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General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
Indications:
First read carefully each topic (see bibliography)
Then, try to tick the correct options (use a pencil) along multiple choice test
If you’ve made any mistakes, re-read the topic, try to clear all specific respect
Then, try again the ticking procedure
Don’t give up, insist until you are able to understand and to keep in your minds the main
features, regarding each parasitic infection
Note
* The correct options are below each test (bolded and underlined)
On test paper, you have to write the title of the scientific paper (in accordance with our
previous promise)
If you have any solid comments or competent recommendations, please contact us, using
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Biliography
General Iimunology / for Students’ Use
Olivia Ligia Burta, Otilia Micle, Teodor Vaida, Faculty of Medicine and Pharmacy,
Oradea, 1999
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
1. The Immune System is organized in:
a.
b.
c.
d.
organs
molecules
cells
antigens
abc
2. Immunity refers to:
a.
b.
c.
d.
e.
f.
the maintenance of the individual integrity
active process of defense
specific homeostasis
specific sensitivity of the human body against immunogens
is not encoded genetic
abcd
3. Indicate by arrows and identify 800-the relation between:
1.The intracellular pathogens
a. The humoral Immune Response
2. The extra cellular pathogens
b.The cellular Immune Response
1-b, 2-a
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
5. Which is the exception which does not belong to non-specific non-immunologic
Response?
a.
b.
c.
d.
mechanical barriers
hypersensitivity
chemical barriers
biological barriers
b
6. Indicate the relation between specific Immune Response types and their definition:
a. Natural Immunity
1.An improper Immune Response against self
structures
b.Acquired Immunity
2.Genetic support; non-receptivity status
c.Immune tolerance
3.A specific sensitivity status regarding a certain
sensitizing-Ag
d.Protection Immunity
4.Capacity to develop an Immune Response
e.Antitumoral Immunity
5.Ability to stop the development of a neoplasic
process
f.Hypersensitivity
6. specific immunity or/and non-specific immunity
which assures protection against a certain infection
g.Autoimmunity
7.The lack of specific reactivity of lymphoid tissue
against a certain Ag
e-5, g-1, f-3, a-2, b-4, d-6, c-7
7. Indicate the mechanism of different types of Acquired Immunity
1. Active natural immunity
2. Passive natural immunity
3. Artificial active immunity
4. Artificial passive immunity
a. Through vaccination
b. Immune sera (antitoxins) or specific
Immunoglobulins, inoculated in
Infected individual
c. The Ag enter the human body,
producing specific Abs
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
d. Transplacental transpher Abs
from immunized mother to fetus
1-c, 2-d, 3-a, 4-b
8. Local microbiocenosis belongs to:
a. skin
b. mucous membranes
c. mechanical barrier
a, b
9. The following cells are phagocytes with an exception:
a.
b.
c.
d.
e.
osteoclasts
Kupffer cells
monocytes
erythrocytes
PMN
d.
10. The compromised host is characterized by:
a. deficit in normal defense mechanism
b. develops severe or recurrent infections with common pathogens
c. often in elderly
a, b
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
11. Immunodeficiency Syndromes may be caused by:
a. T-cell defects;
b. B-cell defects
c. neutrophyles defects
d. complement deficiency
e. coagulation disturbances
a, b, c, d
12. Indicate the belonging structures to lymphoid organs:
a. Primary Lymphoid Organs:
1. appendix
2. thymus
3. bone marrow
b. Secondary Lymphoid Organs:
4. spleen
5. lymph nodes
6. Peyer ‘s patches
a – 2, 3
b – 1, 4, 5, 6
13. The following are the main components of the Immune System, with one exception:
a.
b.
c.
d.
Lymphoid Organs
Cells
Secondary intracellular messenger
Soluble Mediators
c
14. Lymphokines are secreted by:
a. monocytes
b. complement system proteins
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c. macrophages
d. T lymphocytes
d
15. Soluble Mediators are:
a.
b.
c.
d.
e.
f.
g.
PMN phagolysosomes
Immunoglobulins
T lymphocytes
B lymphocytes
Lymphokynes
Complement system proteins
Monokines
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
befg
16. Monokines are secreted by:
a.
b.
c.
d.
complement system proteins
monocytes
macrophages
T lymphocytes
ac
17. For thymus, one of the following is false:
a. has an epithelial primary structure
b. in man, atrophy begins in childhood
c. T cell generation continues into adult life
b
18. Give two examples of MALT (mucosal associated lymphoid tissues):
a…………………………….;
b…………………………….
lamina propria and submucosal areas of gastro-intestinal tract (the Peyer’s patches)
respiratory, genitourinary, the tonsils;
.
19. The spleen and the lymph nodes belong to:
a. primary lymphoid organs
b. secondary lymphoid organs
b
20. The major effectors mechanism at mucosal system is secreted directly onto mucosal
epithelial surfaces of the intestinal, respiratory and genitourinary tracts:
a. IgG
b. IgAs
c. IgE
b
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
21. Indicate by arrows and identify the relations between:
1. white pulp
a. lymphocytes
b. virgin B cell
c. macrophages
d. stimulated follicles
e. erythrocytes
f. granulocytes
g. plasma cells
2. red pulp
1– b d
2–acefg
22. The aged platelets and erythrocytes are destroyed by:
a. phagocytic macrophages
b. T cells
c. T and B cells
a
23. The aged platelets and erythrocytes are destroyed by:
a. phagocytes
b. haemocatheresis
c. pinocytosis
b.
