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PHARMACOLOGY II TUTORING: DRUGS OF ABUSE & ALCOHOL Brandy Hollums [email protected] WHAT IS ADDICTION? • A. Physical Dependence • B. Psychological Dependence WHICH IS A FACTOR THAT INFLUENCES ADDICTION? • A. Agent • B. Host • C. Environment • D. All of the above WHICH SYSTEM IS STILL DEVELOPING IN ADOLESCENTS AND WILL STOP WORKING IN ADDICTS? • A. Striatum • B. Nucleus Accumbens • C. Frontal Cortex • D. Hippocampus WHICH OF THE FOLLOWING IS AN EXAMPLE OF ACUTE TOLERANCE? • A. JH who can naturally drink more than all of his buddies. • B. MJ who likes to binge drink on the weekends. • C. CK who drink 8 to 10 drink daily and has learned to walk a straight line. WHAT IS THE COMPONENT OF THC THAT GETS YOU HIGH? • A. delta-8 THC • B. cannabidiol • C. cannabigerol • D. delta-9 THC WHICH ROUTE OF ADMINISTRATION GIVES THE LONGEST HIGH FOR MARIJUANA? • A. Oral • B. Smoke • C. IV WHICH IS NOT PART OF THE EARLY STAGES OF THE MARIJUANA HIGH? • A. Euphoria • B. Depersonalization • C. Relaxations • D. Uncontrollable laughter WHICH IS AN EFFECT OF CHRONIC MARIJUANA USE? • A. Sharper imagery • B. Bronchodilation • C. Decreased prolactin levels • D. Decreased REM sleep WHAT IS THE MOA FOR THC? • A. g-protein coupled CB-1 and CB-2 receptors • B. g-protein coupled CB-1 receptors • C. Ca channel receptors • D. Na channel receptors WHICH IS NOT TRUE ANANDAMIDE? • A. Endogenous substance that activate CB-1 and CB-2 • B. lipid neurotransmitter • C. synthesized from arachidonic acid • D. synthesized from aminoacids WHICH REGION OF THE BRAIN IS RESPONSIBLE FOR MOTOR FUNCTION? • A. Cerebellum • B. Basal ganglia • C. Hippocampus • D. Nucleus accumbens WHICH IS THE MOST POTENT METABOLITE OF THC? • A. 8-hydroxy-delta-THC • B. 8, 11-dihydroxy-delta-THC • C. 11 nor-delta-THC-9 carboxylic acid • D. 11-hydroxy-delta-THC WHAT ARE THE APPROVED USES FOR MEDICAL MARIJUANA? • A. Antiemetic • B. MS • C. Seizures • D. AIDS wasting WHICH INHALANT IS USED PRIMARILY AS A SEXUAL ENHANCER? • A.Volatile solvents • B. Aerosols • C. Nitrites • D. Nitrous oxide KNOW THE ACUTE, HEAVY, AND COMPULSIVE EFFECTS OF INHALANTS. WHAT IS THE MOA OF LSD? • A. ligand-gated ion channel agonist • B. 5-HT2 partial agonist • C. g-coupled CB-1/CB-2 receptors • D. NMDA receptor antagonist HOW CAN YOU TREAT AN ACUTE BAD TRIP FROM LSD? • A. Propranolol • B. Diazepam • C. Supportive care only • D. more LSD WHICH DRUG CAN CAUSE COLOR PERCEPTION ABNORMALITIES? • A. Psilocybin • B. Salvia divinorum • C. Phencyclidine • D. MDMA WHICH DRUG CAN ACTS ON KAPPA RECEPTORS? • A. Psilocybin • B. Salvia divinorum • C. Phencyclidine • D. MDMA WHICH DRUG IS SIMILAR TO KETAMINE AND ACTS AS AN NMDA ANTAGONIST? • A. Psilocybin • B. Salvia divinorum • C. Phencyclidine • D. MDMA JH OVERDOSED ON PHENCYCLIDINE. WHAT IS AN APPROPRIATE THERAPY? • A. Alkalize urine • B. Dialysis • C. Gastric Lavage • D. Supportive care only WHICH DRUG DECREASES THE NUMBER OF SEROTONIN TRANSPORTERS? • A. MDMA • B. PCP • C. LSD • D. THC WHAT IS POPULAR OTC MEDICINE TEENS ABUSE THAT IS A DISSOCIATIVE ANESTHETIC AT HIGH DOSES? • A. Dimenhydrinate • B. Dextromethorphan • C. Loperamide • D. Pseudophedrine ALCOHOL • T/F: Alcohol has medicinal uses. • T/F: Alcohol shouldn’t be used because it can harm you. • T/F: Excessive alcohol isn’t harmful if you don’t drink and drive. WHICH OF THE FOLLOWING IS FALSE ABOUT ETHANOL? • A. Affects multiple organ systems • B. CNS stimulant • C. Effects are complex and poorly understood • D. Causes fetal alcohol syndrome WHERE IS THE ALCOHOL ABSORBED MOST RAPIDLY? • A. large intestine • B. small intestine • C. stomach • D. bladder Remember: alcohol crosses by PASSIVE DIFFUSION! WHAT IS THE RATE LIMITING STEP OF ETHANOL OXIDATION? • A. alcohol dehydrogenase • B. aldehyde dehydrogenase WHICH RECEPTOR DOES ETHANOL ENHANCE THAT C AUSES NAUSEA AND VOMITING? • A. GABA • B. BK channels • C. NMDA • D. 5-HT3 WHICH IS NOT PROPERLY MATCHED FOR CHRONIC ETHANOL USE? • A. pancreas: acute and chronic pancreatitis • B. liver: fat accumulation • C. gi tract: worsens ulcers • D. libido: enhances WHICH BLOCKS THE OPIOID RECEPTORS ON GABA NEURONS FOR TREATMENT OF ALCOHOLISM? • A. Disulfarim • B. Naltrexone • C. Naloxone • D. Acamprosate WHICH BLOCKS ALDEHYDE DEHYDROGENASE FOR TREATMENT OF ALCOHOLISM? • A. Disulfarim • B. Naltrexone • C. Naloxone • D. Acamprosate QUESTIONS? • [email protected] • GOOD LUCK ON YOUR EXAM!
