Nanotechnology for the Delivery of Therapeutic Nucleic Acids
... almost any disease by targeting otherwise “undruggable” targets such as molecules without ligand-binding domains or enzymatic function. Despite the promise, developing any NA as therapeutics has proven challenging. Like most drug development, there is no quick fix. Although many of the hurdles to de ...
... almost any disease by targeting otherwise “undruggable” targets such as molecules without ligand-binding domains or enzymatic function. Despite the promise, developing any NA as therapeutics has proven challenging. Like most drug development, there is no quick fix. Although many of the hurdles to de ...
Consulta: subjectFacets:"Phenotype" Registros recuperados: 25
... On 398 river buffalo samples, randomly collected in distinct breeding areas of the Campania region, high-resolution analytical systems were used to identify both qualitative and quantitative variations of the Hb phenotype. Polyacrylamide gel isoelectric focusing and HPLC were used to determine the r ...
... On 398 river buffalo samples, randomly collected in distinct breeding areas of the Campania region, high-resolution analytical systems were used to identify both qualitative and quantitative variations of the Hb phenotype. Polyacrylamide gel isoelectric focusing and HPLC were used to determine the r ...
Deletions of NF1 gene and exons detected by multiplex ligation
... (Invitrogen Corporation, Carlsbad, California, USA). To account for possible variation related to DNA input amounts or the presence of PCR inhibitors, the reference gene ZNF80 was simultaneously quantified in a separate tube for each patient sample. SYBR Green amplification mixtures (25 ml) containe ...
... (Invitrogen Corporation, Carlsbad, California, USA). To account for possible variation related to DNA input amounts or the presence of PCR inhibitors, the reference gene ZNF80 was simultaneously quantified in a separate tube for each patient sample. SYBR Green amplification mixtures (25 ml) containe ...
Molecular Imaging - Engineering Computing Facility
... (technological methods) make their usefulness limited in many circumstances. This is mainly due to the fact that most imaging modalities only provide information at the anatomical level, which is insufficient for diseases at the genetic or molecular level. For instance, in cancer diagnosis and follo ...
... (technological methods) make their usefulness limited in many circumstances. This is mainly due to the fact that most imaging modalities only provide information at the anatomical level, which is insufficient for diseases at the genetic or molecular level. For instance, in cancer diagnosis and follo ...
Understanding the Scurred condition in Polled Cattle
... Understanding the Scurred condition in Polled Cattle Most calves that are horned can be identified at birth or shortly after, and almost always by weaning time. Distinguishing between smooth-polled and scurred-polled is more difficult. Scurs, a rudimentary horn growth, are often not seen until cattl ...
... Understanding the Scurred condition in Polled Cattle Most calves that are horned can be identified at birth or shortly after, and almost always by weaning time. Distinguishing between smooth-polled and scurred-polled is more difficult. Scurs, a rudimentary horn growth, are often not seen until cattl ...
Sequence comparison of aflR from different Aspergillus species
... A sequence 68–78 bp upstream of the aflJ ORF was homologous to known binding sites for AflR (50 TCGN5 CGR-30 ) found in other aflatoxin pathway genes (Ehrlich et al., 1999b). This sequence (site 1) was present in all isolates except in most A. nomius (Table 4). A. bombycis, N16, and A. pseudotamarii we ...
... A sequence 68–78 bp upstream of the aflJ ORF was homologous to known binding sites for AflR (50 TCGN5 CGR-30 ) found in other aflatoxin pathway genes (Ehrlich et al., 1999b). This sequence (site 1) was present in all isolates except in most A. nomius (Table 4). A. bombycis, N16, and A. pseudotamarii we ...
Special Report on Genetics and: Gout 23 Selected Articles From 199
... downloaded in PDF format by following the link provided there. This listing is a selected subset of those found on PubMed® with emphasis on the interplay between genetics and the environment, including but not limited to nutrition. The available subset includes many articles related to genetics from ...
... downloaded in PDF format by following the link provided there. This listing is a selected subset of those found on PubMed® with emphasis on the interplay between genetics and the environment, including but not limited to nutrition. The available subset includes many articles related to genetics from ...
Roles of Long Non-coding RNAs in X
... spliced and polyadenylated, and is exclusively nuclear and untranslated (Brockdorff et al. 1992; Brown et al. 1992). Multiple spliceforms exist, some of which appear to lack polyA tails (Brown et al 1991, 1992; Hong et al. 2000; Ma and Strauss 2005; Memili et al. 2001). Consistent with its classific ...