24. The aged platelets and erythrocytes are destroyed in:
a. lymph nodes
b. spleen
c. thymus
b.
25. What is false about lymph nodes?
a. they have 2-10 mm in diameter
b. are round or kidney shaped
c. they filter Abs
c.
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
26. How are termed the superficial lymph nodes?
………………………………….
“somatic nodes”.
27. What is true about visceral nodes?
a. they protect the mucosal surface of the respiratory, digestive and genitourinary
tracts
b. they are superficial
c. they protect the skin and the mucosal surface of the respiratory, digestive and
genitourinary tracts
a.
28. What is true about lymph nodes paracortex:
a.
b.
c.
d.
consists of T cell area
consist of B cell area
contains plasma cells and macrophages
contains APCs (interdigitating cells), which express high levels of MHC class II
surface Ags
ad
29. For PMN, show by arrows the relation between:
1. The primary granules
2. The secondary granules
a. collagenase
b. hydrolytic enzymes (lysosyme)
c. cationic proteins
d. lactoferrin
e. defenssins
1–bce
2–ad
30. The bone marrow could be suppressed by:
a. diseases
b. drugs
c. radiation
abc
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
31. Show by arrows the relation between the mononuclear phagocytic cells and the organs
they belong:
1. blood
2. lung
3. spleen
4. skin
5. liver
a. sinusoidal cells
b. Kupffer cells
c. monocytes
d. Langerhans cells
e. alveolar cells
1 – c, 2 – e, 3 – a, 4 – d, 5 – b
32. APC s has the following roles:
a.
b.
c.
d.
to take up Ags
to present Ags to B cells
to process Ags
to present Ags to TH cells
a, c, d
33. the diameter of the human blood monocytes is about:
a. 10 -18 µm
b. 10 -28 μm
c. 18 – 28 μm
a.
34. Circulating phagocytic monocytes :
a.
b.
c.
d.
don’t have activity at lower pH than granulocytes
have a longer life span than granulocytes
usually have a horse-shoe-shaped nucleus
often contain asurophilic granules
bcd
35. The macrophages “activators” are:
a. inflammation
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
b.
c.
d.
e.
Ag-Ab complexes
Lymphokines
Lysosomes
Sensitized T lymphocytes
abce
36. The study of the cell surface molecules of effectors and regulatory immune cells is
possible by:
a. optical microscopy
b. monoclonal Ab technology
c. opsonization
b.
37. The mature cells antigenically no stimulated are termed:
…………………………….
“virgin” or “naive” cells
38. In periphery, T lymphocytes are ………… % of total circulatory lymphocytes
75%
39. Indicate by arrows and identify the relation between cell and function:
1. Effector T cells
2. regulatory T cells
a. Th
b. Td
c. Ts
d. Tcs
e. Tc
f. Ta
1. b, e; 2 – a, c, d, f
40. In periphery, B lymphocytes are ………… % of total circulatory lymphocytes.
5%
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
41. In optical microscopy, T and B cells are morphological identical. In electronic
microscopy, indicate by arrows the correspondences:
1. T cell
2. B cell
1-a; 2-b
a. smooth surface
b. surface with vilosities
1–a
2–b
42. In periphery, nonB-nonT lymphocytes are ………… % of total lymphocytes
5%
43. The nonB-nonT lymphocytes:
a. are large granular lymphocytes;
b. participate in immune antitumoral reactions;
c. present surface vilosities.
ab
44. Natural killer cells:
a.
b.
c.
d.
are short-lived cells
are able to destroy in few hours the target cell
on their surface exist Fab receptors
have common markers for both lymphoid and myeloid line
abd
45. Natural Killer Cells:
a. synthesize lyzozime
b. have the ability to kill tumoral cells, bacterial and viral infected cells
c. are under the influence of some factors as: age, chronic diseases, stress, diet,
medical treatment…
bc
46. During immune deficiency:
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a. NK and K cells perform same actions
b. NK functions are inhibited (even cancelled)
c. K cells remain non-influenced by this status
bc
47. What is true about LAK?
a. it means “Lymphokine Activating Killer Cells”
b. possess similar antitumoral effects as NK cells
c. possess similar antiviral effects as NK cells.
ab
48. Eosinophils:
a. are a group of erythrocytes
b. they aggress and damage large extracellular parasites
c. are a group of leukocytes
bc
49. The inflammatory reactions are mainly represented by:
a. bringing circulatory phagocytes and serum molecules to the aggressed site
b. increased capillary permeability
c. leukocyte migration
abc
50. The first cellular line of defense, in inflammatory reactions is:
a.
b.
c.
d.
CD4 cells
Neutrophils
B cell
Macrophages
b.
51. In case of parasitic infections will develop an infiltration with:
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a. eosinophils
b. eosinophils, basophiles, macrophages
c. CD4 cells
a.
