TLR3 Signaling in Macrophages Is Indispensable for the
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
Original Article
... maternal immune system.13,14 To date, it has not been determined whether any of these TNF superfamily members and their receptors is expressed in maternal decidual cells. BAFF was known as B cell-activating factor belonging to the TNF family, also called B lymphocyte stimulator (BLyS) TNF- and Apop- ...
... maternal immune system.13,14 To date, it has not been determined whether any of these TNF superfamily members and their receptors is expressed in maternal decidual cells. BAFF was known as B cell-activating factor belonging to the TNF family, also called B lymphocyte stimulator (BLyS) TNF- and Apop- ...
Frequency of Cytokine polymorphisms in populations from
... From the Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland (A.M., F.W., O.A.R., D.M.); School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland (O.A.R., D.M.); Department of Epidemiology and Public Health, Que ...
... From the Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland (A.M., F.W., O.A.R., D.M.); School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland (O.A.R., D.M.); Department of Epidemiology and Public Health, Que ...
Summary of recent significant findings in ME-cfs research
... subjects with longer duration of illness. Analyses based on disease duration revealed that early ME/CFS cases had a prominent activation of both pro- and anti-inflammatory cytokines as well as dissociation of Author comment: intercytokine regulatory networks. We found a stronger correlation of http: ...
... subjects with longer duration of illness. Analyses based on disease duration revealed that early ME/CFS cases had a prominent activation of both pro- and anti-inflammatory cytokines as well as dissociation of Author comment: intercytokine regulatory networks. We found a stronger correlation of http: ...
Chitin, Chitinases and Chitinase
... that IFN-γ produced by NK cells and ragweedspecific Th1 cells was responsible for the inhibition of allergen-induced Th2 cytokine produc31 tion. In a separate study, the same group of investigators have shown that chitin is a strong Th1 adjuvant that up-regulates heat-killed Mycobacterium bovis Calm ...
... that IFN-γ produced by NK cells and ragweedspecific Th1 cells was responsible for the inhibition of allergen-induced Th2 cytokine produc31 tion. In a separate study, the same group of investigators have shown that chitin is a strong Th1 adjuvant that up-regulates heat-killed Mycobacterium bovis Calm ...
Lymphatic
... T cells and B cells protect the body against antigens Antigen – anything the body perceives as foreign Bacteria and their toxins; viruses Mismatched RBCs or cancer cells ...
... T cells and B cells protect the body against antigens Antigen – anything the body perceives as foreign Bacteria and their toxins; viruses Mismatched RBCs or cancer cells ...
Threat of Toxoplasmosis Targeting the Brain for Military Forces and
... IFN-γ that along with IL-12 and CD8+ TL cells promote resistance and control the infection. On the other hand, TNF-α, TNF-β, IFN-γ and IL-2 have anti-inflammatory actions that make it possible to control the development of immune pathological phenomena related to a type-1 immune response (40). The T ...
... IFN-γ that along with IL-12 and CD8+ TL cells promote resistance and control the infection. On the other hand, TNF-α, TNF-β, IFN-γ and IL-2 have anti-inflammatory actions that make it possible to control the development of immune pathological phenomena related to a type-1 immune response (40). The T ...
Immunotherapy of Metastatic Renal Cell Cancer
... phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from an immunological viewpoint, the cancer cell is viewed as a potential target of antibodies, natural killer (NK) cells, or cytotoxic T lymphocytes (CTLs) b ...
... phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from an immunological viewpoint, the cancer cell is viewed as a potential target of antibodies, natural killer (NK) cells, or cytotoxic T lymphocytes (CTLs) b ...
TSH TRH TR TSH TSH - Med
... autoimmune disorders. Normally, the pituitary-hypothalamus axis regulates secretion of the thyroidstimulating hormone (TSH) through thyroid releasing hormone (TRH) (Fig. 1). Circulating auto-antibodies in Grave’s disease stimulate thyroid function through activating the TSH receptor. These antibodie ...
... autoimmune disorders. Normally, the pituitary-hypothalamus axis regulates secretion of the thyroidstimulating hormone (TSH) through thyroid releasing hormone (TRH) (Fig. 1). Circulating auto-antibodies in Grave’s disease stimulate thyroid function through activating the TSH receptor. These antibodie ...
Chapter 21
... – Particulate adjuvants deliver antigen in such a way that both cell-mediated and humoral immunity are enhanced by stimulation of antigen processing – Immunostimulatory adjuvants promote cytokine production – Mixed adjuvants combine a particulate or depot adjuvant with an immunostimulatory agent ...
... – Particulate adjuvants deliver antigen in such a way that both cell-mediated and humoral immunity are enhanced by stimulation of antigen processing – Immunostimulatory adjuvants promote cytokine production – Mixed adjuvants combine a particulate or depot adjuvant with an immunostimulatory agent ...
Immunocompatibility of Bacteriophages as Nanomedicines
... to replicate and in eukaryotic cells in the absence of a suitable prokaryotic host, these therapeutics behave as inert particulate antigens [23]. In recent years, work has shown that whole phage particles can be applied to deliver vaccine expression cassette cloned into their genome or express antig ...
... to replicate and in eukaryotic cells in the absence of a suitable prokaryotic host, these therapeutics behave as inert particulate antigens [23]. In recent years, work has shown that whole phage particles can be applied to deliver vaccine expression cassette cloned into their genome or express antig ...
Type 1 Diabetes
... blood if someone has an allergy (example: milk antibodies might be present if someone has a milk allergy). Autoimmunity (self-allergy): The process of forming an allergic reaction against one’s own tissues. This happens in diseases such as lupus and arthritis. People with type 1 diabetes make an ant ...