... spliced and polyadenylated, and is exclusively nuclear and untranslated (Brockdorff et al. 1992; Brown et al. 1992). Multiple spliceforms exist, some of which appear to lack polyA tails (Brown et al 1991, 1992; Hong et al. 2000; Ma and Strauss 2005; Memili et al. 2001). Consistent with its classific ...
Genomic organisation of the Mal d 1 gene cluster on linkage group
... complex allergen gene family. Not all Mal d 1 members are likely to be involved in allergenicity. Therefore, additional knowledge about the existence and characteristics of the different Mal d 1 genes is required. In the present study, we investigated the genomic organisation of the Mal d 1 gene clu ...
... complex allergen gene family. Not all Mal d 1 members are likely to be involved in allergenicity. Therefore, additional knowledge about the existence and characteristics of the different Mal d 1 genes is required. In the present study, we investigated the genomic organisation of the Mal d 1 gene clu ...
Linköping University Post Print Neuronal Subtype Specification within a Feed-Forward Loops
... (Lundgren et al., 1995; Miguel-Aliaga et al., 2004). Two cells in each cluster are neuropeptideproducing cells; the Ap1/Nplp1 and Ap4/FMRFa neurons, which express the neuropeptide genes FMRFa and Nplp1, respectively (Baumgardt et al., 2007; Benveniste et al., 1998; Park et al., 2004). Each Ap clust ...
... (Lundgren et al., 1995; Miguel-Aliaga et al., 2004). Two cells in each cluster are neuropeptideproducing cells; the Ap1/Nplp1 and Ap4/FMRFa neurons, which express the neuropeptide genes FMRFa and Nplp1, respectively (Baumgardt et al., 2007; Benveniste et al., 1998; Park et al., 2004). Each Ap clust ...
Fulltext PDF - Indian Academy of Sciences
... methylation pattern acquired in response to abiotic or biotic stress is often inherited over one to several subsequent generations. Cytosine methylation marks affect physiological functions of plants via their effect(s) on gene expression levels. They also repress transposable elements that are abun ...
... methylation pattern acquired in response to abiotic or biotic stress is often inherited over one to several subsequent generations. Cytosine methylation marks affect physiological functions of plants via their effect(s) on gene expression levels. They also repress transposable elements that are abun ...
View PDF - G3: Genes | Genomes | Genetics
... libraries and performed paired-end sequencing. Raw reads (50 bp) were aligned separately to the reference genome (Dmel r5) using the default settings of BWA 0.6.2. Three different methods were used to analyze the sequences: split-read mapping, paired-end mapping, and depth of coverage. The split-rea ...
... libraries and performed paired-end sequencing. Raw reads (50 bp) were aligned separately to the reference genome (Dmel r5) using the default settings of BWA 0.6.2. Three different methods were used to analyze the sequences: split-read mapping, paired-end mapping, and depth of coverage. The split-rea ...
AT3 (Acyltransferase) Gene Isolated from Capsicum frutescens cv
... Chili pepper is widely used and cultivated by Indonesian people. There are three species of chili pepper, i.e. Capsicum annuum, Capsicum frutescens, and Capsicum violaceum. C. frutescens has a higher economic value due to its pungency and carotenoid content. C. frutescens has several cultivars, one ...
... Chili pepper is widely used and cultivated by Indonesian people. There are three species of chili pepper, i.e. Capsicum annuum, Capsicum frutescens, and Capsicum violaceum. C. frutescens has a higher economic value due to its pungency and carotenoid content. C. frutescens has several cultivars, one ...
Hox patterning of the vertebrate axial skeleton
... Hox5, Hox6, Hox7, Hox8, and Hox9 group genes have been reported to include defects in the first rib (T1). The reason for the sensitivity of this portion of the rib cage to loss of Hox function and the apparent lack of colinearity in this region of the axial skeleton has not been clear. The accumulate ...
... Hox5, Hox6, Hox7, Hox8, and Hox9 group genes have been reported to include defects in the first rib (T1). The reason for the sensitivity of this portion of the rib cage to loss of Hox function and the apparent lack of colinearity in this region of the axial skeleton has not been clear. The accumulate ...
