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3.1: The Hierarchy of Structure in Animals pg. 73 Hierarchy – an organizational structure, with more complex or important things at the top and simpler or less important things below it. Tissue – a collection of similar cells that perform a particular, but limited, function. Organ – a structure composed of different tissues working together to perform a complex body function. Organ System – a system of one or more organs and structures that work together to perform a major vital body function such as digestion or reproduction. Complex multicellular organisms are made up of many different types of specialized cells, performing a specific function, working together to support the organism. Single celled organisms, bacteria and blue-green algae, must function on their own, with the cellular organelles maintaining cellular homeostasis. The cells that are apart of the a multicellular organism can not live on their own. Levels of Organization There are 7 kingdoms of organisms, where the Animal Kingdom is only one. The Animals which make up this kingdom range from single celled organism (bacteria) to simple mulitcellular (jellyfish), to more complex (earthworm), to highly complex multicellular animals (humans). The animal itself is based on cells organized in a way that allows them to perform all of life’s functions. This hierarchy has the most complex on top and the least complex at the bottom. Cells working together form tissues (Muscle cells). When different tissues work together they create organs (Heart). When organs work together for a common purpose create organ systems (Circulatory System). The functioning of the whole organism depends on the hierarchy of organization within the animal. Organ Systems The task of organ systems is to perform basic functions, obtain oxygen and nutrients and eliminate wastes. Also sense and respond to their environment, grow and repair damage, and reproduce. Organs Each system is made up of specialized organs, working together to perform the overall function. The digestive system is made up of many organs; stomach, small and large intestine, liver and pancreas. Tissues There are four major types of tissues; epithelial, connective, muscle, and nerve tissues. Each of these types of tissues are found in most organ system. Epithelial Tissue – (epithelium) is a thin sheet of tightly packed cells that covers body surfaces and lines internal organs and body cavities. Connective Tissue – a specialized tissue that provides support and protection for various parts of the body. Muscle Tissue – is a group of specialized tissues containing proteins that can contract and enable the body to move. Nerve Tissue – are specialized tissue that conducts chemical electrical signals from one part of the body to another. Check Your Learning: questions 1 – 6, pg. 76 3.2: Stem Cells and Cellular Differentiation pg. 77 Cellular Differentiation – is the process by which a cell becomes specialized to perform a specific function. Cellular differentiation is instructed by the genetic information (DNA) found in the nucleus of the cell. This information is passed on from the parent to its offspring. (Asexual or Sexual) Stem Cells Stem Cells – an undifferentiated cell that can divide to form specialized cells. Figure 1: In this example, each daughter cell differentiates into two different types of specialized cells: a nerve cell and a skin cell. Stem cells can divide into 2 daughter cells through the process of mitosis and cytokinesis. The 2 new daughter cells can differentiate into different types of cells, depending on which part of the DNA instructs the cell. There are 2 types of stem cells, embryonic and tissue stem cells. Embryonic stem cells can differentiate into any type of cells, while tissue stem cells can specialize within specialized tissues, bone morrow produces, red blood cells, white blood cells, and platelets. Cord Blood Cell Banking Blood found in the umbilical cord immediately following birth is a rich source of stem cells. These cells are collected and stored in case it is needed later in the child’s life. (Cancer – leukemia) Tissue Stem Cell Transplantation Cord blood and Tissue stem cells are easily isolated. Bothe can be used to treat diseases. Chemotherapy is used to kill all white blood cells and bone marrow. Health stems are used to replace the bone morrow cells and regenerate health blood cells Regeneration and Tissue Engineering Regeneration refers to the ability or tissue to repair itself. Skin, muscle and bone can re-grow and heal injured tissues. But not all cells are capable of regeneration, nerve cells. Check Your Learning, questions 1 – 7, pg. 79 3.3: The Digestive System pg. 80 Digestive System – the organ system that is made up of the mouth, esophagus, stomach, intestines, liver, pancreas, and gall bladder, the system that takes in, breaks up, and digests food and then excretes wastes. The four components of the digestive system are: Ingestion, Digestion, Absorption, and Elimination. There are two types of digestion: Mechanical Digestion and Chemical (enzyme) Digestion The digestive system is made up of the digestive tract and the accessory organs. The Digestive Tract The digestive tract is a long tube, with two openings at either end, with a series of organs, in which the food must pass through. Some organism digestive tract may be simple, earthworm, or more complex, human. The Human digestive tract is made up of many organs lined with epithelial tissue. There are also Goblet cells that secrete mucus, which protects the tract from digestive enzymes and allows the food to slide through the tract. Nerve and Muscle tissue also support the digestive tract. Vomiting and diarrhea are special occurrences that the system uses to rid itself of bacteria