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Azza Ahmed Ibrahim Abo senna_GST paper
Azza Ahmed Ibrahim Abo senna_GST paper

... Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of several environmental mutagens, carcinogens and anticancer drugs. GST polymorphisms resulting in decreased enzymatic activity have been associated with several types of tumors. Using PCR, GSTT1 and GSTM1 genotypes were d ...
Clinical Update on Progesterone
Clinical Update on Progesterone

... Risk factors for preterm birth Prior PTB ***  Multiple gestation  Short cervical length  Low maternal BMI  African American  Maternal age  Smoking ...
Classification of Centers for Disease Control Group Eugonic
Classification of Centers for Disease Control Group Eugonic

... organisms found in the oral cavity of dogs and cats, although systemic infections in humans and animals have also been reported (Ganière et al., 1995). Two biotypes can be distinguished based on the presence (EF-4a) or absence (EF-4b) of arginine dihydrolase activity (Holmes & Ahmed, 1981). In addi ...
The phenotypic consequences of MECP2 mutations extend beyond
The phenotypic consequences of MECP2 mutations extend beyond

... strikes females, Rett syndrome (RTT) has been an enigmatic disorder since it was first recognized. The identification of mutation in MECP2 as the cause of most cases of RTT affords us the opportunity to explore the mechanisms that underlie the disorder both clinically and molecularly. However, the g ...
Alu - Environmental
Alu - Environmental

... Alu elements • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other pri ...
Nucleic Acids - Farmasi Unand
Nucleic Acids - Farmasi Unand

... Figure 10.27. Examples of topoisomerase inhibitors. Ellipticene acts h intercalation and inhibition of topoisomerase II enzymes. It is active against nasophar ngeal carcinomas. Amsacrinc is used to treat oarian carcinomas. lymphoinas and myelogenous leukaemias. (camptotheci n is an antitumour. ...
CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI The
CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI The

... We recently proposed that the physical isolation of chromosomes in aberrant nuclear structures called micronuclei might explain the localization of DNA lesions in chromothripsis11. Micronuclei are a common outcome of many cell division defects, including mitotic errors that missegregate intact chrom ...
Questions & Answer keys Test 2 Genetic engg.
Questions & Answer keys Test 2 Genetic engg.

... According to the signal hypothesis, the signal peptide for secretory protein is Select one: a. rich in hydrophobic amino acids at the centre of the signal peptide and is attached to the N-terminus of the protein b. rich in hydrophilic amino acids at the centre of the signal peptide and is attached t ...
WOTD - Brookwood High School
WOTD - Brookwood High School

... two or more alleles are expressed at the same time, both are expressed in patches on the organism ...
Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy
Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy

... HBPM is done by the woman using an automated device, with duplicate measurements taken at least twice daily over several days [7,11]. When HBPM values are normal but office values elevated, ABPM or repeated HBPM are recommended [7]. While pregnant women and practitioners prefer HBPM to ABPM [12], pre ...
17 Hydroxyprogesterone for the Prevention of Preterm Delivery
17 Hydroxyprogesterone for the Prevention of Preterm Delivery

... that the results demonstrated by these trials contrast markedly with the poor effectiveness of other efforts to reduce the occurrence of preterm birth, but that since no effect was demonstrated to result in lower perinatal mortality or morbidity, “further well-controlled research would be necessary ...
Molecular genotyping of ABO blood groups in some population
Molecular genotyping of ABO blood groups in some population

... detected in all the three groups in the present study. A non deletional O group allele, O03 (O2) was seen with very low frequency (0.005 - 0.0950) in all the groups, while only one case of O209 or O11 was detected. The frequency distribution of different ABO alleles in different world populations ...
ARTICLES - Weizmann Institute of Science
ARTICLES - Weizmann Institute of Science

... binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it is not known whether these sequence preferences have a significant influence on nucleosome position in vivo, a ...
Wage cuts and health at birth: the adverse effects of in utero
Wage cuts and health at birth: the adverse effects of in utero

... pairs with one child in utero at the time of the announcement whose mother was affected by the austerity measure (the public sector employed women) to the difference between sibling pairs with one sibling in utero on May 7th 2010 belonging to mothers not affected by the measures (housewives women). ...
video slide - Dublin City Schools Home
video slide - Dublin City Schools Home

... The Polymerase Chain Reaction (PCR) • The polymerase chain reaction (PCR) is a technique by which any segment of DNA can be copied quickly and precisely. – Through PCR, scientists can obtain enough DNA from even minute amounts of blood or other tissue to allow DNA profiling. ...
Maintenance of genomic integrity by p53: complementary
Maintenance of genomic integrity by p53: complementary

