Human cytochromes P450 in health and disease
... of CYP enzymes in the eicosanoid pathway is likely to be redundant with lipoxygenases and other peroxidases [40]. There are now more than 150 identified eicosanoids [40], which participate in virtually every imaginable critical life process (table 3). In all likelihood due to redundancy, allelic var ...
... of CYP enzymes in the eicosanoid pathway is likely to be redundant with lipoxygenases and other peroxidases [40]. There are now more than 150 identified eicosanoids [40], which participate in virtually every imaginable critical life process (table 3). In all likelihood due to redundancy, allelic var ...
DNA Sequence Changes of Mutations Altering
... expression along with the attenuator deletion his01242, we selected recombinants that had undergone a recombination event in or near the his control region, and then identified the recombinants that had inherited the 2 desired mutations. The design of these crosses is diagrammed in Fig. 1. To select ...
... expression along with the attenuator deletion his01242, we selected recombinants that had undergone a recombination event in or near the his control region, and then identified the recombinants that had inherited the 2 desired mutations. The design of these crosses is diagrammed in Fig. 1. To select ...
Natural variation in monoterpene synthesis in kiwifruit
... concentrations of linalool, geraniol, nerol, citronellol and α-terpineol co-locate with candidate ...
... concentrations of linalool, geraniol, nerol, citronellol and α-terpineol co-locate with candidate ...
hag expression in Bacillus subtilis is both negatively
... (Caldwell et al., 2001), which are mainly transcribed by the sD-dependent RNA polymerase (Ordal et al., 1993). This conclusion has been derived from the transcription profiling of scoC mutant cells (scoC4), which showed that most of the motility genes, including hag, are transcribed at lower levels ...
... (Caldwell et al., 2001), which are mainly transcribed by the sD-dependent RNA polymerase (Ordal et al., 1993). This conclusion has been derived from the transcription profiling of scoC mutant cells (scoC4), which showed that most of the motility genes, including hag, are transcribed at lower levels ...
The B-cell maturation factor Blimp-1 specifies vertebrate slow
... specification are still obscure. Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers2, encodes the zebrafish homolog of Blimp-1, a SET domain–containing transcription factor that promotes the terminal differentiation of B lymphocytes in ...
... specification are still obscure. Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers2, encodes the zebrafish homolog of Blimp-1, a SET domain–containing transcription factor that promotes the terminal differentiation of B lymphocytes in ...
Creating records and analysis of deposited data
... Scroll down to the “DECIPHER: Sequence Variants” track. Does our variant overlap another variant in DECIPHER? If so, click on this variant to see more information in a pop-up window. Click on the patient ID for this patient from the pop-up menu to see the other patient in a new browser tab. What is ...
... Scroll down to the “DECIPHER: Sequence Variants” track. Does our variant overlap another variant in DECIPHER? If so, click on this variant to see more information in a pop-up window. Click on the patient ID for this patient from the pop-up menu to see the other patient in a new browser tab. What is ...
The costs of immunity and the evolution of immunological defense
... Drosophila there is likely a constant interaction between the host and a host-associated microbial community of natural pathogens, opportunistic pathogens, commensals, and mutualists. Indeed, the first line of defense, acting to limit the per-contact rate of infection, may be niche occupation by nat ...
... Drosophila there is likely a constant interaction between the host and a host-associated microbial community of natural pathogens, opportunistic pathogens, commensals, and mutualists. Indeed, the first line of defense, acting to limit the per-contact rate of infection, may be niche occupation by nat ...
Genome duplications and accelerated evolution of
... SYNOPSIS. The early origin of four vertebrate Hox gene clusters during the evolution of gnathostomes was likely caused by two consecutive duplications of the entire genome and the subsequent loss of individual genes. The presumed conserved and important roles of these genes in tetrapods during devel ...
... SYNOPSIS. The early origin of four vertebrate Hox gene clusters during the evolution of gnathostomes was likely caused by two consecutive duplications of the entire genome and the subsequent loss of individual genes. The presumed conserved and important roles of these genes in tetrapods during devel ...
How to use helper strains for maintaining and crossing handicapped... and resolving heterokaryons, and for determining heterokaryon compatibility.
... Helpers in N. tetrasperma (Perkins 1994) carry the gene E: Eight spore, which prevents the E component of a heterokaryon from contributing progeny when the strain being tested also carries the dominant E allele. Procedure N. crassa helpers. Visible fresh inocula of the two strains to be combined are ...
... Helpers in N. tetrasperma (Perkins 1994) carry the gene E: Eight spore, which prevents the E component of a heterokaryon from contributing progeny when the strain being tested also carries the dominant E allele. Procedure N. crassa helpers. Visible fresh inocula of the two strains to be combined are ...
