Statistical Analysis of Microarray Data
... appear to have Cy3/Cy5 < 0.5, suggesting that they are differentially regulated. No genes have Cy3/Cy5 > 2. However, the average ratio is 0.95, indicating that overall fluorescence is generally 5% greater in the Cy5 (RED) channel. One way to adjust for this is to divide the individual ratios by the ...
... appear to have Cy3/Cy5 < 0.5, suggesting that they are differentially regulated. No genes have Cy3/Cy5 > 2. However, the average ratio is 0.95, indicating that overall fluorescence is generally 5% greater in the Cy5 (RED) channel. One way to adjust for this is to divide the individual ratios by the ...
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... marsupials and eutherians. These genes encode proteins that are homologous to a retrotransposon Gag capsid protein and sometimes also have a Pol-like region. We previously demonstrated that PEG10 (SIRH1) and PEG11/RTL1 (SIRH2) play essential but different roles in placental development. PEG10 is con ...
... marsupials and eutherians. These genes encode proteins that are homologous to a retrotransposon Gag capsid protein and sometimes also have a Pol-like region. We previously demonstrated that PEG10 (SIRH1) and PEG11/RTL1 (SIRH2) play essential but different roles in placental development. PEG10 is con ...
"What is a gene, in the post-ENCODE era?"
... intermediate transcripts) should be used to group together entities associated with a single gene. It also manifests how integral the concept of biological function is in defining genes. ...
... intermediate transcripts) should be used to group together entities associated with a single gene. It also manifests how integral the concept of biological function is in defining genes. ...
embr201439791-sup-0014
... filtered using an expression threshold. For DESeq2 data, we required that at least one comparison have a read count >100 in both replicates. For DEXSeq data, we required that at least one comparison have a read count >1 in both replicates. We next removed all samples where DESeq2/DEXSeq were unable ...
... filtered using an expression threshold. For DESeq2 data, we required that at least one comparison have a read count >100 in both replicates. For DEXSeq data, we required that at least one comparison have a read count >1 in both replicates. We next removed all samples where DESeq2/DEXSeq were unable ...
Gene Section CDKN2a (cyclin dependent kinase 2a / p16)
... all melanoma cases) is a genodermatosis transmitted as an autosomal dominant trait. CDKN2a has been identified as a major susceptibility gene for melanoma. However this gene accounts for a minority of familial melanoma. P16 is functionally inactivated by mutations or deletions, however, because many ...
... all melanoma cases) is a genodermatosis transmitted as an autosomal dominant trait. CDKN2a has been identified as a major susceptibility gene for melanoma. However this gene accounts for a minority of familial melanoma. P16 is functionally inactivated by mutations or deletions, however, because many ...
scylla and charybde, homologues of the human apoptotic gene
... exhibit defects in a subset of dorsally fated cells. Among these more weakly ventralized defects are cyclopia and aberrant head involution (Chang et al., 2003; Wakimoto et al., 1984). While the dpp and zen hypomorphic phenotypes reveal the potential for partitioning of dorsal fates along the anterio ...
... exhibit defects in a subset of dorsally fated cells. Among these more weakly ventralized defects are cyclopia and aberrant head involution (Chang et al., 2003; Wakimoto et al., 1984). While the dpp and zen hypomorphic phenotypes reveal the potential for partitioning of dorsal fates along the anterio ...
Clox, a mammalian homeobox gene related to Drosophila cut
... Rabbit immunization and purification of immunoglobulins by binding to protein A-Sepharose beads (Repligen) were carried out using standard procedures (Harlow and Lane, 1988). A peptide corresponding to amino acids 636-651 of the predicted Clox protein was selected for antibody production based on it ...
... Rabbit immunization and purification of immunoglobulins by binding to protein A-Sepharose beads (Repligen) were carried out using standard procedures (Harlow and Lane, 1988). A peptide corresponding to amino acids 636-651 of the predicted Clox protein was selected for antibody production based on it ...
Gene duplication and divergence in the early evolution of
... different parts of the proteins of paralagous genes [16,17]. We also cannot rule out the possibility that neofunctionalisation followed subfunctionalisation. The evolutionary separation between extant vertebrate and invertebrate lineages is such that subtle subfunctionalisation may have become obscu ...
... different parts of the proteins of paralagous genes [16,17]. We also cannot rule out the possibility that neofunctionalisation followed subfunctionalisation. The evolutionary separation between extant vertebrate and invertebrate lineages is such that subtle subfunctionalisation may have become obscu ...
Chapter 15 The Chromosomal Basis of Inheritance
... Using methods like chromosomal banding, geneticists can develop cytogenetic maps of chromosomes Cytogenetic maps indicate the positions of genes with respect to chromosomal features ...
... Using methods like chromosomal banding, geneticists can develop cytogenetic maps of chromosomes Cytogenetic maps indicate the positions of genes with respect to chromosomal features ...
What is a gene, post-ENCODE? History and updated
... While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non- ...
