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somatic hypermutation of the 5' noncoding region of the Frequent MARTINOrrI*t,
somatic hypermutation of the 5' noncoding region of the Frequent MARTINOrrI*t,

... Considering their combined frequencies, the underestimated frequency of mutated cases due to the limited sensitivity of the SSCP assay, and the incomplete definition of the 3' boundary of the mutated region (see Fig. 3), our results suggest that virtually all DLCL and the majority of FL may contain ...
Genome Biology and
Genome Biology and

... • Certain proteins evolve much more rapidly: positive selection – Proteins implicated in reproduction, host defence and immune response seem to be under, which drives Reprinted from: Mouse Genome Sequencing Consortium, Nature 420, 520 - 562 (2002) ...
Article 1 Title: The pseudoautosomal regions of the U/V sex
Article 1 Title: The pseudoautosomal regions of the U/V sex

... chromosomes occur only in females and males, respectively (in contrast with the X, for example, which can occur in males and females). At present however, few empirical data are available for haploid sexual systems to test these various predictions. We have recently shown that the UV sex chromosomes ...
Other RNA Processing Events
Other RNA Processing Events

... are transcribed as larger precursors must be processed to yield rRNAs of mature size - Several different rRNA molecules are embedded in a long precursor and each must be cut out ...
Molecular genetics of autosomal dominant retinitis pigmentosa
Molecular genetics of autosomal dominant retinitis pigmentosa

... position 1816 (C1816X), was found in the homozygous state in an unaffected relative of an ADRP patient. It was previously reported that premature truncations of the RP1 protein in the C-terminal part (R1933X) were not involved in the retinitis pigmentosa pathogenesis.29 Our data not only extend to t ...
Imprinting and Seed Development
Imprinting and Seed Development

... with an increased transfer of nutrients from mother to seed. However, the authors also reported that tetraploid (2m:2p) endosperm accumulates starch at an earlier stage than their triploid (2m:1p) counterparts, so the classification of the phenotype as one of growth inhibition might not be entirely ...
Article On the Complexity of Chloroplast RNA
Article On the Complexity of Chloroplast RNA

... by immunoblotting, which showed that they all accumulated PsaA protein in amounts similar to the WT (fig. 3A and supplementary fig. S4, Supplementary Material online). RNA blot hybridization further showed that the intron-less psaA mRNA accumulates in these strains to levels similar to the trans-spl ...
Fluorescent - Nanoimaging - Friedrich-Schiller
Fluorescent - Nanoimaging - Friedrich-Schiller

... neutralize foreign substances (antigens)  Antibodies are made of two large heavy chains (~440 amino acids) and two small light chains (~220 amino acids)  C-region is similar for all antibodies, while the V-region is extremely variable and forms the specific binding site for the antigen i.e. every ...
Biocurator_Training_3
Biocurator_Training_3

... I read a review article - Double-strand break end resection and repair pathway choice (Symington & Gautier, 2011). - One protein mentioned is yeast MRE11. - Look up UniProt record for this & find references - First reference looks promising - PMID:7789757 - Make page for yeast MRE11 on GONUTS - Firs ...
Analyses of the E3 ubiquitin-ligase target adapter
Analyses of the E3 ubiquitin-ligase target adapter

... Ubiquitylation, the attachment of ubiquitin to proteins to mark for degradation by proteasomes, is crucial for proper organism function. One family of complexes that play a role in this process is the BTB/Cullin 3/RBX E3 ubiquitinprotein ligases. Three proteins; a BTB (Bric-a-Brac, Tramtrack, Broad ...
Document
Document

... the editing machinery in Arcyria and Clastoderma is not yet fully developed. The fact that Physarum has acquired so many editing sites since the divergence from Arcyria and Clastoderma suggests that editing in Physarum is less expensive and that thus random editing is likely. To study plant mitochon ...
Prediction and Validation of Gene-Disease Associations
Prediction and Validation of Gene-Disease Associations

... the association from just direct protein interactions to more distant connections in various ways. One kind of network that has proven to be particularly useful for predicting biological function is the functional interaction network, where a pair of genes is connected based on the integrated eviden ...
M.Tevfik Dorak, BA (Hons), MD, Ph.D.
M.Tevfik Dorak, BA (Hons), MD, Ph.D.

