Download raise the production of growth hormone naturally

How to naturally raise your Human Growth Hormone levels
By Dr John Pridgeon
HGH is an anabolic hormone that is produced by the somatotrophic cells in your
anterior pituitary gland, it is a protein containing 196 amino acids. 40% of the anterior
pituitary is composed of somatotrophic cells
It is called “the master hormone” because of its role in the proper functioning of so
many bodily systems
Growth hormone will increase / improve / enhance lean body mass, energy levels and
vitality, hormonal regulation, immune function, sexual performance and libido,
cardiac output, capacity for exercise, skin elasticity, vision, cerebral function, sleep
quality, bone mass, cholesterol profiles and decrease body fat, cellulite, wrinkles,
arthritis and blood pressure
It is the most powerful anti-aging molecule causing almost all of the cells and tissues
of the body to regenerate repair and replicate by positively affecting protein synthesis
During body growth HGH increases the size and number of cells in the body and
helps wi5th cell differentiation, also causing the formation of cells that lay down bone
and cartilage, which function continues well past the time when bones stop
lengthening and linear body growth stops
HGH causes a decrease in the utilisation of protein for energy production and
increases the mobilisation of fat as an energy source, burning fat in preference to
protein and carbohydrates, also increasing glycogen formation
HGH exerts its influence via the production of somatomedins by the liver in response
to HGH secretion by the anterior pituitary, the most important of these is
somatomedin C or Insulin like Growth Factor -1. It is normally released in 4-6 short
bursts per day and is only around for a short period of time before being rapidly taken
up by the liver and other tissues – IGF-1 is then released very slowly buy the liver,
and can be found present in the blood up to 20 hours later
Ultimately the control of the secretion of HGH is performed by a negative feedback
loop that is governed by release of HGRH (meditropin) and GHIH (somatostatin)
Somatopause is the name given to the decline in HGH secretion after the age of 20
years – about 14% per decade of life. The protein in the tissues is replaced with fat
and this gives the appearance of aging, as does decrease in muscle mass and strength,
decrease in organ function and wrinkling of the skin
This may be due to
 a decrease in GHRH and GHRH precursors, because of decreasing supply of
the specific amino acids that make upo this hormone (less HCl in older
stomachs, commonly found in degenerative diseases and increased
consumption of alcohol, carbs, sugar, caffeine and refined foods; high levels
of glucose also reduce GHRH activity, as does stress – cortisol stimulates the
release of somatostatin – and obesity
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an increase of GHIH, stress and trauma may cause this as well as a decrease in
the pituitary’s ability to be stimulated by GHRH, via a decrease in choline and
its precursor alpha glyceryl phosphoryl choline
a decrease of the GHRH receptors in the anterior pituitary
Contrary to modern “wisdom” the aging pituitary is quite capable of producing
adequate levels of growth hormone, causing increased stamina, libido, improved body
composition, tissue healing and the amelioration of the signs and symptoms of aging
Natural methods of improving HGH secretion include
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the use of nutrients to stimulate HGH secretion by the pituitary
appropriate diet to increase HGH output and decrease inhibition by GHIH
appropriate exercise to stimulate HGH secretion
the prevention of inhibitory factors
the provision of the correct precursors
Oral HGH is rendered useless by stomach acids. HGH must be injected
Oral secretogogues will raise HGH levels by stimulating its secretion, but a number of
factors need to be addressed before the pituitary can optimally make and release HGH
1. the pituitary needs to be directly stimulated
2. precursors for HGH manufacture need to make it directly to the pituitary
3. factors that inhibit HGH release need to be managed effectively (fluctuating
sugar levels, adrenal stress and weakness, and stress in general)
HGH injections:
Recombinant DNA technology uses E coli to synthesise HGH. In 1990 Dr Daniel
Rudman showed in a very controversial paper that you could reverse the effects of
aging by replacing HGH by injection. The trial was done on men aged 61-81, doses
were given to bring IGF-1 levels to those of a young man – biological age was
reversed by about 20 years, there was an 8.8% increase in lean body mass, and a fat
loss of 14%, improved BMD and reversed skin and muscle atrophy. Certain side
effects were noted (raised BP, carpal tunnel syndrome, antibody development, joint
pain, insulin resistance, water retention) and these and the terrific cost of this
injections prompted the development of secretogogues, amino acids and botanicals
that stimulated HGH secretion by the pituitary gland.
