Methods for pattern discovery in unaligned biological sequences
... algorithm. Methods of this kind were introduced in the 1980s,4±6 and worked well in practice for short patterns and especially on DNA sequences, since in the latter case the alphabet is smaller. This is the approach followed recently by Tompa,7 where it is applied to the identi®cation of ribosome bi ...
... algorithm. Methods of this kind were introduced in the 1980s,4±6 and worked well in practice for short patterns and especially on DNA sequences, since in the latter case the alphabet is smaller. This is the approach followed recently by Tompa,7 where it is applied to the identi®cation of ribosome bi ...
Using Transcriptional Control To Increase Titers of Secreted
... acterial heterologous protein production is a bedrock of modern molecular biology. A gene that codes for a protein of interest can be inserted into a bacterial cell, often Escherichia coli, and the cell is able to produce the desired protein. Bacteria are the preferred organisms for many heterologou ...
... acterial heterologous protein production is a bedrock of modern molecular biology. A gene that codes for a protein of interest can be inserted into a bacterial cell, often Escherichia coli, and the cell is able to produce the desired protein. Bacteria are the preferred organisms for many heterologou ...
Role of tumor necrosis factor alpha gene polymorphism in childhood
... Bronchial asthma is a common disease with multiple determinants that include genetic variation, environmental exposures, and gene–environment interactions. Tumor necrosis factor alpha (TNF-α) has a role in asthma and wheezing pathophysiology. Single nucleotide gene polymorphisms, may be important as ...
... Bronchial asthma is a common disease with multiple determinants that include genetic variation, environmental exposures, and gene–environment interactions. Tumor necrosis factor alpha (TNF-α) has a role in asthma and wheezing pathophysiology. Single nucleotide gene polymorphisms, may be important as ...
Antioxidant and Xenobiotic-metabolizing Enzyme Gene Expression
... MCF-7/Dox was greater than 40-fold (data not shown). Glutathione-dependent H2O2 peroxidase activity was detectable at a very low level in the parent cells but was increased by more than 25-fold in MCF-7/Dox (Table 1); f-butyl hydroperoxidase activity was increased 50-fold in MCF-7/Dox. The glutathio ...
... MCF-7/Dox was greater than 40-fold (data not shown). Glutathione-dependent H2O2 peroxidase activity was detectable at a very low level in the parent cells but was increased by more than 25-fold in MCF-7/Dox (Table 1); f-butyl hydroperoxidase activity was increased 50-fold in MCF-7/Dox. The glutathio ...
This document has been downloaded from Tampub – The
... Cholesterol is an essential component of cellular membranes. Cellular cholesterol homeostasis is controlled by sterol regulatory element-binding transcription factors (SREBFs), which are transcription factors that modulate the transcription of genes involved in lipid and cholesterol metabolism. In s ...
... Cholesterol is an essential component of cellular membranes. Cellular cholesterol homeostasis is controlled by sterol regulatory element-binding transcription factors (SREBFs), which are transcription factors that modulate the transcription of genes involved in lipid and cholesterol metabolism. In s ...
Information Extraction Using Hidden Markov Models
... technology is of limited use in this application. Standard boolean searching, vectorbased approaches and latent semantic indexing are geared more toward open-ended exploration than toward the targeted, detailed subsentence processing necessary for the fact nding or information extraction task. Sinc ...
... technology is of limited use in this application. Standard boolean searching, vectorbased approaches and latent semantic indexing are geared more toward open-ended exploration than toward the targeted, detailed subsentence processing necessary for the fact nding or information extraction task. Sinc ...
Signs of change: hormone receptors that regulate plant development
... that it also targets proteins for destruction. GID1 binds the SLENDER RICE (SLR1) protein (Ikeda et al., 2001), a member of the DELLA class of transcriptional repressors, directly in a gibberellin-dependent manner (Ueguchi-Tanaka et al., 2005). These DELLA proteins may directly block the gibberellin ...
... that it also targets proteins for destruction. GID1 binds the SLENDER RICE (SLR1) protein (Ikeda et al., 2001), a member of the DELLA class of transcriptional repressors, directly in a gibberellin-dependent manner (Ueguchi-Tanaka et al., 2005). These DELLA proteins may directly block the gibberellin ...
