Human RIF1 and protein phosphatase 1 stimulate DNA replication
... Overall, the authors fill two gaps in the literature with this paper: 1. They confirm in humans much of which has been observed in yeast, which lends to RIF1's conserved and important role in genome regulation. 2. They observe a new role for RIF1 in origin stabilization, which adds another chapter t ...
... Overall, the authors fill two gaps in the literature with this paper: 1. They confirm in humans much of which has been observed in yeast, which lends to RIF1's conserved and important role in genome regulation. 2. They observe a new role for RIF1 in origin stabilization, which adds another chapter t ...
... may prove itself to be inadequate. It is very possible that still other bases may be found for the heterosis and inbreeding phenomena.” Other relevant statements could be quoted from this lecture, but since their meaning is in close agreement with the statements above quoted from the paper on duplic ...
Supplementary Legends - Word file
... result by performing ASS plus aster ablation. If both assays failed to give a result they are marked with a dash. We excluded genes from our analysis that failed in cytokinesis because of a missing furrow. If several genes acted in the same pathway, we did not test all components of this pathway but ...
... result by performing ASS plus aster ablation. If both assays failed to give a result they are marked with a dash. We excluded genes from our analysis that failed in cytokinesis because of a missing furrow. If several genes acted in the same pathway, we did not test all components of this pathway but ...
The step-by-step evolution of vertebrate blood coagulation
... Without exception, all of the proteins involved in mammalian blood clotting are descended from other protein families that are not involved in clotting. The backbone of clotting, like many other extracellular processes, is limited proteolysis, especially employing serine proteases. Hundreds of seri ...
... Without exception, all of the proteins involved in mammalian blood clotting are descended from other protein families that are not involved in clotting. The backbone of clotting, like many other extracellular processes, is limited proteolysis, especially employing serine proteases. Hundreds of seri ...
Full Text
... blot analysis revealed that the number of double heterozygous weanlings was significantly reduced below the number expected based on the additive effects predicted from the observed losses due to heterozygosity at the individual loci (Table 1). Incompletely penetrant heterozygous defects have been r ...
... blot analysis revealed that the number of double heterozygous weanlings was significantly reduced below the number expected based on the additive effects predicted from the observed losses due to heterozygosity at the individual loci (Table 1). Incompletely penetrant heterozygous defects have been r ...
no isthmus and pax2.1 in zebrafish tubulogenesis
... associated with deletion of amino acids 263-303 (Lun and Brand, 1998). The noitb21 allele gives rise to a truncated protein detectable on western blots (data not shown). The noitu29a allele is an RNA and protein null allele of pax2.1 resulting from a stop codon mutation at amino acid 139 (Brand et a ...
... associated with deletion of amino acids 263-303 (Lun and Brand, 1998). The noitb21 allele gives rise to a truncated protein detectable on western blots (data not shown). The noitu29a allele is an RNA and protein null allele of pax2.1 resulting from a stop codon mutation at amino acid 139 (Brand et a ...
Intellectual property rights and innovation: Evidence from
... of Celera’s IP across the human genome over time, linked to gene-level measures of scientific research and product development outcomes. Whereas in most contexts it is not straightforward to trace the path of basic scientific discoveries as they are translated into marketable products, I am able to ...
... of Celera’s IP across the human genome over time, linked to gene-level measures of scientific research and product development outcomes. Whereas in most contexts it is not straightforward to trace the path of basic scientific discoveries as they are translated into marketable products, I am able to ...
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... and can be analyzed by macerating the animals in fixed cell suspensions (David, 1973). Hydra anatomy can be summarized as a hollow tube with a tentacles crown. As for many other animals, Hydra is covered by a cuticle, an extracellular matrix secreted by ectodermal cells that forms the distal interfa ...
... and can be analyzed by macerating the animals in fixed cell suspensions (David, 1973). Hydra anatomy can be summarized as a hollow tube with a tentacles crown. As for many other animals, Hydra is covered by a cuticle, an extracellular matrix secreted by ectodermal cells that forms the distal interfa ...
The Homothorax homeoprotein activates the nuclear localization of
... exd has other roles in addition to its homeotic cofactor function. exd mutant clones caused ectopic eye formation in the ventral head, ventral to dorsal transformation in the imaginal abdomen, affected bristle patterning in the thorax and wing, and affected the proximal leg development (Gonzalez-Cre ...
