The Art of Multiple Sequence Alignment in R
... of DNA, RNA, or amino acid (AA) sequences and returns a merged alignment. For more than two sequences, the function AlignSeqs can be used to perform multiple sequence alignment in a progressive/iterative manner on sequences of the same kind. In this case, multiple alignment works by aligning two seq ...
... of DNA, RNA, or amino acid (AA) sequences and returns a merged alignment. For more than two sequences, the function AlignSeqs can be used to perform multiple sequence alignment in a progressive/iterative manner on sequences of the same kind. In this case, multiple alignment works by aligning two seq ...
Transgenic approaches for optogenetics Tim Murphy UBC.
... Cre is often expressed from a randomly integrated transgene, but very few insertion sites are known. Random transgene integration can disrupt an endogenous mouse gene and cause unanticipated side effects. Since hemizygous mice have a wildtype chromosome present, using hemizygous instead of homozygou ...
... Cre is often expressed from a randomly integrated transgene, but very few insertion sites are known. Random transgene integration can disrupt an endogenous mouse gene and cause unanticipated side effects. Since hemizygous mice have a wildtype chromosome present, using hemizygous instead of homozygou ...
2 Changes of Gene Frequency - the UC Davis Plant Breeding
... Mutation rates are generally very low — about 10 -5 or 10 -6 per generation for most loci in most organisms. This means that between about 1 in 100,000 and 1 in 1,000,000 gametes carry a newly mutated allele at any particular locus. With normal mutation rates, therefore, mutation alone can produce o ...
... Mutation rates are generally very low — about 10 -5 or 10 -6 per generation for most loci in most organisms. This means that between about 1 in 100,000 and 1 in 1,000,000 gametes carry a newly mutated allele at any particular locus. With normal mutation rates, therefore, mutation alone can produce o ...
PHI-Canto video tutorial text - PHI-base
... Post-submission or a pause in curation brings the author back to this page where recent sessions are visible for quick access. It is important to note that PHI-Canto can only have 1 assigned curator per PubMed ID to prevent duplication however each author can several papers under curation at the sam ...
... Post-submission or a pause in curation brings the author back to this page where recent sessions are visible for quick access. It is important to note that PHI-Canto can only have 1 assigned curator per PubMed ID to prevent duplication however each author can several papers under curation at the sam ...
Detecting epistasis via Markov bases
... has been given in [15]. In the method described in this paper, we first reduce the potential interacting SNPs to a small number by filtering all SNPs genome-wide with a single locus approach. The loci achieving some threshold are then further examined for interactions. Such a two-stage approach has ...
... has been given in [15]. In the method described in this paper, we first reduce the potential interacting SNPs to a small number by filtering all SNPs genome-wide with a single locus approach. The loci achieving some threshold are then further examined for interactions. Such a two-stage approach has ...
Practice Guidelines for the Molecular Diagnosis of Haemophilia B.
... web resources). A standard questionnaire is used to assess whether or not the variant is predicted to affect protein function, principally by means of cross-species amino acid alignment algorithms, evaluation using splice-site prediction tools and documented searches to demonstrate that the variant ...
... web resources). A standard questionnaire is used to assess whether or not the variant is predicted to affect protein function, principally by means of cross-species amino acid alignment algorithms, evaluation using splice-site prediction tools and documented searches to demonstrate that the variant ...
The msh2 Gene of Schizosaccharomyces pombe Is
... homology to the Msh2 subgroup. msh2 disruption gives rise to increased mitotic mutation rates and increased levels of postmeiotic segregation of genetic markers. In bandshift assays performed with msh2D cell extracts, a general mismatch-binding activity is absent. By complementation assays, we showe ...
... homology to the Msh2 subgroup. msh2 disruption gives rise to increased mitotic mutation rates and increased levels of postmeiotic segregation of genetic markers. In bandshift assays performed with msh2D cell extracts, a general mismatch-binding activity is absent. By complementation assays, we showe ...
(F193L) in the KCNQ1 gene associated with long
... shows the representative current traces recorded from those cells transiently transfected with 8 ng of WT KCNQ1 or F193L KCNQ1 without minK. WT KCNQ1 displayed rapidly activating and non-inactivating outward currents on depolarizing test pulses. F193L KCNQ1 was able to form functional channels that ...
