A MIAME-compliant Microarray Database
... Classifing genes • The gene ontology is used to classify genes • An ontology is a controlled vocabulary. • Contains information about how words in the ontology relate to one another • Allows computers to understand annotation as well as humans ...
... Classifing genes • The gene ontology is used to classify genes • An ontology is a controlled vocabulary. • Contains information about how words in the ontology relate to one another • Allows computers to understand annotation as well as humans ...
CIRCADIAN RHYTHMS IN PLANTS C Robertson McClung
... time, but LUC activity (light production) is unstable; activity over time requires translation of new LUC protein and provides a reliable assessment of LUC transcription (99). The measurement of LUC activity is nondestructive and quantitative and allows both temporal and spatial resolution of gene e ...
... time, but LUC activity (light production) is unstable; activity over time requires translation of new LUC protein and provides a reliable assessment of LUC transcription (99). The measurement of LUC activity is nondestructive and quantitative and allows both temporal and spatial resolution of gene e ...
Phylogenetic analysis of three complete gap
... from the zebrafish genome, some are found as single relatives, and others are found in multiple copies. In addition, the zebrafish has 14 apparently novel connexins, several of which arose by recent tandem duplication events. This analysis provides evidence that the connexin gene family is increasin ...
... from the zebrafish genome, some are found as single relatives, and others are found in multiple copies. In addition, the zebrafish has 14 apparently novel connexins, several of which arose by recent tandem duplication events. This analysis provides evidence that the connexin gene family is increasin ...
Genetic interactions between scribbler, Atrophin and
... which suggests that Sbb cooperates with Atro to provide repressive activity. Comparison of gro and Atro/sbb mutant phenotypes suggests they do not function together, but that they may interact with the same transcription factors, including Engrailed and C15, to provide these proteins with maximal re ...
... which suggests that Sbb cooperates with Atro to provide repressive activity. Comparison of gro and Atro/sbb mutant phenotypes suggests they do not function together, but that they may interact with the same transcription factors, including Engrailed and C15, to provide these proteins with maximal re ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... nucleosomes could confer an epigenetic mark for gene repression. The constitutive DNA binding of the ATF2/JUND heterodimer to the IL-8 enhancer recruits macroH2A-containing nucleosomes in B cells, thus inhibiting transcriptional activation (Agelopoulos and Thanos, 2006). Heat shock or osmotic stress ...
... nucleosomes could confer an epigenetic mark for gene repression. The constitutive DNA binding of the ATF2/JUND heterodimer to the IL-8 enhancer recruits macroH2A-containing nucleosomes in B cells, thus inhibiting transcriptional activation (Agelopoulos and Thanos, 2006). Heat shock or osmotic stress ...
The development and evolutionary origin of barbels in
... Of the 62 orders of fishes listed by Nelson (2006), my survey of the literature suggests that 27 contain at least one species with barbels (Fig. 1). While once proposed to be homologous structures (Balfour 1880), barbels are most commonly thought to have arisen independently in many of these lineage ...
... Of the 62 orders of fishes listed by Nelson (2006), my survey of the literature suggests that 27 contain at least one species with barbels (Fig. 1). While once proposed to be homologous structures (Balfour 1880), barbels are most commonly thought to have arisen independently in many of these lineage ...
Sample pages 2 PDF
... frames for a number of altenative potential splice arrangements such as splicing directly into exon 2. In fact, the elimination of exon 1b, as seen in Mitfmi–rw mice, in which the upstream exon A is spliced directly into exon 2, creates mRNAs with premature stop codons (32,33). Based on the observed ...
... frames for a number of altenative potential splice arrangements such as splicing directly into exon 2. In fact, the elimination of exon 1b, as seen in Mitfmi–rw mice, in which the upstream exon A is spliced directly into exon 2, creates mRNAs with premature stop codons (32,33). Based on the observed ...
