Download Analysis of a cells shows that TK2 is phosphorylated. Is the signal

Analysis of a cells shows that TK2 is phosphorylated.
Is the signal present?
1. Yes
2. No
3. Maybe
The self renewal signaling pathway in a particular stem cell type has an
additional kinase, TK3 that targetsTK1.
How would TK3 change the behavior of the pathway?
1. It would become a temporary circuit, and shut off even when signal is still
present.
2. It would become a permanent circuit, and stay on even when signal is absent.
3. It would not change.
The self renewal signaling pathway in a particular stem cell type has an additional kinase,
TK3 that targetsTK1.
How would TK3 change the behavior of the pathway change?
1. It would become a temporary circuit, and shut off even when signal is still present.
2. It would become a permanent circuit, and stay on even when signal is absent.
3. It would not change.
Which of the following could produce a functional, but temporary signal transduction
pathway?
pick all that apply
1.
2.
3.
4.
5.
TK1 activates a phosphatase that targets TFa
The receptor activates a phosphatase that targets TK2
TK2 activates a phosphatase that targets TK1
TFa activates a gene that encodes a phosphatase that targets the receptor
TK2 targets TK1
Which of the following would produce a functional, but temporary signal transduction
pathway that shuts the pathway off the most quickly?
1. TFa activates a gene that encodes a phosphatase that targets the receptor.
2. TFa activates a gene that encodes a phosphatase that targets TK2.
3. TFa activates a gene that encodes a phosphatase that targets TFa.
You perform an analysis of a stem cell and obtain the following results:
Present?
P04?
Signal
Receptor
TK1
TK2
TFa
Genes
present
present
present
present
present
yes
--Yes
Yes
No
No
Expressed
Which of the following could explain these results? (pick all that apply)
1. Receptor mediated endocytosis
2. Ubiquitin-mediated proteolysis
3. Phosphatase activity
4. Kinase activity
A differentiation signaling pathway can block the activity of the self renewal pathway.
If the self renewal pathway is a receptor kinase cascade, which of the following could
block its function?
Pick all that apply
1. Triggering endocytosis of the self-renewal receptor.
2. Activation of kinases in the differentiation pathway that target kinases in the self
renewal pathway.
3. Activation of phosphatases that target kinases in the differentiation pathway.
4. Inhibition of phosphatases that target the kinases in the self renewal.
A signaling pathway activates the firefly genes that makes the cells glow.
Which of the following would generate cells that flash on and off even though signal was
constantly present?
1.
TFa causes expression of a phosphatase gene that targets TK2.
2.
Phosphorylated TK2 activates receptor mediated endocytosis.
Phosphorylated TK2 activates a phosphatase that targets TFa