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Nutrition Power Point
Nutrition Power Point

Classification and Nomenclature of Enzymes
Classification and Nomenclature of Enzymes

A2 Module 2814: Chains, Rings and Spectroscopy
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Tricarboxylic Acid Cycle and Related Enzymes in Cell
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... Oxidation of substrates. Lactate, citrate, cisaconitate, isocitrate and oxaloacetate were utilized by cell-free extracts only in the presence of added artificial electron acceptors such as methylene blue, menadione, phenazine methosulphate etc. The results with extracts prepared either by grinding o ...
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... chemical process of joining monomers to form polymers. At the end of each monomer is a (H) hydrogen atom and a (-OH) group. Every time a monomer is added a molecule of water is given off. ...
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... *Consider NADH, FADH2, and NADPH to be "consumed" by a pathway if the pathway oxidizes them to NAD +, FAD, and NADP+, respectively. ** Technically, GTP is produced, not ATP. But this is essentially equivalent to ATP, since the two may be interconverted. ***The mitochondrial electron transport chain ...
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... The Krebs cycle completes the energy-yielding oxidation of organic molecules: a closer look (pp. 161166, FIGURES 9.11, 9.12) The conversion of pyruvate to acetyl CoA links glycolysis to the Krebs cycle. The twocarbon acetate of acetyl CoA joins the four-carbon oxaloacetate to form the six-carbon cit ...
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Citric acid cycle



The citric acid cycle – also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle – is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates, fats and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP). In addition, the cycle provides precursors of certain amino acids as well as the reducing agent NADH that is used in numerous other biochemical reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically.The name of this metabolic pathway is derived from citric acid (a type of tricarboxylic acid) that is consumed and then regenerated by this sequence of reactions to complete the cycle. In addition, the cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the TCA cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria which lack mitochondria, the TCA reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion.
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