Two Waves of Nuclear Factor κB Recruitment to Target Promoters
... for the NF-B dependency of MnSOD expression (29); also in this case p65/RelA is recruited quickly and persistently, and transcriptional induction occurs shortly after initial NF-B binding (Fig. 2 a). Thus, NF-B persists on both MnSOD enhancer and MIP-2 promoter long after IB resynthesis has bee ...
... for the NF-B dependency of MnSOD expression (29); also in this case p65/RelA is recruited quickly and persistently, and transcriptional induction occurs shortly after initial NF-B binding (Fig. 2 a). Thus, NF-B persists on both MnSOD enhancer and MIP-2 promoter long after IB resynthesis has bee ...
Chromosome - World of Teaching
... but a point mutation in the CDE-III subdomain completely eliminates the ability of the centromere to function during chromosome segregation. ...
... but a point mutation in the CDE-III subdomain completely eliminates the ability of the centromere to function during chromosome segregation. ...
"Frontmatter". In: Plant Genomics and Proteomics
... comparable processes of pattern formation and the underlying genes appear to be similar, the actual mechanisms of getting to the end points of development are different. Once again, this reinforces the need to look specifically at the plant processes in order to understand how plants function. One o ...
... comparable processes of pattern formation and the underlying genes appear to be similar, the actual mechanisms of getting to the end points of development are different. Once again, this reinforces the need to look specifically at the plant processes in order to understand how plants function. One o ...
New Construct Approaches for Efficient Gene Silencing in Plants
... transcriptional terminator. Here, we show that this regulatory element becomes obsolete when gene fragments are positioned between two oppositely oriented and functionally active promoters. The resulting convergent transcription triggers gene silencing that is at least as effective as unidirectional ...
... transcriptional terminator. Here, we show that this regulatory element becomes obsolete when gene fragments are positioned between two oppositely oriented and functionally active promoters. The resulting convergent transcription triggers gene silencing that is at least as effective as unidirectional ...
ARTICLES - Weizmann Institute of Science
... the genome-wide organization of nucleosomes. Our results demonstrate that genomes encode an intrinsic nucleosome organization and that this intrinsic organization can explain ,50% of the in vivo nucleosome positions. This nucleosome positioning code may facilitate specific chromosome functions inclu ...
... the genome-wide organization of nucleosomes. Our results demonstrate that genomes encode an intrinsic nucleosome organization and that this intrinsic organization can explain ,50% of the in vivo nucleosome positions. This nucleosome positioning code may facilitate specific chromosome functions inclu ...
CHEK2*1100delC Genotyping for Clinical Assessment of Breast
... CHEK2 (cell cycle checkpoint kinase 2) acts as a tumor suppressor in the nucleus, where it blocks cell proliferation and initiates DNA repair in response to DNA double-strand breakage.1,2 A dysfunctional variant, CHEK2*1100delC, has lost this ability. CHEK2*1100delC is primarily present in individua ...
... CHEK2 (cell cycle checkpoint kinase 2) acts as a tumor suppressor in the nucleus, where it blocks cell proliferation and initiates DNA repair in response to DNA double-strand breakage.1,2 A dysfunctional variant, CHEK2*1100delC, has lost this ability. CHEK2*1100delC is primarily present in individua ...
Chpt8_RecombineDNA.doc
... no large-scale sequence similarity is apparent, e.g. translocations between different chromosomes or deletions that remove several genes along a chromosome. However, when the DNA sequence at the breakpoints for these events is analyzed, short regions of sequence similarity are found in some cases. F ...
... no large-scale sequence similarity is apparent, e.g. translocations between different chromosomes or deletions that remove several genes along a chromosome. However, when the DNA sequence at the breakpoints for these events is analyzed, short regions of sequence similarity are found in some cases. F ...