MS26/CYP704B is required for anther and pollen wall
... nexine (foot-layer). Exine development starts with the formation of primexine at tetrad stage (reviewed in Li and Zhang [4]). Primexine, a microfibrillar matrix composed mainly of cellulose, serves as a template for deposition of sporopollenin precursors. Following the release of microspores from te ...
... nexine (foot-layer). Exine development starts with the formation of primexine at tetrad stage (reviewed in Li and Zhang [4]). Primexine, a microfibrillar matrix composed mainly of cellulose, serves as a template for deposition of sporopollenin precursors. Following the release of microspores from te ...
Genetic Counseling
... gene for cystic fibrosis but you’ve been unaware of it. We say that you’re carriers for cystic fibrosis. Laurie inherited a cystic fibrosis gene from each of you and so, with a double dose of the gene, she is affected. “The main problem with cystic fibrosis seems to involve the body’s ducts and glan ...
... gene for cystic fibrosis but you’ve been unaware of it. We say that you’re carriers for cystic fibrosis. Laurie inherited a cystic fibrosis gene from each of you and so, with a double dose of the gene, she is affected. “The main problem with cystic fibrosis seems to involve the body’s ducts and glan ...
ZytoLight ® CLL I Probe SPEC TP53/ATM Dual Color Probe
... The ZytoLight ® CLL I Probe is designed for the detection of deletions affecting the genes TP53 and ATM, and the ZytoLight ® CLL II Probe is designed for the detection of D13S319 deletions as well as for the enumeration of chromosome 12. CLL (chronic lymphocytic leukemia) is the most common form of ...
... The ZytoLight ® CLL I Probe is designed for the detection of deletions affecting the genes TP53 and ATM, and the ZytoLight ® CLL II Probe is designed for the detection of D13S319 deletions as well as for the enumeration of chromosome 12. CLL (chronic lymphocytic leukemia) is the most common form of ...
Experimental and Molecular Pathology
... and has been shown to be necessary for the development of the mature thymic epithelium (Blackburn et al., 1996; Brisette et al., 1996; Lee et al., 1999). Expression of the Foxn1 gene, the subsequent Foxn1 mRNA, and the FOXN1 protein can be detected as early as day 13 of gestation in the developing n ...
... and has been shown to be necessary for the development of the mature thymic epithelium (Blackburn et al., 1996; Brisette et al., 1996; Lee et al., 1999). Expression of the Foxn1 gene, the subsequent Foxn1 mRNA, and the FOXN1 protein can be detected as early as day 13 of gestation in the developing n ...
Genetic Disorders Brochures
... characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics. PROCEDURE: Autosomal Traits. Use the following information to determine which of the fo ...
... characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics. PROCEDURE: Autosomal Traits. Use the following information to determine which of the fo ...
NIH Guidelines - Institutional Biosafety Committee
... III-F regulates experiments involving recombinant or synthetic nucleic acid molecules that are exempt from the NIH Guidelines. • III-F-1: Involving synthetic nucleic acids that: (1) can neither replicate nor generate nucleic acids that can replicate in any living cell (e.g., oligonucleotides or ot ...
... III-F regulates experiments involving recombinant or synthetic nucleic acid molecules that are exempt from the NIH Guidelines. • III-F-1: Involving synthetic nucleic acids that: (1) can neither replicate nor generate nucleic acids that can replicate in any living cell (e.g., oligonucleotides or ot ...
trans - bioRxiv
... 38% of analyzed genes, respectively. Analysis of these effects in diploid embryos revealed that while ...
... 38% of analyzed genes, respectively. Analysis of these effects in diploid embryos revealed that while ...
Estrogen receptor β gene polymorphisms and susceptibility to
... decided to specifically focus on the second type of polymorphisms with potential functional significance, SNPs in the promoter of ESR2 gene. The promoter region of ESR2 gene is only beginning to be characterized, and thus it is possible that SNPs localized in this region are able to affect binding o ...
... decided to specifically focus on the second type of polymorphisms with potential functional significance, SNPs in the promoter of ESR2 gene. The promoter region of ESR2 gene is only beginning to be characterized, and thus it is possible that SNPs localized in this region are able to affect binding o ...
NeuroGeM, a knowledgebase of genetic modifiers
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
Gene Section LIMK1 (LIM domain kinase 1) Atlas of Genetics and Cytogenetics
... belongs to a unique family of LIM domain containing dual specificity (serine threonine and tyrosine) protein kinase. LIMK1 also has a PDZ domain in the middle of the gene and a kinase domain at the C-terminal end. A stretch of basic amino acids resembling nuclear localisation signal is present in th ...
