PTENgene and carcinoma of the endometrium
... disruption of this normal regulatory pattern, leading to uncontrolled cellular growth and proliferation that is recognized as a malignant tumour. ...
... disruption of this normal regulatory pattern, leading to uncontrolled cellular growth and proliferation that is recognized as a malignant tumour. ...
A caudal mRNA gradient controls posterior development in the wasp
... contrast, activation of gap genes in flies relies on redundant functions of Bicoid and Caudal, leading to a lack of dramatic action on gap gene expression: caudal instead plays a limited role as an activator of pair-rule gene expression. These studies, together with studies in short germ insects, sug ...
... contrast, activation of gap genes in flies relies on redundant functions of Bicoid and Caudal, leading to a lack of dramatic action on gap gene expression: caudal instead plays a limited role as an activator of pair-rule gene expression. These studies, together with studies in short germ insects, sug ...
Concentrations of the atherogenic Lp(a) are elevated in FH
... elevated Lp(a) in affected vs non affected family members,17,21,22 whereas others found an effect in some but not other families and suggested ethnic and/or mutation heterogeneity was the explanation.16 Two family studies also considered apo(a) protein phenotypes.16,22 The phenotyping methods used i ...
... elevated Lp(a) in affected vs non affected family members,17,21,22 whereas others found an effect in some but not other families and suggested ethnic and/or mutation heterogeneity was the explanation.16 Two family studies also considered apo(a) protein phenotypes.16,22 The phenotyping methods used i ...
the lkb1 tumor suppressor - E
... divided into gatekeepers and caretakers based on gene function (Kinzler and Vogelstein, 1997). Gatekeepers prevent neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multiple gatekeeper genes have been identified, only one gatekeepe ...
... divided into gatekeepers and caretakers based on gene function (Kinzler and Vogelstein, 1997). Gatekeepers prevent neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multiple gatekeeper genes have been identified, only one gatekeepe ...
... Acetoin is a four carbon acetohydroxy compound that is synthesized in all simple bacteria, plants and animals, as the by-product of branched chain amino acid synthesis. Organisms such as Klebsiella and Bacillus synthesize acetoin during late exponential phase of the growth by alsSD operon. The alsSD ...
A12_ScienceAndFiction - Collegiate Quiz Bowl Packet Archive
... a. This enzyme produced in the pancreas chops proteins into fragments only a few amino acids long in the small intestine. Answer: trypsin (accept chymotrypsin) b. This peptide hormone is released in the pancreas—more specifically in the islets of Langerhans. It increases blood-glucose levels sometim ...
... a. This enzyme produced in the pancreas chops proteins into fragments only a few amino acids long in the small intestine. Answer: trypsin (accept chymotrypsin) b. This peptide hormone is released in the pancreas—more specifically in the islets of Langerhans. It increases blood-glucose levels sometim ...
Trans-acting siRNA-mediated repression of ETTIN
... et al., 2005), which strongly suggests that their mutant phenotype can be attributed to the aberrant expression of genes normally repressed by these small RNAs. Expression profiling of zip, rdr6 and sgs3 revealed several genes whose transcripts accumulate in these mutants (Peragine et al., 2004), bu ...
... et al., 2005), which strongly suggests that their mutant phenotype can be attributed to the aberrant expression of genes normally repressed by these small RNAs. Expression profiling of zip, rdr6 and sgs3 revealed several genes whose transcripts accumulate in these mutants (Peragine et al., 2004), bu ...
Collagens, modifying enzymes and their mutations in humans, flies
... supramolecular assemblies and other features of its members: (a) fibril-forming collagens; (b) fibril-associated collagens with interrupted triple helices (FACITs) located on the surface of fibrils, and structurally related collagens; (c) collagens forming hexagonal networks; (d) the family of type ...
... supramolecular assemblies and other features of its members: (a) fibril-forming collagens; (b) fibril-associated collagens with interrupted triple helices (FACITs) located on the surface of fibrils, and structurally related collagens; (c) collagens forming hexagonal networks; (d) the family of type ...
Tracing the Thread of Plastid Diversity through the Tapestry of Life
... Three mechanisms underlie this reduction of the plastid genome; gene loss, substitution, and transfer. First, in the case of gene loss, genes that no longer confer a selective advantage in the endosymbiotic environment may be lost outright. A probable example of such a loss is that of the cyanobacte ...
... Three mechanisms underlie this reduction of the plastid genome; gene loss, substitution, and transfer. First, in the case of gene loss, genes that no longer confer a selective advantage in the endosymbiotic environment may be lost outright. A probable example of such a loss is that of the cyanobacte ...
CCA Summer 2004 Newsletter - Children`s Craniofacial Association
... The clavicles may be completely absent on one or both sides, but more commonly, they are underdeveloped, usually deficient at the end closest to the shoulder. Occasionally, the clavicle is normally formed on each end with a gap in the middle. Because of these differences in the clavicle, individuals ...
... The clavicles may be completely absent on one or both sides, but more commonly, they are underdeveloped, usually deficient at the end closest to the shoulder. Occasionally, the clavicle is normally formed on each end with a gap in the middle. Because of these differences in the clavicle, individuals ...
