When parasitic wasps hijacked viruses
... host quality before oviposition or to feed on the host. This behaviour may have favoured encounters with viruses, which can themselves use the wasps as vectors for horizontal transmission, as is the case for ascoviruses [51,52]. It should be noted that pathogenic virus infection induced during ovipo ...
... host quality before oviposition or to feed on the host. This behaviour may have favoured encounters with viruses, which can themselves use the wasps as vectors for horizontal transmission, as is the case for ascoviruses [51,52]. It should be noted that pathogenic virus infection induced during ovipo ...
and B-‐cell Responses against Human Cytomegalovirus after
... hematopoietic stem cell transplantation (HSCT). CMV-reactivation may lead to CMVdisease associated with high morbidity and mortality in patients after HSCT. In this PhD thesis I have investigated how specific T- and B-lymphocyte responses against CMV reconstitute after HSCT. In my thesis I will ther ...
... hematopoietic stem cell transplantation (HSCT). CMV-reactivation may lead to CMVdisease associated with high morbidity and mortality in patients after HSCT. In this PhD thesis I have investigated how specific T- and B-lymphocyte responses against CMV reconstitute after HSCT. In my thesis I will ther ...
Giuliana Magri Characterization of natural killer cell response to human cytomegalovirus
... NK cells were originally described in 1975 as large granular lymphocytes with capacity to kill in vitro tumor target cells without previous sensitization2,3. At present, NK cells have gained recognition for their ability to secrete proinflammatory and antiviral cytokines, to recognize and ...
... NK cells were originally described in 1975 as large granular lymphocytes with capacity to kill in vitro tumor target cells without previous sensitization2,3. At present, NK cells have gained recognition for their ability to secrete proinflammatory and antiviral cytokines, to recognize and ...
Antigen Presentation to T Lymphocytes
... The processing and presentation of pathogen-derived antigens has two distinct purposes: inducing the development of armed effector T cells, and triggering the effector functions of these armed cells at sites of infection. MHC class I molecules bind peptides that are recognized by CD8 T cells, and MH ...
... The processing and presentation of pathogen-derived antigens has two distinct purposes: inducing the development of armed effector T cells, and triggering the effector functions of these armed cells at sites of infection. MHC class I molecules bind peptides that are recognized by CD8 T cells, and MH ...
... DCs are leukocytes specialized in presenting antigens. They can activate naïve T and B cells, and thus link the innate and the adaptive immune responses. Immature DCs are widely scattered in peripheral tissues, at the entrance sites of pathogens, and are very efficient in engulfing antigens. Followi ...
Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function
... we wondered whether it would be unusually susceptible to overtrimming by ERAAP, as observed for other CTL epitopes (12). We incubated CT26 tumor cells with MG132 (a proteasome inhibitor), AAF-CMK (an inhibitor of tripeptidyl peptidase II [TPPII]), and leuSH (an ERAAP inhibitor). We also transfected ...
... we wondered whether it would be unusually susceptible to overtrimming by ERAAP, as observed for other CTL epitopes (12). We incubated CT26 tumor cells with MG132 (a proteasome inhibitor), AAF-CMK (an inhibitor of tripeptidyl peptidase II [TPPII]), and leuSH (an ERAAP inhibitor). We also transfected ...
Crossed signals: the role of interleukin-15 and
... discussed the role of the IL-12 and -17 families of cytokines. This review is focused on IL-15 and -18. Both these molecules have pro-inflammatory activity and act on many cell types and because of their broad spectrum of activity they play an important role in autoimmunity and disease pathogenesis. ...
... discussed the role of the IL-12 and -17 families of cytokines. This review is focused on IL-15 and -18. Both these molecules have pro-inflammatory activity and act on many cell types and because of their broad spectrum of activity they play an important role in autoimmunity and disease pathogenesis. ...
Regulatory T Helper Cells in Pregnancy and Tolerance Linköping University Post Print
... development of organ-specific autoimmune diseases such as gastritis, oophoritis and thyroiditis. Notably, inflammatory disease was prevented by co-transfer of CD4+CD25+ cells. Subsequently it was shown that these cells migrate from thymus as a distinct cell subset32. In humans, the cell type corresp ...