Supplementary Table 1 Entrez Gene (http://www.ncbi.nlm.nih.gov
... Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011) This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is in ...
... Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011) This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is in ...
Spectrum of Mutations in MMAB Identified by
... Pathogenic variants in the MMAB gene (OMIM 607958) are responsible for the cblB class of cobalamin-responsive methylmalonic aciduria (MMA) (OMIM 251110). MMAB encodes cobalamin adenosyltransferase, a mitochondrial enzyme responsible for the formation of adenosylcobalamin (AdoCbl). AdoCbl subsequentl ...
... Pathogenic variants in the MMAB gene (OMIM 607958) are responsible for the cblB class of cobalamin-responsive methylmalonic aciduria (MMA) (OMIM 251110). MMAB encodes cobalamin adenosyltransferase, a mitochondrial enzyme responsible for the formation of adenosylcobalamin (AdoCbl). AdoCbl subsequentl ...
Chapter 3
... A comparative analysis of genes involved in mesoderm specification and differentiation across animal taxa may shed light on the homology of the mesoderm. Thus far, most of the knowledge about genes involved in mesoderm formation comes from model systems studied in developmental genetics, e.g. Drosop ...
... A comparative analysis of genes involved in mesoderm specification and differentiation across animal taxa may shed light on the homology of the mesoderm. Thus far, most of the knowledge about genes involved in mesoderm formation comes from model systems studied in developmental genetics, e.g. Drosop ...
Breeding Policy for the RagaMuffin Cat
... where the temperature is generally higher, the colour is lighter. The Burmese colour restriction gene (cb) produces the slight reduction in pigment seen in the Burmese and other breeds, sometimes including the RagaMuffin. This is produced when two copies of the gene are present. A great many genes d ...
... where the temperature is generally higher, the colour is lighter. The Burmese colour restriction gene (cb) produces the slight reduction in pigment seen in the Burmese and other breeds, sometimes including the RagaMuffin. This is produced when two copies of the gene are present. A great many genes d ...
2 Changes of Gene Frequency - the UC Davis Plant Breeding
... Mutation rates are generally very low — about 10 -5 or 10 -6 per generation for most loci in most organisms. This means that between about 1 in 100,000 and 1 in 1,000,000 gametes carry a newly mutated allele at any particular locus. With normal mutation rates, therefore, mutation alone can produce o ...
... Mutation rates are generally very low — about 10 -5 or 10 -6 per generation for most loci in most organisms. This means that between about 1 in 100,000 and 1 in 1,000,000 gametes carry a newly mutated allele at any particular locus. With normal mutation rates, therefore, mutation alone can produce o ...
special - Microbiology
... to an expanding family of regulatory proteins that includes the pathway-specific regulatory gene for daunorubicin production in S t r e p t o m y e s peucetiw (Stutzman-Engwall e t al., 1992), and the putative pleiotropic regulatory gene a f ~ R(Horinouchi e t al., 1990). ActII-ORF4 and RedD show 33 ...
... to an expanding family of regulatory proteins that includes the pathway-specific regulatory gene for daunorubicin production in S t r e p t o m y e s peucetiw (Stutzman-Engwall e t al., 1992), and the putative pleiotropic regulatory gene a f ~ R(Horinouchi e t al., 1990). ActII-ORF4 and RedD show 33 ...
RT2 Profiler™ PCR Arrays: Pathway
... RNA quality and transcription efficiency. Such a result provides a greater degree of confidence in the final results. The RT² First Strand Kit is optimized for use with the RT² SYBR Green qPCR Master Mixes and subsequent gene expression analysis with the RT2 Profiler PCR Arrays as part of the complete ...
... RNA quality and transcription efficiency. Such a result provides a greater degree of confidence in the final results. The RT² First Strand Kit is optimized for use with the RT² SYBR Green qPCR Master Mixes and subsequent gene expression analysis with the RT2 Profiler PCR Arrays as part of the complete ...
Exclusion of PAX9 and MSX1 mutation in six families affected by
... syndromic alterations. However, there is little information in the literature about this. Methylation of PAX9 and MSX1 have been associated with cancer development but have not been described the relation between this phenomenon and dental agenesis (51,52). Another study showed evidence that low lev ...
... syndromic alterations. However, there is little information in the literature about this. Methylation of PAX9 and MSX1 have been associated with cancer development but have not been described the relation between this phenomenon and dental agenesis (51,52). Another study showed evidence that low lev ...
