Genomic imprinting and human disease
... known imprinted genes are arranged in clusters of several tens up to thousands of kilobases (kb) in size. Imprinted gene expression across these evolutionarily conserved clusters is regulated by ICRs (imprinting control regions), essential DNA sequence elements that are up to several kilobases in si ...
... known imprinted genes are arranged in clusters of several tens up to thousands of kilobases (kb) in size. Imprinted gene expression across these evolutionarily conserved clusters is regulated by ICRs (imprinting control regions), essential DNA sequence elements that are up to several kilobases in si ...
- Repository of the Academy`s Library
... success, and early embryogenesis, is of great significance for future practical applications in ...
... success, and early embryogenesis, is of great significance for future practical applications in ...
Reverse Genetic Analysis of Terminal Ear
... As the second part of the thesis, in situ and promoter/reporter GUS fusion analyses indicate TEL1 is preferentially expressed in both the root and shoot apical meristems. Deletion analysis using GFP reporter constructs show that 5' sequences are sufficient to drive quiescent centre (QC) expression i ...
... As the second part of the thesis, in situ and promoter/reporter GUS fusion analyses indicate TEL1 is preferentially expressed in both the root and shoot apical meristems. Deletion analysis using GFP reporter constructs show that 5' sequences are sufficient to drive quiescent centre (QC) expression i ...
Embryonic growth and the evolution of the mammalian Y
... correct parent-dependent expression rules. Thus, as the conditions for both their initial evolution and spread are relatively relaxed, the mammalian Y chromosome is expected to be an attractor for growth-promoting genes. Data from mice and humans indicate that, as expected and in contrast to the Y o ...
... correct parent-dependent expression rules. Thus, as the conditions for both their initial evolution and spread are relatively relaxed, the mammalian Y chromosome is expected to be an attractor for growth-promoting genes. Data from mice and humans indicate that, as expected and in contrast to the Y o ...
Monday March 10th in-class “assignment”: studying SRS and BWS
... the cell, potential effects on the cell; organismal = effects on the entire organism. -At the molecular level, BWS can be caused by a 160kb inverted duplication involving ICR2 and the 5` most 20kb region of the Kcnq1ot1. As a result the maternal copy of the ICR2 is hypomethylated because the duplica ...
... the cell, potential effects on the cell; organismal = effects on the entire organism. -At the molecular level, BWS can be caused by a 160kb inverted duplication involving ICR2 and the 5` most 20kb region of the Kcnq1ot1. As a result the maternal copy of the ICR2 is hypomethylated because the duplica ...
- American Diabetes Association
... matched healthy control subjects. Since the follow-up series is not fully synchronized in time between the different individuals, we first applied a similar approach as in Elo et al. (9) and Huang et al. (10) that avoids the need of a direct alignment. More specifically, for each individual, the expre ...
... matched healthy control subjects. Since the follow-up series is not fully synchronized in time between the different individuals, we first applied a similar approach as in Elo et al. (9) and Huang et al. (10) that avoids the need of a direct alignment. More specifically, for each individual, the expre ...
nCounter PanCancer Pathways Panel
... Studying the deregulation of molecular pathways impacted by mutational events as well as monitoring expression of these driver genes is critical to gaining a complete understanding of the biology underlying cancer. Molecular pathways are an attractive organizing principle for analysis of gene expres ...
... Studying the deregulation of molecular pathways impacted by mutational events as well as monitoring expression of these driver genes is critical to gaining a complete understanding of the biology underlying cancer. Molecular pathways are an attractive organizing principle for analysis of gene expres ...
Technologies to keep an eye on: alternative hosts for protein
... Number of expression hosts used for recombinant protein production for structural biology, expressed either as percentage of unique protein chains in the PDB or as a count of unique chains and PDBs per host. Only PDB entries with a non-empty ‘Expression Host’ field are considered, amounting to 67 69 ...
... Number of expression hosts used for recombinant protein production for structural biology, expressed either as percentage of unique protein chains in the PDB or as a count of unique chains and PDBs per host. Only PDB entries with a non-empty ‘Expression Host’ field are considered, amounting to 67 69 ...
