Room Temperature Activates Human Blood Platelets
... Activated GPIIb-IIIa is expressed on platelets activated by chemical agonists. Elevated levels of the activated form of this integrin are correlated to cytoskeletal rearrangements (Fox et al, 1993), as well as to the initiation of secretory pathways (Hawiger, 1989). To determine whether the morpholo ...
... Activated GPIIb-IIIa is expressed on platelets activated by chemical agonists. Elevated levels of the activated form of this integrin are correlated to cytoskeletal rearrangements (Fox et al, 1993), as well as to the initiation of secretory pathways (Hawiger, 1989). To determine whether the morpholo ...
Glycosyltransferases and Transpeptidases/Penicillin-Binding
... A deep knowledge of peptidoglycan metabolism, particularly networks decryption, a better A deep knowledge of peptidoglycan metabolism, particularly networks decryption, a better characterization of all the potential targets involved, and the use of this knowledge to develop characterization of all t ...
... A deep knowledge of peptidoglycan metabolism, particularly networks decryption, a better A deep knowledge of peptidoglycan metabolism, particularly networks decryption, a better characterization of all the potential targets involved, and the use of this knowledge to develop characterization of all t ...
Serine Residues 286, 288, and 293 within the CIITA: A
... factor Pho4 (31), can alter their subcellular localization. We previously showed that CIITA is phosphorylated on a variety of different serine residues, including a serine at aa 286 (32). Recently, additional phosphorylation sites have been assigned to the general region between aa 253–321 using del ...
... factor Pho4 (31), can alter their subcellular localization. We previously showed that CIITA is phosphorylated on a variety of different serine residues, including a serine at aa 286 (32). Recently, additional phosphorylation sites have been assigned to the general region between aa 253–321 using del ...
Functional characterization of rare FOXP2 variants in
... Background: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encode ...
... Background: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encode ...
Chromatin Association of Gcn4 Is Limited by Post
... stimulus for Cdk8-mediated phosphorylation and degradation. These results support a novel function for SUMO in marking the DNA-bound form of a transcription factor, which triggers downstream processes that limit its association with chromatin, thus preventing uncontrolled expression of target genes. ...
... stimulus for Cdk8-mediated phosphorylation and degradation. These results support a novel function for SUMO in marking the DNA-bound form of a transcription factor, which triggers downstream processes that limit its association with chromatin, thus preventing uncontrolled expression of target genes. ...
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... elegans homolog of Neurabin (NAB-1) that physically interacts with SAD-1 both in vivo and in vitro. Mammalian Neurabin (NeurabinI) and Spinophilin (NeurabinII) were first isolated as F-actin-binding proteins from the rat brain (Allen et al., 1997; Nakanishi et al., 1997; Satoh et al., 1998). They ar ...
... elegans homolog of Neurabin (NAB-1) that physically interacts with SAD-1 both in vivo and in vitro. Mammalian Neurabin (NeurabinI) and Spinophilin (NeurabinII) were first isolated as F-actin-binding proteins from the rat brain (Allen et al., 1997; Nakanishi et al., 1997; Satoh et al., 1998). They ar ...
Arabidopsis VILLIN4 is involved in root hair growth through
... 2007). This superfamily is a group of proteins sharing three or six tandem 125–150-aa gelsolin homology domains, designated G1–G6. Gelsolin, the founding member of the family, is composed of six gelsolin homology domains that have distinct properties, endowing this protein with various activities, i ...
... 2007). This superfamily is a group of proteins sharing three or six tandem 125–150-aa gelsolin homology domains, designated G1–G6. Gelsolin, the founding member of the family, is composed of six gelsolin homology domains that have distinct properties, endowing this protein with various activities, i ...
Dissection of molecular interactions of replication protein A in
... DNA binds to these domains by interacting with polar and aromatic residues in a DNAbinding cleft in each domain. The aromatic residues are highly conserved and when mutated cause a separation-of-function phenotype. Mutation of the conserved aromatic residues in the high-affinity binding domains of R ...
... DNA binds to these domains by interacting with polar and aromatic residues in a DNAbinding cleft in each domain. The aromatic residues are highly conserved and when mutated cause a separation-of-function phenotype. Mutation of the conserved aromatic residues in the high-affinity binding domains of R ...
The Strawberry Plant Defense Mechanism: A
... strawberry defense network remain poorly understood. However, from current knowledge, it seems clear that the ability of a strawberry plant to respond efficiently to pathogens relies first on the physiological status of injured tissue (pre-formed mechanisms of defense) and secondly on the general ab ...
