IBDfinder and SNPsetter: tools for pedigree
... replaced by chips offering ~50k, ~250k and ~1M SNPs. Such advances can outstrip the pace of a clinical project, so that patients ascertained over a period of years may have been genotyped with a mixture of array types. Because different arrays may not share SNPs, integrating data from these differen ...
... replaced by chips offering ~50k, ~250k and ~1M SNPs. Such advances can outstrip the pace of a clinical project, so that patients ascertained over a period of years may have been genotyped with a mixture of array types. Because different arrays may not share SNPs, integrating data from these differen ...
Genetic studies of psoriasis and psoriatic arthritis
... occupational aspects. Psoriasis patients suffer impaired quality of life similar to or worse than patients with other chronic diseases such as ischemic heart disease and diabetes (Finlay et al. 1987). Over the past 20 years, our understanding of the disease mechanisms has advanced significantly and ...
... occupational aspects. Psoriasis patients suffer impaired quality of life similar to or worse than patients with other chronic diseases such as ischemic heart disease and diabetes (Finlay et al. 1987). Over the past 20 years, our understanding of the disease mechanisms has advanced significantly and ...
Imprinting and Seed Development
... straightforward. Other theories have been proposed to explain imprinting. These include imprinting as a defense against chromosome loss or gain or as a means to accurately control gene expression (Hurst, 1997). Or, imprinting could be a by-product of maintaining chromatin structural differences betw ...
... straightforward. Other theories have been proposed to explain imprinting. These include imprinting as a defense against chromosome loss or gain or as a means to accurately control gene expression (Hurst, 1997). Or, imprinting could be a by-product of maintaining chromatin structural differences betw ...
Molecular Cloning and Expression of a 2-Arylpropionyl
... worth, CA). The 59- and 39-end of the cDNA was modified by PCR amplification, with primers incorporating the desired sequences, which included a BamHI site in front of the starting methionine codon and a SacI site 39 behind the termination codon. The PCR product was ligated directly into the pCRII v ...
... worth, CA). The 59- and 39-end of the cDNA was modified by PCR amplification, with primers incorporating the desired sequences, which included a BamHI site in front of the starting methionine codon and a SacI site 39 behind the termination codon. The PCR product was ligated directly into the pCRII v ...
Restless Legs Syndrome
... • Disease nosologies are human constructs informed by physician experience, clinical expediency, and regulatory agencies, but are most often lack a complete understanding of the biology of the disease. • The RLS story provides the best example to date of how discovery of sequence variants can influ ...
... • Disease nosologies are human constructs informed by physician experience, clinical expediency, and regulatory agencies, but are most often lack a complete understanding of the biology of the disease. • The RLS story provides the best example to date of how discovery of sequence variants can influ ...
Abundant Genetic Overlap between Blood Lipids and Immune
... (CeD), psoriasis (PSOR) and sarcoidosis (SARC)[1–5]. In addition to diet and other environmental factors, it is possible that the increased occurrence of dyslipidemia and subsequent atherosclerosis in patients with immune-mediated diseases could reflect genetically determined factors influencing bot ...
... (CeD), psoriasis (PSOR) and sarcoidosis (SARC)[1–5]. In addition to diet and other environmental factors, it is possible that the increased occurrence of dyslipidemia and subsequent atherosclerosis in patients with immune-mediated diseases could reflect genetically determined factors influencing bot ...
Fingerprinting the Fungal Community
... under the microscope. The very nature of physiological, and biochemical studies requires organisms that can be cultured, and consequently such studies have a tendency to revolve around a few model ‘ideal’ organisms. There have been enormous efforts to isolate fungi from diverse marine and terrestria ...
... under the microscope. The very nature of physiological, and biochemical studies requires organisms that can be cultured, and consequently such studies have a tendency to revolve around a few model ‘ideal’ organisms. There have been enormous efforts to isolate fungi from diverse marine and terrestria ...
Identity elements in tRNA-mediated transcription
... role for stem–loop structures II and IV in the establishment or maintenance of the mRNA–tRNA interaction. If these complementary regions were important for an efficient mRNA–tRNA interaction, it would be expected that tRNAAsn would show less, or differently structured, complementarity to the trp lea ...
... role for stem–loop structures II and IV in the establishment or maintenance of the mRNA–tRNA interaction. If these complementary regions were important for an efficient mRNA–tRNA interaction, it would be expected that tRNAAsn would show less, or differently structured, complementarity to the trp lea ...
