Download Lecture 1: Key Concepts in Stereoselective Synthesis

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Transcript
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Update to 2012
Bode Research Group
3.6.2 Cross-aldol reactions of aldehyde
http://www.bode.ethz.ch/
MacMillan ACIE 2008, 47, 3568
3.6.3
Activated ketone electrophiles
Zhao TL 2006, 47, 3383; Jorgensen Chem. Comm. 2002, 620
4
ENANTIOSELECTIVE C=N ADDITIONS
4.1
Comparision of C=O and C=N bonds
4.2
Enantioselective Mannich reactions
4.2.1 Silyl ketene acetals and thio-derived silyl ketene acetals
- The first catalytic enantioselective Mannich reations was reported by Kobayashi in 1997
- This system is restricted to imines with N-aryl and a chelating group for two-point binding to the catalyst.
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