... shows the representative current traces recorded from those cells transiently transfected with 8 ng of WT KCNQ1 or F193L KCNQ1 without minK. WT KCNQ1 displayed rapidly activating and non-inactivating outward currents on depolarizing test pulses. F193L KCNQ1 was able to form functional channels that ...
genes-157686-revisions v2_untracked
... the ages of 2 and 10, before the classical Fragile X phenotype would be manifest, and hence their clinical features are typically common conditions (developmental delay, autism, ADHD, speech and language delay, challenging behaviour etc.) which are not specific to Fragile X syndrome; therefore an in ...
... the ages of 2 and 10, before the classical Fragile X phenotype would be manifest, and hence their clinical features are typically common conditions (developmental delay, autism, ADHD, speech and language delay, challenging behaviour etc.) which are not specific to Fragile X syndrome; therefore an in ...
Gene Section ALDOB (aldolase B, fructose-bisphosphate) Atlas of Genetics and Cytogenetics
... Many types of mutation in human ALDOB gene were reported, including missense mutations, nonsense mutations, deletions, insertions and mutation at the splicing regions (list in the diagram above). The mutations bring about reduced enzyme activity and affect structural stability. Mutants that retained ...
... Many types of mutation in human ALDOB gene were reported, including missense mutations, nonsense mutations, deletions, insertions and mutation at the splicing regions (list in the diagram above). The mutations bring about reduced enzyme activity and affect structural stability. Mutants that retained ...
Molecular genetics of Rett syndrome and clinical
... mechanism that might account for this is dif®cult to predict. These genes may be neuronal-speci®c or widely expressed but detrimental only to neuronal development when misexpressed. In support of the idea that MeCP2 might regulate only a subset of genes, the CpG islands associated with the promoters ...
... mechanism that might account for this is dif®cult to predict. These genes may be neuronal-speci®c or widely expressed but detrimental only to neuronal development when misexpressed. In support of the idea that MeCP2 might regulate only a subset of genes, the CpG islands associated with the promoters ...
Alpha and beta subunits of pyruvate dehydrogenase E1
... and 100%). This position for the microsporidian sequence is exactly what one would expect for a mitochondrial PDH gene. The Nosema sequences are both more divergent than other mitochondrial homologues, but not as divergent as many microsporidian genes. Probably as a result of this divergence, the No ...
... and 100%). This position for the microsporidian sequence is exactly what one would expect for a mitochondrial PDH gene. The Nosema sequences are both more divergent than other mitochondrial homologues, but not as divergent as many microsporidian genes. Probably as a result of this divergence, the No ...
Metabolomic and flux‐balance analysis of age‐related decline of
... fly genes have been discovered that are similar in sequence and function to human genes for regulation of metabolism, signalling, and transcription during hypoxia (Wingrove and O’Farrell, 1999; Lavista-Llanos et al, 2002; Pan and Hardie, 2002). Although the hypoxia response in flies and humans seems t ...
... fly genes have been discovered that are similar in sequence and function to human genes for regulation of metabolism, signalling, and transcription during hypoxia (Wingrove and O’Farrell, 1999; Lavista-Llanos et al, 2002; Pan and Hardie, 2002). Although the hypoxia response in flies and humans seems t ...
Sequence variation in the dihydrofolate reductase
... 11 amino acid polymorphisms in TR . No amino acid replacements occur in regions that are important for the enzymatic activity of these proteins, but some polymorphisms occur in sites previously assumed to be invariant. The sequences from both genes cluster in four major groups, a result that is not ...
... 11 amino acid polymorphisms in TR . No amino acid replacements occur in regions that are important for the enzymatic activity of these proteins, but some polymorphisms occur in sites previously assumed to be invariant. The sequences from both genes cluster in four major groups, a result that is not ...
Wnt Signaling and an APC-Related Gene Specify Endoderm in
... be determined by the site of sperm entry (Goldstein and Hird, 1996). A second source of a–p polarity requires a cell–cell interaction at the 4-cell stage of embryogenesis between blastomeres called EMS and P 2 (Goldstein, 1992, 1993). In normal development, the EMS blastomere divides into an anterio ...