Substances that naturally raise HGH – the second Generation
secretogoues
Alpha glyceryl phosphoro choline αGPC – specialised AA
1. enhances the receptivity of the cellular membrane of the somatotrophic cells
of the anterior pituitary to GHRH (also to ACTH, FSH / LH, and TSH)
2. boosts HGH by increasing GHRH output
3. decreases somatostatin
4. improves muscular strength and cognitive function
5. lowers homocysteine
GABA – AA that is a neurotransmitter
1. potent stimulator of HGH release
2. improves sleep cycle, calms nervous system
3. stimulates protein synthesesis and release of FFF from adipocyte
Ornithine alpha ketoglucarate OKG – precursor of glutamine and arginine, both
strong HGH secretogogues
1. stimulates secretion and enhances effects of HGH
2. reduces healing time, relieves post exercise muscle stress, improves lining of
GIT
3. immune modulator, increases cytotoxic activity
Branch chain AAs – Valine and Leucine
1. increase HGH output
2. increase protein synthesis, anabolic properties
L-Arginine – 1,200-2,400mg
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HGH secretogogue - inhibits somatostatin
increases response of somatotrophic cells of pituitary to GHRH
works synergistically with lysine
blood vessel dilatation – increases blood flow, lowers BP
improves tissue repair
L-Lysine – 1,200mg
1. works well only in combination with L-Arginine
2. may promote bone growth
3. boosts HGH secretion
L-Glutamine
1. increases secretion of GHRH
2. improve cognition and GIT lining
3. is a primary energy source for immune cells
L-Tyrosine
1. essential for thyroid hormone synthesis
2. also essential for production of dopamine, adrenaline and nor adrenaline
3. improves athletic performance
L-Glycine
1. improves tissue repair, muscle development
2. stimulates HGH secretion
3. essential component of glutathione
Mucuna pruriens
1. richest natural source of L-dopa
2. increases HGH secretion
3. increases libido and boosts testosterone
Mumie (also Moomivo or Shilajoit)
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increases strength
remedies declining mental function
promotes muscle growth anti inflammatory / arthritis
treats allergies by stabilising immune cells
The effectiveness of these seems to be compromised by taking them orally, they lack
an effective delivery system, which has prompted the delivery fo the 3rd Generation
secretogogues. These use a unique delivery system that bypasses the gut and deliver
direct to the pituitary using liposomes – these are made with phopholipids and can
fuse themselves directly to cellular membranes and release their contents directly into
the cell. Targeted liposomal delivery suing a “key” that targets pituitary cell receptors
may increase IGF-1 by 25% with no additional side effects
The ideal secretogogue should
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have a liposomal targeted delivery system
contain nutrients that stimulate the pituitary and supply HGH precursors
be made by a reputable company with a documented success rate
presence of fillers and preservatives
be taken last thing at night, first thing in the morning to mimic natural output
best also one hour before exercise (which is also a strong stimulator of HGH
secretion)
Cycling your course is unnecessary with secretogogues (vs injectable HGH)
Secretogogues may be safely used without increasing any cancer risk, as natural
control mechanisms are not interfered with.
Anyone over 40 should consider using secretogogues, but they are especially useful
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after hysterectomy
in obese or overweight people
people with chronic degenerative disease
post trauma or surgery
NOT if you have active cancer
if taken in conjunction with dietary, exercise and lifestyle changes
Exercise as a way to stimulate HGH secretion:
The higher the intensity, the greater the stimulation. Interval training combines short
15-90 second high intensity (anaerobic) exercise within longer periods of about 300
second lower intensity (aerobic) exercises. Exercising above the lactic acid threshold
(lactic acid is produced faster than it can be cleared) is one of the strongest stimuli for
HGH production. You can lose up to 9 times more fat in half the time it takes people
who do not use the lactic acid threshold to their advantage, even though they did more
than twice the exercise and lost double the calories.
A few caveats are worth considering regarding exercise:
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make sure you are capable of the exercise – have an exam / an ECG etc if you
are not sure your body can take it
overtraining is worse for you than no training
set realistic goals
the lower your glucose levels are during exercise, the greater the HGH spike
produced – at least 3 hours after a meal
take a secretogoue 30 minutes prior to exercise
eat a high protein low carb meal 15-45 minutes after your workout to sustain
the HGH secretion
IGF-1 will remain high for 20 hours following a burst of HGH
interval training of 30-60 minutes 3-5 times a week is ideal
the hormonal shift during exercise is away from storage hormones like insulin,
toward fuel mobilising hormones like HGH
use as many different muscles as possible, upper and lower body together, use
weights for upper body, lift for 4-5 secs and return to neutral while not
releasing completely, keeping muscle tension
Other lifestyle changes that help:
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remove sources of toxicity: limit alcohol, stop smoking
limit stress
reduce high blood sugar levels – low carb, low GI carb diet
improve sleep
supplements and omega 3 fat intake are useful adjuncts – you are tomorrow
what you eat today