... blood if someone has an allergy (example: milk antibodies might be present if someone has a milk allergy). Autoimmunity (self-allergy): The process of forming an allergic reaction against one’s own tissues. This happens in diseases such as lupus and arthritis. People with type 1 diabetes make an ant ...
Immune mechanisms in Borrelia burgdorferi sensu lato
... persistent infection, but could instead be affected by the host’s ability to mount an optimal immune response to the spirochaete. The hypothesis of this thesis was that a strong inflammatory Th1-like immune response is required in the early stage of infection in order to achieve both an optimal erad ...
... persistent infection, but could instead be affected by the host’s ability to mount an optimal immune response to the spirochaete. The hypothesis of this thesis was that a strong inflammatory Th1-like immune response is required in the early stage of infection in order to achieve both an optimal erad ...
Cannabinoid receptors in microglia of the central nervous system
... observed [17]. Microglia constitute a resident population of macrophages in the brain, the spinal cord, and retina and are morphologically, phenotypically, and functionally related to cells of macrophage lineage [18 –21]. The function of quiescent microglia in normal brain is not well understood, bu ...
... observed [17]. Microglia constitute a resident population of macrophages in the brain, the spinal cord, and retina and are morphologically, phenotypically, and functionally related to cells of macrophage lineage [18 –21]. The function of quiescent microglia in normal brain is not well understood, bu ...
Differential Immune Responses to New World and Old World
... can actually provide protection against LASV infection in a nonhuman primate model [29]. Like LASV, MOPV infection also fails to activate DCs in culture [30] as evidenced by the failure to upregulate CD80, CD86, CD54, CD40, and HLA-abc. However, MOPV infection of cultured macrophages does increase t ...
... can actually provide protection against LASV infection in a nonhuman primate model [29]. Like LASV, MOPV infection also fails to activate DCs in culture [30] as evidenced by the failure to upregulate CD80, CD86, CD54, CD40, and HLA-abc. However, MOPV infection of cultured macrophages does increase t ...
Effects of Fish Oil and Corn Oil Diets on
... Modul itors which regulate immune responses, in many in stances, also influence myelopoiesis (1-9). Attention has been focused on arachidonic acid metabolites, predominantly PGE2,3 as mediators of both immune suppression and as negative regulators of myelopoiesis. PGE2 has been shown to be inhibi to ...
... Modul itors which regulate immune responses, in many in stances, also influence myelopoiesis (1-9). Attention has been focused on arachidonic acid metabolites, predominantly PGE2,3 as mediators of both immune suppression and as negative regulators of myelopoiesis. PGE2 has been shown to be inhibi to ...
Immunomodulating polysaccharides from the lichen Thamnolia
... TNF-a secretion by rat peritoneal macrophages, thus showing similar pattern of activity apart from death of the rat spleen cells caused by Ths-4. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. Molecular size-immunomod ...
... TNF-a secretion by rat peritoneal macrophages, thus showing similar pattern of activity apart from death of the rat spleen cells caused by Ths-4. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. Molecular size-immunomod ...
Mesenchymal Stem Cells
... MHC II⫺, CD40⫺, CD80⫺, CD86⫺) is regarded as nonimmunogenic and, therefore, transplantation into an allogeneic host may not require immunosuppression. MHC class I may activate T cells, but, with the absence of costimulatory molecules, a secondary signal would not engage, leaving the T cells anergic ...
... MHC II⫺, CD40⫺, CD80⫺, CD86⫺) is regarded as nonimmunogenic and, therefore, transplantation into an allogeneic host may not require immunosuppression. MHC class I may activate T cells, but, with the absence of costimulatory molecules, a secondary signal would not engage, leaving the T cells anergic ...
• - Utrecht University Repository
... Several published papers link a high CD8+ T-cell activity in peripheral blood or AD lesions to increased AD disease severity. Seneviratne et al. describe a correlation between the amount of dustmite allergen specific CD8+ T-cells present in the peripheral blood of AD patients and disease severity [2 ...
... Several published papers link a high CD8+ T-cell activity in peripheral blood or AD lesions to increased AD disease severity. Seneviratne et al. describe a correlation between the amount of dustmite allergen specific CD8+ T-cells present in the peripheral blood of AD patients and disease severity [2 ...
M261 MHC class I antigen presentation April 17, 2000
... Houde, et. al., Nature 425:402-406, 2003. ...
... Houde, et. al., Nature 425:402-406, 2003. ...
Plant-Microbe Interaction
... the harmless non-self (microbial mutualists and commensals) from the detrimental nonself (pathogens). Danger signals are “damage-associated molecular patterns” (DAMPs) that are released from the disrupted host tissue or exposed on stressed cells. Seemingly ubiquitous DAMPs are extracellular ATP or e ...
... the harmless non-self (microbial mutualists and commensals) from the detrimental nonself (pathogens). Danger signals are “damage-associated molecular patterns” (DAMPs) that are released from the disrupted host tissue or exposed on stressed cells. Seemingly ubiquitous DAMPs are extracellular ATP or e ...
Phagocyte-specific S100 proteins are released from affected
... Crohn’s disease (CD; n = 30), ulcerative colitis (UC; n = 30), irritable bowel syndrome (IBS; n = 30) or without inflammation (n = 30) were obtained during endoscopy. After 24 h culture, S100A12 and MRP8/14 were analysed in supernatants. Endoscopic, histological, laboratory and clinical disease acti ...
... Crohn’s disease (CD; n = 30), ulcerative colitis (UC; n = 30), irritable bowel syndrome (IBS; n = 30) or without inflammation (n = 30) were obtained during endoscopy. After 24 h culture, S100A12 and MRP8/14 were analysed in supernatants. Endoscopic, histological, laboratory and clinical disease acti ...