transposon
... Transposition in maize was discovered because of the effects of the chromosome breaks generated by transposition of "controlling elements". The break generates one chromosome that has a centromere and a broken end and one acentric fragment. The acentric fragment is lost during mitosis, and thi ...
... Transposition in maize was discovered because of the effects of the chromosome breaks generated by transposition of "controlling elements". The break generates one chromosome that has a centromere and a broken end and one acentric fragment. The acentric fragment is lost during mitosis, and thi ...
Bonus, a Drosophila TIF1 homologue, is a chromatin
... (GREWAL and MOAZED 2003). One of these families of proteins is the TIF1 family. The TIF1 family of proteins, TIF1α (LE DOUARIN et al. 1995), TIF1β [also called KAP-1 (FRIEDMAN et al. 1996) or KRIP-1 (KIM et al. 1996)], and TIF1γ (VENTURINI et al. 1999), are all structurally and functionally similar. ...
... (GREWAL and MOAZED 2003). One of these families of proteins is the TIF1 family. The TIF1 family of proteins, TIF1α (LE DOUARIN et al. 1995), TIF1β [also called KAP-1 (FRIEDMAN et al. 1996) or KRIP-1 (KIM et al. 1996)], and TIF1γ (VENTURINI et al. 1999), are all structurally and functionally similar. ...
CYP2B6 NESTED PCR: A GOOD APPROACH FOR PATIENTS ON METHADONE Original Article
... treatment of opioid dependency and the management of pain. It has high, 70-90%, oral bioavailability and a long plasma elimination half-life when administered in a racemic mixture [1–4], as shown by studies of differential blood-methadone concentrations among samples of the approximately one million ...
... treatment of opioid dependency and the management of pain. It has high, 70-90%, oral bioavailability and a long plasma elimination half-life when administered in a racemic mixture [1–4], as shown by studies of differential blood-methadone concentrations among samples of the approximately one million ...
2- pcr primer design and reaction optimisation
... The optimum length of a primer depends upon its (A+T) content, and the Tm of its partner if one runs the risk of having problems such as described above. Apart from the Tm, a prime consideration is that the primers should be complex enough so that the likelihood of annealing to sequences other than ...
... The optimum length of a primer depends upon its (A+T) content, and the Tm of its partner if one runs the risk of having problems such as described above. Apart from the Tm, a prime consideration is that the primers should be complex enough so that the likelihood of annealing to sequences other than ...
Altered cellular proliferation and mesoderm
... expand in vitro of several cell types including lymphocytes and fibroblasts. In addition, M33 null mutant mice show an aggravation of the skeletal malformations when treated to RA at embryonic day 7.5, leading to the hypothesis that, during development, the M33 gene might play a role in defining acc ...
... expand in vitro of several cell types including lymphocytes and fibroblasts. In addition, M33 null mutant mice show an aggravation of the skeletal malformations when treated to RA at embryonic day 7.5, leading to the hypothesis that, during development, the M33 gene might play a role in defining acc ...
Charge Transport in DNA - Insights from
... The state of knowledge of DNA stretching in 2000 was summarized in two reviews. [24, 25] At that time, a dispute on the nature of the overstretched state of dsDNA started, and it is in fact still going on. In contrast to the proposal of S-DNA, the overstretching profile of DNA was attributed to force ...
... The state of knowledge of DNA stretching in 2000 was summarized in two reviews. [24, 25] At that time, a dispute on the nature of the overstretched state of dsDNA started, and it is in fact still going on. In contrast to the proposal of S-DNA, the overstretching profile of DNA was attributed to force ...
![Crystal structures of -[Ru(phen)2dppz]2+ 1 with oligonucleotides](http://s1.studyres.com/store/data/023790436_1-6c83654c03a0a35fc50303cc056eabf6-300x300.png)
Crystal structures of -[Ru(phen)2dppz]2+ 1 with oligonucleotides
... This self-complementary sequence crystallizes to give a symmetrical duplex with a stoichiometry of three cations of 1 per duplex, or 1.5 cations of 1 per decamer strand. All the nucleic acid strands are equivalent in the crystal lattice, with the packing shown in Figure 1a. The conformation of a sin ...
... This self-complementary sequence crystallizes to give a symmetrical duplex with a stoichiometry of three cations of 1 per duplex, or 1.5 cations of 1 per decamer strand. All the nucleic acid strands are equivalent in the crystal lattice, with the packing shown in Figure 1a. The conformation of a sin ...
