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HER2-positive breast cancer Breast cancer is the most common cancer among women worldwide More than 460,000 women will be diagnosed with the disease in Europe each year1 137 France UK 129 Germany 122 Italy 118 Spain 85 25 50 75 100 125 150 Figures show number diagnosed per 100,000 people Every 20 seconds a woman is diagnosed with breast cancer2 HER2-positive breast cancer is an aggressive type of the disease3 Around one in five women will have HER2-positive disease4 HER2 is a receptor found on the surface of all cells The binding of growth factors to the HER2 receptor triggers a signalling pathway Cell membrane Site binding Signals sent to cell nucleus HER2 is like a transmitter, sending messages or ‘signals’ into the cell, telling it to survive and multiply HER2 overexpression on the surface of a HER2-positive cancer cell sends more signals causing cells to grow and divide more rapidly HER2 signalling In HER2-positive breast cancer, there are too many HER2 receptors on the surface of cancerous cells References: 1. Ferlay J, et al. Eur J Cancer 2013;49(6):1374-403. 2. Ferlay J, et al. [Online]. Available from: http://globocan.iarc.fr [Accessed 12 September 2014]. 3. Slamon D, et al. N Engl J Med 2001;344(11):783-92. 4. Wolff AC, et al. J Clin Oncol 2013;31(31):3997-4013. HER2-positive cancer cell