Unbalanced translocation, a major chromosome alteration
... number changes at breakpoints, and were detected in seven cases (70%; Figure 3b). The LOHs were further classified into (b) mitotic recombination and (c) mitotic gene conversion based on the region of LOHs (Figures 1B and 2). These alterations were detected in 14 and 17 LOHs without copy number chang ...
... number changes at breakpoints, and were detected in seven cases (70%; Figure 3b). The LOHs were further classified into (b) mitotic recombination and (c) mitotic gene conversion based on the region of LOHs (Figures 1B and 2). These alterations were detected in 14 and 17 LOHs without copy number chang ...
Confrontation of scabrous expressing and non
... Fig. 1. Schematic structure and expression patterns of sca ectopic expression constructs. A, C and E show the expression constructs and B wild-type sca expression for comparison. D and F illustrate the expression patterns in the eye disc for constructs shown in C and E respectively. The MF is indica ...
... Fig. 1. Schematic structure and expression patterns of sca ectopic expression constructs. A, C and E show the expression constructs and B wild-type sca expression for comparison. D and F illustrate the expression patterns in the eye disc for constructs shown in C and E respectively. The MF is indica ...
Investigating the functional significance of evolutionarily conserved
... and hypomorphic-antimorph. Null alleles were nonsense mutations resulting in truncation and loss of highly conserved protein domains. Hypomorphic alleles were missense and small deletion mutations in highly conserved protein domains, including the DYTQL motif, YPWM motif and C-terminal domain (CTD). ...
... and hypomorphic-antimorph. Null alleles were nonsense mutations resulting in truncation and loss of highly conserved protein domains. Hypomorphic alleles were missense and small deletion mutations in highly conserved protein domains, including the DYTQL motif, YPWM motif and C-terminal domain (CTD). ...
Swartzlander_ku_0099D_15051_DATA_1
... males; 7,11-HD in females). D. erecta has a similar profile in that the predominant female CHCs are longer and less saturated than those of the males (Jallon and David 1987). The predominance of 7-T in both sexes of D. simulans is the same in the sister species, D. mauritiana. These patterns of CHC ...
... males; 7,11-HD in females). D. erecta has a similar profile in that the predominant female CHCs are longer and less saturated than those of the males (Jallon and David 1987). The predominance of 7-T in both sexes of D. simulans is the same in the sister species, D. mauritiana. These patterns of CHC ...
Close - Journal of Integrated OMICS
... Fifty-five of the 96 enterococci isolates (57%) showed susceptibility to all the antimicrobial agents tested (24 E. hirae, 19 E. faecium, 8 E. faecalis, and 4 E. durans). Most of E. faecalis isolates showed a multiresistant phenotype. No ampicillin-, vancomycin- or teicoplanin-resistant enterococcal ...
... Fifty-five of the 96 enterococci isolates (57%) showed susceptibility to all the antimicrobial agents tested (24 E. hirae, 19 E. faecium, 8 E. faecalis, and 4 E. durans). Most of E. faecalis isolates showed a multiresistant phenotype. No ampicillin-, vancomycin- or teicoplanin-resistant enterococcal ...
Whole-transcriptome RNAseq analysis from minute amount of total
... RNA-seq methods, some of which are described in literature (10): library complexity, the number of unique reads, ribosomal RNA read-count in comparison to total reads, reproducibility, evenness of coverage at annotated transcripts, performance at 50 - and 30 -ends and cross-platform consistency. In ...
... RNA-seq methods, some of which are described in literature (10): library complexity, the number of unique reads, ribosomal RNA read-count in comparison to total reads, reproducibility, evenness of coverage at annotated transcripts, performance at 50 - and 30 -ends and cross-platform consistency. In ...
A survey on computational methods for enhancer and
... also depends on factors other than the sequence, sequence motifs can be considered a weak feature for enhancer prediction. As discussed above, using these static features to predict enhancers could at best identify regions with a potential to be an enhancer, without telling the contexts in which the ...
... also depends on factors other than the sequence, sequence motifs can be considered a weak feature for enhancer prediction. As discussed above, using these static features to predict enhancers could at best identify regions with a potential to be an enhancer, without telling the contexts in which the ...
Endothelin signaling activates Mef2c expression in the neural crest
... knockout (Mef2cflox/−; Wnt1a::Cre) [Mef2cNCKO] embryos were explanted and treated with ET-1 or PBS. Neural crest cells were then sorted, and Mef2c expression was determined by qPCR using primers recognizing both wild-type and mutant transcripts. Importantly, ET-1 induced Mef2c expression more than f ...
... knockout (Mef2cflox/−; Wnt1a::Cre) [Mef2cNCKO] embryos were explanted and treated with ET-1 or PBS. Neural crest cells were then sorted, and Mef2c expression was determined by qPCR using primers recognizing both wild-type and mutant transcripts. Importantly, ET-1 induced Mef2c expression more than f ...