Rhom-2 Expression Does Not Always Correlate With
... ern blot was prepared using BamHI-digested DNA. Hybridization of the Southern blot with a TCR-p probez4is shown in Fig 1A. As controls, DNAs from the KB and HPB cell lines were included. A germline band of 23 kb and two smaller rearranged bands for the TCR-p gene were observed for the Kl3 and HPB ce ...
... ern blot was prepared using BamHI-digested DNA. Hybridization of the Southern blot with a TCR-p probez4is shown in Fig 1A. As controls, DNAs from the KB and HPB cell lines were included. A germline band of 23 kb and two smaller rearranged bands for the TCR-p gene were observed for the Kl3 and HPB ce ...
Lect2_NormExprIndex
... • Assumption: most genes / probes don’t change between two conditions • Normalization can have larger effect on analysis than downstream steps (e.g. group comparisons) ...
... • Assumption: most genes / probes don’t change between two conditions • Normalization can have larger effect on analysis than downstream steps (e.g. group comparisons) ...
IGR-ANNOT: A Multiagent System for InterGenic - Inf
... computerized tools to analyze this data. • A new genome sequencing does not answer all questions about the organism. Progress is more likely to come from comparing the genomes of different organisms. ...
... computerized tools to analyze this data. • A new genome sequencing does not answer all questions about the organism. Progress is more likely to come from comparing the genomes of different organisms. ...
Identification of Differentially Expressed Genes in Blood Cells of
... genes—MX1 and MX2. These gene are specifically induced by IFN-alpha and beta.10,11 MX proteins belong to the family of large GTPases and are highly homologous with dynamins within their GTP-binding domain. MX proteins have a conserved C-terminal leucine zipper element. MX2 exists in 78-kDa and a 76-k ...
... genes—MX1 and MX2. These gene are specifically induced by IFN-alpha and beta.10,11 MX proteins belong to the family of large GTPases and are highly homologous with dynamins within their GTP-binding domain. MX proteins have a conserved C-terminal leucine zipper element. MX2 exists in 78-kDa and a 76-k ...
Gene ORGANizer: linking genes to the organs they
... (29), we performed simulations that account for such dependencies (see online Methods for details). We show that our false discovery rates are well <0.05, except for unrealistically high levels of dependency between genes (Supplementary Figure S1). To further assess the level of accuracy in of our D ...
... (29), we performed simulations that account for such dependencies (see online Methods for details). We show that our false discovery rates are well <0.05, except for unrealistically high levels of dependency between genes (Supplementary Figure S1). To further assess the level of accuracy in of our D ...
Folie 1 - ERA-NET PathoGenoMics
... Antimicrobial Action of Interferons • Type II IFN (IFN-g) activates macrophages and enhances immunity to predominantly nonviral pathogens, particularly when intracellular. • Type I IFN (>10 genes) mediate antiviral innate immunity. It is unclear why their synthesis is an obligatory response to many ...
... Antimicrobial Action of Interferons • Type II IFN (IFN-g) activates macrophages and enhances immunity to predominantly nonviral pathogens, particularly when intracellular. • Type I IFN (>10 genes) mediate antiviral innate immunity. It is unclear why their synthesis is an obligatory response to many ...
Array normalization, Gene expression index
... • Assumption: most genes / probes don’t change between two conditions • Normalization can have larger effect on analysis than downstream steps (e.g. group comparisons) ...
... • Assumption: most genes / probes don’t change between two conditions • Normalization can have larger effect on analysis than downstream steps (e.g. group comparisons) ...
Transcription Factors Underlying the Development and Endocrine
... FIG. 1. Summary of the trophoblast cell lineage outlining the alternative differentiated trophoblast cell fates and the expression of key regulatory transcription factors. ⫹ indicates that the gene is expressed, whereas ⫺ indicates that the gene is not expressed. ...