Curr. Microbiol. 42
... four amplicons (Fig. 2) of the predicted sizes with the set of primers (Table 1). None of the 27 field-collected isolates tested yielded amplicons with this same set of primers. This result could be a consequence of an unfortunate mismatch of the reverse primer (even of the terminal 3⬘-nucleotide), ...
... four amplicons (Fig. 2) of the predicted sizes with the set of primers (Table 1). None of the 27 field-collected isolates tested yielded amplicons with this same set of primers. This result could be a consequence of an unfortunate mismatch of the reverse primer (even of the terminal 3⬘-nucleotide), ...
Short Tandem Repeat Polymorphism and Cancer Risk: Influence of
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
Binding of Hoechst with nucleic acids using fluorescence spectroscopy
... on DNA and RNA can optimize the use of these compounds and their analogues as medical drugs. Hoechst dyes 33342 and 33258 are closely related bisbenzimides. Hoechst 33258 is 2’-(4-hydroxyphenyl)-5[5-(4-methylpiperazine-1-yl) benzimidazo-2-yl]-benzimidazole. Hoechst 33342 contains additional ethyl gr ...
... on DNA and RNA can optimize the use of these compounds and their analogues as medical drugs. Hoechst dyes 33342 and 33258 are closely related bisbenzimides. Hoechst 33258 is 2’-(4-hydroxyphenyl)-5[5-(4-methylpiperazine-1-yl) benzimidazo-2-yl]-benzimidazole. Hoechst 33342 contains additional ethyl gr ...
Genetics of mammalian meiosis: regulation, dynamics and impact
... chromosomes begin to align but are not yet paired. A chromosomal scaffold begins to form through the assembly of axial elements (AEs) from cohesin proteins (for example, REC8 and structural maintenance of chromosomes 1B (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP ...
... chromosomes begin to align but are not yet paired. A chromosomal scaffold begins to form through the assembly of axial elements (AEs) from cohesin proteins (for example, REC8 and structural maintenance of chromosomes 1B (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP ...
hag expression in Bacillus subtilis is both negatively
... regulates hag transcription. This result was in contrast to that observed from the transcription profiles of B. subtilis 168 and scoC4, which demonstrated decreased hag transcription in scoC4 (Caldwell et al., 2001). To determine if the negative regulation of hag by ScoC is due to a direct binding o ...
... regulates hag transcription. This result was in contrast to that observed from the transcription profiles of B. subtilis 168 and scoC4, which demonstrated decreased hag transcription in scoC4 (Caldwell et al., 2001). To determine if the negative regulation of hag by ScoC is due to a direct binding o ...
Standard
... Taken together, these results confirm a significant function for FTa1 in the control of flowering time in Medicago. However, the molecular mechanisms by which the environmental cues of LD and vernalisation upregulate FTa1 are ...
... Taken together, these results confirm a significant function for FTa1 in the control of flowering time in Medicago. However, the molecular mechanisms by which the environmental cues of LD and vernalisation upregulate FTa1 are ...
Eds., N. Hamamura, S. Suzuki, S. Mendo, C. M. Barroso,... © by TERRAPUB, 2010.
... collected in Ria de Aveiro, to perform the microcosm experiment, were 7.5, 35 g·l–1 and 26°C, respectively. A preliminary experiment was performed to evaluate the influence of Av27 and TBT in the natural microbial community. Figure 3(A) shows that the samples containing TBT and inoculated with the r ...
... collected in Ria de Aveiro, to perform the microcosm experiment, were 7.5, 35 g·l–1 and 26°C, respectively. A preliminary experiment was performed to evaluate the influence of Av27 and TBT in the natural microbial community. Figure 3(A) shows that the samples containing TBT and inoculated with the r ...
Demarcation of coding and non-coding regions of DNA using linear
... codons, code for amino acids. There are two distinct regions in DNA, the gene and the intergenic DNA, or the junk DNA. Two regions can be distinguished in the gene- the exons, or the regions that code for amino acid, and the introns, or the regions that do not code for amino acid. The main aim of th ...
... codons, code for amino acids. There are two distinct regions in DNA, the gene and the intergenic DNA, or the junk DNA. Two regions can be distinguished in the gene- the exons, or the regions that code for amino acid, and the introns, or the regions that do not code for amino acid. The main aim of th ...
Complete
... as Brownian ratchets, structures that permit Brownian motion in only one direction [1–7]. When particles flow through such an array driven by an electric field (Fig. 2.1A), particles diffusing to the left (path 1; Fig. 2.1A) are blocked and deflected back to gap B, whereas those diffusing to the rig ...
... as Brownian ratchets, structures that permit Brownian motion in only one direction [1–7]. When particles flow through such an array driven by an electric field (Fig. 2.1A), particles diffusing to the left (path 1; Fig. 2.1A) are blocked and deflected back to gap B, whereas those diffusing to the rig ...
