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incidence, risk factors and neonatal outcomes of placenta
incidence, risk factors and neonatal outcomes of placenta

... outcomes including preterm delivery, admission to NICU and low APGAR scores. These adverse neonatal outcomes were because most of the women presented with antepartum hemorrhage with severe bleeding, which necessitated an early delivery (McCormack, 2008; Asicioglu, 2014). The rate of NICU admission a ...
Management of hematological malignancies during pregnancy
Management of hematological malignancies during pregnancy

... Case series: Ten children, four with exposure during first trimester, none with abnormalities. Series of 26 patients, one infant born with hydrocephalus with exposure at Week 3, one infant with cleft palate exposed during first trimester.a Six patients with no congenital anomalies abnormalities. First ...
Preview the material
Preview the material

... prediction of the due date, the less likely complications related to unnecessary medical interventions will arise.1 Evaluation of Gestational Age and Expected Date of Delivery The estimated date of delivery (EDD) method2 has been the principal method in determining a pregnant woman’s due date for mo ...


... determine if the Kcnq1 promoter associated with specific DNA sequences in the neonatal heart, we performed an unbiased, systematic 3C scan extending 12.6 kb upstream of the promoter, spanning the 320 kb Kcnq1 gene and 31.3 kb downstream of the last exon. Our strategy was to anchor the 3C assays with ...
LIST OF CHECK-UP QUESTIONS for
LIST OF CHECK-UP QUESTIONS for

... c) infl uenza CORRECT d) color blindness 7. What type of mutations has the greatest probability to be expressed in the next generation? a) recessive, linked with a sex, which arises in X-chromosome; b) recessive, which arises in autosomes; c) dominant autosomal mutation CORRECT d) all of these avove ...
UCSD_PevznerMolecula.. - Purdue University :: Computer Science
UCSD_PevznerMolecula.. - Purdue University :: Computer Science

... • DNA was later discovered to be the molecule that makes up the inherited genetic material. • Experiments performed by Fredrick Griffith in 1928 and experiments with bacteriophages in 1952 led to this discovery. (BILD 1 Lecture, UCSD,Fall 2003) • DNA provides a code, consisting of 4 letters, for all ...
a method for detecting and typing of salmonella by multiplex pcr
a method for detecting and typing of salmonella by multiplex pcr

... CCGCACAACACATCAGAAAG ...
Primer on Molecular Biology
Primer on Molecular Biology

... • DNA was later discovered to be the molecule that makes up the inherited genetic material. • Experiments performed by Fredrick Griffith in 1928 and experiments with bacteriophages in 1952 led to this discovery. (BILD 1 Lecture, UCSD,Fall 2003) • DNA provides a code, consisting of 4 letters, for all ...
Primer on Molecular Biology
Primer on Molecular Biology

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Bilateral Macronodular Adrenal Hyperplasia (BMAH)
Bilateral Macronodular Adrenal Hyperplasia (BMAH)

... apparently sporadic BMAH and in large families with BMAH - Armadillo repeat containing 5(ARMC5) o Located on Chromosome 16p11.2 o Unknown function; behaved as a tumor suppressor gene, second hit is needed for disease development o Its inactivation decreased the expression of MC2R and steroidogenic e ...
History of Discoveries in Molecular Biology
History of Discoveries in Molecular Biology

... invented a technique for multiplying DNA sequences in vitro by, the polymerase chain reaction - PCR. PCR has been called the most revolutionary new technique in molecular biology in the 1980s. Cetus patented the process, and in the summer of 1991 sold the patent to Hoffman-La Roche, Inc. for $300 mi ...
Type I Factor XI11 Deficiency Is Caused By a
Type I Factor XI11 Deficiency Is Caused By a

... between various proteins in plasma and an extracellular matrix. Thus, deficiency of factor XI11 results in defective crosslinking reactions. More than 200 cases of factor XI11 deficiency have been identified. Its frequency is calculated to be one in 10,000.* In most cases, the diagnosis for factor X ...
Retinoblastoma: Evaluation and Differential Diagnosis
Retinoblastoma: Evaluation and Differential Diagnosis

... In developed nations, the common presenting features of intraocular retinoblastoma are leukocoria and strabismus. Abnormal pupil reflex is also frequently observed in several pediatric ocular conditions, including cataracts, and it is important to clinically differentiate retinoblastoma from simulat ...
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Trichothiodystrophy: Update on the sulfur
Trichothiodystrophy: Update on the sulfur