52. Basophils:
a. attract leukocytes and the soluble mediators of immunity toward the site of
infection
b. contain one mediator (histamine)
c. are functionally similar to mast cells but are circulating
ac
53. Put in order the cell migration toward the inflammatory site:
a. chemotactic stimuli interventions
b. the endothelial wall penetration (due to local vasodilatation)
c. attachment to endothelial cells
cba
54. Some of the chemotactic stimuli involved in cell migration, are represented by:
a.
b.
c.
d.
e.
f.
C3a
C5a
Acute phase proteins
cytokines
TH
Leucotrienes
a, b, d, f
55. The leucocytes migration across endothelium depends on:
a. the surface charge of the interacting cells
b. the haemodynamic shear force in the vascular bed
c. the expression of complementary sets of adhesion molecules on both the
leucocytes and the endothelium
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
abc
56. What is true about fever?
a.
b.
c.
d.
e.
is the most common systemic manifestation of the inflammatory response
is a cardinal symptom of infectious diseases
under the influence of the hypophysis thermoregulatory centre
is induced by pyogens
is induced by pyrogens
abe
57. Endotoxins:
a. are heat-stable lipopolysaccarides
b. after i.v. injection, the latent period until the onset of fever is 60-90 minutes
c. after i.v. injection, the latent period until the onset of fever is 10-30 minutes
ab
58. IL-1:
a.
b.
c.
d.
is an endogenous pyrogen
is heat-labile protein
after i.v. injection, the latent period until the onset of fever is 60-90 minutes
after i.v. injection, the latent period until the onset of fever is few minutes
abd
59. What is false about suspension of fever by drugs:
a. is harmful during infections
b. Ab production is more efficient at higher body temperature than at normal levels
c. T cell proliferation is not so efficient at higher temperature
ac
60. What is true about antigen?
a. It’s a substance, alive or inert particle
b. It’s recognized as “non-self’ by the organism
c. It’s able to induce a specific immune response
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
abc
61. To be imunogen, an Ag must be:
a. recognized as non-self
b. a lipopolysaccharide
c. on its surface to exist determinant groups (epitops), which induce
antigeneity and immunogeneity
ac
62. The antigeneity depends on:
a.
b.
c.
d.
e.
the persistence of Agenic molecules in organism
the chemical structure
the way of epitop presentation on the cell surface
the way of Ag inoculation
epitops number
abcd
63. What is true about haptens?
a. their molecular weight is less than 10 kD
b. they are complete Ag
c. they are able to induce Ab synthesis only when bound by a carrier protein
ac
64. The following sentence: “To be synthesized Abs against hapten, must exist cooperation
between T and B lymphocytes (cellular cooperation)” is:
a. true
b. false
a.
65. What is true about epitop?
a. is the determinant group of Ag
b. is also called “paratop”
c. their total number are higher when the molecule is larger
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
d. in case of protein Ag exist different epitops, but in polysaccharidic Ag exist
repetitive epitops (some of them are dominants)
acd
66. regarding the structure, the antigens may be classified as follows:
a.
b.
c.
d.
e.
natural Ag
foreign Ag
incomplete Ag
self Ag
histocompatibility Ag
abde
67. The antigenic specificity:
a. is determined by whole molecule
b. is determined only by antigenic group
c. is determined by repetitive epitops
b.
68. Heterophile Ags:
a.
b.
c.
d.
are found at different species
are called Forssman Ags
exist in cold-blood reptiles, fish, mammals, bacteria….
there are specific organ antigens
abc
69. Indicate by arrows and identify the relation between antigenic classification regarding:
1. the receptor organism
which recognize”non-self” structures
2. the cellular classes which may
be activated by Ags
a. allo Ags (isoAgs)
b. thymodependent Ags
c. type I (Ags do not suffer any molecular
changes)
d. autologue Ags
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
3. the way used by phagocytes cells
in processing the Ags
e type II (Ags are unfolded, to put in
evidence the epitops)
f. . . xeno Ags
g. type III (Ags require to be divided into
fragments by phagocytic cell)
h. thymoindependent Ags
1–adf
2–bh
3–ceg
70. The family of molecules belonging either to bacterial toxins or to products encoded by
retroviral genes is named:
a.
b.
c.
d.
allo Ags
cell specific Ags
super Ags
xeno Ags
c.
71. Which of the following germs produces the exfoliating toxins and the toxic shock
syndrome toxin-1?
a.
b.
c.
d.
Streptococcus pyogenes group A
Cl.perfringens
Staphylococcus aureus
Yersinia enterocolitica
c.
72. What percent of T cell could be activated by a small quantity of A enterotoxin?
a. 10-40%
b. 60-80%
c. 50-100%
a.
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
73. The minor lymphocyte superAg (MLS) belongs to:
a. bacterial toxins
b. products encoded by retroviral genes
b.
74. The main benefit of superAgs activity is:
a. vaccine preparation
b. searching new treatments for arthritis, cancer, AIDS
c. auto-antibodies’ synthesis
b.
