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Transcript
Tumor Immunology
and Immunotherapy
Edited by
Robert C. Rees
Director and Professor of Tumor Biology
The John van Geest Cancer Research Centre
Nottingham Trent University
Nottingham, UK
1
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Contents
Abbreviations xvii
Contributor List xxi
1
Adaptive T-cell immunity and tumor antigen recognition 1
Pedro Romero and Pierre G Coulie
2
Impact of ageing and body mass on cancer immunotherapy outcomes 15
Gail D Sckisel, Arta M Monjazeb, Annie Mirsoian, Anthony E Zamora,
Steven Grossenbacher, and William J Murphy
3
The potential of natural killer cells in cancer immunotherapy 31
Thomas CC Tan, Jean-Marc Doisne, and Francesco Colucci
4
The tumor microenvironment: The role of tumor-associated macrophages
in cancer progression and responses to therapy 43
Russell Hughes and Munitta Muthana
5
‘Hard’ and ‘soft’ loss of MHC class I expression in cancer cells 63
Natalia Aptsiauri, Angel M. Garcia-Lora, and Federico Garrido
6
Modulation of the adaptive immune system through chronic inflammation
and T-regulatory responses 79
Angus G Dalgleish
7
Myeloid-derived suppressor cells: Immune-suppressive cells
that facilitate tumor progression and promote and deter cancer-associated
inflammation 95
Pratima Sinha, Virginia Clements, Meghan Burke, Catherine Fenselau,
and Suzanne Ostrand-Rosenberg
8
Triggering death receptors to promote cancer cell death 113
Thomas J Sayers and Neil A Cross
9
Identification of tumor antigens for clinical evaluation 127
Jayakumar Vadakekolathu, Amanda K Miles, David J Boocock,
and Stephanie EB McArdle
10
Viral antigens as targets for prophylactic and therapeutic intervention
in cancer 141
Peter L Stern and Kenneth Oguejiofor
11
HER2/neu as a target for vaccine and antibody-directed therapies 155
Constantin N Baxevanis and Sonia A Perez
12
Pre-clinical evaluation of immunotherapy: The case for prostate cancer
and the TRAMP model 173
Matteo Bellone, Sara Martina Parigi, and Elena Jachetti
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xiv
C ontents
13
Tumor-associated antigens characterized in a conceptual framework
of biology, microenvironment, and therapy 189
Per thor Straten, David Schrama, Jürgen C Becker, and Mads Hald Andersen
14
Predictive biomarkers to better select patients for cancer immunotherapy 203
Marius Strioga and Eric Tartour
15
Viral platforms for expression of tumor antigens in cancer
immunotherapy 217
Karishma Rajani, Vanesa Alonso-Camino, Nicolas Boisgerault,
and Richard Vile
16
Translating research into clinical practice: lessons from the immunology
and immunotherapy of haemopoietic malignancies 235
Paul Moss
17
DNA vaccines 251
Lindy G Durrant, Wei Xue, Lee R Machado, Rachael L Metheringham,
and Victoria A Brentville
18
Programming the immune system through childhood infections: MUC1
tumor-associated antigen (TAA) as a disease-associated antigen (DAA) 265
Uzoma K Iheagwara, Pamela L Beatty, Bianca Su-Wan Chan, Lora H Rigatti,
Ted Ross, and Olivera J Finn
19
Vaccination against myeloid leukaemias using newly defined antigens 281
Susanne Hofmann, Ghazala Khan, Viktoriya Boncheva, Jochen Greiner,
and Barbara-ann Guinn
20
Immune-checkpoint blockade in cancer immunotherapy 295
Patrick A Ott and F Stephen Hodi
21
Multi-peptide cancer vaccines for clinical application 309
Harpreet Singh-Jasuja, Toni Weinschenk, and Steffen Walter
22
Adoptive T-cell therapy using TILs for the treatment of metastatic
melanoma 327
Marco Donia, Eva Ellebæk, and Inge Marie Svane
23
Chimeric antigen receptor gene therapy in cancer 343
John S Bridgeman and David E Gilham
24
The vaccinal effect of monoclonal antibodies in cancer therapy 357
Claire Deligne, Sophie Sibéril, and Jean-Luc Teillaud
25
Antibody therapies: defining appropriate cell surface epitopes for targeting
tumors 373
Gabriele Multhoff and Michael Stanglmaier
26
Adoptive lymphocyte (stem cell) therapy in cancer 387
Sophie Derniame and Aurore Saudemont
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Contents
xv
27
Cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT):
Tumor cell plasticity challenges immunotherapy 401
Tarik Regad and Morgan G Mathieu
28
Immune escape and ageing of the immune system compromises the immune
response to tumor antigens 415
Ludmila Müller and Graham Pawelec
Index 433
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