... Trichothiodystrophy: Update on the sulfurdeficient brittle hair syndromes Peter H. Itin, MD,a Alain Sarasin, PhD,b and Mark R. Pittelkow, MDc Aarau, Switzerland, Villejuif, France, and Rochester, Minnesota Trichothiodystrophy (TTD) refers to a heterogeneous group of autosomal recessive disorders tha ...
Figures 1
Figures 1

... that it may have a beneficial effect on weight gain, and possibly appetite, in individuals with PWS.33,35 Infants with PWS treated with GH therapy have improvements in head circumference, height, BMI, body composition (with improvement of lean muscle mass and delay of fat tissue accumulation), body ...
Gestational Diabetes
Gestational Diabetes

... blood glucose level to make more nutrients available to the baby. The mother’s body makes more insulin to keep the blood glucose level normal. In a small number of women, even this increase is not enough to keep their blood glucose levels in the normal range. As a result, they develop gestational di ...
Full-Text PDF
Full-Text PDF

... of any threshold effect, and the presence or absence of respiratory growth defects in cells carrying a presumed pathological mutation provides strong evidence for the classification as pathological or not in humans. ...
Nucleotide sequence and taxonomic value of the
Nucleotide sequence and taxonomic value of the

... = 1.5 kb insert was separated by agarose gel electrophoresis. The liberated fragment, containing 898 bp of the coding sequence of C. trachomatis L1/440/LN MOMP, was excised from the gel, purified by Geneclean (Stratech Scientific) and labelled with digoxigenin. Genomic library construction. Restrict ...
English - Illumina
English - Illumina

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Detection of Activated Platelets in Normal Pregnancy and
Detection of Activated Platelets in Normal Pregnancy and

... Q ...
Imprinting of the Y Chromosome Influences Dosage Compensation
Imprinting of the Y Chromosome Influences Dosage Compensation

... region on the Y chromosome (Dp(1;Y)Bsv1y1) were mated to C(1)DX y1f1; [w14D4.3] females. To obtain males with maternal and paternal roX1 roX2 chromosomes from the same mothers, roX1ex6 roX2/Df(1)nod FM7a; [w14D4.3]/1 females were generated. These females have nonexchange X chromosomes, lack nod, and ...
8. Principles of Genetics and Cytogenetics
8. Principles of Genetics and Cytogenetics

... Publication of the DNA sequencing techniques of Maxam and Gilbert and of Sanger, Nicklen and Coulson (Sanger and Gilbert, Noble Prize ...
Disintegrin, hemorrhagic, and proteolytic activities of Mohave
Disintegrin, hemorrhagic, and proteolytic activities of Mohave

... the neurotoxic component and have predominately hemorrhagic venom (Glenn and Straight, 1978; Glenn et al., 1983; Glenn and Straight, 1989; Wilkinson et al., 1991). Furthermore, some specimens within this area of Arizona have also been documented to posses both neurotoxic and hemorrhagic venom compon ...
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Cell-free fetal DNA

Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin. The fetal DNA is fragmented and makes its way into the maternal bloodstream via shedding of the placental microparticles into the maternal bloodstream (figure 1). Studies have shown that cffDNA can first be observed as early as 7 weeks gestation, and the amount of cffDNA increases as the pregnancy progresses. cffDNA diminishes quickly after the birth of the baby, so that it is no longer detectable in the maternal blood approximately 2 hours after birth. cffDNA is significantly smaller than the maternal DNA in the bloodstream, with fragments approximately 200bp in size. Many protocols to extract the fetal DNA from the maternal plasma use its size to distinguish it from the maternal DNA.Studies have looked at, and some even optimized, protocols for testing non-compatible RhD factors, sex determination for X-linked genetic disorders and testing for single gene disorders. Current studies are now looking at determining aneuploidies in the developing fetus. These protocols can be done earlier than the current prenatal testing methods, and have no risk of spontaneous abortion, unlike current prenatal testing methods. Non-invasive prenatal diagnosis (NIPD) has been implemented in the UK and parts of the US; it has clear benefits above the standard tests of chorionic villi sample (CVS) and amniocentesis which have procedure-related miscarriage risks of about 1 in 100 pregnancies and 1 in 200 pregnancies, respectively.As a method of prenatal diagnosis, cell-free fetal DNA techniques share the same ethical and practical issues, such as the possibility of prenatal sex discernment and sex selection.
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