... strawberry defense network remain poorly understood. However, from current knowledge, it seems clear that the ability of a strawberry plant to respond efficiently to pathogens relies first on the physiological status of injured tissue (pre-formed mechanisms of defense) and secondly on the general ab ...
serum-free media for cell culture
... Recent years have seen an increased awareness of foetal sensitivity to pain and growing evidence of resistance to anoxia in mammalian foetuses. Consequently calf foetuses are likely to be alive and have normal brain function during blood collection, and can be expected to experience suffering unti ...
... Recent years have seen an increased awareness of foetal sensitivity to pain and growing evidence of resistance to anoxia in mammalian foetuses. Consequently calf foetuses are likely to be alive and have normal brain function during blood collection, and can be expected to experience suffering unti ...
Glutamate 83 and arginine 85 of helix H3 bend are key residues for
... sequential addition of at least twelve other membrane proteins responsible for peptidoglycan assembly and membrane constriction [3]. Inactivation of the corresponding genes blocks the cell division and give rise to long multinucleated cells that fail to propagate and eventually die [4]. The Z-ring a ...
... sequential addition of at least twelve other membrane proteins responsible for peptidoglycan assembly and membrane constriction [3]. Inactivation of the corresponding genes blocks the cell division and give rise to long multinucleated cells that fail to propagate and eventually die [4]. The Z-ring a ...
Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation
... Identification and Cloning of DGK—Hypothalamus from 10 rats on a high-fat (60%) or low-fat (10%) diet were dissected and pooled for the purification of mRNA, which was then used for representational difference analysis as described (33). The cDNA fragment of rat Ob-Rbc, obtained by RT-PCR with prim ...
... Identification and Cloning of DGK—Hypothalamus from 10 rats on a high-fat (60%) or low-fat (10%) diet were dissected and pooled for the purification of mRNA, which was then used for representational difference analysis as described (33). The cDNA fragment of rat Ob-Rbc, obtained by RT-PCR with prim ...
Plakoglobin domains that define its association with the
... acting with filamentous actin (Rimm et al., 1995) and indirectly through an interaction with α-actinin (Knudsen et al., 1995). In previous studies we have shown that a central domain of plakoglobin is required for its interactions with N-cadherin (Sacco et al., 1995). In this report we extend our st ...
... acting with filamentous actin (Rimm et al., 1995) and indirectly through an interaction with α-actinin (Knudsen et al., 1995). In previous studies we have shown that a central domain of plakoglobin is required for its interactions with N-cadherin (Sacco et al., 1995). In this report we extend our st ...
Biology: Concepts and Connections, 6e (Campbell)
... 25) Which of the following statements is true among all types of passive diffusion? A) Proteins are needed to transport molecules across the membrane. B) The concentration gradient is the driving force. C) Only small polar molecules are able to cross the plasma membrane. D) Only small nonpolar molec ...
... 25) Which of the following statements is true among all types of passive diffusion? A) Proteins are needed to transport molecules across the membrane. B) The concentration gradient is the driving force. C) Only small polar molecules are able to cross the plasma membrane. D) Only small nonpolar molec ...
Donohoe, B.S., B. - University of Colorado-MCDB
... that the coupling of Golgi stacks to ER export sites in plant cells is transient, and occurs only when an ER export site is actively producing COPII buds and vesicles for export to the Golgi. To this end, budding COPII vesicles are born within a 40 nm thick scaffold layer that contains Atp115 (Arabi ...
... that the coupling of Golgi stacks to ER export sites in plant cells is transient, and occurs only when an ER export site is actively producing COPII buds and vesicles for export to the Golgi. To this end, budding COPII vesicles are born within a 40 nm thick scaffold layer that contains Atp115 (Arabi ...
Glutamine metabolism and its effects on immune response
... of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted. Some important immune response pathways modulated by glutami ...
... of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted. Some important immune response pathways modulated by glutami ...
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca
... 5-MeO-DMT, respectively, with significant post-hoc differences between 5-MeO-DMT and saline in all posttreatment periods (Fig. 2). Since hallucinogenic drugs are known to have clear effects on the autonomic nervous system and blood pressure (McCall et al., 1987; McCall and Harris, 1988). In order to ...