Molecular Mechanisms of Floral Boundary Formation in Arabidopsis
... to be implicated in the floral O–O boundary formation. CUC1, CUC2 and CUC3 are all expressed in the floral organ primordia and boundaries, and the double mutant combinations of the three CUC genes form fusions between adjacent floral organs [5,6,61]. More importantly, CUC genes are key nodes of the ...
... to be implicated in the floral O–O boundary formation. CUC1, CUC2 and CUC3 are all expressed in the floral organ primordia and boundaries, and the double mutant combinations of the three CUC genes form fusions between adjacent floral organs [5,6,61]. More importantly, CUC genes are key nodes of the ...
Assessing in silico the recruitment and functional spectrum of
... means of specific biosynthetic pathways and the corresponding genes are organized in biosynthetic gene clusters (BGCs) [5]. Compared to products of PM, secondary metabolites have a wider range of structures and biological activities [6]. This remarkable diversity reflects the random manner in which ...
... means of specific biosynthetic pathways and the corresponding genes are organized in biosynthetic gene clusters (BGCs) [5]. Compared to products of PM, secondary metabolites have a wider range of structures and biological activities [6]. This remarkable diversity reflects the random manner in which ...
Sequencing Grade Modified Trypsin, Frozen, Product Information
... Description: Trypsin specifically hydrolyzes peptide bonds at the carboxyl side of lysine and arginine residues. Unmodified trypsin is subject to auto-proteolysis, generating fragments that can interfere with protein sequencing or HPLC peptide analysis. In addition, auto-proteolysis can result in th ...
... Description: Trypsin specifically hydrolyzes peptide bonds at the carboxyl side of lysine and arginine residues. Unmodified trypsin is subject to auto-proteolysis, generating fragments that can interfere with protein sequencing or HPLC peptide analysis. In addition, auto-proteolysis can result in th ...
Product description P003-D1 MLH1-MSH2-v01 - MRC
... Reference samples should be derived from unrelated individuals who are from families without a history of hereditary predisposition to cancer. More information regarding the selection and use of reference samples can be found in the MLPA General Protocol. Positive control DNA samples: The NIBSC Inst ...
... Reference samples should be derived from unrelated individuals who are from families without a history of hereditary predisposition to cancer. More information regarding the selection and use of reference samples can be found in the MLPA General Protocol. Positive control DNA samples: The NIBSC Inst ...
Identity elements in tRNA-mediated transcription
... role for stem–loop structures II and IV in the establishment or maintenance of the mRNA–tRNA interaction. If these complementary regions were important for an efficient mRNA–tRNA interaction, it would be expected that tRNAAsn would show less, or differently structured, complementarity to the trp lea ...
... role for stem–loop structures II and IV in the establishment or maintenance of the mRNA–tRNA interaction. If these complementary regions were important for an efficient mRNA–tRNA interaction, it would be expected that tRNAAsn would show less, or differently structured, complementarity to the trp lea ...
Population Genetics 2: Linkage disequilibrium Consider two loci and
... Random association of alleles at a single locus: HWE What about random association of alleles at different loci after ...
... Random association of alleles at a single locus: HWE What about random association of alleles at different loci after ...
Characterization of mutations induced by N-methyl-N´-nitro
... in the patterns of base substitutions in our study might reflect the differences in DNA ...
... in the patterns of base substitutions in our study might reflect the differences in DNA ...
Query Results
... Layout and flowchart of the SAGExplore server. The core of the server is a MySQL database of virtual genomic SAGE tags with confidence assignments The module I is linked to NCBI BLAST server and to the Saccharomyces Genome Database (SGD) and does not require any input from the user. The modules II ...
... Layout and flowchart of the SAGExplore server. The core of the server is a MySQL database of virtual genomic SAGE tags with confidence assignments The module I is linked to NCBI BLAST server and to the Saccharomyces Genome Database (SGD) and does not require any input from the user. The modules II ...
The Arabidopsis WAVY GROWTH 2 Protein Modulates Root
... inclined agar surfaces, as described previously (Figure 1A; Okada and Shimura, 1990). We measured the wave tangent angle (the angle between a tangent to the root growth direction and a hypothetical axis at each intersection between that axis and the root), wavelength, and growth rate of the wild-typ ...
