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I N T ROD UC I N G Lyc-O-ProTM Discover how years of clinical research on our ingredients lead to the development of our once a-day supplement blend. Our standardized men’s health-grade tomato extract, curcumin, zinc, and omega-3s blend: Promotes prostate health and comfort* Maintains healthy zinc levels in prostate tissue* Supports hormonal balance as we age* Supports healthy prostate cell growth Who Should Take Lyc-O-ProTM ? Our blend of standardized tomato extract, curcumin, zinc, and omega-3s is the result of years of research, pre-clinical, and clinical trials.* • Continue to support their overall prostate health and comfort* • Increase their zinc levels* • Support their hormone levels* Wellness You Can Feel. The bioactive ingredients in Lycored Lyc-O-ProTM successfully target and address key issues middle-aged men frequently face with urinary function and overall prostate health.* Men’s Health-Grade Tomato Extract: Our whole-food extract contains five potent phytonutrients that have been optimized at levels to encourage healthy prostate function.* This formula includes our standardized, bioavailable lycopene.* Zinc: This mineral has been found in high concentrations in healthy prostate tissue.* Curcumin: Our standardized complex of turmeric-derived curcumin and its demethoxy derivatives has been shown to support prostate health.* It’s also highly synergistic with our standardized lycopene for even greater support.* Black Pepper: Piperine is known to enhance the bioavailability of curcumin.* Omega-3s: These EPA and DHA essential fatty acids are known to have a protective effect on prostate cells.* Vitamin E: Our vitamin blend includes natural d-alpha tocopherol. Our Commitment To You At Lycored, we believe that by combining natural nutrition, rigorous clinical testing, and patent-protected processes and ingredients we can offer real solutions supported by real science. Lyc-O-ProTM Takeaways Combines curcumin and piperine to ensure optimal absorption* Once-a-day serving packaged in bioavailable capsule promises long-term compliance Proven synergy betweem the ingredients Standardized ingredients blended at effcacious levels* Formulated using generally recognized as safe (GRAS) ingredients Combines our patent-protected carotenoid extract with mineral, essential fatty acid, tocopherol, and phytonutrient ingredients for proven effectiveness* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases. Earth-Made Ingredients. Science-Driven Results. We did extensive investigations into publicly available data and conducted a number of trials to develop the proprietary blend found in Lycored Lyc-O-ProTM. This analysis and research effort included epidemiological results, in-vitro mechanism-of-action studies, and formulation-specific studies. Prostate Health and Comfort Studies Supplementation decreases PSA concentration1 Baseline 7.0 6 month Serum PSA (µg/L) BPH is a common condition in older men causing very disturbing symptoms. Inflammation, oxidative stress as well as androgenic activity in the prostate have been found to play a key role in the etiology of BPH, Eventually leading to increased cell proliferation. Enlarged prostate is associated with urinary tract symptoms The benefit of lycopene on PSA levels and prostate gland enlargement 1 A six-month double-blind, randomized, placebo-controlled study on men with benign prostate hyperplasia (BPH) measured PSA levels (a well known clinical marker for determining the risk of prostate-related conditions) and prostate gland size. Over the course of six months, men taking a tomato lycopene supplement blend experienced a reduction in PSA levels and better control of prostate gland size. 6.0 5.0 4.0 Placebo Lycopene Reduction in PSA levels is following tomato lycopene supplementation in men with BPK1 1. Schwartz, S. et al., 2008. Lycopene Inhibits Disease Progression in Patients with Benign Prostate Hyperplasia. J Nutr. 138(1): 49-53. Ingredient Studies The effects of our proprietary tomato extract and omega-3 on modulating prostate gene expression2 A double-blind, randomized placebo-controlled study tested the effect of tomato extract and omega-3s on gene expression. Results found that the ingredients modulated two important regulatory pathways in prostate: • Antioxidant defense mechanism (Nrf2) • Androgen metabolism pathway How our combined ingredients effect activate the antioxidant defense mechanism A recent study demonstrated a synergistic activation of the antioxidant defense mechanism in prostate cells by a combination of our ingredients: curcumin lycopene and vitamin-E5. Activation of this transcription system is indicative of prostate health. Our ingredients synergistically activate the antioxidant defense mechanism of prostate cells5 Triple combination 500 ARE reporter activity (Fold induction) How our combined ingredients inhibit cell and prostate growth An in-vitro study using a combination of lycopene and vitamin E showed that the combination inhibited prostate cell proliferation3 An animal study combining lycopene and vitamin E showed that the combination suppressed orthotopic growth of prostate tumors by 73%.4 400 300 200 100 0 Vitamin E: Curcumin: Tomato Extract: Double combination Effective Synergy Single ingredients + + + + + + + + + + + + Activation of antioxidant response element (ARE) in prostate cells 2. Magbanua, MJM. et al., Gene Expression and Biological Pathways in Tissue of Men with Prostate Cancer in a Randomized Clinical Trial of Lycopene and Fish Oil Supplementation. PLoS ONE. 6(9): e24004. 3. Pastori, M. et al., 1998. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells, Biochem Biophys Res Commun . 250: 582-5. 4. Limpens, J. et al., 2006. Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice. J Nutr.136(5): 1287-1293. 5. Linnewiel-Hermoni, K. et al 2015. The anti-cancer effects of carotenoids and other phytonutrients residues in their combined activity. Archives of Biochemistry and Biophysics 572, 28–35 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases. To learn more about Lyc-O-ProTM and our entire range of products email info@lycored or call 844-668-2483. 377 Crane Street, Orange, NJ, 07050 www.Lycored.com Supplement Facts Suggested Use: As a dietary supplement. Take one soft gel daily, preferably with a meal. Supplement Facts Serving Size: 1 soft gel Servings per container: 30 Amount Per Serving % Daily Value Vitamin E (as d-alpha-tocopherol) 22.4 IU Zinc (as zinc oxide) 15 mg 75% 100% Standardized Tomato Extract 225 mg EPA (Eicosapentaenoic Acid) 90 mg DHA (Docosahexaenoic Acid) 60 mg Piperine 5 mg (from Black Pepper Fruit Extract) Curcuminoids 50 mg (from Turmeric Rhizome Extract) † † † † † Other Ingredients: Gelatin, Glycerin, Purified Water, Caramel Color, Annatto Extract Color Contains:Fish Contains No: Peanuts, Tree Nuts, Shellfish, Eggs, Milk, Wheat, Soy