75. The superAgs action in human body is followed by:
a. the replication of T cells
b. hemolytic
c. the amounts of IL-2, IFN-γ and other cytokines secretion
ac
76. Which is the main cellular receptor for bacterial superAgs (SAG)?
a. class II MHC molecules
b. cellular protease
c. chemokines
a
77. SAG recognition by T cells starts with:
a. leukocytes migration
b. Abs secretion
c. binding with class II MHC molecules
c
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
78. The trimolecular complex is composed by:
a. TCR (T cell receptor) – SAG - II MHC
b. TCR – SAG – APC
c. APC – SAG – II MHC
a
79. Indicate by arrows and identify the relation between the cytokine cellular secretions under
staphylococcal enterotoxin influence:
1. naïve CD4
a. IL-2;
2. memory Th cells
b. Many kind of cytokines (including IFN- γ, IL-4)
1–a
2–b
80. Two types of molecules are involved in Ags recognition. Which of them:
a.
b.
c.
d.
immunoglobulin
T – cell receptors
B – cell receptors
Class II MHC molecules
a b.
81. Igs are:
a.
b.
c.
d.
proteins
glycoprotein’s
lipopolysaccharides
glucides
b.
82. Human Igs are present in:
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a.
b.
c.
d.
serum
tissues
exocrine fluids
mucosal surfaces
abc
83. In human body Igs exist in different forms:
a.
b.
c.
d.
Ag-Ab complexes
Fixed molecules on the surface of B cell – as Ag receptors
Cytophilic fixed molecules
Free molecules in body fluids
abcd
84. The plasma cells are:
a. T cell
b. B cells
c. B cells developed into AFCs (Ab forming cells)
c
85. The Igs features are:
a.
b.
c.
d.
e.
f.
are divided in classes and subclasses
they fix the C’ components
they use the paratop to react in a specific manner with the Ag
they activate phagocytic processes
they have sensitivity to certain enzymes: pepsin, papaine
Are synthesized by B cells
abcde
86. The classes of human Igs are:
a. IgA
b. IgB
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c.
d.
e.
f.
g.
IgD
IgG
IgE
IgF
IgM
acdeg
87. This classification of human Igs was made in accord with their:
a.
b.
c.
d.
e.
f.
g.
size
basic shape
electric charge
CH (carbohydrate) content;
AA sequences
Power of Ag recognition and binding power by a single or by all combinative sites;
Stain properties
acdef
88. The Ab shape, shown by X-ray crystallography is:
a.
b.
c.
d.
“k”shaped molecule
“Y” shaped molecule
“L” shaped molecule
“H” shaped molecule
b
89. What is true about L (light) chain?
a.
b.
c.
d.
e.
f.
is the larger chain
its molecular weight is about 25,000 D
its molecular weight is about 250,000 D
is more common to all classes than “H” chains
In humans exists in following forms: γ, λ, κ;
It has one constant region (CL) and one variable region (VL), which show much
sequence variability
bdf
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
90. What is false about H (heavy) chain?
a.
b.
c.
d.
it is the smaller chain
its molecular weight is about 50,000 – 70,000 D
is common to all classes and subclasses
exist 5 different types (γ, µ, α, δ, ε) which determine the class of Ig molecule
ac
91. Mark the true sentences:
a. all the Ig classes have subclasses
b. only two Ig classes have subclasses
c. in IgG class exist 4 different isotypes: γ1, γ2, γ3, γ4 (leading to IgG1, IgG2, IgG3,
IgG4 immunoglobulin subclasses)
d. in IgA class exist 2 different isotypes: α1, α2 (the name of subclasses are IgA1 and
IgA2)
bcd
92. In case of four Ig classes exist three constant regions CH (CH1, CH2, CH3). Only in the
class with the larger molecule exists the fourth domain (CH4). Which is this Ig class?
a.
b.
c.
d.
e.
IgA
IgM
IgE
IgG
IgD
b
93. In any Ig molecule both L chains are identical (either λ, κ) as well as the two heavy chains
(either γ, µ, α, δ, ε):
a. false
b. true
b
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
94. Choose the correct answers:
a.
b.
c.
d.
e.
f.
Fab (Antigen Binding Fragment) is involved in Ag-Ac binding
Fc (Crystallized Fragment) is involved in tissue fixation
Fc (Crystallized Fragment) is involved in activation of C’ system
The hinge region is located between CH1 and CH2 domains
The hinge region is a fixed region
The hinge region is flexible (allows the adaptation process, according with the epitop
shape)
abcdf
95. Show by arrows the relation between:
1. isotypic variation
a. is a variation in the variable domain
(in the hyper variable regions, usually for individual
B cell clones)
2. allotypic variation
b. Is responsible in synthesis of a unique allotypic Ab
(specific to billions of Ag met by a human body along
the whole life)
3. idiotypic variation
c. the genes for isotypic variants are present in all
healthy members of a species
4. allelic exclusion
d. this refers to genetic variation between individuals
within a species, involving different alleles at a given
locus (for example: the variant of IgG 3- is not found in
all people)
1234-
c
d
a
b
96. What is true about IgG?
a. hasn’t a typical Ab structure
b. the differentiation in IgG subclasses consists in their AA sequences, clustered in the
hinge region
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c.
d.
e.
f.
g.
is the major Ig in normal human serum
from the total Ig pool it represents 70-75%
is the major Ab of secondary I.R.