... Humans have 23 pairs of chromosomes. Twenty two pairs, the autosomes, are the same in either sex and are numbered from 1 - 22 in order of diminishing size. One pair, the sex chromosomes are either a pair of X chromosomes (in females) or an X and the very much smaller Y chromosome (in males). One co ...
Attanasio et al.
Attanasio et al.

... This region included the GLIS2 gene, which encodes a Kruppel-like zinc finger transcription factor8. Glis2 is most abundantly expressed in adult mouse kidney and, during metanephric development, in the ureteric bud, the inductor of mesenchymal-to-epithelial conversion during nephronic tubule formati ...
EMBL-EBI Powerpoint Presentation
EMBL-EBI Powerpoint Presentation

... • What is the current release (version) of Ensembl Plants? • On which data are the genome sequence and gene annotation for Arabidopsis thaliana based? ...
8th grade Chapter 8
8th grade Chapter 8

... B. Genes normally work in pairs. Living things have one copy of each gene from each biological parent. C. The chances are that for some genes, the alleles that an organism inherits will be different. D. Due to the way that genes are inherited, the probability of offspring inheriting certain alleles, ...
Low-Level Analysis of Affymetrix Data
Low-Level Analysis of Affymetrix Data

... – Noise levels comparable at different levels of signal – Small number of factors combine in linear function or simple algebraic form to give predicted levels ...
How does chromosome behavior account for Mendel`s Principles ?
How does chromosome behavior account for Mendel`s Principles ?

... A geneticist wants to map the position of three dominant/recessive allele pairs (A/a, B/b, and F/f) relative to each other in D. melanogaster (fruit flies). For simplicity let’s say all the dominant alleles are on the same chromosome. Where should she begin? 1. Do AaBb x aabb and look for recombinan ...
Human cytochromes P450 in health and disease
Human cytochromes P450 in health and disease

... of CYP enzymes in the eicosanoid pathway is likely to be redundant with lipoxygenases and other peroxidases [40]. There are now more than 150 identified eicosanoids [40], which participate in virtually every imaginable critical life process (table 3). In all likelihood due to redundancy, allelic var ...
Sequence Note Complete 59 Long  Terminal Repeat, nef,
Sequence Note Complete 59 Long Terminal Repeat, nef,

... TV004, TV010, and TV014 have a putative serine residue instead of the prevalently conserved cysteine. Similarly to Tat, Rev shows well-conserved amino acid sequences with some variation in the C-terminal region and intact reading frames in all isolates (Fig. 3C). The truncation in exon 2 of Rev at p ...
Localization and structural analysis of the ribosomal RNA operons of
Localization and structural analysis of the ribosomal RNA operons of

... post-transcriptional levels. The cellular content of specific mRNA and protein components unique to photosynthetic growth are either not detectable or present at extremely low levels in aerobically growing cells (3). Because of the apparent translational coupling between the synthesis of specific IC ...
New Phytologist Supporting Information Notes S1  Populus trichocarpa
New Phytologist Supporting Information Notes S1 Populus trichocarpa

... (http://www.phytozome.org). Reads were aligned to the target genomes using Tophat version 2.0.8 and differential gene expression analysis performed with Cuffdiff version 2.1.1 (see the Materials and Methods section in the main paper). Reads from the same tissue were used as biological repeats, and t ...
Plant centromeres: structure and control Eric J Richards and R Kelly
Plant centromeres: structure and control Eric J Richards and R Kelly

... controlling sister chromatid adhesion and driving chromosome movement. Despite their importance, centromeres remain poorly understood, especially in multicellular eukaryotes with large chromosomes. One of the themes developing from work on centromeres in humans and Drosophila is that the centromeric ...
Genetic interaction of Lhx4 and Prop1 - Development
Genetic interaction of Lhx4 and Prop1 - Development

... Sheng et al., 1996). Both Lhx3 and Lhx4 are expressed in Rathke’s pouch. The Lhx3-deficient phenotype is similar to that of Pitx2, consisting of pouch hypoplasia and absence of most of the pituitary cell types (Sheng et al., 1996). The phenotype of Lhx4 mutants suggests a minor role for this gene re ...
Genetic interaction of Lhx4 and Prop1
Genetic interaction of Lhx4 and Prop1

... Sheng et al., 1996). Both Lhx3 and Lhx4 are expressed in Rathke’s pouch. The Lhx3-deficient phenotype is similar to that of Pitx2, consisting of pouch hypoplasia and absence of most of the pituitary cell types (Sheng et al., 1996). The phenotype of Lhx4 mutants suggests a minor role for this gene re ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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