Gene Section AIP (aryl hydrocarbon receptor interacting protein) in Oncology and Haematology
... large deletions of whole exons or the entire AIP gene. Mutations are present throughout the whole length of the gene and disrupt the protein. Sixty five percent of known AIP variants result in a truncated protein. The majority of the missense mutations are typically clustered around the C-terminal p ...
... large deletions of whole exons or the entire AIP gene. Mutations are present throughout the whole length of the gene and disrupt the protein. Sixty five percent of known AIP variants result in a truncated protein. The majority of the missense mutations are typically clustered around the C-terminal p ...
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... result therefore suggests that regulatory elements may be more common in long than short introns. A significant negative correlation between divergence and intron length has also been observed in other species that have been investigated (such as rodents and Drosophila) [1115]. ...
... result therefore suggests that regulatory elements may be more common in long than short introns. A significant negative correlation between divergence and intron length has also been observed in other species that have been investigated (such as rodents and Drosophila) [1115]. ...
Foundations of Biology - Geoscience Research Institute
... Generally mtDNA and ctDNA is circular and contains genes for multimeric proteins, some portion of which are also coded for in the nucleus Extranuclear DNA has a rate of mutation that is independent of nuclear DNA Generally, but not always, all the RNAs needed for transcription and translation are fo ...
... Generally mtDNA and ctDNA is circular and contains genes for multimeric proteins, some portion of which are also coded for in the nucleus Extranuclear DNA has a rate of mutation that is independent of nuclear DNA Generally, but not always, all the RNAs needed for transcription and translation are fo ...
Identification of genes involved in the same
... networks. Several promising approaches have also been undertaken in combining both protein–protein interaction data and gene microarray expression data to derive functional modules at both levels (Tornow and Mewes, 2003). Other approaches integrate yet more data, such as growth phenotype data, trans ...
... networks. Several promising approaches have also been undertaken in combining both protein–protein interaction data and gene microarray expression data to derive functional modules at both levels (Tornow and Mewes, 2003). Other approaches integrate yet more data, such as growth phenotype data, trans ...
Somatic Cell Gene Mutations in Humans
... each measuring changes in a different "recorder" gene, are available for detecting mutations of the hemoglobin (Hb) and glycophorin A (gpa) genes in red blood cells and the hypoxanthine-guanine phosphoribosyltransferase (hprt) and HLA genes in T-lymphocytes. Mean adult background mutant frequencies ...
... each measuring changes in a different "recorder" gene, are available for detecting mutations of the hemoglobin (Hb) and glycophorin A (gpa) genes in red blood cells and the hypoxanthine-guanine phosphoribosyltransferase (hprt) and HLA genes in T-lymphocytes. Mean adult background mutant frequencies ...
Leukaemia Section MLL amplification in leukemia Atlas of Genetics and Cytogenetics
... Genes involved and proteins Note Generally MLL amplification is not associated with rearrangement of this gene. RNA overexpression is the result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the ...
... Genes involved and proteins Note Generally MLL amplification is not associated with rearrangement of this gene. RNA overexpression is the result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the ...
factor occupancy and gene expression Effects of
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
factor occupancy and gene expression Effects of sequence variation
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
Import of genetically modified carnation `Moonaqua`
... genes and theoretically give rise to the formation of new open reading frames (ORFs) consisting of host and donor sequences. Therefore, applicants are required to analyse the border and bordering sequences of the insertion for the presence of chimer ORFs. The applicant characterised the T-DNA coding ...
... genes and theoretically give rise to the formation of new open reading frames (ORFs) consisting of host and donor sequences. Therefore, applicants are required to analyse the border and bordering sequences of the insertion for the presence of chimer ORFs. The applicant characterised the T-DNA coding ...
Novel Blocked-Cleavable Primers for Quantitative Detection of
... prime DNA synthesis. A cleavable RNA linkage is positioned near the 3’ end of the primer. Following hybridization to a complementary sequence, the terminal blocking group is removed by action of a thermostable RNase H2 enzyme. Importantly, the RNase H2 enzyme, which is simply added as a component of ...