Genetics of Clubroot Resistance inBrassicaSpecies | SpringerLink
... studied in B. rapa. All eight possible CR genes present in B. rapa have been identified through QTL mapping by research groups using a range of resistant sources and marker systems (Table 2). Kuginuki and others (1997) identified three random amplified polymorphic DNA (RAPD) markers linked to a CR l ...
... studied in B. rapa. All eight possible CR genes present in B. rapa have been identified through QTL mapping by research groups using a range of resistant sources and marker systems (Table 2). Kuginuki and others (1997) identified three random amplified polymorphic DNA (RAPD) markers linked to a CR l ...
REVIEWS
... biosynthesis of a particular cellular constituent are typically regulated by the accumulation of the end-product. As far as we know, virtually all bacteria have additional layers of control that coordinate the use of nutrients of the same type (for example, carbon or nitrogen) using global regulator ...
... biosynthesis of a particular cellular constituent are typically regulated by the accumulation of the end-product. As far as we know, virtually all bacteria have additional layers of control that coordinate the use of nutrients of the same type (for example, carbon or nitrogen) using global regulator ...
Homeotic genes regulate the spatial expression
... been found to autoregulate, including one, Ubx, that activates its own expression in the visceral mesoderm (Bienz and Tremml, 1988). There must, however, be other genes that are controlled by homeotic genes but are more directly linked to the processes of cell differentiation and morphogenesis. In a ...
... been found to autoregulate, including one, Ubx, that activates its own expression in the visceral mesoderm (Bienz and Tremml, 1988). There must, however, be other genes that are controlled by homeotic genes but are more directly linked to the processes of cell differentiation and morphogenesis. In a ...
A Genome-Wide Survey of the NAC Transcription
... likelihood that these genes play important roles in the physiology of plants. Substantial experimental work will be required to determine the specific biological function of each NAC gene. Through phylogenetic analysis, it has become apparent that this large family of transcription factors consists ...
... likelihood that these genes play important roles in the physiology of plants. Substantial experimental work will be required to determine the specific biological function of each NAC gene. Through phylogenetic analysis, it has become apparent that this large family of transcription factors consists ...
CS790 – Introduction to Bioinformatics
... Global alignments – score the entire alignment Semi-global alignments – allow unscored gaps at the beginning or end of either sequence Local alignment – find the best matching subsequence CGATG AAATGGA ...
... Global alignments – score the entire alignment Semi-global alignments – allow unscored gaps at the beginning or end of either sequence Local alignment – find the best matching subsequence CGATG AAATGGA ...
O4 M.A. Rouf Mian
... PI 567324) were identified as resistant to the SA biotype from Ohio. PI 243540 displayed strong antibiosis resistance such that SA was unable to survive on this PI in a non-choice test. The other two resistant PIs possessed mainly antixenosis type resistance. PI 243540 and PI 567301B were also resis ...
... PI 567324) were identified as resistant to the SA biotype from Ohio. PI 243540 displayed strong antibiosis resistance such that SA was unable to survive on this PI in a non-choice test. The other two resistant PIs possessed mainly antixenosis type resistance. PI 243540 and PI 567301B were also resis ...
Genomic imprinting in the development and evolution of
... ‘autistic spectrum’ used for Kanner (infantile) autism, Asperger syndrome, Rett syndrome, and some other conditions (Table 1). I thus refer to ‘psychosis’ throughout this paper in a general sense as disordered cognition, emotionality, or both, commonly involving some component of positive symptoms s ...
... ‘autistic spectrum’ used for Kanner (infantile) autism, Asperger syndrome, Rett syndrome, and some other conditions (Table 1). I thus refer to ‘psychosis’ throughout this paper in a general sense as disordered cognition, emotionality, or both, commonly involving some component of positive symptoms s ...
Gene Section CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6)
... CYP2A6 is an enzyme responsible for the metabolism of clinically used pharmaceuticals such as coumarin and valproic acid, several carcinogens such as 4(methylnitrosamine)-1-(3-pyridyl)-1-butanone and aflatoxin B1, nicotine and for the bioactivation process of tegafur to 5-FU. The formation of 5-FU f ...
... CYP2A6 is an enzyme responsible for the metabolism of clinically used pharmaceuticals such as coumarin and valproic acid, several carcinogens such as 4(methylnitrosamine)-1-(3-pyridyl)-1-butanone and aflatoxin B1, nicotine and for the bioactivation process of tegafur to 5-FU. The formation of 5-FU f ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.