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Transcript
Genes and Chromosomes
DNA molecules are the largest
macromolecules in the cells and are
commonly packed into structures called
chromosomes.
A single chromosome may carry thousand
of genes
Together, all of a cell’s gene and intergenic
DNA (DNA between genes) is called
GENOME
Chromosome
Genes
introns – intervening sequences
exons – coding sequences
Eukaryotic chromosomes
Supercoiling of DNA
Plectonemic and solenoidal supercoiling
Nucleosome = histone + DNA
Nucleosomes are packed in 30nm fiber
Loops of 30nm fiber attached to nuclear scaffold