producing toxins, very rapidly. Figure 1: In a human, the breakdown of food starts in the mouth and continues until nutrient absorption occurs in the small intestine. The Mouth (Ingestion & Digestion) The mouth is the entry point for food, and is where digestion, mechanical – chewing and chemical – amylase enzyme, starts. Saliva is secreted in the mouth which contains the enzymes and lubricates the food. The Esophagus This is a muscular tube, responsible for transporting the food from the mouth to the stomach. This is done through rhythmic contractions called peristalsis. This is controlled through the nerve tissue. The Stomach (Digestion) The main function of the stomach is to hold food, churn (mechanical) it and release an enzyme use for protein digestion. Hydrochloric acid is released, with a goal to kill and microbes found in the food. Muscle and nerve tissues are important here. The Intestine (Small and Large) (Digestion & Absorption) The lining of the intestine secrete mucus and has a high concentration of blood vessels. The Small intestines are roughly 6 to 7 m long and 2.3 cm in diameter. Most of the digestion occurs here, and absorption of nutrients into the circulatory system. The Large intestines are roughly 1.5 m long and 7.5 cm in diameter. Here waste materials are stored and water and vitamins are absorbed. The waste products are released into the environment. (Elimination) Accessory Organs The Liver, Gall Bladder and Pancreas are organs involved in the digestive system, but food does not pass through them, they secrete enzymes into the digestive tract. The Liver produces bile which is stored in the Gall Bladder. The bile is used to emulsify fats. The Pancreas secretes many different enzymes to breakdown food molecules, but most importantly it secretes Insulin, which controls blood sugar levels and controls Diabetes. 3.4: The Circulatory System pg. 83 Circulatory System – the organ system that is made up of the heart, the blood, and the blood vessels; the system that transports oxygen and nutrients throughout the body and carries away wastes. The five components of the Circulatory System; Pump, Vessels, Transport Medium, Exchange Area, and Valves. The function of the Circulatory System is to transport substances around the body, such as; oxygen from the lungs and nutrients from the small intestines, and carry wastes to lungs and kidneys. The Circulatory System is also responsible for maintaining homeostasis, such as; body temperature, and fight diseases. Figure 1: The circulatory system connects all parts of the body. In this diagram, the oxygenated blood is shown in red. The deoxygenate blood is shown in blue. Parts of the Circulatory System Blood (Transport Medium) Blood is connective tissue that circulates throughout. There are four components that make up blood; a) Red Blood Cells – the greatest percentage, 45% of the blood’s volume. Contains a protein called hemoglobin, which increase the oxygen carrying capacity by 70%. Hemoglobin mixed with oxygen causes your blood to turn red. b) White Blood Cells – are infection fighting cells (Immune response), which recognize and destroy bacteria and viruses. These cells make up less than1% of your blood volume. c) Platelets – are tiny cells responsible for blood clotting. These cells make up less than 1% of your blood volume d) Plasma – is a protein rich liquid that carries the blood cells. This fluid makes up 55% of your blood volume. The Heart (Pump) There three types of tissue which make up the heart; cardiac muscle tissue, nerve tissue, and connective tissue. Cardiac muscle tissue is found only in the heart and is capable of synchronized contractions and can conduct nerve impulses. The heart’s rate of contraction at rest is usually 60 beats per minute and increases depending on your physical activity, stress, temperature, time of day, and when you have eaten. Blood volume is 5 L, which passes through your heart every minute. The heart has four chambers, Left/Right Atrium, and Left/Right Ventricle. Blood is pumped into two different pathways: the Systemic system and the Pulmonary System. The heart has valves to maintain one way directional blood flow. Blood Vessels (Vessels, Valves, and Exchange Area) There are three types of blood vessels: Arteries – carry blood away from the heart. Aorta carries blood to the Systemic System and your body tissues. The Pulmonary Arteries carries blood to the Lungs. Veins – carry blood to your heart. Vena Cava delivers blood to the Right Atrium from the Systemic System, while the Pulmonary Veins deliver blood to the Left Atrium. Veins also contain valves to maintain one way directional flow of blood. Capillaries (Exchange Area) – Capillaries link the arteries and veins together. This is also the area for nutrient and waste exchange between the cell tissues and blood vessels. Every part of your body is supplied with blood through a network of capillaries. Diseases and Disorders of the Circulatory System Coronary Artery Disease - Heart Attack Check Your Learning: questions 1 – 9, pg. 87 pg. 85 3.5: The Respiratory System pg. 91 You take a breath fifteen times within a minute. Your breathing rate is controlled automatically, when you begin to exercise, your breathing rate increases. The respiratory system is responsible for gas exchange. Oxygen is taken in, while carbon dioxide is released as a waste gas from cellular respiration. Glucose + Oxygen → Water + Carbon dioxide + ATP The circulatory system works with the respiratory system and carries the gases to and from the body tissues. Structural Features There are three components of a gas exchange system; A moist and thin membrane A sufficient size gas exchange area A transport system The structures responsible for gas exchange are the lungs and other organs that connect them to the outer