Positive and negative regulation of Natural Killer cells: Therapeutic
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...
... into NK cells following stimulation with IL-2 or IL-15 [34,35]. Later studies showed that the stromal cell requirements could be bypassed by the addition of stem cell factor, (SCF, also known as c-kit ligand), fetal liver kinase 2 ligand (FLK2, also known as FMS-like tyrosine kinase 3 ligand or FLT3 ...
(Poly(I:C)) Induces Stable Maturation of Polyriboinosinic
... clearly inferior in stimulating capacity at all stimulator:responder ratios. Thus, poly(I:C) treatment induced DC that were potent inducers of primary allo T cell responses. The stimulation of low, but significant, T cell proliferation in an auto mixed lymphocyte reaction is a property described onl ...
... clearly inferior in stimulating capacity at all stimulator:responder ratios. Thus, poly(I:C) treatment induced DC that were potent inducers of primary allo T cell responses. The stimulation of low, but significant, T cell proliferation in an auto mixed lymphocyte reaction is a property described onl ...
Markers of melanocytic tumours - iPath
... melanoma/melanocytic tumours -sentinel node As a help in the distinction between benign and malignant lesions?? ...
... melanoma/melanocytic tumours -sentinel node As a help in the distinction between benign and malignant lesions?? ...
Major histocompatability complex (MHC) and T cell receptors
... • Groove binds peptides 13-25 AA long (some outside groove) ...
... • Groove binds peptides 13-25 AA long (some outside groove) ...
Nitric oxide—Important messenger in human body
... NO could be either direct or indirect. Direct action is mediated by activation of soluble guanylyl cyclase (GC-S) with production of second messenger cyclic guanosine monophosphate (cGMP), or direct activation of ion channels. Indirect effect is usually mediated by the production of reactive oxygen ...
... NO could be either direct or indirect. Direct action is mediated by activation of soluble guanylyl cyclase (GC-S) with production of second messenger cyclic guanosine monophosphate (cGMP), or direct activation of ion channels. Indirect effect is usually mediated by the production of reactive oxygen ...
2003 ARS Immunology Research Workshop
... people and public health systems; moreover, many zoonotic pathogens are also known as “select agents,” which by definition could be used for bioterrorism or warfare. This illustrates the need for new, improved animal models for studies of zoonotic agents and their interaction within definitive and s ...
... people and public health systems; moreover, many zoonotic pathogens are also known as “select agents,” which by definition could be used for bioterrorism or warfare. This illustrates the need for new, improved animal models for studies of zoonotic agents and their interaction within definitive and s ...
Diagnosis and treatment of patients with virus induced inflammatory cardiomyopathy U. Kühl
... T-cell activation, induced by intrinsic myocardial antigens that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and escapes regular control mechanisms[12] (see the review by Afanasyeva and Rose, in the present supplement). Resulting imm ...
... T-cell activation, induced by intrinsic myocardial antigens that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and escapes regular control mechanisms[12] (see the review by Afanasyeva and Rose, in the present supplement). Resulting imm ...
Microbiota-mediated colonization resistance against intestinal
... Box 2 | Microbiota-derived molecules enhance mucosal immunity ...
... Box 2 | Microbiota-derived molecules enhance mucosal immunity ...
Protective influenza-specific CD8 T cell responses require
... subsequently migrate to the LN, the role of these recruited pulmonary DCs remains unclear because they do not fit within the classical paradigm of peripheral DCs, which acquire antigens and then migrate into lymphoid tissues to initiate adaptive immune responses. In this study, we demonstrate that s ...
... subsequently migrate to the LN, the role of these recruited pulmonary DCs remains unclear because they do not fit within the classical paradigm of peripheral DCs, which acquire antigens and then migrate into lymphoid tissues to initiate adaptive immune responses. In this study, we demonstrate that s ...
PDF - Oxford Academic - Oxford University Press
... reveals a shared U-box domain (amino acids 300–363 in StPUB17), and three ARM repeat domains (amino acids 430–470, 515–555, 556–594 in StPUB17) in the C-terminal halves of the proteins (see Supplementary Fig. S1 at JXB online). To test whether StPUB17 possesses E3 ubiquitin ligase activity, full-len ...
... reveals a shared U-box domain (amino acids 300–363 in StPUB17), and three ARM repeat domains (amino acids 430–470, 515–555, 556–594 in StPUB17) in the C-terminal halves of the proteins (see Supplementary Fig. S1 at JXB online). To test whether StPUB17 possesses E3 ubiquitin ligase activity, full-len ...
Tips to Remember: What is an allergic reaction
... vasoactive amine) causes several allergic symptoms. 1) It contributes to an inflammatory response. 2) It causes constriction of smooth muscle. Histamine can cause inflammation directly as well as indirectly. Upon release of histamine by an antigen activated mast cell, permeability of vessels near th ...
... vasoactive amine) causes several allergic symptoms. 1) It contributes to an inflammatory response. 2) It causes constriction of smooth muscle. Histamine can cause inflammation directly as well as indirectly. Upon release of histamine by an antigen activated mast cell, permeability of vessels near th ...
Journal of Autoimmunity
... While both T1D and T2D result in relative insulin deficiency, the underlying b-cell destruction in T1D is much more rapid and severe (reviewed in Ref. [21]). Additional analyses using a topological approach for detecting nonlinear patterns in high-dimensional data in an unsupervised fashion [22,23] r ...