... development of organ-specific autoimmune diseases such as gastritis, oophoritis and thyroiditis. Notably, inflammatory disease was prevented by co-transfer of CD4+CD25+ cells. Subsequently it was shown that these cells migrate from thymus as a distinct cell subset32. In humans, the cell type corresp ...
final thesis benoit - edoc
... The immune system is a broad organization constituted of multiple effectors, cells, tissues and organs that work together to protect the body against attacks by pathogenic invaders or against cancer development. The mammalian body actually provides an ideal niche for many microbes. The immune system ...
... The immune system is a broad organization constituted of multiple effectors, cells, tissues and organs that work together to protect the body against attacks by pathogenic invaders or against cancer development. The mammalian body actually provides an ideal niche for many microbes. The immune system ...
Teil 1: „Studies on the extracellular matrix enzyme
... overlapping with the LTQ site is the cytokine receptor-like (CRL) domain whose name results from its sequence homology to the N-terminal consensus sequence of class I cytokine receptors (Figure 5) {Bazan, 1990}. The function of this domain in the lysyl oxidase family of proteins is not known. ...
... overlapping with the LTQ site is the cytokine receptor-like (CRL) domain whose name results from its sequence homology to the N-terminal consensus sequence of class I cytokine receptors (Figure 5) {Bazan, 1990}. The function of this domain in the lysyl oxidase family of proteins is not known. ...
Innate Type 2 Immunity Is Associated with Eosinophilic Pleural
... Rationale: Eosinophilic pleural effusion (EPE) is characterized by greater than 10% eosinophilia and is frequently associated with air and/or blood in the pleural cavity. Primary spontaneous pneumothorax (PSP), defined as the spontaneous presence of air in the pleural space, is one of the most commo ...
... Rationale: Eosinophilic pleural effusion (EPE) is characterized by greater than 10% eosinophilia and is frequently associated with air and/or blood in the pleural cavity. Primary spontaneous pneumothorax (PSP), defined as the spontaneous presence of air in the pleural space, is one of the most commo ...
Liver immunology and its role in inflammation and
... in the liver.14 KCs are equipped with a massive array of PPRs,15 complement receptors16 and Fc receptors,17 through which they respond with increased phagocytic activity and production of inflammatory cytokines. They have essential roles in immune regulation, tissue repair and liver regeneration18 an ...
... in the liver.14 KCs are equipped with a massive array of PPRs,15 complement receptors16 and Fc receptors,17 through which they respond with increased phagocytic activity and production of inflammatory cytokines. They have essential roles in immune regulation, tissue repair and liver regeneration18 an ...
Reciprocal modulation between TH17 and other helper T cell lineages
... can be detected in vitro and in mice or humans (Beriou et al., 2009; Kryczek et al., 2009). However, it is not known whether these IL-17þ Foxp3þ T cells originate from TH17 cells or from Treg cells and also cannot make sure these cells have the functions of conventional TH17 cells (Voo et al., 2009; ...
... can be detected in vitro and in mice or humans (Beriou et al., 2009; Kryczek et al., 2009). However, it is not known whether these IL-17þ Foxp3þ T cells originate from TH17 cells or from Treg cells and also cannot make sure these cells have the functions of conventional TH17 cells (Voo et al., 2009; ...
Activation of a Nonclassical NKT Cell Subset in a Transgenic
... et al., 1995). However, adoptive transfer of lymphocytes from syngeneic, HBV-immunized donor mice into such recipients results in both suppression of viral replication and the induction of liver injury that recapitulates many features of human hepatitis. These studies not only demonstrated the poten ...
... et al., 1995). However, adoptive transfer of lymphocytes from syngeneic, HBV-immunized donor mice into such recipients results in both suppression of viral replication and the induction of liver injury that recapitulates many features of human hepatitis. These studies not only demonstrated the poten ...
Author`s personal copy
... maturation of infected dendritic cells, which undergo apoptosis. The dendritic cells display impaired ability to upregulate cell surface expression of costimulatory, maturation, and major histocompatibility complex molecules, resulting in reduced T cell stimulatory capacity. There is also an impaire ...
... maturation of infected dendritic cells, which undergo apoptosis. The dendritic cells display impaired ability to upregulate cell surface expression of costimulatory, maturation, and major histocompatibility complex molecules, resulting in reduced T cell stimulatory capacity. There is also an impaire ...
