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- SlideBoom
- SlideBoom

... Bodybuilding and Fitness supplements are dietary supplements suited for those who are crazy about bodybuilding, weightlifting and athletics. Among the most widely used are MultiVitamins, Whey Proteins, Isolate Proteins, Soy Proteins, Branched-Chain Amino Acids (BCAA), Glutamine, Essential Fatty Acid ...
Liver funtions part
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Topic 2: Molecular biology (21 hours)
Topic 2: Molecular biology (21 hours)

... carbohydrates, lipids, proteins and nucleic acids. • Aim 7: ICT can be used for molecular visualization of • Metabolism is the web of all the enzyme-catalysed carbohydrates, lipids and proteins in this sub-topic and reactions in a cell or organism. in 2.3 and 2.4. • Anabolism is the synthesis of com ...
UNDERSTANDING GYRATE ATROPHY What is gyrate atrophy?
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... tissue. When someone eats food that contains protein, the body uses what it needs by breaking it down into amino acids (the building blocks of protein). Amino acids are used by the body to build skin, muscle, blood and other tissues. Arginine and ornithine are 2 amino acids. Gyrate atrophy is caused ...
Quantitative profiling of differentiation
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... eluted in ion-exchange fractions spanning a significant part of the separation range (Fig. 4B; first experiment). The data indicated variability in quantification of <20%. Furthermore, consistent variability was found when two additional small-scale experiments were carried out in a single LC-MS/MS ...
genomics to identify virulence factors
genomics to identify virulence factors

... • Sometimes the function of a hypothetical protein can be predicted by searching for domains in a protein database, often though they are annotated as function “unknown” • Even in the genome of “the most studied microorganism”, nonpathogenic E. coli K-12, ~30% of the genes are annotated as hypotheti ...
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... cells. Null phenotypes are generally rare. They are usually only found when individuals with these phenotypes may make antibodies to the missing proteins following immunization by blood transfusion or pregnancy. Such antibodies are then identified in immunohaematology reference laboratories. Null ph ...
Topic 2: Molecular biology (21 hours)
Topic 2: Molecular biology (21 hours)

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Αρχές Ιατρικής Γενετικής - e
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... chromosome fragments are fused with rodent chromosomes so that they will survive. The presence of human chromosome material in rodent cells can be detected by the presence of Alu sequences. Closely linked loci, such as A and B, are frequently found on the same chromosome fragment, whereas loosely li ...
The Genetics and Molecular Biology of Huntington*s Disease
The Genetics and Molecular Biology of Huntington*s Disease

... disease becomes degenerative. This implies that similar molecular mechanisms involved in neurodegeneration may be at play in humans and mice. ...
The challenge: sifting through piles of variants
The challenge: sifting through piles of variants

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Genetically engineered single-chain antibody fusion proteins
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From ORFeome to Biology: A Functional Genomics Pipeline
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Chapter 16 - Important Tools of Molecular Biology
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RLIMS-P Annotation guidelines This document describes some
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... mention of substrate in the abstract, we would not annotate the kinase Y. However e.g. we would not annotate kinase in these examples because no substrates are mentioned (we show a sentence but it is true for the abstract): “Here we review evidence that inhibition of glycogen synthase kinase-3 (GSK3 ...
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Genetically modified medicinal plants

... Phenotype analysis The expression of the nptII marker gene as its corresponding NPT II polypeptide has been estimated by the detection of the native 59 kDa dimer into the total protein extract obtained from the regenerated shoots (Fig.3). The transformed (T1,2) shoots actively expressed the NPT II f ...
H3 Turnover - [c] crabrock.net
H3 Turnover - [c] crabrock.net

... • Can measure the C14/C12 ratio and if the H3 protein at time of death was made before or after the bomb pulse • This shows that early neurodevelopment during the bomb trials results in more C14 in H3.3 at death ...
Gene Section GLTSCR2 (glioma tumor suppressor candidate region gene 2)
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... altered in glioma and neuroblastoma; however, a tumor suppressor gene(s) specifically encoded in this region has yet to be identified and the implication of GLTSCR2 gene in these tumors remains controversial. Recent studies show aberrations in GLTSCR2 expression in glioblastoma and neuroblastoma. ...
Dosage sensitivity and the evolution of gene families in yeast
Dosage sensitivity and the evolution of gene families in yeast

... chance; P , 1025 from randomization; see Methods). There is also a large excess of solo copy pairs (1,541 observed but only about 878 are expected by chance; P , 1025). After polyploidization the loss of duplicate copies of interacting genes one at a time leads to imbalance. The balance hypothesis t ...
CHAPTER 5 CARBON CONTENT: LOW LARGE HYDROPHOBIC
CHAPTER 5 CARBON CONTENT: LOW LARGE HYDROPHOBIC

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- Wiley Online Library
- Wiley Online Library

... assays. Our results showed that the maize protein MA16 is an RNA-binding protein that binds preferentially to uridine and guanosine-rich RNAs (Ludevid et al., 1992). Regulation studies indicated that MA16 mRNA had a basal level of expression in several tissues including embryos and seedlings. We als ...
Gene Section SPINK7 (serine peptidase inhibitor, Kazal type 7 (putative))
Gene Section SPINK7 (serine peptidase inhibitor, Kazal type 7 (putative))

... esophageal epithelia, 51 esophageal cancers and 33 tumor adjacent tissues were 100%, 21% and 52% respectively. About 79% of ECRG2 gene was no expressed in the esophageal cancer. ECRG2 was highly expressed in the adult normal esophageal tissue, low expressed in the fetal esophageal tissue and complet ...
Gene Section RBL2 (retinoblastoma-like 2) Atlas of Genetics and Cytogenetics
Gene Section RBL2 (retinoblastoma-like 2) Atlas of Genetics and Cytogenetics

... Other names: PRB2; RBR-2; 130 kDa retinoblastoma-associated protein; H. sapiens p130 mRNA for 130K protein; P130; Retinoblastoma-related gene RB2; Rb2; Retinoblastoma-like protein 2 HGNC (Hugo): RBL2 Location: 16q12.2 ...
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Protein moonlighting



Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.
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