... inclined agar surfaces, as described previously (Figure 1A; Okada and Shimura, 1990). We measured the wave tangent angle (the angle between a tangent to the root growth direction and a hypothetical axis at each intersection between that axis and the root), wavelength, and growth rate of the wild-typ ...
The Mutant of sll1961, Which Encodes a Putative
... to encode a transcriptional regulator so that it may be involved in the regulation of photosystem stoichiometry (Yu et al., 2003; Wang et al., 2004). However, only a few cases have been reported for the regulatory mutant of photosystem stoichiometry under high-light condition (Hihara et al., 1998). ...
... to encode a transcriptional regulator so that it may be involved in the regulation of photosystem stoichiometry (Yu et al., 2003; Wang et al., 2004). However, only a few cases have been reported for the regulatory mutant of photosystem stoichiometry under high-light condition (Hihara et al., 1998). ...
one in three hundred sixty thousand
... hen Amy Frohnmayer started kindergarten in the early 1990s, no one knew which genes caused Fanconi anemia, the disease she shares with roughly 3,000 people worldwide, including Nina Morrison. By the time Amy started college last year, scientists had identified 11 genes, and had begun to understand h ...
... hen Amy Frohnmayer started kindergarten in the early 1990s, no one knew which genes caused Fanconi anemia, the disease she shares with roughly 3,000 people worldwide, including Nina Morrison. By the time Amy started college last year, scientists had identified 11 genes, and had begun to understand h ...
High-Level Expression in Escherichia coli of Alkaline Phosphatase
... the recombinant plasmid was grown overnight at 37oC in L-broth containing 100 µg/ml ampicillin [14]. A 10 ml aliquot of seed culture was inoculated into 1 liter of the same medium and cultured at 37oC. When the A600 of the culture was about 0.8, the culture was induced by the addition of isopropyl-β ...
... the recombinant plasmid was grown overnight at 37oC in L-broth containing 100 µg/ml ampicillin [14]. A 10 ml aliquot of seed culture was inoculated into 1 liter of the same medium and cultured at 37oC. When the A600 of the culture was about 0.8, the culture was induced by the addition of isopropyl-β ...
Histones - scientia.global
... Histone mRNAs are synthesised in a distinct subcompartment of the nucleus, termed the histone locus body (HLB), that concentrates many of the factors that are required for histone mRNA biosynthesis. As mentioned above, the protein FLASH and U7 snRNP are components of the HLB that participate in 3′ p ...
... Histone mRNAs are synthesised in a distinct subcompartment of the nucleus, termed the histone locus body (HLB), that concentrates many of the factors that are required for histone mRNA biosynthesis. As mentioned above, the protein FLASH and U7 snRNP are components of the HLB that participate in 3′ p ...
Prediction of B cell epitopes
... antigen complexes in the PDB The data set has been used for developing a method for predictions of discontinuous B cell epitopes Since about 30 of the PDB entries represented Lysozyme, I have used homology grouping (25 groups of non-homologous antigens) and 5 fold cross-validation for training o ...
... antigen complexes in the PDB The data set has been used for developing a method for predictions of discontinuous B cell epitopes Since about 30 of the PDB entries represented Lysozyme, I have used homology grouping (25 groups of non-homologous antigens) and 5 fold cross-validation for training o ...
Cytogenetic genotype-phenotype studies: Improving genotyping
... In summary, although molecular analysis allows a more detailed view of the WHS critical regions, the exact contribution of each of the proposed critical regions to the WHS phenotype still remains to be determined. ...
... In summary, although molecular analysis allows a more detailed view of the WHS critical regions, the exact contribution of each of the proposed critical regions to the WHS phenotype still remains to be determined. ...
Transcriptional Regulation by FOXP1, FOXP2, and
... FOXP2, and FOXP4 proteins homodimerize with themselves and heterodimerize with each other in transfected HEK293 cells (Li et al. 2004). We performed coimmunoprecipitation assays to confirm that FOXP1, FOXP2, and FOXP4 heterodimerize in the HEK293 cells expressing FOXP1-Flag with FOXP2-Myc, FOXP1-Fla ...
... FOXP2, and FOXP4 proteins homodimerize with themselves and heterodimerize with each other in transfected HEK293 cells (Li et al. 2004). We performed coimmunoprecipitation assays to confirm that FOXP1, FOXP2, and FOXP4 heterodimerize in the HEK293 cells expressing FOXP1-Flag with FOXP2-Myc, FOXP1-Fla ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.