... prime DNA synthesis. A cleavable RNA linkage is positioned near the 3’ end of the primer. Following hybridization to a complementary sequence, the terminal blocking group is removed by action of a thermostable RNase H2 enzyme. Importantly, the RNase H2 enzyme, which is simply added as a component of ...
factor occupancy and gene expression Effects of sequence variation
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
... an allelic imbalance in occupancy. At many sites, TFs clustered in TF-binding hubs on the same homolog in especially open chromatin. While genetic variation in core TF binding motifs generally resulted in large allelic differences in TF occupancy, most allelic differences in occupancy were subtle an ...
Parallels between UNUSUAL FLORAL ORGANS and FIMBRIATA
... EcoRI fragment, pJAM199, which contains the entire genomic region hybridizing to FIM but not to the downstream gene, was inserted into a binary vector conferring kanamycin resistance (Kanr). Agrobacterium-mediated transformation was used to introduce this plasmid directly into either ufo-1 mutants o ...
... EcoRI fragment, pJAM199, which contains the entire genomic region hybridizing to FIM but not to the downstream gene, was inserted into a binary vector conferring kanamycin resistance (Kanr). Agrobacterium-mediated transformation was used to introduce this plasmid directly into either ufo-1 mutants o ...
Expression of floricaula in single cell layers of
... indicating that they were chimeras in which flo activity had been restored only in L1 (L1 chimeras, plants 1 and 2, Fig. 1D,E). The third near wild-type plant gave variable results: some inflorescences showed expression in L1 alone whereas others showed expression in all three layers. This was consi ...
... indicating that they were chimeras in which flo activity had been restored only in L1 (L1 chimeras, plants 1 and 2, Fig. 1D,E). The third near wild-type plant gave variable results: some inflorescences showed expression in L1 alone whereas others showed expression in all three layers. This was consi ...
Complex Inheritance of the 5-Lipoxygenase Locus
... the expression level of 5LO is elevated in symptomatic compared to asymptomatic plaques and is associated with acute ischemic syndromes. Despite the mounting evidence favoring the hypothesis that 5LO pathway plays a role in atherosclerosis, a recent study by Zhao et al. (2004) observed little or no ...
... the expression level of 5LO is elevated in symptomatic compared to asymptomatic plaques and is associated with acute ischemic syndromes. Despite the mounting evidence favoring the hypothesis that 5LO pathway plays a role in atherosclerosis, a recent study by Zhao et al. (2004) observed little or no ...
Specification of floral organs in Arabidopsis
... Arabidopsis and what is found in other angiosperms, however, is the apparent absence of bona fide A function genes in many flowering plants (Litt and Kramer, 2010). This finding has led to a re-evaluation of the concept of A function and to the proposal of a modified model for floral organ identity ...
... Arabidopsis and what is found in other angiosperms, however, is the apparent absence of bona fide A function genes in many flowering plants (Litt and Kramer, 2010). This finding has led to a re-evaluation of the concept of A function and to the proposal of a modified model for floral organ identity ...
Specialized adaptation of a lactic acid bacterium to the milk
... Regarded As Safe― (GRAS). Accordingly, S. thermophilus plays a prominent role in food biopreservation. Notably, the species is used extensively in yogurt, cheese, and other dairy fermentations, where it is traditionally paired with Lactobacillus delbrueckii subsp. bulgaricus or Lactobacillus helve ...
... Regarded As Safe― (GRAS). Accordingly, S. thermophilus plays a prominent role in food biopreservation. Notably, the species is used extensively in yogurt, cheese, and other dairy fermentations, where it is traditionally paired with Lactobacillus delbrueckii subsp. bulgaricus or Lactobacillus helve ...