In-class assignment: Fukuda et al. (2016) paper
... 7. Xist and Tsix have antagonistic functions.Are the results in 5a consistent with this? Why or why not? Explain. The results in Fig 5a indicate that Xist and Tsix are regulated similarly by Oct4. When Oct4 is knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of ...
... 7. Xist and Tsix have antagonistic functions.Are the results in 5a consistent with this? Why or why not? Explain. The results in Fig 5a indicate that Xist and Tsix are regulated similarly by Oct4. When Oct4 is knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of ...
Severe Combined Immunodeficiency (SCID)
... • SCID is a group of very rare-and potentially fatal-inherited disorders related to the immune system. • SCID makes those affected highly susceptible to life-threatening infections by viruses, bacteria and fungi. ...
... • SCID is a group of very rare-and potentially fatal-inherited disorders related to the immune system. • SCID makes those affected highly susceptible to life-threatening infections by viruses, bacteria and fungi. ...
Genetics - York University
... The nucleus of the sperm cell joined with the nucleus of the egg in fertilization. The process of cell division was studied carefully. Chromosomes were identified and tracked through cell division and fertilization processes. Everything pointed to the cell nucleus as the location of activity. ...
... The nucleus of the sperm cell joined with the nucleus of the egg in fertilization. The process of cell division was studied carefully. Chromosomes were identified and tracked through cell division and fertilization processes. Everything pointed to the cell nucleus as the location of activity. ...
Commentary: A century of Mendelism: on Johannsen`s genotype
... could claim that ‘Galtonian law of regression and its corollaries elaborated by Pearson pretended to have established the laws of “ancestral influences” in mathematical terms’ were an artefact. They were nothing but ‘interesting products of mathematical genius. . .but they have nothing at all to do ...
... could claim that ‘Galtonian law of regression and its corollaries elaborated by Pearson pretended to have established the laws of “ancestral influences” in mathematical terms’ were an artefact. They were nothing but ‘interesting products of mathematical genius. . .but they have nothing at all to do ...
Provisional PDF
... homologous with genes from other species belonging to the Mycoplasmataceae family. For example, an alignment showed all 134 genes to be 33–93% homologous with their corresponding genes in Candidatus Hepatoplasma crinochetorum. The gene with the highest homology (93%) was rpoB. These results indicate ...
... homologous with genes from other species belonging to the Mycoplasmataceae family. For example, an alignment showed all 134 genes to be 33–93% homologous with their corresponding genes in Candidatus Hepatoplasma crinochetorum. The gene with the highest homology (93%) was rpoB. These results indicate ...
The red head and neck of Boer goats may be controlled by the
... Abstract – The Melanocortin-1-receptor (MC1R) gene is an important candidate gene for the coat color trait. In order to understand the molecular genetic basis of the red head and neck of Boer goats, a comparative analysis of MC1R gene polymorphism in imported foreign breed Boer goats and another 26 ...
... Abstract – The Melanocortin-1-receptor (MC1R) gene is an important candidate gene for the coat color trait. In order to understand the molecular genetic basis of the red head and neck of Boer goats, a comparative analysis of MC1R gene polymorphism in imported foreign breed Boer goats and another 26 ...
Horizontal transfer generates genetic variation in an asexual
... CG (15 to 25) was found in strains DVD-3, DVD-31, DVD-161 and DVD-s29. There was no coverage of the region by reads from DVD-s29. Similarly, another example with type 2 SNPs at positions 615,713 and 615,747 bp of VdLs17 supercontig 1.9 illustrates that JR2 was composed of three types of highly simil ...
... CG (15 to 25) was found in strains DVD-3, DVD-31, DVD-161 and DVD-s29. There was no coverage of the region by reads from DVD-s29. Similarly, another example with type 2 SNPs at positions 615,713 and 615,747 bp of VdLs17 supercontig 1.9 illustrates that JR2 was composed of three types of highly simil ...
Control of human β-globin mRNA stability and its impact on beta
... ancestral gene, share general and specific structural features, and both encode extraordinarily stable mRNAs in erythroid cells, which allow co-expression of α- and bglobin proteins to reach high levels. Human globin gene expression is a highly regulated process requiring transcriptional and post-tr ...
... ancestral gene, share general and specific structural features, and both encode extraordinarily stable mRNAs in erythroid cells, which allow co-expression of α- and bglobin proteins to reach high levels. Human globin gene expression is a highly regulated process requiring transcriptional and post-tr ...
The new cardiac genetic testing panels
... wider approach would involve sequencing the whole exome or whole genome. The advantage of panel testing is that it supports interrogation of several genes in conditions which have a polygenic aetiology and is useful when the phenotype does not point towards a particular gene as, for example, with di ...
