Th1, Th2 and Treg associated factors in relation to allergy Camilla Janefjord
... induced both Th1 and Th2 related transcription factors and cytokines. The combination also hampered the CD2 induced expression of Foxp3. Conclusions: The CD2 pathway and the response to IL-2 may be impaired in allergic children as lower IL-12Rβ2 and IFN-γ were found in allergic, compared to non-alle ...
... induced both Th1 and Th2 related transcription factors and cytokines. The combination also hampered the CD2 induced expression of Foxp3. Conclusions: The CD2 pathway and the response to IL-2 may be impaired in allergic children as lower IL-12Rβ2 and IFN-γ were found in allergic, compared to non-alle ...
Papillary Renal Cell Carcinoma Presenting with Hemoptysis
... promoting immune responses • IL-2: potent T cell growth factor • Interferon alpha: critical in for anti-viral responses, makes infected cells (or tumors) more susceptible killing by cytotoxic cells (CD8 T cells, and NK cells) ...
... promoting immune responses • IL-2: potent T cell growth factor • Interferon alpha: critical in for anti-viral responses, makes infected cells (or tumors) more susceptible killing by cytotoxic cells (CD8 T cells, and NK cells) ...
Molecular Imagaing Annual Report
... fascinated by how the immune system functions; its failure or unwanted activities underpin most of the conditions that beset humans as they age. Accordingly, imaging and immunity have made excellent and productive bedfellows over the development of modern biological chemistry. For example, some of t ...
... fascinated by how the immune system functions; its failure or unwanted activities underpin most of the conditions that beset humans as they age. Accordingly, imaging and immunity have made excellent and productive bedfellows over the development of modern biological chemistry. For example, some of t ...
The SCIentinel study - prospective multicenter study to define the
... ischemic CNS injury [14,15]. Therefore, we apply methods established in humans, such as human leukocyte antigen (HLA)-DR expression on monocytes [14] and Concanavalin A (ConA)-induced cytokine expression in whole blood samples, as surrogate markers of SCI-IDS. HLA-DR expression on monocytes serves a ...
... ischemic CNS injury [14,15]. Therefore, we apply methods established in humans, such as human leukocyte antigen (HLA)-DR expression on monocytes [14] and Concanavalin A (ConA)-induced cytokine expression in whole blood samples, as surrogate markers of SCI-IDS. HLA-DR expression on monocytes serves a ...
Reprogramming of Myeloid Compartments Supporting Tissue
... We show that the immature myeloid compartment expands in bone marrow (BM) specifically at the resolution phase of inflammation during colitis transition to recovery. Additionally, we found enhanced levels of IL-17 in the serum of colitis mice tightly correlates with expansion of the IMC compartment, ...
... We show that the immature myeloid compartment expands in bone marrow (BM) specifically at the resolution phase of inflammation during colitis transition to recovery. Additionally, we found enhanced levels of IL-17 in the serum of colitis mice tightly correlates with expansion of the IMC compartment, ...
Wetting: Unobtrusive graphene coatings
... from the rather undefined alum to tailormade adjuvants with highly specific and predictable functions. Further work is needed to investigate the mechanisms by which the encapsulated cytokines mediate the observed immune responses. The authors suggest that the synthetic mast-cell particles may modula ...
... from the rather undefined alum to tailormade adjuvants with highly specific and predictable functions. Further work is needed to investigate the mechanisms by which the encapsulated cytokines mediate the observed immune responses. The authors suggest that the synthetic mast-cell particles may modula ...
Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
... the unique ability to rapidly recognize herpesviruses for consecutive high level production of IFNI [36,37]. We reported the first evidence that pDCs actually constitute the major source of systemic IFN-I production during a viral infection in vivo using MCMV as a model [12,32]. To the best of our k ...
... the unique ability to rapidly recognize herpesviruses for consecutive high level production of IFNI [36,37]. We reported the first evidence that pDCs actually constitute the major source of systemic IFN-I production during a viral infection in vivo using MCMV as a model [12,32]. To the best of our k ...