Amplification of 16S rRNA Genes from Frankia Strains in Root
... from nonnodule plant roots yielded a single band that, when digested, gave a restriction pattern consistent with the pattern of the initial amplification minus Frankia-specific bands. Because the plastid DNA amplified from plant tissue accounted for all of the additional bands seen in the initial di ...
... from nonnodule plant roots yielded a single band that, when digested, gave a restriction pattern consistent with the pattern of the initial amplification minus Frankia-specific bands. Because the plastid DNA amplified from plant tissue accounted for all of the additional bands seen in the initial di ...
Sleeping Beauty - Weber State University
... inactive due to the accumulation of mutations. Molecular phylogenetic data were used to construct a synthetic transposon, Sleeping Beauty, which could be identical or equivalent to an ancient element that dispersed in fish genomes in part by horizontal transmission between species. A consensus seque ...
... inactive due to the accumulation of mutations. Molecular phylogenetic data were used to construct a synthetic transposon, Sleeping Beauty, which could be identical or equivalent to an ancient element that dispersed in fish genomes in part by horizontal transmission between species. A consensus seque ...
Differentiated thyroid cancer: growth factors, oncogenes
... Importance of iodine in the development of goiter and its influence on distribution of thyroid cancer - physiological and pathophysiological explanations The growth inhibiting effect of iodine in thyroid tissues and thyroid cells in culture was well known for a long time but its molecular mechanism ...
... Importance of iodine in the development of goiter and its influence on distribution of thyroid cancer - physiological and pathophysiological explanations The growth inhibiting effect of iodine in thyroid tissues and thyroid cells in culture was well known for a long time but its molecular mechanism ...
pdf
... recombination. Illegitimate or nonhomologous recombination occurs in regions where no largescale sequence similarity is apparent, e.g. translocations between different chromosomes or deletions that remove several genes along a chromosome. However, when the DNA sequence at the breakpoints for these e ...
... recombination. Illegitimate or nonhomologous recombination occurs in regions where no largescale sequence similarity is apparent, e.g. translocations between different chromosomes or deletions that remove several genes along a chromosome. However, when the DNA sequence at the breakpoints for these e ...
The Mean Between Meme and Gene Comparison
... first year class, are passed on in a linked-loci fashion where a meme is attached to a fit meme, a comparison to a good philosophical argument. However, these examples do not imply an automatic or mindless passing along of information. Rather they show the “fitness” of a meme to being so strong as t ...
... first year class, are passed on in a linked-loci fashion where a meme is attached to a fit meme, a comparison to a good philosophical argument. However, these examples do not imply an automatic or mindless passing along of information. Rather they show the “fitness” of a meme to being so strong as t ...
Datasheet - Santa Cruz Biotechnology
... nuclei that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP α regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP α uses a bipartite structural m ...
... nuclei that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP α regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP α uses a bipartite structural m ...
The Mobile Genetic Element Alu in the Human Genome
... for Alu transcription in vivo, the vast majority of Alu elements are transcriptionally silent unless inserted into a favorable genomic location that fortuitously provides them with the 5' cis regulatory sequences. In addition, after insertion most SINEs are subject to methylation that is tissue and ...
... for Alu transcription in vivo, the vast majority of Alu elements are transcriptionally silent unless inserted into a favorable genomic location that fortuitously provides them with the 5' cis regulatory sequences. In addition, after insertion most SINEs are subject to methylation that is tissue and ...
Cloning and Expression of Cellulosimicrobium cellulans β
... for feeding at a later date [7]. Therefore, ensiled forages are the most commonly used feeds for ruminants all over the world [8]. Lactobacillus plantarum and other Lactobacillus species, Enterococcus faecium and Pediococcus species are most common silage inoculant bacteria and one or more of these ...
... for feeding at a later date [7]. Therefore, ensiled forages are the most commonly used feeds for ruminants all over the world [8]. Lactobacillus plantarum and other Lactobacillus species, Enterococcus faecium and Pediococcus species are most common silage inoculant bacteria and one or more of these ...