cross the placenta and confer a high degree of passive immunity to the newborn
IgG derived from the maternal milk selectively crosses the gastrointestinal tract
bcdefg
97. Which of the followings are the roles of IgG?
a.
b.
c.
d.
participate in neutralization reactions (as neutralizing Ab)
are involved in ADCC (through opsonic phagocytosis)
interfere with the development of cellular memory
activate C’ system proteins (during Complement fixation reactions)
abd
98. What is true about IgM ?
a.
b.
c.
d.
e.
f.
it is bimolecular
µ chains possess their own AA sequences
it is pentamolecular
it has an extra constant region domain
represents 10% of the Ig pool
it is very large, being able to cross the placenta barrier
bcde
99. What is false about IgM?
a. when it bind to bacterial flagella, adopt a “stample” configuration
b. it has an additional peptide chain, the “J” (joining) chain, thought to assist the process
of polymerization
c. participates in decreasing the ability in agglutination, precipitation and Complement
System activation.
c
100. What is false about IgA?
a. α chain possesses two domains;
b. C – terminal fragment is not able to bind covalently to a “J” chain to form dimmers;
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c.IgA dimmers structure is double-Y-shaped
d.Represents 10% of the human serum Ig in pool
abd
101. Choose the false answer:
a. secretory IgA is made up of two units of IgA (one secretory component and one “J”
chain)
b. secretory component is synthesized by plasma cells
c. secretory component is synthesized by epithelial cells
d. “J” chain is held in the configuration by IgA dimmer, secreted by submucousal plasma
cells
b
102. In serum, the predominant IgA subclass is:
a. IgA1
b. IgA2
a
103. In secretions, the predominant IgA subclass is:
c. IgA1
d. IgA2
b
104. Choose the true answers about IgD:
a. represents 1% of total plasmatic Igs
b. it is present as receptors on the membrane of many B cells
c. probably interfere with the development of cellular memory
ab
105. What is true about IgE?
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a.
b.
c.
d.
exists in large quantities in serum
are cytophilic
are involved in immunity to helminthic infestation
are involved in allergic diseases
bcd
106. The predominant Ig in seromucous secretions (saliva, colostrum, and milk,
tracheobronchial and genitourinary secretions) is:
a.
b.
c.
d.
e.
IgG
IgA
IgM
IgD
IgE
b
107. What is true about Igs?
a. are molecules synthesized under a rigorous genetic control
b. their both anabolic and catabolic processes are interfering
c. in time, synthesized molecules are getting older and will be decayed, being replaced
by new formed molecules
abc
108. About Ig anabolism, which of the followings is false?
a.
b.
c.
d.
e.
f.
represents the replace of old Ig by new-formed molecules
represents the polypeptide chains synthesis
represents molecules assembly
represents addition of CH components
represents polymerization and the release of Ig molecules
represents the switch process in Ig molecules synthesis
a
109. Which of the next sentences are true?
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a. aged Ig molecules are permanent replaced by young molecules at a constant level
b. the Ig catabolism depends on: class type, the speed in molecules synthesis, site of
catabolism
c. Ig anabolic and catabolic processes maintain the homeostasis in humoral-mediated
immune response
abc
110. Which are the most probably sites of Ig catabolism? In:
a.
b.
c.
d.
liver
small intestine
kidney
spleen
ab
111. What is true about IgG receptors?
a.
b.
c.
d.
e.
they are localized on the cell surface
participate in phagocytosis
release mediators
enhance Ag presentation
there are 3 groups of human IgG-R
abcd e
112. All the IgG-R are characterized by extra cellular domains. The correct distribution is:
1. Fcγ-R I
a. on mononuclear cells and neutrophils
2. Fcγ-R II
b. on mononuclear cells
3. Fcγ-R III
c. on macrophages, PMN, NK and some T cells
1–b
2–a
3–c
113. How many different receptors are in IgE molecule?
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a. one
b. two
c. three
b
114. Which are the Ab effector functions?
a. to bind Ag
b. to bind other Ab
c. to activate the C’ system
ac
115. Clinical applications of Abs are:
a.
b.
c.
d.
passive transpher of an immune or hyper immune serum
in different immunologic laboratory methods
in identifying certain Ab subclasses in blood, serum and urine
monoclonal Abs: in identifying certain Ags or trying to destroy malignant cells
abcd
116. Cellular markers and receptors belong to cellular membranes of:
a.
b.
c.
d.
lymphocytes
Abs
Ags
Macrophages
ad
117. What are false about the cellular markers?
a. are recognizing elements
b. permit the receive, translation and transmission of the messages toward internal
cellular structures
c. allow the differentiation between the types o cells
d. the limit between cellular markers and receptors is very labile
ab
118. Cellular markers:
a. have morphologic, functional and antigenic characteristics
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
b.
c.
d.
e.
