Understanding Autoimmune Disease – a review article for the layman
... Both T and B cells are derived from stem cells within the bone marrow. Immature T lymphocytes travel from the bone marrow to the thymus where they grow into mature T lymphocytes. This development includes proliferation, rearrangement of TCR genes and acquisition of the surface receptors and accessor ...
... Both T and B cells are derived from stem cells within the bone marrow. Immature T lymphocytes travel from the bone marrow to the thymus where they grow into mature T lymphocytes. This development includes proliferation, rearrangement of TCR genes and acquisition of the surface receptors and accessor ...
PD-1 Blockade in Chronically HIV-1
... during chronic infections with SIV in primates, as well as chronic HIV, hepatitis B, hepatitis C, and human T lymphotropic virus (HTLV) infections in humans [13]. Programmed Death 1 (PD-1, CD279) is highly expressed on exhausted CD8+ T cells in chronic LCMV infected mice [14]. Inhibiting PD-1 signal ...
... during chronic infections with SIV in primates, as well as chronic HIV, hepatitis B, hepatitis C, and human T lymphotropic virus (HTLV) infections in humans [13]. Programmed Death 1 (PD-1, CD279) is highly expressed on exhausted CD8+ T cells in chronic LCMV infected mice [14]. Inhibiting PD-1 signal ...
WHO Meeting on Immunological Endpoints for TB Vaccine Trials
... tends to merely increase the cytokine concentrations measured, and may therefore be selected to suit local logistic requirements. However, when measuring cytokines that are labile and produced in low quantities, such as IL-4, or which are consumed by proliferating cells, for example IL-2, longer inc ...
... tends to merely increase the cytokine concentrations measured, and may therefore be selected to suit local logistic requirements. However, when measuring cytokines that are labile and produced in low quantities, such as IL-4, or which are consumed by proliferating cells, for example IL-2, longer inc ...
Perforin and interferon- activities independently
... cytotoxicity in immunity against tumor development. The development of gene-targeted mice deficient in perforin (pfp)2 and the discovery of several members of the tumor necrosis factor (TNF) superfamily with the capacity to induce tumor cell apoptosis3-5 have paved the way to determining which effec ...
... cytotoxicity in immunity against tumor development. The development of gene-targeted mice deficient in perforin (pfp)2 and the discovery of several members of the tumor necrosis factor (TNF) superfamily with the capacity to induce tumor cell apoptosis3-5 have paved the way to determining which effec ...
immunology syllabus 2013 - The University of Texas Medical School
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
6- review article Tolou.indd
... A further advance was the improvement of liver preservation by the introduction of University of Wisconsin Solution (Viaspan) in 1987 extending periods of cold storage in Collins solution by two to three fold (1, 10, 11). 3.2 Mechanisms of rejection Rejection can be defined as graft damage arising fr ...
... A further advance was the improvement of liver preservation by the introduction of University of Wisconsin Solution (Viaspan) in 1987 extending periods of cold storage in Collins solution by two to three fold (1, 10, 11). 3.2 Mechanisms of rejection Rejection can be defined as graft damage arising fr ...
full text pdf
... are intended for parenteral administration. This not only results in poor patient compliance but is also unable to elicit mucosal immunity, eliciting only a systemic antibody response, which is often insufficient to tackle pathogens that employ mucosal surfaces for ingress into the host or which res ...
... are intended for parenteral administration. This not only results in poor patient compliance but is also unable to elicit mucosal immunity, eliciting only a systemic antibody response, which is often insufficient to tackle pathogens that employ mucosal surfaces for ingress into the host or which res ...
Composition and Modulation Puppies -
... Puppy survival within the early weeks is particularly dependent on colostrum, a specific secretion of the mammary gland produced during the first two days post-partum. Colostrum is source of nutrients and immunoglobulins (crucial, as puppies are almost agammaglobulinemic at birth). It also contribut ...
... Puppy survival within the early weeks is particularly dependent on colostrum, a specific secretion of the mammary gland produced during the first two days post-partum. Colostrum is source of nutrients and immunoglobulins (crucial, as puppies are almost agammaglobulinemic at birth). It also contribut ...
Characterisation of interleukin-10 expression on different vascular
... (marked with an ‘A’ in Figure 1), arteries/veins (marked with a ‘B’ in Figure 1), and sinusoids (marked with a ‘C’ in Figure 1), based on morphology. On a successive slide we subsequently determined IL-10 expression and enumerated IL-10 positivity for each of the three types of blood vessels. A repr ...