REVIEWS
... a bona fide neural crest, Slug (a Snail family member) seems to be involved in neural-crest specification in both the chick and Xenopus embryos9,14,45,46. Having been specified, both the mesoderm and the neural crest have to delaminate from the tissue in which they originate — the PRIMITIVE STREAK a ...
... a bona fide neural crest, Slug (a Snail family member) seems to be involved in neural-crest specification in both the chick and Xenopus embryos9,14,45,46. Having been specified, both the mesoderm and the neural crest have to delaminate from the tissue in which they originate — the PRIMITIVE STREAK a ...
Leukaemia Section 3q rearrangements in myeloid malignancies Atlas of Genetics and Cytogenetics
... frequently reside 5' to EVI1. In addition expression of GR6/EVI1 and RPN1/EVI1 chimeras have been described in the t(3;3). Alternatively, AML1/MDS1, AML1/MDS1/EVI1 and AML1/ EVI1 fusion transcripts are produced by the t(3;21)(q26;q22), while ETV6/MDS1/EVI1 and ETV6/EVI1 fusions are related to the t( ...
... frequently reside 5' to EVI1. In addition expression of GR6/EVI1 and RPN1/EVI1 chimeras have been described in the t(3;3). Alternatively, AML1/MDS1, AML1/MDS1/EVI1 and AML1/ EVI1 fusion transcripts are produced by the t(3;21)(q26;q22), while ETV6/MDS1/EVI1 and ETV6/EVI1 fusions are related to the t( ...
Disruption and aberrant expression of HMGA2 as a
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
A TaqI polymorphism in the 3 UTR of the IL-12
... polymorphism in the coding sequence, indicating a high level of conservation in humans. Several intronic polymorphisms however were identified, as well as a TaqI RFLP at position 1188 in the 30 UTR.14 The latter is of particular interest, since it has been shown to be associated with susceptibility ...
... polymorphism in the coding sequence, indicating a high level of conservation in humans. Several intronic polymorphisms however were identified, as well as a TaqI RFLP at position 1188 in the 30 UTR.14 The latter is of particular interest, since it has been shown to be associated with susceptibility ...
Molecular characterization of glutathione peroxidase
... of the start codon respectively. Furthermore, there were two homologous sex-determining region Y sites (SRY) and one MYB recognition element found in the region at 611 bp, 655 bp, 9 bp upstream of the start codon respectively (Fig. 1). Cis-acting DNA elements in promoters are responsible for interac ...
... of the start codon respectively. Furthermore, there were two homologous sex-determining region Y sites (SRY) and one MYB recognition element found in the region at 611 bp, 655 bp, 9 bp upstream of the start codon respectively (Fig. 1). Cis-acting DNA elements in promoters are responsible for interac ...
Gene Section ATF4 (activating transcription factor 4 (tax responsive enhancer element B67)) -
... DNA binding, and the regulation of ATF4 at the protein stability level. The organization of the motifs modulating ATF4 protein stability is potentially essential for the regulation of ATF4 stability in response to stress, including hypoxic and anoxic insult. ATF4 has an oxygen dependent degradation ...
... DNA binding, and the regulation of ATF4 at the protein stability level. The organization of the motifs modulating ATF4 protein stability is potentially essential for the regulation of ATF4 stability in response to stress, including hypoxic and anoxic insult. ATF4 has an oxygen dependent degradation ...
The Complex Inheritance of Maize Domestication Traits and Gene
... Candidate genes enriched in various functional categories . . . . . . 86 ...
... Candidate genes enriched in various functional categories . . . . . . 86 ...
Perspectives in Diabetes Glucokinase Gene Structure
... in the glucokinase gene are located at least 12 kilobases (kb) apart, with the p-cell control region located further upstream than the liver control region. The large amount of intervening DNA that separates the two transcription control regions results in a transcriplion unit for the p-cell glucoki ...
... in the glucokinase gene are located at least 12 kilobases (kb) apart, with the p-cell control region located further upstream than the liver control region. The large amount of intervening DNA that separates the two transcription control regions results in a transcriplion unit for the p-cell glucoki ...