The amphioxus hairy family: differential fate after duplication.
... Several representatives of the hairy family have been so far isolated from a range of protostome and vertebrate species. In protostomes such as Drosophila they have been implicated in segmentation, peripheral nervous system development, and in somatic sex determination. In Tribolium, only a role dur ...
... Several representatives of the hairy family have been so far isolated from a range of protostome and vertebrate species. In protostomes such as Drosophila they have been implicated in segmentation, peripheral nervous system development, and in somatic sex determination. In Tribolium, only a role dur ...
The Mycobacterium tuberculosis katG promoter region contains a
... Bashyam et al., 1996) ; however, many of these promoters are specifically regulated in vivo and may not be typical. Some of the mycobacterial promoters resemble the typical Escherichia coli σ(! consensus promoter and function in this organism, but most have a higher GjC content and differ from the E ...
... Bashyam et al., 1996) ; however, many of these promoters are specifically regulated in vivo and may not be typical. Some of the mycobacterial promoters resemble the typical Escherichia coli σ(! consensus promoter and function in this organism, but most have a higher GjC content and differ from the E ...
Distortion of quantitative genomic and expression
... Synthetic repetitive DNA. Synthetic repetitive DNA was prepared from genomic regions selected based on the families of repetitive sequences contained within them, since each is enriched in the Cot-1 manufacturing process. However, any representative genomic region containing sc regions adjacent to m ...
... Synthetic repetitive DNA. Synthetic repetitive DNA was prepared from genomic regions selected based on the families of repetitive sequences contained within them, since each is enriched in the Cot-1 manufacturing process. However, any representative genomic region containing sc regions adjacent to m ...
Tumor metastasis-associated human MTA1 gene and its MTA1
... MTA1 protein has been localized in the cell nucleus, and it is thought that its major function is associated with its nuclear location [14, 15]. Recently, two groups reported that nucleosome remodeling histone deacetylase complex (NuRD complex), which is involved in chromatin remodeling, contains MT ...
... MTA1 protein has been localized in the cell nucleus, and it is thought that its major function is associated with its nuclear location [14, 15]. Recently, two groups reported that nucleosome remodeling histone deacetylase complex (NuRD complex), which is involved in chromatin remodeling, contains MT ...
Equilibrium Statistics of Channel-confined DNA
... (a polymer) that is confined to a channel which is much narrower than the size of the molecule. The primary motivation is recent experiments where DNA molecules are inserted into channels with a width of about 100 nm. The research in this thesis attempts to explain the observations of these experime ...
... (a polymer) that is confined to a channel which is much narrower than the size of the molecule. The primary motivation is recent experiments where DNA molecules are inserted into channels with a width of about 100 nm. The research in this thesis attempts to explain the observations of these experime ...
Replication timing as an epigenetic mark
... the finding that early replicating genes could be either expressed or silent, while late replicating genes were almost always silent, leading to the hypothesis that early replication is necessary for transcriptional competence but is not sufficient for transcription per se.12 This notion was support ...
... the finding that early replicating genes could be either expressed or silent, while late replicating genes were almost always silent, leading to the hypothesis that early replication is necessary for transcriptional competence but is not sufficient for transcription per se.12 This notion was support ...
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... diverged. In an elegant study, Shaver et al (Shaver et al., 2010) identified the novel computational PRC2-homologs in several unicellular species and showed that E(z)-homolog in unicellular green algae Chlamydomonas reinhardtii is responsible for mono- and di-methylation of lysine 27 on histone H3. ...
... diverged. In an elegant study, Shaver et al (Shaver et al., 2010) identified the novel computational PRC2-homologs in several unicellular species and showed that E(z)-homolog in unicellular green algae Chlamydomonas reinhardtii is responsible for mono- and di-methylation of lysine 27 on histone H3. ...
Two Waves of Nuclear Factor κB Recruitment to Target Promoters
... for the NF-B dependency of MnSOD expression (29); also in this case p65/RelA is recruited quickly and persistently, and transcriptional induction occurs shortly after initial NF-B binding (Fig. 2 a). Thus, NF-B persists on both MnSOD enhancer and MIP-2 promoter long after IB resynthesis has bee ...
... for the NF-B dependency of MnSOD expression (29); also in this case p65/RelA is recruited quickly and persistently, and transcriptional induction occurs shortly after initial NF-B binding (Fig. 2 a). Thus, NF-B persists on both MnSOD enhancer and MIP-2 promoter long after IB resynthesis has bee ...
Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.