Broad and direct interaction between TLR and Siglec families of
... interaction between Siglec-E and Tlr4 using both pull down and bi-directional immunoprecipitation assays. Siglec-E-Fc, but not control IgG, pulled down Tlr4 in the spleen cell lysates (Figure 1D). AntiSiglec-E monoclonal antibodies co-precipitated Tlr4, while anti-Tlr4 co-precipitated Siglec-E (Figu ...
... interaction between Siglec-E and Tlr4 using both pull down and bi-directional immunoprecipitation assays. Siglec-E-Fc, but not control IgG, pulled down Tlr4 in the spleen cell lysates (Figure 1D). AntiSiglec-E monoclonal antibodies co-precipitated Tlr4, while anti-Tlr4 co-precipitated Siglec-E (Figu ...
An Analytical Approach to Modulating Effects of Heat Shock Proteins
... Heat shock proteins (Hsp) as the scholars held, are found immune protection. to carry on antigenic profile or fingerprint of the cells from Thus the potential roles of Hsp being complexes with which they are derived, possess adjuvant activity and bind to antigenic peptides released from tumor cell i ...
... Heat shock proteins (Hsp) as the scholars held, are found immune protection. to carry on antigenic profile or fingerprint of the cells from Thus the potential roles of Hsp being complexes with which they are derived, possess adjuvant activity and bind to antigenic peptides released from tumor cell i ...
Role and regulation of interleukin-1 molecules in pro-asthmatic
... The IL-1 type-I (IL-1RI) and type-2 (IL-1RII) receptor molecules are two distinct receptors that bind to both IL-1a and IL-1b [13]. The IL-1RI receptor is responsible for producing the biological effects that are attributed to IL-1 signalling [14, 15]. In contrast, the IL-1RII receptor does not poss ...
... The IL-1 type-I (IL-1RI) and type-2 (IL-1RII) receptor molecules are two distinct receptors that bind to both IL-1a and IL-1b [13]. The IL-1RI receptor is responsible for producing the biological effects that are attributed to IL-1 signalling [14, 15]. In contrast, the IL-1RII receptor does not poss ...
Expanding roles for CD4+ T cells in immunity to viruses
... neutralizing antibody responses. Antibody-mediated protection can be extraordinarily long-lived 33, and neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ immunity. Thus, it is crucial to understand the mechanis ...
... neutralizing antibody responses. Antibody-mediated protection can be extraordinarily long-lived 33, and neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ immunity. Thus, it is crucial to understand the mechanis ...
An Introduction to Artificial Immune Systems
... may have something to say to AIS AIS – October 2003 – 47 ...
... may have something to say to AIS AIS – October 2003 – 47 ...
Biosketch - University of Florida
... 1. My early publications directly addressed the deficit in mechanistic studies of neonatal-specific sepsis pathophysiology. First, we developed and characterized a model of polymicrobial sepsis that recapitulates the pathophysiology of septic peritonitis. The availability of this model allowed a dir ...
... 1. My early publications directly addressed the deficit in mechanistic studies of neonatal-specific sepsis pathophysiology. First, we developed and characterized a model of polymicrobial sepsis that recapitulates the pathophysiology of septic peritonitis. The availability of this model allowed a dir ...
Human-specific evolution of killer cell immunoglobulin
... In placental mammals, natural killer (NK) cells are a population of lymphocytes that make unique contributions to immune defence and reproduction, functions essential for survival of individuals, populations and species. Modulating these functions are conserved and variable NK-cell receptors that re ...
... In placental mammals, natural killer (NK) cells are a population of lymphocytes that make unique contributions to immune defence and reproduction, functions essential for survival of individuals, populations and species. Modulating these functions are conserved and variable NK-cell receptors that re ...
Document
... pathological patterns9,10. Certain myelin epitopes that are encephalitogenic in experimental allergic encephalomyelitis (EAE) are also immunodominant in humans11–15 in the context of MS-associated human leukocyte antigen (HLA) DR molecules12,16,17. The myelin basic protein (MBP) peptide of amino aci ...
... pathological patterns9,10. Certain myelin epitopes that are encephalitogenic in experimental allergic encephalomyelitis (EAE) are also immunodominant in humans11–15 in the context of MS-associated human leukocyte antigen (HLA) DR molecules12,16,17. The myelin basic protein (MBP) peptide of amino aci ...