... While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non- ...
asexual seed formation for agricultural crop improvement
... transcription factors. Computational annotation of the remaining sequences, according to the main vocabularies of Gene Ontology and Plant Ontology, allowed us to select GO terms related to transcription factor and protein binding activities as well as germ cell differentiation and embryo sac develop ...
... transcription factors. Computational annotation of the remaining sequences, according to the main vocabularies of Gene Ontology and Plant Ontology, allowed us to select GO terms related to transcription factor and protein binding activities as well as germ cell differentiation and embryo sac develop ...
Transvection, nuclear structure, and chromatin proteins.
... including plants and vertebrates, also exists (reviewed by Grell, 1969). For example, Arnoldus et al. (1991) have found evidence for tissue specific somatic pairing in humans, suggesting that pairing is not only developmentally regulated but a form of regulation in itself. ...
... including plants and vertebrates, also exists (reviewed by Grell, 1969). For example, Arnoldus et al. (1991) have found evidence for tissue specific somatic pairing in humans, suggesting that pairing is not only developmentally regulated but a form of regulation in itself. ...
Gene Section GMPS (guanine monphosphate synthetase) Atlas of Genetics and Cytogenetics
... nucleotides: amidotransferase that catalyzes the amination of xanthosine 5 prime monophosphate to form GMP in the presence of ATP and glutamine; GTP is also involved in many enzymatic reactions important for cell division. ...
... nucleotides: amidotransferase that catalyzes the amination of xanthosine 5 prime monophosphate to form GMP in the presence of ATP and glutamine; GTP is also involved in many enzymatic reactions important for cell division. ...
Barley Cbf3 Gene Identification, Expression Pattern, and Map Location
... Although cold and drought adaptation in cereals and other plants involve the induction of a large number of genes, inheritance studies in Triticeae (wheat [Triticum aestivum], barley [Hordeum vulgare], and rye [Secale cereale]) have revealed only a few major loci for frost or drought tolerance that ...
... Although cold and drought adaptation in cereals and other plants involve the induction of a large number of genes, inheritance studies in Triticeae (wheat [Triticum aestivum], barley [Hordeum vulgare], and rye [Secale cereale]) have revealed only a few major loci for frost or drought tolerance that ...
Combined expression patterns of QTL
... complex traits such as KRHT. If the goal is rather limited to dissect some candidate genes within QTL regions, we can otherwise use more routine and sensitive expression technologies, such as quantitative real-time polymerase chain reaction or ‘‘qRT-PCR’’ (Brown et al., 2005). For instance, screenin ...
... complex traits such as KRHT. If the goal is rather limited to dissect some candidate genes within QTL regions, we can otherwise use more routine and sensitive expression technologies, such as quantitative real-time polymerase chain reaction or ‘‘qRT-PCR’’ (Brown et al., 2005). For instance, screenin ...
Poster
... In alternative splicing, precursor messenger RNA is processed to produce many different messenger RNAs. The expression of these different RNAs from one gene makes possible the enormous protein diversity found in humans. Alternative splicing affects over 90 percent of our genome, allowing humans to b ...
... In alternative splicing, precursor messenger RNA is processed to produce many different messenger RNAs. The expression of these different RNAs from one gene makes possible the enormous protein diversity found in humans. Alternative splicing affects over 90 percent of our genome, allowing humans to b ...
Genome Assembly and Annotation
... – Attempts to use as little a priori information as possible (codon usage, polyA signals) – Alternate RefSeq derived models sharing one or more exons on same strand are grouped under the same gene – Requirements for gene annotation • Defining RefSeq transcript alignment is >=95% identity • Aligned r ...
... – Attempts to use as little a priori information as possible (codon usage, polyA signals) – Alternate RefSeq derived models sharing one or more exons on same strand are grouped under the same gene – Requirements for gene annotation • Defining RefSeq transcript alignment is >=95% identity • Aligned r ...
Heritable genome-wide variation of gene expression and promoter methylation between
... Background: Variations in gene expression, mediated by epigenetic mechanisms, may cause broad phenotypic effects in animals. However, it has been debated to what extent expression variation and epigenetic modifications, such as patterns of DNA methylation, are transferred across generations, and the ...
... Background: Variations in gene expression, mediated by epigenetic mechanisms, may cause broad phenotypic effects in animals. However, it has been debated to what extent expression variation and epigenetic modifications, such as patterns of DNA methylation, are transferred across generations, and the ...
2017 Reg of Mitosis Genetics Protein Synth Regulation Review
... Be able to explain pre-transcriptional control mechanisms, RNA processing, and post translational control mechanisms that are utilized by eukaryotic cells Be able to explain our regulation activity and use specific genes that are turned on or off in red blood cells, intestinal lining cells, smooth m ...
... Be able to explain pre-transcriptional control mechanisms, RNA processing, and post translational control mechanisms that are utilized by eukaryotic cells Be able to explain our regulation activity and use specific genes that are turned on or off in red blood cells, intestinal lining cells, smooth m ...