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Staffing (Please give details as at April 1st of the year of application)
Staffing (Please give details as at April 1st of the year of application)

... includes support for technical trouble shooting, advice on clinical interpretation and reporting and a scientific and management objective setting environment capable of absorbing and integrating new scientific and technical developments relevant to the specialist service. ...
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Inhibition of RNA Synthesis by Anthracycline Analogs
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... tive after mature virions appear (DiMarco et al., 1968). Daunomycin is ineffective against the replication of animal RNAviruses with the exception of Newcastle Disease Virus (NDV) providing that the daunomycin-NOV mixtures are exposed to light (Verini et al., ...
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... are termed “hot spot survey crosses.” These crosses are carried out using conditions which block nearly all DNA synthesis (MCMILINand Russo 1972). Though there is some residual DNA synthesis, which is potentially very interesting (J. SIEGEL,nianuscript in preparation), it is convenient and justifiab ...
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Cell-free fetal DNA

Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin. The fetal DNA is fragmented and makes its way into the maternal bloodstream via shedding of the placental microparticles into the maternal bloodstream (figure 1). Studies have shown that cffDNA can first be observed as early as 7 weeks gestation, and the amount of cffDNA increases as the pregnancy progresses. cffDNA diminishes quickly after the birth of the baby, so that it is no longer detectable in the maternal blood approximately 2 hours after birth. cffDNA is significantly smaller than the maternal DNA in the bloodstream, with fragments approximately 200bp in size. Many protocols to extract the fetal DNA from the maternal plasma use its size to distinguish it from the maternal DNA.Studies have looked at, and some even optimized, protocols for testing non-compatible RhD factors, sex determination for X-linked genetic disorders and testing for single gene disorders. Current studies are now looking at determining aneuploidies in the developing fetus. These protocols can be done earlier than the current prenatal testing methods, and have no risk of spontaneous abortion, unlike current prenatal testing methods. Non-invasive prenatal diagnosis (NIPD) has been implemented in the UK and parts of the US; it has clear benefits above the standard tests of chorionic villi sample (CVS) and amniocentesis which have procedure-related miscarriage risks of about 1 in 100 pregnancies and 1 in 200 pregnancies, respectively.As a method of prenatal diagnosis, cell-free fetal DNA techniques share the same ethical and practical issues, such as the possibility of prenatal sex discernment and sex selection.
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