may be expressed during the whole life of the cell
may be expressed only in a certain period of its development
may be identified using monoclonal Abs or molecular clonation
were identified T, B, K, NK, macrophages specific markers, termed “cluster
differentiation” (CD)
abcde
119. What is true about antigenic markers?
a. are involved in cellular cooperation during the immune response
b. if these are inactivated will follow an increase in the immune response
c. they are always receptor, too
a
120. What is false about markers modulation?
a. is an irreversible process
b. represents the alternance between the expression and the lack of an antigenic marker
on a cell surface, in different moments
c. may be under the influence of physiological and pathological causes
d. is independent on cellular metabolism
e. the induced influences are represented by: antiserum therapy, drug therapy
ad
121. What is true about ligands?
a.
b.
c.
d.
e.
they are substances which bind to the receptors
they could be erythrocyte compounds, bacterial compounds, bacteria
they couldn’t be recognized by membrane receptors
they may be divides in classes
are formed in cells during cellular development and maturation
abde
122. Regarding their functions, T-cell subpopulations may be divided in two kinds. Indicate
by arrows the relation between:
1. cells with regulatory functions
a. Th cells
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
b. Tc cells
c. Ts cells
2. cells with effector functions
1 – a, c
2–b
123. Indicate by arrows the relation between:
1. Th cells
a. activate B ly, Tc, Ts cells
2. Ts cells
b. are involved in the destruction of virusinfected cells, tumoral cells, graft rejection
3. Tc cells
c. limit both humoral and cellular response
1–a
2–c
3–b
124. What is true about BCR (B-cell receptor)?
a. recognizes the Ags in solution
b. recognizes the Ags bound to cell surface
c. both of them
c.
125. What is true about B lymphocytes ?
a. each of their subclasses is programmed to produce all the types of Igs subclasses
b. each B ly has approximative 105 molecules of receptors for a single type of epitop
c. when B cells come in contact with the Ag, will develop a clone of plasmocytes
bc
126. Put in logical order the following events
After Ag recognition by the receptor, the next step is:
a. the expression of new membrane receptors
b. the binding between Ag and receptors, with cytoskeleton modifications
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c. producing and activation of some intracellular messengers
b–c–a
127. What is true about Th cells receptors ?
a.
b.
c.
d.
abc
the Ag is recognized by two different types of receptors
one of them recognizes the epitop
one of them recognizes the MHC molecules
one of them recognizes the paratop
128. What is false about T and B cells?
a. both have dimmeric structure
b. their NH2 – ends form combinative situses
c. their COOH – ends are transmembranar
a
129. What is true about the receptor for Fc: FcR?
a. belongs to Ig molecules
b. they are membrane structure
c. they have an important role in the transcellular and transmembranar transport for some
IG)
abc
130. Show the relations between:
1. FcγRI
a. is expressed mainly on PMN and macrophages
2. FcγRII
b. is expressed on all hematopoetic (excepting the
erythrocytes)
c. is expressed almost on all mononuclear cell surfaces
3. FcγRIII
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
1–c
2–b
3–a
131. What is false about the receptors for Complement?
a. are proteo-glucidic structure
b. the components’ activation is individual
c. allow the binding of C’ to an Ag-Ab complex
ab
132. What is false about the receptors for mitogens?
a. recognize substances obtained from plants
b. are exposed on some lymphocyte surfaces
c. are present on those cells which are able to bind specifically IgG-coated erythrocytes
c
133. What is true about the receptor for Cytokines?
a.
b.
c.
d.
they are involved in binding mediators
are classified in families, regarding the structures
usually, are present on cellular membrane in reduced number
their number increases after cellular activation
abcd
134. Is the rejection an immune phenomenon due to incompatibility between donor and
acceptor Ags?
a. Yes
b. No
a
135. Mark the true affirmations:
a. in cellular rejection lymphokines are not involved
b. the most important lymphokine in cellular rejection is IL-2
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c. TNF β (lymphotoxin) activates macrophages.
bc
136. The antigen presentation (as immunogen) by APC to TH lymphocytes:
a. is conditioned by the presence of self MHC class II molecules
b. isn’t conditioned by the presence of self MHC class II molecules
a
137. Which of the following functions belong to MHC class III molecules?
a.
b.
c.
d.
lytic enzymes activation
target cell lysis (using specific Abs)
opsonization
anaphylatoxins decay
abc
138. Which of the followings are the roles of MHC molecules?
a.
b.
c.
d.
interfering in graft rejection and in the defense against self structures anomalies
in Agnic recognition
in modified cells cytolysis
mediating the end reactions of immune responses
abc
139. Indicate the associations between the deficiencies in MHC molecule and the following
diseases:
1. HLA-B associated diseases
a. endocrine, neurological,
dermatological , autoimmune diseases
2. HLA-B and HLA-D associated
Diseases
b. arthropathies
3. MHC – associated diseases
c. hepatic diseases with immune
deficiency
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
1–b
2–a
3–c
140. What is true about cytokines?
a.
b.
c.
d.
could be protein molecules
could be lipoprotein molecules
are synthesized by lymphoid and non-lymphoid cells
their synthesis occurs during the Immune Response
acd
141. What is false about cytokines?
a. are mediators of immunity, inflammation, proliferation and cell lines differentiation
b. possess a low MW
c. exist over 35 types of cytokines
c
142. Cytokines family is divided in:
a.
b.
c.
d.
e.
f.
g.