... (marked with an ‘A’ in Figure 1), arteries/veins (marked with a ‘B’ in Figure 1), and sinusoids (marked with a ‘C’ in Figure 1), based on morphology. On a successive slide we subsequently determined IL-10 expression and enumerated IL-10 positivity for each of the three types of blood vessels. A repr ...
Food allergy: separating the science from the mythology
... microorganisms and to inhibit the penetration of potentially harmful agents; and immunosuppression to counteract local and peripheral hypersensitivity against innocuous antigens, such as food proteins. The latter strategy is called oral tolerance when induced via the gut. Homeostatic mechanisms also ...
... microorganisms and to inhibit the penetration of potentially harmful agents; and immunosuppression to counteract local and peripheral hypersensitivity against innocuous antigens, such as food proteins. The latter strategy is called oral tolerance when induced via the gut. Homeostatic mechanisms also ...
B Cells
... • During this time, effector B cells called plasma cells are generated, and T cells are activated to their effector forms • In the secondary immune response, memory cells facilitate a faster, more efficient response ...
... • During this time, effector B cells called plasma cells are generated, and T cells are activated to their effector forms • In the secondary immune response, memory cells facilitate a faster, more efficient response ...
Immunoglobulin and T cell receptor genes: IMGT® and
... creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamil ...
... creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamil ...
... T-cell activation requires T-cell receptor (TCR) engagement by antigen and interaction between costimulatory molecules on T-cells and their ligands on APCs [2]. Interaction between ICAM-1 and its ligand LFA-1 may be bidirectional in that both can be expressed by T-cells as well as some APCs. However ...
Review
... Jonathan D. G. Jones1 & Jeffery L. Dangl2 Top of page Abstract Many plant-associated microbes are pathogens that impair plant growth and reproduction. Plants respond to infection using a two-branched innate immune system. The first branch recognizes and responds to molecules common to many classes o ...
... Jonathan D. G. Jones1 & Jeffery L. Dangl2 Top of page Abstract Many plant-associated microbes are pathogens that impair plant growth and reproduction. Plants respond to infection using a two-branched innate immune system. The first branch recognizes and responds to molecules common to many classes o ...
Sleep April.indd
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
Cell Dynamics in the Wound Healing Process in Tumor
... p65 were seen in NSCLC tumors with node metastasis [7]. Nasopharyngeal carcinoma (NPC) patients with high levels of HMGB1 expression had poor overall, disease-free survival [8]. These insights imply that most common cancer therapies such as surgery, radiation, and chemotherapy cause necrotic cell de ...
... p65 were seen in NSCLC tumors with node metastasis [7]. Nasopharyngeal carcinoma (NPC) patients with high levels of HMGB1 expression had poor overall, disease-free survival [8]. These insights imply that most common cancer therapies such as surgery, radiation, and chemotherapy cause necrotic cell de ...
Cell Dynamics in the Wound Healing Process in Tumor Environment
... p65 were seen in NSCLC tumors with node metastasis [7]. Nasopharyngeal carcinoma (NPC) patients with high levels of HMGB1 expression had poor overall, disease-free survival [8]. These insights imply that most common cancer therapies such as surgery, radiation, and chemotherapy cause necrotic cell de ...
... p65 were seen in NSCLC tumors with node metastasis [7]. Nasopharyngeal carcinoma (NPC) patients with high levels of HMGB1 expression had poor overall, disease-free survival [8]. These insights imply that most common cancer therapies such as surgery, radiation, and chemotherapy cause necrotic cell de ...
The ontogeny of the common carp (Cyprinus carpio L.) immune system
... vertebrates offers new insights into developmental biology in general and the generation of a functional immune system in particular. Second, knowledge of the developmental sequence of immune function is imperative to design preventive measures against ...
... vertebrates offers new insights into developmental biology in general and the generation of a functional immune system in particular. Second, knowledge of the developmental sequence of immune function is imperative to design preventive measures against ...
Table S2 Biomarker Functions discussed in Publications
... a key enzyme in the valine oxidation pathway ...
... a key enzyme in the valine oxidation pathway ...
Profiling adaptive immune repertoires across multiple human tissues
... Assay-based approaches provide a detailed view of the adaptive immune system by profiling T and B cell receptor repertoires. However, these methods carry a high cost and lack the scale of standard RNA sequencing (RNA-Seq). Here we report the development of ImReP, a novel computational ...
... Assay-based approaches provide a detailed view of the adaptive immune system by profiling T and B cell receptor repertoires. However, these methods carry a high cost and lack the scale of standard RNA sequencing (RNA-Seq). Here we report the development of ImReP, a novel computational ...
Positive and negative regulation of Natural Killer cells: Therapeutic
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...