... result, DNA damage will be repaired during a growth arrest, or the damaged cells will be eliminated, thereby preventing ®xation of DNA damage as mutations. This function of p53 led to the now famous coining of p53 as the `guardian of the genome' by Lane (1992). Although the main features of p53's ro ...
Statistical analysis of simple repeats in the human genome
Statistical analysis of simple repeats in the human genome

... Experiments on kinetics of DNA denaturation and renaturation and the analysis of DNA sequences have revealed that most of our genome is populated by DNA repeats of different length, number and degree of dispersion [1]. Long repeats in few copies are usually orthologous genes, which may contain hidde ...
Slide 1
Slide 1

... Introduction ...
Whole-transcriptome RNAseq analysis from minute amount of total
Whole-transcriptome RNAseq analysis from minute amount of total

... biased toward higher GC content of transcriptome and Illumina Genome analyzer IIx is biased away from neutral to lower GC content of the transcriptomics regions. INTRODUCTION High-throughput (HT) sequencing technologies provide a powerful tool for transcriptome analysis and bring great advantages ov ...
Genetic Transformation of Poinsettia (Euphórbia
Genetic Transformation of Poinsettia (Euphórbia

... In nature, A. tumefaciens will infect dicotyledonous plants to produce crown-gall disease by transferring genes coding for crown-gall into the plant (Hoekema et al. 1983; Stachel & Nester 1986). This is done by a virulence region (vir-region) located in a tumour inducing plasmid (Tiplasmid) in the A ...
Application Note: Targeted sequencing and chromosomal haplotype
Application Note: Targeted sequencing and chromosomal haplotype

... complete loci on the basis of crosslinking physically proximal sequences. Unlike other targeted sequencing methods, TLA works without prior detailed locus information, as one primer pair is sufficient to amplify tens to hundreds of kilobases of DNA surrounding that locus. In a separate application o ...
Analysis of acid-induced asr gene promoter of Enterobacteriaceae
Analysis of acid-induced asr gene promoter of Enterobacteriaceae

... asr mRNA is a long-lived and one of the most abundant RNA messages in E. coli cells at maximal levels of induction [5]. This was confirmed by mRNA expression profiling of E. coli cells grown in a supplemented minimal medium and subjected to acid shock [7]. Search for the trans-acting regulatory comp ...
DNA cytosine methylation in plant development
DNA cytosine methylation in plant development

... opinion that cytosine methylation is indispensible for normal plant development has been reinforced by using single or combinations of diverse loss-of-function mutants for DNA methyltransferases, DNA glycosylases, components involved in siRNA biogenesis and chromatin remodeling factors. Patterns of ...
Genomic rearrangements account for more than one
Genomic rearrangements account for more than one

... unexpected additional products are likely derived from alternative aberrant splicing events. Similar to the common observation made with certain splice site mutations, these data confirm the concept that acceptor and donor splicing sequences require some degree of specificity for their recognition. ...
HUMAN PAPILLOMAVIRUS (HPV)
HUMAN PAPILLOMAVIRUS (HPV)

... Current recommendations for cervical cancer screening have not changed for females who receive quadrivalent HPV vaccine. Females who have an equivocal or abnormal Pap test, a positive Hybrid Capture II high-risk test, or genital warts can receive the quadrivalent HPV vaccine. – Recipients should be ...
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Cell-free fetal DNA

Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin. The fetal DNA is fragmented and makes its way into the maternal bloodstream via shedding of the placental microparticles into the maternal bloodstream (figure 1). Studies have shown that cffDNA can first be observed as early as 7 weeks gestation, and the amount of cffDNA increases as the pregnancy progresses. cffDNA diminishes quickly after the birth of the baby, so that it is no longer detectable in the maternal blood approximately 2 hours after birth. cffDNA is significantly smaller than the maternal DNA in the bloodstream, with fragments approximately 200bp in size. Many protocols to extract the fetal DNA from the maternal plasma use its size to distinguish it from the maternal DNA.Studies have looked at, and some even optimized, protocols for testing non-compatible RhD factors, sex determination for X-linked genetic disorders and testing for single gene disorders. Current studies are now looking at determining aneuploidies in the developing fetus. These protocols can be done earlier than the current prenatal testing methods, and have no risk of spontaneous abortion, unlike current prenatal testing methods. Non-invasive prenatal diagnosis (NIPD) has been implemented in the UK and parts of the US; it has clear benefits above the standard tests of chorionic villi sample (CVS) and amniocentesis which have procedure-related miscarriage risks of about 1 in 100 pregnancies and 1 in 200 pregnancies, respectively.As a method of prenatal diagnosis, cell-free fetal DNA techniques share the same ethical and practical issues, such as the possibility of prenatal sex discernment and sex selection.
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