... 5-MeO-DMT, respectively, with significant post-hoc differences between 5-MeO-DMT and saline in all posttreatment periods (Fig. 2). Since hallucinogenic drugs are known to have clear effects on the autonomic nervous system and blood pressure (McCall et al., 1987; McCall and Harris, 1988). In order to ...
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... extending from the eye disc (ED) through the OS into the optic lobe (Silies et al., 2007; Tayler and Garrity, 2003). In early larval stages the two CG, which are specialized subperineurial glia (SPG), form a tubular glial structure encircled by a monolayer of PG. Photoreceptor axons from the develop ...
... extending from the eye disc (ED) through the OS into the optic lobe (Silies et al., 2007; Tayler and Garrity, 2003). In early larval stages the two CG, which are specialized subperineurial glia (SPG), form a tubular glial structure encircled by a monolayer of PG. Photoreceptor axons from the develop ...
Hormone sensitive lipase: structure, function and
... Every organism continuously uses energy; not only for movement or to perform labor, but also for maintenance, regulation and almost any other process. Organisms derive their energy from the breakdown of nutrients they take up. The type of nutrients can roughly be divided in three groups: proteins, c ...
... Every organism continuously uses energy; not only for movement or to perform labor, but also for maintenance, regulation and almost any other process. Organisms derive their energy from the breakdown of nutrients they take up. The type of nutrients can roughly be divided in three groups: proteins, c ...
Protein phosphatase 1 down regulates ZYG
... subunit of PP1 can directly bind a subset of substrates, but functional specificity is largely conferred by its interaction with regulatory proteins. Over 200 PP1 interactors exist, which regulate PP1 through modulating substrate specificity, enzyme localization or by inhibition or activa ...
... subunit of PP1 can directly bind a subset of substrates, but functional specificity is largely conferred by its interaction with regulatory proteins. Over 200 PP1 interactors exist, which regulate PP1 through modulating substrate specificity, enzyme localization or by inhibition or activa ...
The Role of the N-Terminal Domains of Bacterial Initiator DnaA in
... 108 amino acids in Mycobacterium tuberculosis DnaA), and in contrast to a well-conserved secondary structure, its sequence is poorly conserved among unrelated bacterial species. Domain IV is responsible for DNA binding via a helix-turn-helix motif (Figure 1). The domain recognizes 9-mer, non-palindr ...
... 108 amino acids in Mycobacterium tuberculosis DnaA), and in contrast to a well-conserved secondary structure, its sequence is poorly conserved among unrelated bacterial species. Domain IV is responsible for DNA binding via a helix-turn-helix motif (Figure 1). The domain recognizes 9-mer, non-palindr ...
Plant hormones and growth regulators
... growth, whereas reducing its concentration promoted cell and tissue elongation (Bennet-Clark, 1956 ; Tagawa and Bonner, 1957 ). Strong support for the Ca2+/pectate interaction came from a quantitative examination of the cation exchange capacity of the coleoptile cell wall, which was shown to be due ...
... growth, whereas reducing its concentration promoted cell and tissue elongation (Bennet-Clark, 1956 ; Tagawa and Bonner, 1957 ). Strong support for the Ca2+/pectate interaction came from a quantitative examination of the cation exchange capacity of the coleoptile cell wall, which was shown to be due ...
Organization of Physical Interactomes as
... We also uncover S. cerevisiae emergent pair schemas using a hand-chosen set of GO molecular function annotations (Figure 2B and Tables S1 and S6). As with the Pfam schemas, the GO pair schemas represent many types of functions including transport, signaling, DNA and RNA processing, ubiquitination, p ...
... We also uncover S. cerevisiae emergent pair schemas using a hand-chosen set of GO molecular function annotations (Figure 2B and Tables S1 and S6). As with the Pfam schemas, the GO pair schemas represent many types of functions including transport, signaling, DNA and RNA processing, ubiquitination, p ...
Development of in vitro procedures that can predict the safety of
... investigated in terms of predicting cytokine release. Immobilisation of TGN1412 may mimic the immunological synapse formed between this mAb and target cells in vivo. In a more physiologically relevant procedure, TGN1412 incubated in aqueous phase with PBMC over a monolayer of human endothelial cells ...
... investigated in terms of predicting cytokine release. Immobilisation of TGN1412 may mimic the immunological synapse formed between this mAb and target cells in vivo. In a more physiologically relevant procedure, TGN1412 incubated in aqueous phase with PBMC over a monolayer of human endothelial cells ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.