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli
... The resulting hybrids were tested for co-inheritance of the donor M R H + phenotype which was taken as evidence for the expression of F8 fimbriae. Although the yield of hybrids was very poor it soon came to light that the M R H + phenotype must be associated with gal and pyrD genes of the donor (see ...
... The resulting hybrids were tested for co-inheritance of the donor M R H + phenotype which was taken as evidence for the expression of F8 fimbriae. Although the yield of hybrids was very poor it soon came to light that the M R H + phenotype must be associated with gal and pyrD genes of the donor (see ...
Mining Multi-Faceted Overviews of Arbitrary Topics in a Text Collection
... • We evaluated the effectiveness of different facet modeling approaches in Table.4. • Pri and Reg are our prior-based and regularizerbased approacheswith most extensive facet expansion; • Sup represents the result of the system by [11] using the supervised approach • MQR casts this task as a multi-q ...
... • We evaluated the effectiveness of different facet modeling approaches in Table.4. • Pri and Reg are our prior-based and regularizerbased approacheswith most extensive facet expansion; • Sup represents the result of the system by [11] using the supervised approach • MQR casts this task as a multi-q ...
Genomic Survey and Gene Expression Analysis
... bZIP domain with confidence (E value ,1.0) as given by SMART revealed 89 potential nonredundant bZIP transcription factor genes, which were designated as OsbZIP genes. The OsbZIP genes were given a number designation from 1 to 89 to provide a unique identifier for each bZIP transcription factor gene ...
... bZIP domain with confidence (E value ,1.0) as given by SMART revealed 89 potential nonredundant bZIP transcription factor genes, which were designated as OsbZIP genes. The OsbZIP genes were given a number designation from 1 to 89 to provide a unique identifier for each bZIP transcription factor gene ...
Advances in maize genomics: the emergence of positional cloning
... magnitude as that required in Arabidopsis [24], even though the maize genome is about 20 times larger than that of Arabidopsis. In retrospect, this finding is not too surprising, as recombination occurs mostly within genes [25], and the gene numbers in Arabidopsis and maize might not be too differen ...
... magnitude as that required in Arabidopsis [24], even though the maize genome is about 20 times larger than that of Arabidopsis. In retrospect, this finding is not too surprising, as recombination occurs mostly within genes [25], and the gene numbers in Arabidopsis and maize might not be too differen ...
The novel Cer-like protein Caronte mediates the establishment of
... growth factor-b (TGF-b) family member, that has been proposed to act as a molecular midline barrier that would con®ne and prevent the `X' factor from diffusing from the left to the right side of the embryo12,13. Here we show that an excess of Lefty-1 in the left side of the embryo blocks activation ...
... growth factor-b (TGF-b) family member, that has been proposed to act as a molecular midline barrier that would con®ne and prevent the `X' factor from diffusing from the left to the right side of the embryo12,13. Here we show that an excess of Lefty-1 in the left side of the embryo blocks activation ...
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics
... al., 2002 ; Lo Iacono et al., 2008). However recently, two rare familial cases of SHFM1 have been demonstrated to result, with highest probability, from intragenic missense mutations of two critical glutamine residues in the third helix of the DLX5 homeodomain (Q178P reported in Shamseldin et al., 2 ...
... al., 2002 ; Lo Iacono et al., 2008). However recently, two rare familial cases of SHFM1 have been demonstrated to result, with highest probability, from intragenic missense mutations of two critical glutamine residues in the third helix of the DLX5 homeodomain (Q178P reported in Shamseldin et al., 2 ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... respectively). This finding suggests that the PROGINS polymorphism is not involved in the genesis of the disease in the population studied (Table 1&2). Our results point to no association between endometriosis and the PROGINS polymorphism; however, the power calculation of the sample was low, sugges ...
... respectively). This finding suggests that the PROGINS polymorphism is not involved in the genesis of the disease in the population studied (Table 1&2). Our results point to no association between endometriosis and the PROGINS polymorphism; however, the power calculation of the sample was low, sugges ...
Hypoxia-inducible factor 1 is a new target of microphthalmia
... HIF1, a master regulator of oxygen homeostasis. After dimerization with HIF1 (also named ARNT), HIF1 binds to a consensus sequence 5-RCGTG-3 called hypoxia-responsive element (HRE), and controls the expression of several genes involved in many aspects of cancer progression, including metabolic a ...
... HIF1, a master regulator of oxygen homeostasis. After dimerization with HIF1 (also named ARNT), HIF1 binds to a consensus sequence 5-RCGTG-3 called hypoxia-responsive element (HRE), and controls the expression of several genes involved in many aspects of cancer progression, including metabolic a ...