The following paper was originally published in the
... becomes inert. A third point about cfengine is that its decision making process is based on abstract classes which allows for more powerful administration models than we have traditionally been used to. Finally it offers protection against unfortunate repetition of tasks and hanging processes in sit ...
... becomes inert. A third point about cfengine is that its decision making process is based on abstract classes which allows for more powerful administration models than we have traditionally been used to. Finally it offers protection against unfortunate repetition of tasks and hanging processes in sit ...
Document
... gradual process known as antigenic drift, in which mutations within the virus antibody-binding sites accumulate over time. Through this mechanism, the virus is able to largely circumvent the body's immune system, which may not be able to recognize and confer immunity to a new influenza strain even i ...
... gradual process known as antigenic drift, in which mutations within the virus antibody-binding sites accumulate over time. Through this mechanism, the virus is able to largely circumvent the body's immune system, which may not be able to recognize and confer immunity to a new influenza strain even i ...
Structural and functional aspects of factor viii in the initiation of the
... severe hemophilia A patients. Though a significant advancement has been accomplished in the development of newer FVIII molecules, the factors that drive FVIII immune responses remain elusive. Many genetic and environmental risk factors have been identified or suggested but a complete understanding o ...
... severe hemophilia A patients. Though a significant advancement has been accomplished in the development of newer FVIII molecules, the factors that drive FVIII immune responses remain elusive. Many genetic and environmental risk factors have been identified or suggested but a complete understanding o ...
Aging of the hematopoietic system
... HSCs. HSCs, the only persistent lineage of hematopoietic cells, serve as a repository for accumulating DNA mutations that can confer abnormal selfrenewal properties to downstream progenitor cells, leading to leukemia [1]. Furthermore, the lower incidence of lymphoid malignancies originating from dev ...
... HSCs. HSCs, the only persistent lineage of hematopoietic cells, serve as a repository for accumulating DNA mutations that can confer abnormal selfrenewal properties to downstream progenitor cells, leading to leukemia [1]. Furthermore, the lower incidence of lymphoid malignancies originating from dev ...
Iris 29 - Body Glyphix Studio
... Many people who suffer from Hashimoto’s should be aware that there may be problems caused by eating gluten and related proteins. However, because of misinformation and the inconvenience of going gluten free, many people ignore these warnings or don’t think this really applies to them. I have had a n ...
... Many people who suffer from Hashimoto’s should be aware that there may be problems caused by eating gluten and related proteins. However, because of misinformation and the inconvenience of going gluten free, many people ignore these warnings or don’t think this really applies to them. I have had a n ...
Altitude, exercise and immune function
... in the face of declining β-adrenergic stimulation. This is supported by a significant correlation (p=0.004) between resting IL-6 and urinary norepinephrine excretion rates for subjects over the course of time while at altitude (Figure 5). Other studies have reported a similar relationship between pe ...
... in the face of declining β-adrenergic stimulation. This is supported by a significant correlation (p=0.004) between resting IL-6 and urinary norepinephrine excretion rates for subjects over the course of time while at altitude (Figure 5). Other studies have reported a similar relationship between pe ...
Metastatic melanoma patients treated with dendritic cell
... Dendritic cells (DC) are the most potent antigen presenting cells and have proven eVective in stimulation of speciWc immune responses in vivo [8, 9]. Immature DCs take up antigens in the periphery, present them on the surface through their major histocompatibility complex (MHC), and migrate to the l ...
... Dendritic cells (DC) are the most potent antigen presenting cells and have proven eVective in stimulation of speciWc immune responses in vivo [8, 9]. Immature DCs take up antigens in the periphery, present them on the surface through their major histocompatibility complex (MHC), and migrate to the l ...
Brain-resident memory T cells represent an autonomous cytotoxic
... of circulating TM was not required for bTRM-mediated virus clearance from the brain. Conflicting reports exist about TRM dependency on CD4+ T help in different organs (Jiang et al., 2012; Laidlaw et al., 2014).To address the role of CD4+ T cells for the generation and function of bTRM, we depleted C ...
... of circulating TM was not required for bTRM-mediated virus clearance from the brain. Conflicting reports exist about TRM dependency on CD4+ T help in different organs (Jiang et al., 2012; Laidlaw et al., 2014).To address the role of CD4+ T cells for the generation and function of bTRM, we depleted C ...