Catabolic Plasmids - UQ eSpace
... cAMP-independent systems of Bacillus, acting in opposition to specific, plasmid-borne positive regulation. This is based generally on a two-component sensor/regulator ...
... cAMP-independent systems of Bacillus, acting in opposition to specific, plasmid-borne positive regulation. This is based generally on a two-component sensor/regulator ...
Meiosis/Crossing Over - Peoria Public Schools
... Mendel’s law of independent assortment could not account for. Thomas Hunt Morgan developed the notion of linked genes to account for the anomalies. (1.8) ...
... Mendel’s law of independent assortment could not account for. Thomas Hunt Morgan developed the notion of linked genes to account for the anomalies. (1.8) ...
Intelligent Icons: Integrating Lite-Weight Data Mining
... our first example. We recognize that DNA is a rather specialized file type. However there are two reasons for using it as the introductory example. First, its special structure lends itself to simple elucidation. Second, DNA is unique in that it is the only dataset for which there exists a unique ta ...
... our first example. We recognize that DNA is a rather specialized file type. However there are two reasons for using it as the introductory example. First, its special structure lends itself to simple elucidation. Second, DNA is unique in that it is the only dataset for which there exists a unique ta ...
Loss-of-function of a Rice Gibberellin Biosynthetic Gene, GA20
... amino acid sequence of GA20ox-2 showed a 47.8 % identity to that of GA20ox-1 and 49.5 % identity to that of Arabidopsis GA5 (Fig. 4). We cloned and sequenced the GA20ox-2 genes from four sd1 mutants and found that one sd1 allele showd a 383 bp deletion (Dee-geo-woo-gen and IR8 have the same sd1 alle ...
... amino acid sequence of GA20ox-2 showed a 47.8 % identity to that of GA20ox-1 and 49.5 % identity to that of Arabidopsis GA5 (Fig. 4). We cloned and sequenced the GA20ox-2 genes from four sd1 mutants and found that one sd1 allele showd a 383 bp deletion (Dee-geo-woo-gen and IR8 have the same sd1 alle ...
Lesson08Phylogenetics
... If can understand biological systems and how they came to be… Why study phylogenetics? ...
... If can understand biological systems and how they came to be… Why study phylogenetics? ...
Three-dimensional Structures of Bulge
... the site of mutation, usually resulting in a non-functioning gene product. Frameshifts that result from unpaired nucleotides can arise from recombination processes or from displacement of bases during replication (Streisinger et al., 1966), e.g. when the template strand contains an unpaired base, th ...
... the site of mutation, usually resulting in a non-functioning gene product. Frameshifts that result from unpaired nucleotides can arise from recombination processes or from displacement of bases during replication (Streisinger et al., 1966), e.g. when the template strand contains an unpaired base, th ...
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... Rate estimates for nitrification have largely been derived from the use of 15N tracer techniques. That approach has so far had very limited application for measurement of denitrification in the water column. Direct measurement of dinitrogen production in the ocean is difficult due to the dilution of ...
... Rate estimates for nitrification have largely been derived from the use of 15N tracer techniques. That approach has so far had very limited application for measurement of denitrification in the water column. Direct measurement of dinitrogen production in the ocean is difficult due to the dilution of ...
Figure S1. Interactions between AS1 and CO proteins that contains
... “No protein” sample. Empty vector and 6xHis-AS1 indicate 1.25 μg of total extracts containing 6xHis protein or 6xHis-AS1 fusion protein, respectively. (a) The DNA-AS1 protein complex was only detected in the 32P-labeled amplicon 11 (-482/-189) fragment. (b) The effect of CO on the binding of AS1 to ...
... “No protein” sample. Empty vector and 6xHis-AS1 indicate 1.25 μg of total extracts containing 6xHis protein or 6xHis-AS1 fusion protein, respectively. (a) The DNA-AS1 protein complex was only detected in the 32P-labeled amplicon 11 (-482/-189) fragment. (b) The effect of CO on the binding of AS1 to ...