... wider approach would involve sequencing the whole exome or whole genome. The advantage of panel testing is that it supports interrogation of several genes in conditions which have a polygenic aetiology and is useful when the phenotype does not point towards a particular gene as, for example, with di ...
Direct control of shoot meristem activity by a cytokinin
... The growth of plants depends on continuous function of the meristems. Shoot meristems are responsible for all the post-embryonic aerial organs, such as leaves, stems and flowers1. It has been assumed that the phytohormone cytokinin has a positive role in shoot meristem function2–4. A severe reductio ...
... The growth of plants depends on continuous function of the meristems. Shoot meristems are responsible for all the post-embryonic aerial organs, such as leaves, stems and flowers1. It has been assumed that the phytohormone cytokinin has a positive role in shoot meristem function2–4. A severe reductio ...
(reversed and/or heterotaxic) phenotype in SWV mice
... the IV phenotype. Test matings of these phenodcviants, corroborated by PCR, have confirmed them to be + I + . Although the phenotypes of the affected SWV + I + and ivl + mice resembled those found in iviiu mice, the occurrence of situs inversus and heterotaxia were not independent of each other, and ...
... the IV phenotype. Test matings of these phenodcviants, corroborated by PCR, have confirmed them to be + I + . Although the phenotypes of the affected SWV + I + and ivl + mice resembled those found in iviiu mice, the occurrence of situs inversus and heterotaxia were not independent of each other, and ...
Natural rules for Arabidopsis thaliana
... observed as AG|GUA and UNCAG|GU (N could be any nucleotide) respectively, which is consistent with previous studies [3,12,15]. The results indicated that consensus sequences at splicing sites are important for site recognition but are not enough to define the sites alone. The distributions of A, G, ...
... observed as AG|GUA and UNCAG|GU (N could be any nucleotide) respectively, which is consistent with previous studies [3,12,15]. The results indicated that consensus sequences at splicing sites are important for site recognition but are not enough to define the sites alone. The distributions of A, G, ...
Cerberus regulates left–right asymmetry of the embryonic head and
... later (stage 8–9) stages had little or no effect on the direction of heart looping or head turning compared with mocktransfected controls (Table 1). These results suggest that there is a narrow time window during which cCer can regulate left–right polarity. Does cCer act on the heart and the head to ...
... later (stage 8–9) stages had little or no effect on the direction of heart looping or head turning compared with mocktransfected controls (Table 1). These results suggest that there is a narrow time window during which cCer can regulate left–right polarity. Does cCer act on the heart and the head to ...
Syntabulin, a motor protein linker, controls dorsal
... gene expression (reviewed by Hibi et al., 2002). These data place canonical Wnt pathway function downstream of the DDs. In zebrafish, the b-catenin accumulates in the nuclei of dorsal blastomeres by the 128-cell stage and in the dorsal blastoderm and dorsal yolk syncytial layer of mid-blastula stage ...
... gene expression (reviewed by Hibi et al., 2002). These data place canonical Wnt pathway function downstream of the DDs. In zebrafish, the b-catenin accumulates in the nuclei of dorsal blastomeres by the 128-cell stage and in the dorsal blastoderm and dorsal yolk syncytial layer of mid-blastula stage ...
genomebiology.com
... = 0, for a comparison of TEs either in G. gallus, D. rerio, or C. intestinalis versus human). In the genome of D. melanogaster, the fraction of intronic TEs is 60%, similar to that of mammals (χ2, P-value = 0.3 compared with human); in C. elegans 53% of TEs reside within intronic sequences, signific ...
... = 0, for a comparison of TEs either in G. gallus, D. rerio, or C. intestinalis versus human). In the genome of D. melanogaster, the fraction of intronic TEs is 60%, similar to that of mammals (χ2, P-value = 0.3 compared with human); in C. elegans 53% of TEs reside within intronic sequences, signific ...
Relation of the Wnt/β-catenin signaling pathway
... (18). They also studied in terms of diagnostic and therapeutic aspects. Thus, effects of cytokines on the activity of Wnt signaling should be examined because of their importance in inflammation (4,10). In recent years, related studies about the Wnt signaling and components have increased. In partic ...
... (18). They also studied in terms of diagnostic and therapeutic aspects. Thus, effects of cytokines on the activity of Wnt signaling should be examined because of their importance in inflammation (4,10). In recent years, related studies about the Wnt signaling and components have increased. In partic ...
Gene replacement with the human BRCA1 locus
... otherwise lethal phenotype observed in the homozygous Brca17/7 mice. We isolated human BRCA1 protein from these lines and found a correlation between expression level and rescue. Furthermore, the protein was correctly translated and stabilized following exposure to DNA damage. From these results, it ...
... otherwise lethal phenotype observed in the homozygous Brca17/7 mice. We isolated human BRCA1 protein from these lines and found a correlation between expression level and rescue. Furthermore, the protein was correctly translated and stabilized following exposure to DNA damage. From these results, it ...