Development of a repressible mycobacterial
... these tools proved to be quite useful, they have the disadvantage that Tc functions as an inducer of gene expression and has therefore to be removed to silence the gene under investigation. For this reason Guo et al. (13) developed a modified system using a mutated TetR able to bind tetO only in the ...
... these tools proved to be quite useful, they have the disadvantage that Tc functions as an inducer of gene expression and has therefore to be removed to silence the gene under investigation. For this reason Guo et al. (13) developed a modified system using a mutated TetR able to bind tetO only in the ...
The splanchnic mesodermal plate directs spleen and
... Targeted mutations in capsulin/Pod1 (Lu et al., 2000) and Wt1 (Herzer et al., 1999) show that both genes are required in spleen formation. The expression patterns of Wt1 and capsulin overlap with those of Hox11 and Nkx2.5 in the dorsal region of the mesenchyme (Fig. 1F,G), indicating that this regio ...
... Targeted mutations in capsulin/Pod1 (Lu et al., 2000) and Wt1 (Herzer et al., 1999) show that both genes are required in spleen formation. The expression patterns of Wt1 and capsulin overlap with those of Hox11 and Nkx2.5 in the dorsal region of the mesenchyme (Fig. 1F,G), indicating that this regio ...
The splanchnic mesodermal plate directs spleen and
... Targeted mutations in capsulin/Pod1 (Lu et al., 2000) and Wt1 (Herzer et al., 1999) show that both genes are required in spleen formation. The expression patterns of Wt1 and capsulin overlap with those of Hox11 and Nkx2.5 in the dorsal region of the mesenchyme (Fig. 1F,G), indicating that this regio ...
... Targeted mutations in capsulin/Pod1 (Lu et al., 2000) and Wt1 (Herzer et al., 1999) show that both genes are required in spleen formation. The expression patterns of Wt1 and capsulin overlap with those of Hox11 and Nkx2.5 in the dorsal region of the mesenchyme (Fig. 1F,G), indicating that this regio ...
Regulation of limb bud initiation and limbtype
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
Imprinting of the Y Chromosome Influences Dosage Compensation
... MSL complex is required for normal chromatin modification by the complex (Park et al. 2008). In spite of the importance of the roX genes in dosage compensation, how roX RNA regulates changes in the localization and activity of the MSL complex is poorly understood. We observed that reversal of sex ch ...
... MSL complex is required for normal chromatin modification by the complex (Park et al. 2008). In spite of the importance of the roX genes in dosage compensation, how roX RNA regulates changes in the localization and activity of the MSL complex is poorly understood. We observed that reversal of sex ch ...
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... regulators are the Polycomb group (PcG) proteins, which form several distinct multiprotein complexes with specific histonemodifying activities (reviewed by Schwartz and Pirrotta, 2008; Müller and Verrijzer, 2009; Beisel and Paro, 2011; Lanzuolo and Orlando, 2012; O’Meara and Simon, 2012; Scheuermann ...
... regulators are the Polycomb group (PcG) proteins, which form several distinct multiprotein complexes with specific histonemodifying activities (reviewed by Schwartz and Pirrotta, 2008; Müller and Verrijzer, 2009; Beisel and Paro, 2011; Lanzuolo and Orlando, 2012; O’Meara and Simon, 2012; Scheuermann ...
lilliputian - Development - The Company of Biologists
... rescue and used as probes to screen various cDNA libraries to isolate a large number of alternatively spliced cDNA clones, including one species that apparently encoded a full-length cDNA (Fig. 1D). Comparison of cDNA sequence to genomic sequence revealed a large transcription unit that spans approx ...
... rescue and used as probes to screen various cDNA libraries to isolate a large number of alternatively spliced cDNA clones, including one species that apparently encoded a full-length cDNA (Fig. 1D). Comparison of cDNA sequence to genomic sequence revealed a large transcription unit that spans approx ...