colony stimulating factors
interleukins
growth factors
MHC molecules
tumor necrosis factors
interferons
chemokines
abcefg
143. What is false about interleukines?
a.
b.
c.
d.
are cytokines with mediator and adjustment activities in I.R.
induce the growth and differentiation on erythrocyte line
their activity is mediated by interleukin receptors
exist over 20 types of cytokines
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
bd
144. Which of this cells/cell group secrete each interleukins type?
1. macrophages and monocytes
a. IL-4, IL-5
2. activated T-CD4+ (mainly)
and T-CD8+
b. IL-10
3. activated Th2, under the influence
of IgM
c. IL-16
4. activated T lymphocytes (mainly),
monocytes, macrophages,
endothelial cells, fibroblasts
d. IL-6
5. thymic stroma
e. IL-1
6. monocytes, endothelial cells,
epithelial cells, PMN,
macrophages, T lymphocytes
f. IL-7
7. activated Th1, Th2,
intracellular pathogens,
mature B cells
g.IL-12
8. T cells
h. IL-8
9. stromal thymic cells
i. IL-11
10. T lymphocytes
j. IL-2
11. lymphoid and
non-lymphoid cells
k. 14
1-e
2-j
3 –a
4-d
5-f
6-h
7-b
8-i
9-g
10-k
11-c
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
145. Which of them are proinflammatory cytokines?
a.
b.
c.
d.
e.
f.
IL-1
IL-2
IL-6
IL-8
IL-10
TNF
acdf
146. Which are the two protein molecules that compose TNF (Tumor Necrosis Factor)?
a. casectine
b. papain
c. lymphotoxine
ac
147. Which are the main immunoregulatory cytokines?
a.
b.
c.
d.
e.
IL-1
IL-2
IL-4
IL-5
IL-10
acde
148. The main immunoregulatory cytokines are synthesized by:
a. T lymphocytes
b. B lymphocytes
c. Macrophages
a.
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
149. What is true about CSF (Colony Stimulating Factors)?
a.
b.
c.
d.
e.
intracellular messengers are very important in stimulation of CSF
possess different structures
have specific cellular receptors
are coded by different distinct genes
are stimulated by B cell
abcd
150. Which are the biological effects of Colony Stimulating Factors (CSF)?
a. regulatory activity in hematopoesis
b. stimulate chemotaxis
c. stimulate neutrophil adhesion
abc
151. What is true about prostaglandins (Pgs) with immunoregulatory activity?
a. are biological structures, synthesized by all types of tissues and cells, which
suffered already a stimulatory process at cytoplasm membrane level
b. are locally synthesized in minute quantities
c. have a rapid catabolism
abc
152. Which statement is false? Hypersensitivity means:
a. Exaggerated adaptative immune response
b. Inappropriate adaptative immune response
c. 5 different types of abnormal immune reactions
ab
153. What is true about hypersensitivity?
a. always causes inflammatory reactions
b. may be induced by many Ags
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c. is manifested on the first contact with the Ag
ab
154. How many types of Hypersensibility Reactions were describes by Gell and
Coombs?
a.
b.
c.
d.
2
4
3
6
b
155. Which are the two types of Immune Response reactions?
a)……………………………………..
b)………………………………………
a) immediate
b) delayed
156. Show with arrow the relations between:
1. immediate reactions
a. require many hours, even up to several
days to become manifest;
b.are mostly initiated by T lymphocytes
c. do not involved humoral response
d. require within minutes or few hours to
become manifest
2. delayed reactions
e.are initiated by humoral antibodies
1 – d, e
2 – a, b, c
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
157. Type I HS occurs:
a. immediately after the second contact with a certain Ag (called allergen)
b. in many hours after the contact with a certain Ag (called allergen)
c. in several days after the contact with a certain Ag (called allergen)
a
158. What is false about allergy?
a. it means “changed reactivity”
b. it’s a term introduced by Gell and Coombs
c. was described by Coca&Cooke
c
159. What is true about atopy?
a. usually appears in individual with a familial history of these or similar conditions;
b. is the clinical presentation of Type I HS
c. with 2 allergic parents there is a greater than 50% chance of the children in having
allergy
d. a single parental history of allergy isn’t a risk factor for atopy
a,b,c
160. Atopy includes:
a.
b.
c.
d.
e.
asthma
eczema
food allergy
hay fever
urticaria
a,b,c,d,e
161. Which of the next non-genetic factors have role in allergy?
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
a.
b.
c.
d.
the level of allergen exposure
the presence of chronic underlying infections
the acute viral illness
the nutritional status of the individual
a, b, c, d.
162. Initial contact of an allergen with the mucosa is followed by production of:
a.
b.
c.
d.
