RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR I
... Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order. Precautions: IGF1 protein is for in vitro research use only. Not for use in diagnostics or therapeutic ...
... Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order. Precautions: IGF1 protein is for in vitro research use only. Not for use in diagnostics or therapeutic ...
The database of epoxide hydrolases and
... III includes the microsomal hydrolyse superfamily. Despite their sequence diversity, all enzymes share three highly conserved sequence motifs: the GXSXG/GXDXG motif of the catalytic nucleophile, the HGX motif of the oxyanion hole and the GXGXS-motif. The residues of the GXGXS-motif form a structural ...
... III includes the microsomal hydrolyse superfamily. Despite their sequence diversity, all enzymes share three highly conserved sequence motifs: the GXSXG/GXDXG motif of the catalytic nucleophile, the HGX motif of the oxyanion hole and the GXGXS-motif. The residues of the GXGXS-motif form a structural ...
An Opposing View on WWOX Protein Function
... metastatic activity in prostatic cancer cell lines, indicating the presence of a major tumor suppressor gene associated with cancer progression on 16q23.3-24.2. WW domain-containing oxidoreductase (WWOX) was cloned from this FRA16D site (9, 10). From its deduced amino acid sequence, two functional d ...
... metastatic activity in prostatic cancer cell lines, indicating the presence of a major tumor suppressor gene associated with cancer progression on 16q23.3-24.2. WW domain-containing oxidoreductase (WWOX) was cloned from this FRA16D site (9, 10). From its deduced amino acid sequence, two functional d ...
A Novel H-NS-like Protein from an Antarctic Psychrophilic Bacterium
... reduced thermal energy, enzymatic proteins with a high specific activity are produced (4). At the molecular level, all proteins from psychrotrophic organisms studied so far have shown a decrease in their intramolecular interactions, usually associated with both higher flexibility and lower thermal s ...
... reduced thermal energy, enzymatic proteins with a high specific activity are produced (4). At the molecular level, all proteins from psychrotrophic organisms studied so far have shown a decrease in their intramolecular interactions, usually associated with both higher flexibility and lower thermal s ...
Recombinant Human TSLP (Carrier
... Thymic Stromal Lymphopoietin (TSLP) is a hemopoietic cytokine that shares some biological activities with IL-7. It is found in many tissues, but has highest expression in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex comprised of the IL-7Ralpha (CD127) and ...
... Thymic Stromal Lymphopoietin (TSLP) is a hemopoietic cytokine that shares some biological activities with IL-7. It is found in many tissues, but has highest expression in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex comprised of the IL-7Ralpha (CD127) and ...
Translation
... ¾ cloverleaf folding pattern (stem-loop structures) ¾ contain modified bases (>60 possible) ¾ amino acyl tRNA synthetase= enzyme that conjugates appropriate amino acid to the 3’ end of tRNA (20 of them, one for each a.a.) ¾ Wobble hypothesis= codon-anticodon recognition tolerates mismatches in the t ...
... ¾ cloverleaf folding pattern (stem-loop structures) ¾ contain modified bases (>60 possible) ¾ amino acyl tRNA synthetase= enzyme that conjugates appropriate amino acid to the 3’ end of tRNA (20 of them, one for each a.a.) ¾ Wobble hypothesis= codon-anticodon recognition tolerates mismatches in the t ...
Brooker Chapter 13
... Recognition Between tRNA and mRNA • During mRNA-tRNA recognition, the anticodon in tRNA binds to a complementary codon in mRNA ...
... Recognition Between tRNA and mRNA • During mRNA-tRNA recognition, the anticodon in tRNA binds to a complementary codon in mRNA ...
(PUNCH-P) reveals cell cycle
... attracts increasing attention at the systems biology level. In past decades, major efforts were invested in studying transcription regulation, while research focusing on posttranscriptional control has lagged behind. Although mRNA levels are commonly used as a proxy of protein amounts, comparative g ...
... attracts increasing attention at the systems biology level. In past decades, major efforts were invested in studying transcription regulation, while research focusing on posttranscriptional control has lagged behind. Although mRNA levels are commonly used as a proxy of protein amounts, comparative g ...
Degradation of Mutant Proteins, Underlying “Loss of Function
... of a single amino acid residue, while many others represent only small inframe deletions or insertions. It is increasingly apparent that very few of these mutations alter amino acid residues in catalytic sites, ligand binding sites or other locations critical for function. This then has highlighted ...