Biology Course Descriptions
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
Effect of Antigen/Antibody Ratio on Macrophage
... by B lymphocytes, have long been known to act also as positive or negative regulatory elements of the antibody response at different levels (1, 2). More recently, it has been demonstrated that antibodies complexed with soluble antigens interfere with the T cell response . Inhibitory effect has been ...
... by B lymphocytes, have long been known to act also as positive or negative regulatory elements of the antibody response at different levels (1, 2). More recently, it has been demonstrated that antibodies complexed with soluble antigens interfere with the T cell response . Inhibitory effect has been ...
Aspergillus fumigatus conidia induce interferon-b signalling in respiratory epithelial cells C. Beisswenger*
... immune functions of respiratory epithelial cells are well described in the response to bacteria and viruses, little is known about the response of these cells to fungal pathogens such as A. fumigatus and its spores, the conidia. It has been shown that surfactant found in the fluids lining the epithe ...
... immune functions of respiratory epithelial cells are well described in the response to bacteria and viruses, little is known about the response of these cells to fungal pathogens such as A. fumigatus and its spores, the conidia. It has been shown that surfactant found in the fluids lining the epithe ...
Biology Course Descriptions
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
Immune Senescence A Role for Immature Myeloid Cells in
... The reduced efficiency of the mammalian immune system with aging increases host susceptibility to infectious and autoimmune diseases. However, the mechanisms responsible for these pathologic changes are not well understood. In this study, we demonstrate that the bone marrow, blood, and secondary lym ...
... The reduced efficiency of the mammalian immune system with aging increases host susceptibility to infectious and autoimmune diseases. However, the mechanisms responsible for these pathologic changes are not well understood. In this study, we demonstrate that the bone marrow, blood, and secondary lym ...
PROBING IMMUNE FUNCTION DURING AGING IN ADULT DROSOPHILA MELANOGASTER
... the adaptive and innate immune system. This complexity, however, can be circumvented by studying invertebrate model organisms, which lack an adaptive immune system, thus eliminating the complicated interplay between the adaptive and innate immune systems. One such model organism is Drosophila melano ...
... the adaptive and innate immune system. This complexity, however, can be circumvented by studying invertebrate model organisms, which lack an adaptive immune system, thus eliminating the complicated interplay between the adaptive and innate immune systems. One such model organism is Drosophila melano ...
Type I interferons produced by hematopoietic cells protect
... herpesvirus family, several of which have developed strategies to attenuate NK cell killing (26). Given this central role for NK cells in innate immunity to viral infection and the capacity of type I IFNs to mediate NK cell activation, killing, and survival, we next sought to determine whether NK ce ...
... herpesvirus family, several of which have developed strategies to attenuate NK cell killing (26). Given this central role for NK cells in innate immunity to viral infection and the capacity of type I IFNs to mediate NK cell activation, killing, and survival, we next sought to determine whether NK ce ...
T cells - Amazon S3
... within plasma Antibodies resist disease first by recognizing foreign or abnormal substances (Figure 21-19) ...
... within plasma Antibodies resist disease first by recognizing foreign or abnormal substances (Figure 21-19) ...
An HIV infection model based on a vectored immunoprophylaxis
... been made in mathematical modeling of dynamics of viral infections. Some researchers have taken into account the effect of immune responses including CTL responses or humoral immunity or both (Wodarz, 2003; Pang et al., 2005; Wang et al., 2006a,b; Iwami et al., 2009). Some other researchers have inc ...
... been made in mathematical modeling of dynamics of viral infections. Some researchers have taken into account the effect of immune responses including CTL responses or humoral immunity or both (Wodarz, 2003; Pang et al., 2005; Wang et al., 2006a,b; Iwami et al., 2009). Some other researchers have inc ...
In Vitro Generation of Interleukin 10–producing - Direct-MS
... number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These regulatory T cells could thus be of potential use in therapeutic intervention during inflammatory pathology. For exampl ...
... number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These regulatory T cells could thus be of potential use in therapeutic intervention during inflammatory pathology. For exampl ...