... exd has other roles in addition to its homeotic cofactor function. exd mutant clones caused ectopic eye formation in the ventral head, ventral to dorsal transformation in the imaginal abdomen, affected bristle patterning in the thorax and wing, and affected the proximal leg development (Gonzalez-Cre ...
emboj7601705-sup
... expression back to control levels and below. These curves suggest that notochord and somites are formed in regions of intermediate Gsc. We observed very similar expression profiles for notochord and somites - rather than more separate peaks, with notochord being formed at lower Gsc MO doses than som ...
... expression back to control levels and below. These curves suggest that notochord and somites are formed in regions of intermediate Gsc. We observed very similar expression profiles for notochord and somites - rather than more separate peaks, with notochord being formed at lower Gsc MO doses than som ...
The Genetics of CFTR: Genotype – Phenotype Relationship
... The topic of mutational classes and personalized therapy is not devoid of problems. Some mutations produce multiple effects and should be classified in multiple classes. An emblematic example is the CFTR worldwide most common mutation, the F508del, a deletion of phenylalanine at position 508 of the ...
... The topic of mutational classes and personalized therapy is not devoid of problems. Some mutations produce multiple effects and should be classified in multiple classes. An emblematic example is the CFTR worldwide most common mutation, the F508del, a deletion of phenylalanine at position 508 of the ...
Hox patterning of the vertebrate axial skeleton
... through E12.5 demonstrate both anterior and posterior changes before fixed boundaries are established (Deschamps and Wijgerder, 1993; Chen and Capecchi, 1997; Deschamps et al., 1999; Iimura and Pourquié, 2006; McIntyre, et al., 2007). Expression boundary changes are not due to migration of cells alr ...
... through E12.5 demonstrate both anterior and posterior changes before fixed boundaries are established (Deschamps and Wijgerder, 1993; Chen and Capecchi, 1997; Deschamps et al., 1999; Iimura and Pourquié, 2006; McIntyre, et al., 2007). Expression boundary changes are not due to migration of cells alr ...
Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy
... the genotype test report about how a given phenotype prediction has been arrived at. There is only limited accuracy in calling an allele normal/ functional on the basis of the nucleotide sequence detected. This is because genotyping is not comprehensive enough to identify all currently known sequenc ...
... the genotype test report about how a given phenotype prediction has been arrived at. There is only limited accuracy in calling an allele normal/ functional on the basis of the nucleotide sequence detected. This is because genotyping is not comprehensive enough to identify all currently known sequenc ...
Genetics - York University
... Since Aristotle, it had been noted that animals (warm(warmblooded animals, anyway) produce heat when they are alive. • This was a mystery awaiting an explanation, which came from organic chemistry. ...
... Since Aristotle, it had been noted that animals (warm(warmblooded animals, anyway) produce heat when they are alive. • This was a mystery awaiting an explanation, which came from organic chemistry. ...
Disclosure All authors have no competing financial relationships to
... TLR7 in PBMCs, resulting in a trend of decreased downstream production of type I IFNs; whereas inhibition of miR-3148 has an opposite effect. ...
... TLR7 in PBMCs, resulting in a trend of decreased downstream production of type I IFNs; whereas inhibition of miR-3148 has an opposite effect. ...
Building Individualized Medicine: Prevention of Adverse Reactions
... vivo and in vitro. Structural analysis revealed that Ile359 lies outside the active site in the vicinity of an important residue Phe476 (Williams et al., 2003); the proximity of Leu359 to Phe476 supposedly abrogates substrate binding. Several variants of VKORC1 gene associated with decreased enzymat ...
... vivo and in vitro. Structural analysis revealed that Ile359 lies outside the active site in the vicinity of an important residue Phe476 (Williams et al., 2003); the proximity of Leu359 to Phe476 supposedly abrogates substrate binding. Several variants of VKORC1 gene associated with decreased enzymat ...
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... Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation of H3-K27me3 by Utx and/or its paralogs has consequently been proposed to be important for counteracting Polycomb repressio ...
... Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation of H3-K27me3 by Utx and/or its paralogs has consequently been proposed to be important for counteracting Polycomb repressio ...