... of a single amino acid residue, while many others represent only small inframe deletions or insertions. It is increasingly apparent that very few of these mutations alter amino acid residues in catalytic sites, ligand binding sites or other locations critical for function. This then has highlighted ...
§S0.1 Gene Prediction Methodology Gene structures were predicted
... The Neurospora automated gene predictions were validated against a set of previously characterized ESTs. The ESTs were not used as evidence during the automated gene calling, and could thus be used as an independent measure of the accuracy of the gene calls. To assess gene call accuracy, EST alignme ...
... The Neurospora automated gene predictions were validated against a set of previously characterized ESTs. The ESTs were not used as evidence during the automated gene calling, and could thus be used as an independent measure of the accuracy of the gene calls. To assess gene call accuracy, EST alignme ...
1, 2, 5, 6, 7 Time: 08:00
... 5. Plan and carry out investigations to Sum up polarity and pH of water by applying M properties of water. concepts questions and concept map explain how the unique properties of O Differentiate between water (e.g., polarity, cohesion, Review concepts from 2.2 section N solutions and adhesion) are v ...
... 5. Plan and carry out investigations to Sum up polarity and pH of water by applying M properties of water. concepts questions and concept map explain how the unique properties of O Differentiate between water (e.g., polarity, cohesion, Review concepts from 2.2 section N solutions and adhesion) are v ...
Vapor Sensors Using Olfactory Proteins Coupled to Carbon
... • experiments showin responses for mOR 203-1 • mOR 203-1 responds to 2-heptanone in vivo • fMRI studies show identical responses to 2-heptanone and n-amyl acetate in mice ...
... • experiments showin responses for mOR 203-1 • mOR 203-1 responds to 2-heptanone in vivo • fMRI studies show identical responses to 2-heptanone and n-amyl acetate in mice ...
Gene Section SNAI2 (SNAIL homolog 2) Atlas of Genetics and Cytogenetics
... It is involved in chick limb development and has conserved and divergent roles in the chick and mouse embryo. Human SNAI2 maps to the long arm of chromosome 8 (8q11.21), contains 3 exons and codes for a protein of 268bp (29KDa) with 5 zinc finger regions. This gene has been identified as downstream ...
... It is involved in chick limb development and has conserved and divergent roles in the chick and mouse embryo. Human SNAI2 maps to the long arm of chromosome 8 (8q11.21), contains 3 exons and codes for a protein of 268bp (29KDa) with 5 zinc finger regions. This gene has been identified as downstream ...
1+1+1 - Computer Science, Columbia University
... Domain Identification and Boundary Detection Protein Ranking with Network Diffusion Conserved Motifs between Remote Homologs ...
... Domain Identification and Boundary Detection Protein Ranking with Network Diffusion Conserved Motifs between Remote Homologs ...
The effect of isozymes on metabolic activity analysis
... The activity score represents the expected number of solutions in which a gene is active. For an active reaction associated with several isozymes, we think of each isozyme as having equal probability of being active and catalyzing the reaction. That is, we assume that isozymes are not concurrently a ...
... The activity score represents the expected number of solutions in which a gene is active. For an active reaction associated with several isozymes, we think of each isozyme as having equal probability of being active and catalyzing the reaction. That is, we assume that isozymes are not concurrently a ...
Plant Genetics HS Workshop - McMaster Department of Biology
... Genotyping: The transgenic plants we use are distinguished from wild-type plants by the presence of the GUSA reporter-transgene. After setting up and performing PCR, students use agarose gel electrophoresis to identify the presence of a DNA fragment arising from the transgene. Reporter gene use in m ...
... Genotyping: The transgenic plants we use are distinguished from wild-type plants by the presence of the GUSA reporter-transgene. After setting up and performing PCR, students use agarose gel electrophoresis to identify the presence of a DNA fragment arising from the transgene. Reporter gene use in m ...
Inhibition of Pax 5 activity by expression of its DNA binding domain
... phBSAPl s. This confirms the previous observation that the Pax 5 gene product is not sufficient to activate target genes. Co-transfection of the reporter constructs with phBSAP.VP16 results in the expression of CAT activity (Fig. I). The level of expression is dependant both on the number of Pax 5 b ...
... phBSAPl s. This confirms the previous observation that the Pax 5 gene product is not sufficient to activate target genes. Co-transfection of the reporter constructs with phBSAP.VP16 results in the expression of CAT activity (Fig. I). The level of expression is dependant both on the number of Pax 5 b ...