ADP Ribosylation Factor is an Essential Protein in Saccharomyces cerevisiae and is Encoded by Two Genes.
... Strains and plasmids. The yeast strains and plasmids used listed in Table 1. Strains bearing disruptions of the ARF genes were constructed by direct replacement of the wildtype chromosomal loci with disrupted loci constructed in vitro (31). ARFI was disrupted by replacing the BglII-XbaI fragment of ...
... Strains and plasmids. The yeast strains and plasmids used listed in Table 1. Strains bearing disruptions of the ARF genes were constructed by direct replacement of the wildtype chromosomal loci with disrupted loci constructed in vitro (31). ARFI was disrupted by replacing the BglII-XbaI fragment of ...
Recruitment of 5! Hoxa genes in the allantois is
... Hoxa13 is the only member required for embryonic survival (Fromental-Ramain et al., 1996; Shaut et al., 2008). Unexpectedly, whereas live Hoxa13–/– embryos can be recovered at embryonic day (E) 14.5 (Fromental-Ramain et al., 1996; Shaut et al., 2008), we found that embryos homozygous for the deletio ...
... Hoxa13 is the only member required for embryonic survival (Fromental-Ramain et al., 1996; Shaut et al., 2008). Unexpectedly, whereas live Hoxa13–/– embryos can be recovered at embryonic day (E) 14.5 (Fromental-Ramain et al., 1996; Shaut et al., 2008), we found that embryos homozygous for the deletio ...
Glioma heterogeneity and the LAT-1
... Glioma heterogeneity and the L-Amino acid transporter-1 (LAT1): A first step to stratified BPA-based BNCT? ...
... Glioma heterogeneity and the L-Amino acid transporter-1 (LAT1): A first step to stratified BPA-based BNCT? ...
Role of Genes - Native American Cancer Research
... The injury is a mutation resulting in damage that is passed on from the first body (somatic) cell as it divides into additional cells It gives the cells harboring the mutation an advantage to outgrow other cells For example in lung cancer the carcinogens in cigarette smoke may cause damage in severa ...
... The injury is a mutation resulting in damage that is passed on from the first body (somatic) cell as it divides into additional cells It gives the cells harboring the mutation an advantage to outgrow other cells For example in lung cancer the carcinogens in cigarette smoke may cause damage in severa ...
Life 9e - Garvness
... DNA yields no surprises. However, it is found that a codon for this life-form is just two bases in length. How many different amino acids could this organism be composed of? ...
... DNA yields no surprises. However, it is found that a codon for this life-form is just two bases in length. How many different amino acids could this organism be composed of? ...
MA112 Expresso® Rhamnose SUMO Cloning and
... precisely at its carboxyl terminus, allowing recovery of the intact protein of interest with no extra residues (1-3). The 6xHis-SUMO fragment and the protease (which also has a 6xHis tag) can then be captured by metal affinity, leaving the protein of interest in solution. The SUMO fusion tag and SUM ...
... precisely at its carboxyl terminus, allowing recovery of the intact protein of interest with no extra residues (1-3). The 6xHis-SUMO fragment and the protease (which also has a 6xHis tag) can then be captured by metal affinity, leaving the protein of interest in solution. The SUMO fusion tag and SUM ...
Structure, expression and chromosomal location of the Oct
... the relationship between Oct-4 and t 12 is to analyze the genomic structure and sequence of Oct-4 from the t 12 haplotype. A t w5 homozygous revertant ( t w5g unpublished) cosmid library was screened with the same Oct-4 probe to exclude trivial differences between the t- and wild-type sequences. A c ...
... the relationship between Oct-4 and t 12 is to analyze the genomic structure and sequence of Oct-4 from the t 12 haplotype. A t w5 homozygous revertant ( t w5g unpublished) cosmid library was screened with the same Oct-4 probe to exclude trivial differences between the t- and wild-type sequences. A c ...
Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.