... be determined by the site of sperm entry (Goldstein and Hird, 1996). A second source of a–p polarity requires a cell–cell interaction at the 4-cell stage of embryogenesis between blastomeres called EMS and P 2 (Goldstein, 1992, 1993). In normal development, the EMS blastomere divides into an anterio ...
Evolutionary dynamics of RNA-like replicator systems
... reactions occurring in the cell. Nevertheless, RNA molecules are the actual catalyst of protein synthesis, one of the most vital reactions for life. It seems as if this role of RNA is a historical contingency. The second implication is that not only proteins, but also RNA can function as an efficien ...
... reactions occurring in the cell. Nevertheless, RNA molecules are the actual catalyst of protein synthesis, one of the most vital reactions for life. It seems as if this role of RNA is a historical contingency. The second implication is that not only proteins, but also RNA can function as an efficien ...
X r Y
... – The factors separated when the gametes were formed during meiosis, each gamete would get either the tall or short gene. – When random fusion of the gametes occurred during fertilization, the combinations were brought together in a 3:1 ratio, as indicated by the Punnett square. ...
... – The factors separated when the gametes were formed during meiosis, each gamete would get either the tall or short gene. – When random fusion of the gametes occurred during fertilization, the combinations were brought together in a 3:1 ratio, as indicated by the Punnett square. ...
The role of humans in facilitating and sustaining coat
... molecular mechanisms are involved regardless of when or how animals were domesticated (Table 1). Since so many of the same genes underlie common coat colour variations, and because only a few domestic animal species followed the commensal pathway in which tameness was an important prerequisite, it i ...
... molecular mechanisms are involved regardless of when or how animals were domesticated (Table 1). Since so many of the same genes underlie common coat colour variations, and because only a few domestic animal species followed the commensal pathway in which tameness was an important prerequisite, it i ...
1 - University of Pennsylvania
... • Collaboration with Division of Oncology, Children’s Hospital of Philadelpia • PubMed abstracts – mining cancer literature for associations that link variations in genes with malignancies • http://bioie.ldc.upenn.edu - release 0.9 available 1157 abstracts entity annotated, 318 also treebanked ...
... • Collaboration with Division of Oncology, Children’s Hospital of Philadelpia • PubMed abstracts – mining cancer literature for associations that link variations in genes with malignancies • http://bioie.ldc.upenn.edu - release 0.9 available 1157 abstracts entity annotated, 318 also treebanked ...
Journal of Bacteriology
... process; e.g., R. leguminosarum bv. viciae nodulates common vetch, pea, sweet pea, and lentil but not clover or bean, whereas R. leguminosarum bv. trifolii nodulates only clover. Many genes required for root nodule formation (nod genes) by Rhizobium species, including those of R. leguminosarum, are ...
... process; e.g., R. leguminosarum bv. viciae nodulates common vetch, pea, sweet pea, and lentil but not clover or bean, whereas R. leguminosarum bv. trifolii nodulates only clover. Many genes required for root nodule formation (nod genes) by Rhizobium species, including those of R. leguminosarum, are ...
Alu Human Polymorphism
... • Each Alu insertion is a unique event and is inherited from each parent – Most occurred millions of years ago and are often on both pairs of chromosomes – There are Alu elements that have occurred since humans branched from other primates – This gives rise to dimorphic Alus from the last hundreds o ...
... • Each Alu insertion is a unique event and is inherited from each parent – Most occurred millions of years ago and are often on both pairs of chromosomes – There are Alu elements that have occurred since humans branched from other primates – This gives rise to dimorphic Alus from the last hundreds o ...
SNP Analysis (GAW15 data)
... the MHC region makes the largest single contribution (relative recurrence risk ~1.8 ) to disease susceptibility7 A set of alleles at the DRB1 locus, many of which share a common polymorphic sequence, the “shared epitope”, explain a large portion, but not all, of the genetic risk within the MHC. ...
... the MHC region makes the largest single contribution (relative recurrence risk ~1.8 ) to disease susceptibility7 A set of alleles at the DRB1 locus, many of which share a common polymorphic sequence, the “shared epitope”, explain a large portion, but not all, of the genetic risk within the MHC. ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.