... While both T1D and T2D result in relative insulin deficiency, the underlying b-cell destruction in T1D is much more rapid and severe (reviewed in Ref. [21]). Additional analyses using a topological approach for detecting nonlinear patterns in high-dimensional data in an unsupervised fashion [22,23] r ...
Suppression of Proinflammatory Cytokines Interleukin-1 and Tumor Necrosis Factor- 
... treated with V1 agonist or control vehicle for 24 hr. After treatment, astrocytes were rinsed twice with ice-cold PBS, and total RNA was extracted using TRIzol (Invitrogen) according to the instructions of the manufacturer and resuspended in 10 l of DEPC-treated water. RNA concentration was determi ...
... treated with V1 agonist or control vehicle for 24 hr. After treatment, astrocytes were rinsed twice with ice-cold PBS, and total RNA was extracted using TRIzol (Invitrogen) according to the instructions of the manufacturer and resuspended in 10 l of DEPC-treated water. RNA concentration was determi ...
Host manipulation by cancer cells: Expectations, facts, and
... expected that manipulative strategies similar to those of parasites could have evolved, provided that enough evolutionary time and variation in cancer cell lineages have been available for selection to favor such adaptations. In addition, manipulative strategies leading to fitness benefits inside th ...
... expected that manipulative strategies similar to those of parasites could have evolved, provided that enough evolutionary time and variation in cancer cell lineages have been available for selection to favor such adaptations. In addition, manipulative strategies leading to fitness benefits inside th ...
Literatuur - MySignal.be
... Wilder-Smith A, Mustafa F, Earnest A, Gen L, MacAry P. Impact of partial sleep deprivation on immune markers. Sleep medicine. Elsevier; 2013;14:1031–1034. Background: Sleep quality is considered to be an important predictor of immunity. Lack of sleep therefore may reduce immunity, thereby increasin ...
... Wilder-Smith A, Mustafa F, Earnest A, Gen L, MacAry P. Impact of partial sleep deprivation on immune markers. Sleep medicine. Elsevier; 2013;14:1031–1034. Background: Sleep quality is considered to be an important predictor of immunity. Lack of sleep therefore may reduce immunity, thereby increasin ...
Virulence and Pathogenicity of Fungal Pathogens with
... by inducing transcriptional and translational changes that promote survival under the newest environmental conditions. When fungi enter the mammalian host their lifestyle changes from saprophytic to parasitic. As saprophytes, fungi survive in an environment with a moderate ambient temperature and pH ...
... by inducing transcriptional and translational changes that promote survival under the newest environmental conditions. When fungi enter the mammalian host their lifestyle changes from saprophytic to parasitic. As saprophytes, fungi survive in an environment with a moderate ambient temperature and pH ...
Oncolytic Virotherapy
... pox, measles, or hepatitis (7). The dominant theory at the time was that the remissions were caused by a direct and specific infection of tumor cells by the invading infectious agent, even though viruses were just in the process of being discovered and characterized. In the ensuing decades, viruses w ...
... pox, measles, or hepatitis (7). The dominant theory at the time was that the remissions were caused by a direct and specific infection of tumor cells by the invading infectious agent, even though viruses were just in the process of being discovered and characterized. In the ensuing decades, viruses w ...
Host manipulation by cancer cells
... expected that manipulative strategies similar to those of parasites could have evolved, provided that enough evolutionary time and variation in cancer cell lineages have been available for selection to favor such adaptations. In addition, manipulative strategies leading to fitness benefits inside th ...
... expected that manipulative strategies similar to those of parasites could have evolved, provided that enough evolutionary time and variation in cancer cell lineages have been available for selection to favor such adaptations. In addition, manipulative strategies leading to fitness benefits inside th ...
Mycobacterium bovis Subsets following Infection with Virulent T Cell
... itself in this recognition. In this study, we demonstrate that both WC1.1+ and WC1.2+ bovine gd T cell subsets from virulent M. bovis–infected animals proliferate and produce IFN-g in specific and direct response to complex, as well as defined, nonprotein and protein mycobacterial Ags but that WC1.2 ...
... itself in this recognition. In this study, we demonstrate that both WC1.1+ and WC1.2+ bovine gd T cell subsets from virulent M. bovis–infected animals proliferate and produce IFN-g in specific and direct response to complex, as well as defined, nonprotein and protein mycobacterial Ags but that WC1.2 ...
Virulence and Pathogenicity of Fungal
... by inducing transcriptional and translational changes that promote survival under the newest environmental conditions. When fungi enter the mammalian host their lifestyle changes from saprophytic to parasitic. As saprophytes, fungi survive in an environment with a moderate ambient temperature and pH ...
... by inducing transcriptional and translational changes that promote survival under the newest environmental conditions. When fungi enter the mammalian host their lifestyle changes from saprophytic to parasitic. As saprophytes, fungi survive in an environment with a moderate ambient temperature and pH ...
Article
... shared by HCMV-infected and tumor cells [15,18,20]. In agreement with this, HCMV-infection and/or γδ T cell expansion have been associated with reduced cancer risk in kidney transplant recipients [21] and with graft-versus leukemia effect in bone marrow transplant recipients [22,23,24]. All these sp ...
... shared by HCMV-infected and tumor cells [15,18,20]. In agreement with this, HCMV-infection and/or γδ T cell expansion have been associated with reduced cancer risk in kidney transplant recipients [21] and with graft-versus leukemia effect in bone marrow transplant recipients [22,23,24]. All these sp ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