... belongs to a unique family of LIM domain containing dual specificity (serine threonine and tyrosine) protein kinase. LIMK1 also has a PDZ domain in the middle of the gene and a kinase domain at the C-terminal end. A stretch of basic amino acids resembling nuclear localisation signal is present in th ...
comparing quantitative trait loci and gene expression data
... developed in this work is complementary to the analyses that can be performed on the GeneNetwork website (WebQTL, www.genenetwork.org), which allows assessment of the relationship between gene expression and QTLs in Recombinant Inbred mice (Wang et al., 2003). The major advantage of a dual approach ...
... developed in this work is complementary to the analyses that can be performed on the GeneNetwork website (WebQTL, www.genenetwork.org), which allows assessment of the relationship between gene expression and QTLs in Recombinant Inbred mice (Wang et al., 2003). The major advantage of a dual approach ...
A-10484A SNPs. Mutations and DNA Sequence
... for repeats using the human repeat database. PCR products were verified on a agarose gel or Agilent chip to make sure there were no artifact bands. If artifact bands were present the PCR conditions were altered to obtain a clean single band. A clean PCR product is one of the most important criteria ...
... for repeats using the human repeat database. PCR products were verified on a agarose gel or Agilent chip to make sure there were no artifact bands. If artifact bands were present the PCR conditions were altered to obtain a clean single band. A clean PCR product is one of the most important criteria ...
Genetic Epidemiology of Obesity
... that might contain hundreds of susceptibility genes for diseases of interest. This method has been remarkably successful in identifying disease genes for monogenic disorders (19). When applied to the common complex disease, however, linkage analysis has less power, and success has been limited. In a ...
... that might contain hundreds of susceptibility genes for diseases of interest. This method has been remarkably successful in identifying disease genes for monogenic disorders (19). When applied to the common complex disease, however, linkage analysis has less power, and success has been limited. In a ...
Depleting Gene Activities in Early Drosophila Embryos
... 1994). D-raf mutant offspring derived from heterozygous females die during larval–pupal development. However, embryos derived from D-raf mutant GLCs exhibit two classes of phenotypes: embryos that receive a WT paternal copy display a “terminal class” phenotype, with the acron and telson missing, bec ...
... 1994). D-raf mutant offspring derived from heterozygous females die during larval–pupal development. However, embryos derived from D-raf mutant GLCs exhibit two classes of phenotypes: embryos that receive a WT paternal copy display a “terminal class” phenotype, with the acron and telson missing, bec ...
Future Dog Breeding for Genetic Soundness
... Foundation to further its activities promoting the health of our canine companions. This publication was produced through the auspices of the Communication and Educational Technology Services unit of the University of Minnesota Extension Service. This project was supported by the American Kennel Clu ...
... Foundation to further its activities promoting the health of our canine companions. This publication was produced through the auspices of the Communication and Educational Technology Services unit of the University of Minnesota Extension Service. This project was supported by the American Kennel Clu ...
Unexpected requirements for neural induction in the
... The molecular mechanism underlying neural induction became clear when binary protein complexes between BMP4 and Chordin, BMP4 and Noggin, and Follistatin and BMP7 were found2. These observations suggest that the function of a neural inducing factor is to remove free BMP proteins from the area around ...
... The molecular mechanism underlying neural induction became clear when binary protein complexes between BMP4 and Chordin, BMP4 and Noggin, and Follistatin and BMP7 were found2. These observations suggest that the function of a neural inducing factor is to remove free BMP proteins from the area around ...
Wnt Signaling and an APC-Related Gene Specify Endoderm in
... significant homologies are observed outside of these domains. APR-1 is much smaller than the 2843-amino-acid APC protein in humans (Groden et al., 1991); however, both proteins contain seven arm motifs, and APR-1 and APC are 31% identical in these regions. APC and APR-1 contain three and two copies, ...
... significant homologies are observed outside of these domains. APR-1 is much smaller than the 2843-amino-acid APC protein in humans (Groden et al., 1991); however, both proteins contain seven arm motifs, and APR-1 and APC are 31% identical in these regions. APC and APR-1 contain three and two copies, ...