IgG
IgE
IgG and IgM
IgM
b
163. The production of IgE is a:
a. local event
b. systemic event
a
164. What is true about IgE production?
a.
b.
c.
d.
e.
is activated by T cells
depends on allergen presentation by MHC class II molecules
is activated by B cells
depends on allergen presentation by Ag presenting cells (APCs)
depends on cooperation between the B cells and Th2 cells
c, d, e
165. Which is the first action of produced IgE in HS type I reaction?
a. The produced IgE – first binds to specific receptors on both circulating basophiles
and tissue-fixed mast cells
b. The produced IgE – first sensitized local mast cells
c. The produced IgE – first enters the circulation
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
b
166. Put in the logical order:
a. The produced IgE – binds to specific receptors on both circulating basophiles and
tissue-fixed mast cells
b. The produced IgE – sensitized local mast cells
c. The produced IgE – enters the circulation
b–c–a
167. The IgE molecule binds mast cells and basophiles through its:
a. Fc fragment
b. Fab fragment
a
168. The serum half-time of free IgE is:
a. few hours
b. few days
c. few weeks
b
169. Mast cells may remain sensitized by IgE for:
a. days
b. month
c. hours
b
170. IgE is protected from destruction by serum proteases by:
a. FcεRI
b. Fab
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
c. Fc
a
171. IgE levels are elevated in:
a.
b.
c.
d.
allergic diseases
viral infections
parasitic infections
carcinoma
a, c
172. The mediators that produce the inflammatory responses typically for type I HS are
released by:
a. mast cells
b. neutrophiles
c. platelets
a
173. What is true about cytokines in type I HS:
a. they are released by IgE-mediated mast cell activation
b. The released cytokines are IL-2, IL-4
c. The released cytokines are IL-1, IL-4
b
174. What is true about C3a and C5a?
a.
b.
c.
d.
e.
are active in degranulating mast cells
aren’t active in degranulating mast cells
are anaphylatoxins
are convertases
affect other cells like PMN, platelets, macrophages
a, c, e
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
175. Type II HS is mediated by:
a.
b.
c.
d.
IgE
IgG
IgG and IgM
IgG and IgE
c
176. The damages in type II HS:
a. are restricted to the specific cells and tissues which bear Ags
b. affect the whole body
a
177. Type II HS may be developed during:
a.
b.
c.
d.
e.
f.
g.
parasitic infections
incompatible blood transfusions
autoimmune hemolytic anemia
hemolytic disease of new-born
Good pasture’s syndrome
Myasthenia gravis
Pemphigus
b, c, d, e, f, g
178. Put in the logical order the steps occur in Arthus reaction:
a.
b.
c.
d.
The initial deposition in the vessels wall
Vascular occlusion
Neutrophyl infiltration and intravascular clumping platelets
Necrosis
a, c, b, d
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General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
179. In Arthus reaction, the replace of the neutrophyles by mononuclear cells occurs in:
a. 12 – 18 hours
b. 24 – 48 hours
c. 72 hours
b
180. Type III HS causes diseases divided in:
a. 6 groups
b. 2 groups
c. 3 groups
c
181. Show with arrows the relation between:
a. leprosy
b. staphylococcal infective carditis
1. persistent infection
c. rheumatoid arthritis
d. farmer lung
2. autoimmune process
e. malaria
f. systemic lupus erythematosus
g. pigeon fancier lung
3. inhalation of antigenic
material
h. viral hepatitis
i. polyomyositis
1 – a, b, e, h
2 – c, f, i
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The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
3 – d, g
182. Type IV HS is:
a.
b.
c.
d.
e.
f.
a delayed reaction
take more than 24 hours to develop
take more than 12 hours to develop
involve cell-mediated immune reactions
can be transferred from one animal to another by serum
can be transferred from one animal to another by T cells
a, c, d, f
183. What is true about type IV HS?
a. there are 2 variants, according to the reaction they produce when Ag was applied
directly to the skin (epicutaneously) or infected intradermally
b. there are 3 variants, according to the reaction they produce when Ag was applied
directly to the skin (epicutaneously) or infected intradermally
b
184. Contact Hypersensitivity:
a.
b.
c.
d.
e.
occurs after the contact with haptens
is primarily an epidermal reaction
involve local Langerhans cells
involve keratinocytes
was originally described by Robert Koch
a, b, c, d
185. Tuberculin-type Hypersensitivity:
a. was originally described by Koch
b. the skin reaction is used to test the sensitivity to the organisms following previous
exposure
c. a patient with tuberculosis, injected subcutaneously with tuberculin culture filtrate,
never develop fever
d. in this reaction are involved PMN
-----------------------------------------------------------------------------------Dr. Olivia Ligia Burta Dr. Patricia Ramona Marusca
The team representatives
General Immunology Exam / General Medicine 3rd Year/February 2007
Microbiology Dpt./ Faculty of Medicine and Pharmacy/ University of Oradea
e. in this reaction are involved “armed” macrophages
a, b, e
186. Granulomatous Hypersensitivity:
a. is the most important clinical type of type IV HS
b. is caused by persistence within macrophages of intracellular microorganism
c. is caused by persistence of immune complexes which will produce further
epitheloid cell granuloma formation
d. is caused by persistence of immune complexes which will produce further
epitheloid cell granuloma formation and persistence within macrophages of
intracellular microorganism
a, d
187. Diseases produced by type IV HS are represented by:
a.
b.
c.
d.
e.
f.
g.
tuberculosis and leprae
Sarcoidosis
Protozoan diseases
Schistosomiasis
Fungal diseases
Crohn’s disease
Viral diseases
a, b, c, d, e, f
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The team representatives