environment. The path in which oxygen will follow to enter your body is, mouth or nose, pharynx, trachea, bronchi, bronchioles, and alveoli. The trachea is lined with epithelial cells, which are responsible for trapping foreign particles from entering your lungs. These cells will secrete mucus which traps the particles and have cilia (hair like projections) which sweep the particles up and out of the windpipe. The trachea is supported by cartilage rings, which keeps the trachea open at all times. Figure 2: (a) the human respiratory system, (b) Epithelial cells with cilia. Gas Exchange Alveolus (Alveoli – plural) is a tiny sac of air in the lungs that is surrounded by a network of capillaries; where gas exchange takes place between air and blood. The main purpose of the respiratory system is gas exchange. Oxygen reaches the Alveoli sacs, which are surrounded by capillaries. Here oxygen diffuses from the alveoli into the capillaries. At the same time carbon dioxide diffuses from the capillaries into the alveoli, to be transported out of the body. Figure 3: (a) Each alveolus is surrounded by a capillary network to ensure a good blood supply. (b) the alveoli provide a huge surface area in the lungs across which oxygen and carbon dioxide can diffuse. Concentration gradients are responsible for this continuous movement of gases. The Alveoli always has a high concentration of oxygen, while the blood has a low concentration. It is vice versa, for carbon dioxide, produced in the cells traveling back to the lungs. Breathing Breathing is made up of inhalation and exhalation. Inhalation – the taking air into the lungs Exhalation – releasing air out of the lungs These processes are controlled by the diaphragm and intercostals muscles of the ribs. When you inhale, the diaphragm contracts and the ribs move up and outward, which increases the chest cavity volume and drops air pressure. Air enters the lungs. When you exhale, the diaphragm relaxes, along with your ribs, the cheat cavity volume decreases, pressure increase and air moves out of your lungs. Breathing is involuntary, we do not think about breathing, it just occurs. You can hold your breath but not indefinitely. Your brain will override our will, and cause you to breathe. Your brain detects the carbon dioxide concentration in your blood. If it is high, the brain will cause you to breathe faster. The Respiratory System in Other Animals The role of all respiratory systems is to gas exchange, deliver oxygen to the circulatory system and to all the body cells, and remove carbon dioxide. All respiratory systems do this through the process of diffusion. The Fish Fish have gills which is their gas exchange system. Water passes over the gills and oxygen is diffused out of the water into the capillaries found in the gills. Carbon dioxide diffuses from the gills into the water. Water passes over the gills when fish uses their mouths to create water flow over the gills. Figure 5: Fish ensure a constant flow of water over their gills by opening and closing their mouths or by swimming. Diseases of the Respiratory System (Symptoms??) Tuberculosis – is an infectious disease, which means that it is easily passed between people. Bacteria can enter your lungs and begins to grow. This disease can be fatal if untreated. It is easily diagnosed by having a chest x-ray. Cancers – Cause by first and second hand smoking. The smoke contains carcinogens, causing lung, mouth, esophagus, pancreas, and bladder cancer. SARS – Severe Acute Respiratory Syndrome, caused by a virus. Check Your Learning, questions 1 – 6, pg. 95 3.7: Organ Transplantation pg. 96 Tissue transplants have been performed since the early 1800’s. The first organ transplant occurred in 1954, a kidney was transplanted between identical twins. Science and technology has advanced very quickly, now successful organ transplants include the heart, live, lung, pancreas, and intestines, and tissue transplants include cornea, skin, bone, bone marrow, tendons, and blood vessels. Organs and tissues can come from living donors, and some other body parts are taken from deceased donors. Benefits and Risks Both the recipient and donor may benefit from the transplant. First the recipient has their life extended, with the ability to live normally and healthy. For the donor it is the satisfaction of saving someone. The medical researchers benefit also, they gain knowledge which eventually helps society. With every type of transplant surgery, there are risks; rejection of the organ, and infection. Usually the recipient’s immune system is suppressed to increase the acceptance of the organ. The donor may also become ill after the operation. Figure 1: Many Tissues and Organs can be transplanted. Living Donor Organs Living donor organs come from living individuals who choose to donate a kidney, a lobe of their lung, part of a liver. Lung donations require two donors, portion of a right and left lung. Only one person is required to donate a kidney, the door has two and can live with one kidney. The Liver transplant is special. A lobe of a liver from the donor is transplanted, and can regenerate and grow, by forming new tissue, in both the donor and recipient. Most donors are usually living relatives of the recipient. This increases the chance of success, decreasing rejection probability, and decreases waiting time. Deceased Donor Organs The majority of organs for transplantation come from deceased individuals. This decision to donate organs is usually done while the individual is alive, driver’s license or organ donor cards. Your family can also donate your organs after death if they so choose. Xeno-transplantation Is the transplanting of body parts from one specie to another species. eg. Heart valves from pigs, chemically treated, but rejection is still a big issue.