Useful Information for Lay People
... rogue gene. In 1996, it was finally discovered on chromosome 9 – by Massimo Pandolfo (an Italian scientist working in Houston, Texas) and confirmed by Michel Koenig (Strasbourg, France). The scientists discovered that a lack of hitherto unknown protein – which they have named FRATAXIN – in the spina ...
... rogue gene. In 1996, it was finally discovered on chromosome 9 – by Massimo Pandolfo (an Italian scientist working in Houston, Texas) and confirmed by Michel Koenig (Strasbourg, France). The scientists discovered that a lack of hitherto unknown protein – which they have named FRATAXIN – in the spina ...
Datasheet - Santa Cruz Biotechnology, Inc.
... Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination duri ...
... Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination duri ...
Gene expression analysis
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
Causes that Make a Difference - Philsci
... concerning whether such universality is an appropriate ideal for physical sciences, but probably everyone, or at least nearly everyone, would concede that physical scientists are seldom satisfied with generalizations that do not hold under a wide variety of artificial and natural conditions and cont ...
... concerning whether such universality is an appropriate ideal for physical sciences, but probably everyone, or at least nearly everyone, would concede that physical scientists are seldom satisfied with generalizations that do not hold under a wide variety of artificial and natural conditions and cont ...
Regulation of meiotic progression by the meiosis
... Eukaryotic cell division consists of a highly regulated sequence of events that must occur in the appropriate order. Checkpoints are control mechanisms that prevent initiation of late events until earlier events have been successfully completed, thus ensuring faithful transmission of genetic informa ...
... Eukaryotic cell division consists of a highly regulated sequence of events that must occur in the appropriate order. Checkpoints are control mechanisms that prevent initiation of late events until earlier events have been successfully completed, thus ensuring faithful transmission of genetic informa ...
A role for wingless in the segmental gradient of Drosophila?
... metric; in both thorax and abdomen, the denticles of each segment are oriented towards a central mirror plane. The mirror plane runs through the middle of the belt, irrespective of the belt size (compare, for example, T1 with T2 in Fig. 2C). Furthermore, each belt is symmetrical with respect to the ...
... metric; in both thorax and abdomen, the denticles of each segment are oriented towards a central mirror plane. The mirror plane runs through the middle of the belt, irrespective of the belt size (compare, for example, T1 with T2 in Fig. 2C). Furthermore, each belt is symmetrical with respect to the ...
Ret/PTC3 is the most frequent form of gene rearrangement
... gene in this study population. No TRK rearrangement was detected in this study, although we cannot rule out the remote possibility of experimental failure that may have led to the apparent lack of TRK fusion. We also identified a novel type of fusion gene involving RET. Since the 59 portion of this ...
... gene in this study population. No TRK rearrangement was detected in this study, although we cannot rule out the remote possibility of experimental failure that may have led to the apparent lack of TRK fusion. We also identified a novel type of fusion gene involving RET. Since the 59 portion of this ...
Article (Published version)
... develop diabetes and die after birth42. NEUROD1 also functions as an activator of both GCK and insulin (INS)43. In humans, a homozygous mutation leads to permanent neonatal diabetes associated with cerebellar hypoplasia, learning difficulties, profound sensorineural deafness, and visual impairment as ...
... develop diabetes and die after birth42. NEUROD1 also functions as an activator of both GCK and insulin (INS)43. In humans, a homozygous mutation leads to permanent neonatal diabetes associated with cerebellar hypoplasia, learning difficulties, profound sensorineural deafness, and visual impairment as ...
What percentage of students have a dominant learning style
... chromosome breaks off, flips over, reattaches ...
... chromosome breaks off, flips over, reattaches ...
Inheritance involved in the pathogenesis of idiopathic scoliosis
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
Different susceptibility of two animal species infected with isogenic
... Since the identification of the first genes involved in mycobacterial virulence (Collins et al., 1995; Wilson et al., 1995), further development and improvement of molecular genetic techniques has enabled the discovery of an increasing number of such genes (de Mendonca-Lima et al., 2003; Glickman & ...
... Since the identification of the first genes involved in mycobacterial virulence (Collins et al., 1995; Wilson et al., 1995), further development and improvement of molecular genetic techniques has enabled the discovery of an increasing number of such genes (de Mendonca-Lima et al., 2003; Glickman & ...
FUNCTIONAL INVESTIGATION OF ARABIDOPSIS
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
A novel role for the floral homeotic gene APETALA2
... and valve, respectively (Ferrándiz et al., 2000a; Liljegren et al., 2000; Roeder et al., 2003; Liljegren et al., 2004). In rpl ful double mutants, epidermal ovary cells adopt valve margin identity, leading to a uniformly smooth surface and no apparent replum growth (Fig. 2D-F). Because even slight p ...
... and valve, respectively (Ferrándiz et al., 2000a; Liljegren et al., 2000; Roeder et al., 2003; Liljegren et al., 2004). In rpl ful double mutants, epidermal ovary cells adopt valve margin identity, leading to a uniformly smooth surface and no apparent replum growth (Fig. 2D-F). Because even slight p ...