The Documented Health Risks of Genetically Engineered Foods
... A fatty acid An essential amino acid Phytoestrogens Increased: Anti-nutrient (soy lectin) Allergen (trypsin inhibitor) Lignin (disease related?) ...
... A fatty acid An essential amino acid Phytoestrogens Increased: Anti-nutrient (soy lectin) Allergen (trypsin inhibitor) Lignin (disease related?) ...
Arabidopsis Gene Project Slides
... You are working on an Arabidopsis gene discovery project, and your job is to sequence cDNAs and then learn all you can about the genes from all types of databases: DNA sequence, genome, and publication databases. Query sequence: TCCTGCATTCAATGTGATCAATGGAGGCAGTCATGCTGGGAATAGTTT GGCTATGCAAGAGTTTATGATA ...
... You are working on an Arabidopsis gene discovery project, and your job is to sequence cDNAs and then learn all you can about the genes from all types of databases: DNA sequence, genome, and publication databases. Query sequence: TCCTGCATTCAATGTGATCAATGGAGGCAGTCATGCTGGGAATAGTTT GGCTATGCAAGAGTTTATGATA ...
Power Point presentation
... Definition of chaperones – Chaperones are assigned as a family of proteins that assist other proteins to fold into their active forms. – If chaperones in fact exist, their functions would include prevention of inactive structural forms as well as aiding in the reversal of misfolding that result from ...
... Definition of chaperones – Chaperones are assigned as a family of proteins that assist other proteins to fold into their active forms. – If chaperones in fact exist, their functions would include prevention of inactive structural forms as well as aiding in the reversal of misfolding that result from ...
Transcription and Translation
... don’t appear in the final mRNA molecule. Protein-coding sections of a gene (called exons) are interrupted by introns. • The function of introns remains unclear. They may help is RNA transport or in control of gene expression in some cases, and they may make it easier for sections of genes to be shuf ...
... don’t appear in the final mRNA molecule. Protein-coding sections of a gene (called exons) are interrupted by introns. • The function of introns remains unclear. They may help is RNA transport or in control of gene expression in some cases, and they may make it easier for sections of genes to be shuf ...
From Digital Genetics to Knowledge Discovery: Perspectives
... molecular biology”: The information flows linearly from DNA to the phenotype through the RNA and protein levels. However, with the work of Monod and Jacob in the early 60’s, things turn out to be far more complex. In particular, it is now well known that proteins can regulate the RNA transcription ...
... molecular biology”: The information flows linearly from DNA to the phenotype through the RNA and protein levels. However, with the work of Monod and Jacob in the early 60’s, things turn out to be far more complex. In particular, it is now well known that proteins can regulate the RNA transcription ...
The mammalian oxysterol-binding protein
... Families of proteins with homology to the C-terminal ligandbinding domain of OSBP (oxysterol-binding protein) are present in eukaryotic organisms from Saccharomyces cerevisiae to human, and have been implicated in various cellular processes such as lipid metabolism, intracellular lipid transport, me ...
... Families of proteins with homology to the C-terminal ligandbinding domain of OSBP (oxysterol-binding protein) are present in eukaryotic organisms from Saccharomyces cerevisiae to human, and have been implicated in various cellular processes such as lipid metabolism, intracellular lipid transport, me ...
Coloration in Jaguars Have you ever seen a jaguar in a zoo? Most
... the effort was successful in wiping out malaria by the late 1970’s. In other parts of the world, there was not as much success. As it turned out, a mutation in the DNA of the mosquitoes had caused them to be resistant to insecticides. The live mosquitoes were still able to carry the malaria parasite ...
... the effort was successful in wiping out malaria by the late 1970’s. In other parts of the world, there was not as much success. As it turned out, a mutation in the DNA of the mosquitoes had caused them to be resistant to insecticides. The live mosquitoes were still able to carry the malaria parasite ...
What determines the size and shape of a cell?
... Specific membrane proteins on the vesicle exterior interact with docking proteins on the target membranes (SNAREs) This leads to fusion with the target membrane (may be regulated eg Ca2+ regulates fusion of synaptic vesicles) Soluble contents are released and membrane proteins can diffuse laterally ...
... Specific membrane proteins on the vesicle exterior interact with docking proteins on the target membranes (SNAREs) This leads to fusion with the target membrane (may be regulated eg Ca2+ regulates fusion of synaptic vesicles) Soluble contents are released and membrane proteins can diffuse laterally ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.