Ethylene hormone receptor action in Arabidopsis
... the receptors is in vitro autophosphorylation of ETR1 on the conserved histidine residue.(32) If the ethylene receptors function as prototypical twocomponent signaling proteins, then each of the hybrid HPK receptors should act in a multistep phosphorelay employing an HPt protein followed by a respon ...
... the receptors is in vitro autophosphorylation of ETR1 on the conserved histidine residue.(32) If the ethylene receptors function as prototypical twocomponent signaling proteins, then each of the hybrid HPK receptors should act in a multistep phosphorelay employing an HPt protein followed by a respon ...
International Agency for Research on Cancer (IARC)
... aflatoxin B1-N7-guanine adducts by humans, and the ability of human tissues to activate aflatoxin B1 to form DNA adducts in vitro provide evidence that humans have the biochemical pathways required for aflatoxin-induced carcinogenesis. The following evidence is consistent with those biochemical mech ...
... aflatoxin B1-N7-guanine adducts by humans, and the ability of human tissues to activate aflatoxin B1 to form DNA adducts in vitro provide evidence that humans have the biochemical pathways required for aflatoxin-induced carcinogenesis. The following evidence is consistent with those biochemical mech ...
Rotaphor System 6.0
... The thermostatic circulator can be ordered separately and is not part of the Rotaphor® System. The applied electrical field produces heat of 30 W that needs to be removed from the electrophoresis chamber. We recommend a thermostatic circulator to cool the Rotaphor® System electrophoresis chamber eff ...
... The thermostatic circulator can be ordered separately and is not part of the Rotaphor® System. The applied electrical field produces heat of 30 W that needs to be removed from the electrophoresis chamber. We recommend a thermostatic circulator to cool the Rotaphor® System electrophoresis chamber eff ...
Chapter 1: What is PKU?
... is a precursor to neurotransmitters and hormones3. There are different categories of PKU that are determined based on diagnostic Phe level, mutation testing (if performed) and the amount of Phe that an individual can tolerate. ...
... is a precursor to neurotransmitters and hormones3. There are different categories of PKU that are determined based on diagnostic Phe level, mutation testing (if performed) and the amount of Phe that an individual can tolerate. ...
Original article MOLECULAR CHARACTERISATION OF LUMPY
... detection and phylogenic analysis of Capripoxvirus were performed in Sulaimani province in Kurdistan region of Iraq to analyse the genetic relationship with the other Capripoxvirus worldwide and to understand the epidemiology of the new LSDV outbreaks in Iraq. Several researches used the P32 gene to ...
... detection and phylogenic analysis of Capripoxvirus were performed in Sulaimani province in Kurdistan region of Iraq to analyse the genetic relationship with the other Capripoxvirus worldwide and to understand the epidemiology of the new LSDV outbreaks in Iraq. Several researches used the P32 gene to ...
Genetic Determinants Differences between Vibrio cholerae Biotypes
... encoding an RTX toxin (rtxA), together with its activator (rtxC) and transporter (rtxBD) genes (36). RTX gene cluster in El Tor V. cholerae encodes a cytotoxic activity for HEp-2 cells in vitro. The toxin, RtxA, resembles members of the RTX toxin family as it contains a GD-rich repeated motif. Like ...
... encoding an RTX toxin (rtxA), together with its activator (rtxC) and transporter (rtxBD) genes (36). RTX gene cluster in El Tor V. cholerae encodes a cytotoxic activity for HEp-2 cells in vitro. The toxin, RtxA, resembles members of the RTX toxin family as it contains a GD-rich repeated motif. Like ...
Two Classes of sir3 Mutants Enhance the sir1
... temperature-sensitive allele sir3-8 has an eso phenotype at permissive temperature, yet acts as a null allele at restrictive temperature due to loss of sir3-8 protein. Sequence analysis showed that eight of the nine sir3-eso alleles have mutations within the N-terminal region that is highly similar ...
... temperature-sensitive allele sir3-8 has an eso phenotype at permissive temperature, yet acts as a null allele at restrictive temperature due to loss of sir3-8 protein. Sequence analysis showed that eight of the nine sir3-eso alleles have mutations within the N-terminal region that is highly similar ...
MRSA - Infectious Diseases
... (PBP2’ or PBP2a) with low affinity for ß-lactams, and able to fulfill functions of other PBPs ...
... (PBP2’ or PBP2a) with low affinity for ß-lactams, and able to fulfill functions of other PBPs ...