dormant virus is stimulated it can replicate and eventually burst out of the host cell killing the host cell going on to infect other cells causing secondary pathology. Once free from the host cell, the new viruses can attack other cells. Because one virus can reproduce thousands of new viruses, viral infections can spread quickly throughout the body. A virus particle or virion consists of the following: • • • Nucleic acid - a macromolecule composed of chains of monomeric nucleotides that carry genetic information or form structures within cells. The most common nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Coat of protein - Surrounds the DNA or RNA to protect it Lipid membrane - Surrounds the protein coat (found only in some viruses, including influenza; these types of viruses are called enveloped viruses as opposed to naked viruses) Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 2 Copyright © 2008 Sequoia Education Systems, Inc Features of Viruses • • • • • • Small size cannot be viewed with a light microscope pass through filters that retain bacteria Characteristic shapes - spherical (complex), helical, rod or polyhedral, sometimes with tails or envelopes. No built-in metabolic machinery Viruses have no metabolic enzymes and cannot generate their own energy. No ribosomes Viruses cannot synthesize their own proteins. For this they utilize host cell ribosomes during replication. Only one type of nucleic acid Viruses contain either DNA or RNA (never both) as their genetic material. The nucleic acid can be single-stranded or double stranded. Do not grow in size Unlike cells, viruses do not grow in size and mass leading to a division process. Rather viruses grow by separate synthesis and assembly of their components resulting in production of a "crop" of mature viruses. Some Nomenclature Cytomegalovirus (CMV) – A member of the herpes family of viruses, CMV is the virus most often transmitted to a developing child before birth. For most healthy persons who acquire CMV after birth there are usually few symptoms, however some persons experience a mononucleosis-like syndrome with prolonged fever and a mild hepatitis. CMV usually remains dormant unless the person's immune system is suppressed due to drugs or disease. Epstein-Barr virus (EBV) – A member of the herpes family of viruses, EBV infects most people during some point of their lives. When infection occurs during adolescence or young adulthood, it causes infectious mononucleosis 35% to 50% of the time. Symptoms of infectious mononucleosis are fever, sore throat, swollen lymph glands and extreme fatigue. Rarely a swollen spleen or liver involvement may develop; even more rarely heart problems and central nervous system involvement occur. Transmission of EBV requires intimate contact with the saliva of an infected person. Herpes-1 Virus – A member of the herpes family of viruses, Herpes-1 is the virus that causes cold sores. Many people infected with the Herpes-1 virus were infected as children. By the time they're adults only 5% of those infected with Herpes-1 are bothered enough to consider it a medical problem. Herpes-1 can be spread by a social kiss, as a relative would give to a child. Herpes-2 Virus – A member of the herpes family of viruses, Herpes-2 is the virus that causes genital herpes. Herpes-2 is usually spread through sexual contact with an infected person who is shedding Herpes-2 virus at the time. Symptoms include outbreaks of painful sores on the genitals and surrounding areas. Since the Herpes-2 virus is very similar to Herpes-1, there is some reason to believe that prior exposure to Herpes-1 significantly reduces the acquisition of subsequent Herpes-2 infection. Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 3 Copyright © 2008 Sequoia Education Systems, Inc Treatment Removing a virus is extremely difficult. There are many prescription anti-virals on the market but none are 100% effective, and because they usually work on the genetic material of the virus, they have also the potential of being pro-carcinogens years later in the unsuspecting patient. Novel Natural Agent Monolaurin is an anti-viral agent found naturally in breast milk as well as in amniotic fluid and also in some foods like butter and heavy cream, but especially in coconut oil. In studies performed at the United States governments Communicable Diseases Center, CDC, monolaurin has been able to actually dissolve the protective membrane from 14 types of human viruses (Hierholzer). These viruses included measles, flu, herpes simplex, chickenpox, Epstein-Barr Virus, cytomegalovirus virus (a big cause of vascular, brain and heart disease), and SARS-type viruses. Monolaurin actually disintegrates the lipid envelope or membrane of viruses, destroying their main defense. Monolaurin's activity against viruses involves its component lauric acid, binding to the lipidprotein envelope of the virus and inactivating it. By binding to the virus' coat it prevents the virus from uncoating; now it cannot replicate and disseminate its infection throughout the body. Also by dissolving the viral envelope, monolaurin inhibits the virus from binding to host cells (your body) and grabbing on for dear life in preparation for releasing an onslaught of virus into your innocent cells. Hence, two mechanisms result from the disintegration of the viral envelope: the virus cannot attach to cells, and it cannot reproduce, since both mechanisms depend upon an intact virus envelope. Monolaurin 300 mg capsules (Ecological Formulas) are often taken as two capsules three times a day at the first sign of infection and continued for a few days or weeks until the virus is completely gone. (Hierholzer, Ismail-Cassim , Sands, Karbara, Boddie). http://www.lauricidin.com Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 4 Copyright © 2008 Sequoia Education Systems, Inc Practical Application: Case Review The following case represents a patient by the name of Laurie. She initially was seen in my office in June of 2006 suffering with long term symptomology of herpes (Chronic Fatigue) since 1980. Her primary symptoms consisted of fatigue, difficulty concentrating, headache, muscle aches, joint aches, feverishness, and difficulty sleeping. Comments: The above labs reveal a confirmed viral infection. Of interest is the fact that her LDH was outside the normal range of 200 indicating a probable viral infection. Also make note that her SigA was significantly depressed at 6. SigA has a critical role in viral and toxin neutralization. It was imperative to improve her primary immune function in order to achieve a favorable outcome. Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 5 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 6 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 7 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 8 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 9 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 10 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 11 Copyright © 2008 Sequoia Education Systems, Inc Comments: As the above grid reveals, Laurie’s post viral labs do show improvement. Although a small improvement she is moving in the right direction. This is more than she had achieved over the last 10 years. As you will see on her progress questionnaires, she had achieved both subjective and objective improvements. Comments: This progress report clearly shows improvement and a patient who is finally seeing a light at the end of the tunnel. Please make note that she mentions “cost” as a frustration. I must emphasize the fact that cost on some situations “may” be an issue, however, I can tell you first hand that the issue is NOT whether they have to think about it but rather how they will obtain the funds to do the tests. The majority of my patients can not wait to order the necessary labs to identify the underlying cause(s) of their health challenges. It comes down to “you” the clinician “knowing” that the ordering of a lab or labs is going to provide a significant piece of the puzzle to help your patient get well. That is value of mastering the science of FDM. You will be astounded with the clinical outcomes you will achieve not to mention the referrals you be get from satisfied patients. Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 12 Copyright © 2008 Sequoia Education Systems, Inc Functional Medicine Training Program Insider’s Guide – Interpretation of Food Allergy, Sensitivity and Intolerance Page of 13 13 Copyright © 2008 Sequoia Education Systems, Inc