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Tumor Immunology and Immunotherapy Edited by Robert C. Rees Director and Professor of Tumor Biology The John van Geest Cancer Research Centre Nottingham Trent University Nottingham, UK 1 9780199676866-Rees.indb 3 08/05/14 7:11 PM Contents Abbreviations xvii Contributor List xxi 1 Adaptive T-cell immunity and tumor antigen recognition 1 Pedro Romero and Pierre G Coulie 2 Impact of ageing and body mass on cancer immunotherapy outcomes 15 Gail D Sckisel, Arta M Monjazeb, Annie Mirsoian, Anthony E Zamora, Steven Grossenbacher, and William J Murphy 3 The potential of natural killer cells in cancer immunotherapy 31 Thomas CC Tan, Jean-Marc Doisne, and Francesco Colucci 4 The tumor microenvironment: The role of tumor-associated macrophages in cancer progression and responses to therapy 43 Russell Hughes and Munitta Muthana 5 ‘Hard’ and ‘soft’ loss of MHC class I expression in cancer cells 63 Natalia Aptsiauri, Angel M. Garcia-Lora, and Federico Garrido 6 Modulation of the adaptive immune system through chronic inflammation and T-regulatory responses 79 Angus G Dalgleish 7 Myeloid-derived suppressor cells: Immune-suppressive cells that facilitate tumor progression and promote and deter cancer-associated inflammation 95 Pratima Sinha, Virginia Clements, Meghan Burke, Catherine Fenselau, and Suzanne Ostrand-Rosenberg 8 Triggering death receptors to promote cancer cell death 113 Thomas J Sayers and Neil A Cross 9 Identification of tumor antigens for clinical evaluation 127 Jayakumar Vadakekolathu, Amanda K Miles, David J Boocock, and Stephanie EB McArdle 10 Viral antigens as targets for prophylactic and therapeutic intervention in cancer 141 Peter L Stern and Kenneth Oguejiofor 11 HER2/neu as a target for vaccine and antibody-directed therapies 155 Constantin N Baxevanis and Sonia A Perez 12 Pre-clinical evaluation of immunotherapy: The case for prostate cancer and the TRAMP model 173 Matteo Bellone, Sara Martina Parigi, and Elena Jachetti 9780199676866-Rees.indb 13 08/05/14 7:11 PM xiv C ontents 13 Tumor-associated antigens characterized in a conceptual framework of biology, microenvironment, and therapy 189 Per thor Straten, David Schrama, Jürgen C Becker, and Mads Hald Andersen 14 Predictive biomarkers to better select patients for cancer immunotherapy 203 Marius Strioga and Eric Tartour 15 Viral platforms for expression of tumor antigens in cancer immunotherapy 217 Karishma Rajani, Vanesa Alonso-Camino, Nicolas Boisgerault, and Richard Vile 16 Translating research into clinical practice: lessons from the immunology and immunotherapy of haemopoietic malignancies 235 Paul Moss 17 DNA vaccines 251 Lindy G Durrant, Wei Xue, Lee R Machado, Rachael L Metheringham, and Victoria A Brentville 18 Programming the immune system through childhood infections: MUC1 tumor-associated antigen (TAA) as a disease-associated antigen (DAA) 265 Uzoma K Iheagwara, Pamela L Beatty, Bianca Su-Wan Chan, Lora H Rigatti, Ted Ross, and Olivera J Finn 19 Vaccination against myeloid leukaemias using newly defined antigens 281 Susanne Hofmann, Ghazala Khan, Viktoriya Boncheva, Jochen Greiner, and Barbara-ann Guinn 20 Immune-checkpoint blockade in cancer immunotherapy 295 Patrick A Ott and F Stephen Hodi 21 Multi-peptide cancer vaccines for clinical application 309 Harpreet Singh-Jasuja, Toni Weinschenk, and Steffen Walter 22 Adoptive T-cell therapy using TILs for the treatment of metastatic melanoma 327 Marco Donia, Eva Ellebæk, and Inge Marie Svane 23 Chimeric antigen receptor gene therapy in cancer 343 John S Bridgeman and David E Gilham 24 The vaccinal effect of monoclonal antibodies in cancer therapy 357 Claire Deligne, Sophie Sibéril, and Jean-Luc Teillaud 25 Antibody therapies: defining appropriate cell surface epitopes for targeting tumors 373 Gabriele Multhoff and Michael Stanglmaier 26 Adoptive lymphocyte (stem cell) therapy in cancer 387 Sophie Derniame and Aurore Saudemont 9780199676866-Rees.indb 14 08/05/14 7:11 PM Contents xv 27 Cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT): Tumor cell plasticity challenges immunotherapy 401 Tarik Regad and Morgan G Mathieu 28 Immune escape and ageing of the immune system compromises the immune response to tumor antigens 415 Ludmila Müller and Graham Pawelec Index 433 9780199676866-Rees.indb 15 08/05/14 7:11 PM