... FIG. 1. Summary of the trophoblast cell lineage outlining the alternative differentiated trophoblast cell fates and the expression of key regulatory transcription factors. ⫹ indicates that the gene is expressed, whereas ⫺ indicates that the gene is not expressed. ...
ppt_I
... ~96% (99.999% accurate) 30-40% repetitive elements (eg Alpha satellite, Alu repeats) All known genes, correctly identified (99.74%) heterochromatin ~4% grey ...
... ~96% (99.999% accurate) 30-40% repetitive elements (eg Alpha satellite, Alu repeats) All known genes, correctly identified (99.74%) heterochromatin ~4% grey ...
Overexpression of miR165 Affects Apical
... the mRNAs for cleavage and degradation (Kinder and Martiensen 2005a). In plants, several hundred miRNAs have been identified from a diverse group of species and, of them, many putative target genes have been predicted (Dugas and Bartel 2004, Kidner and Martienssen 2005a, Zhang et al. 2006). It has b ...
... the mRNAs for cleavage and degradation (Kinder and Martiensen 2005a). In plants, several hundred miRNAs have been identified from a diverse group of species and, of them, many putative target genes have been predicted (Dugas and Bartel 2004, Kidner and Martienssen 2005a, Zhang et al. 2006). It has b ...
IAP workshop, Ghent, Sept.
... nearby polymorphism (SNP) that controls expression in LD; We indeed found 96.5% selected cis-regulated genes have associated polymorphisms (haplotype blocks ) nearby. ...
... nearby polymorphism (SNP) that controls expression in LD; We indeed found 96.5% selected cis-regulated genes have associated polymorphisms (haplotype blocks ) nearby. ...
A Survey of Intron Research in Genetics
... The existence of the intron-exon structure has been particularly intriguing. Introns are only found in eukaryotic genomes and make up a large portion of the DNA in eukaryotic genomes. In humans, for example, approximately 30% of the human genome is made up of introns [1]. Only about 3% consists of c ...
... The existence of the intron-exon structure has been particularly intriguing. Introns are only found in eukaryotic genomes and make up a large portion of the DNA in eukaryotic genomes. In humans, for example, approximately 30% of the human genome is made up of introns [1]. Only about 3% consists of c ...
Differential chromatin packaging of genomic
... of both types of cross between C57BL/6 and MSM strains, whereas a non-imprinted gene, Sod-2, in the vicinity of Igf2r does not show such a difference. This indicates a close correlation between imprinting and the differential packaging of chromatin. On the other hand, the Zfp127/Snrpn locus showed s ...
... of both types of cross between C57BL/6 and MSM strains, whereas a non-imprinted gene, Sod-2, in the vicinity of Igf2r does not show such a difference. This indicates a close correlation between imprinting and the differential packaging of chromatin. On the other hand, the Zfp127/Snrpn locus showed s ...
Isolation and characterization of Viviparous
... PHS tolerance is one of the most important traits in wheat breeding. Two new Vp-1B alleles related to PHS tolerance were identified on the 3BL chromosome of bread wheat and were designated Vp-1Bb and Vp-1Bc. Sequence analysis showed that Vp-1Bb has a 193 bp insertion and Vp-1Bc has a 83 bp deletion l ...
... PHS tolerance is one of the most important traits in wheat breeding. Two new Vp-1B alleles related to PHS tolerance were identified on the 3BL chromosome of bread wheat and were designated Vp-1Bb and Vp-1Bc. Sequence analysis showed that Vp-1Bb has a 193 bp insertion and Vp-1Bc has a 83 bp deletion l ...
Resistance gene evolution Pamela C Ronald
... CACTA-like element and a retrotransposable element are present at the Xa21 locus [24•,49,50]. Integration of two of these elements into coding sequences creates open reading frames (ORFs) that encode truncated proteins. At least one of these truncated proteins can confer an attenuated resistance wit ...
... CACTA-like element and a retrotransposable element are present at the Xa21 locus [24•,49,50]. Integration of two of these elements into coding sequences creates open reading frames (ORFs) that encode truncated proteins. At least one of these truncated proteins can confer an attenuated resistance wit ...