Roles of maltodextrin and glycogen phosphorylases in maltose
... on glucose and other sugars as a source of carbon and energy. Apart from the debranching enzyme GlgX, which is required for the formation of maltodextrins from glycogen, a-glucan phosphorylases were assumed to be involved in glycogen degradation, forming a-glucose 1phosphate from glycogen and from m ...
... on glucose and other sugars as a source of carbon and energy. Apart from the debranching enzyme GlgX, which is required for the formation of maltodextrins from glycogen, a-glucan phosphorylases were assumed to be involved in glycogen degradation, forming a-glucose 1phosphate from glycogen and from m ...
The p57 CDKi integrates stress signals into cellcycle progression to
... In contrast, the p57T143A mutant was not phosphorylated by p38 (Figure 3A). Importantly, incubation of the cells with the p38 SAPK inhibitor SB203580 precluded p57 phosphorylation indicating that in vivo p57 phosphorylation required p38 activation (Figure 3B). To rule out that p57 phosphorylation wa ...
... In contrast, the p57T143A mutant was not phosphorylated by p38 (Figure 3A). Importantly, incubation of the cells with the p38 SAPK inhibitor SB203580 precluded p57 phosphorylation indicating that in vivo p57 phosphorylation required p38 activation (Figure 3B). To rule out that p57 phosphorylation wa ...
Bovine pneumonic pasteurellosis, more commonly known as
... Exposure of cattle to stress factors or viral or other bacterial infections leads to proliferation of M. haemolytica in the upper respiratory tract. Once present in high levels, it enters the alveolar spaces through repeated aspiration of infected droplets and sloughed cells/tissues. Here, it initia ...
... Exposure of cattle to stress factors or viral or other bacterial infections leads to proliferation of M. haemolytica in the upper respiratory tract. Once present in high levels, it enters the alveolar spaces through repeated aspiration of infected droplets and sloughed cells/tissues. Here, it initia ...
FLRT proteins act as guidance cues for migrating cortical interneurons
... WARNING. Access to the contents of this doctoral thesis and its use must respect the rights of the author. It can be used for reference or private study, as well as research and learning activities or materials in the terms established by the 32nd article of the Spanish Consolidated Copyright Act (R ...
... WARNING. Access to the contents of this doctoral thesis and its use must respect the rights of the author. It can be used for reference or private study, as well as research and learning activities or materials in the terms established by the 32nd article of the Spanish Consolidated Copyright Act (R ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
... a central role in maintaining optimal performance of the heart. ‘Mitochondrial dynamics’, the processes of mitochondrial fusion, fission, biogenesis and mitophagy that determine mitochondrial morphology, quality and abundance have recently been implicated in cardiovascular disease. Studies link mito ...
... a central role in maintaining optimal performance of the heart. ‘Mitochondrial dynamics’, the processes of mitochondrial fusion, fission, biogenesis and mitophagy that determine mitochondrial morphology, quality and abundance have recently been implicated in cardiovascular disease. Studies link mito ...
The secreted cell signal Folded Gastrulation regulates glial
... because the glia are smaller. (C and D) Lateral view of the ventral nerve cord of late stage 16 embryos stained with mAb BP102 (red), which marks the axon scaffold, and anti-GFP (green) to reveal the glial extensions of mCD8-GFP expressing glia. d, dorsal; v, ventral. (C) Htl-GAL4::UAS-mCD8GFP. Arro ...
... because the glia are smaller. (C and D) Lateral view of the ventral nerve cord of late stage 16 embryos stained with mAb BP102 (red), which marks the axon scaffold, and anti-GFP (green) to reveal the glial extensions of mCD8-GFP expressing glia. d, dorsal; v, ventral. (C) Htl-GAL4::UAS-mCD8GFP. Arro ...
Bioinformatics analysis of FRG1
... 2015).The inability to restore muscle strength and contractile properties may be attributed to altered splice isoforms of TNNT3. FHL1 over-expression does not affect the pathogenic pathway involving FRG1/Suv-20h/Eid3. FRG1 might affect muscle physiology independent of FHL1 expression explaining inab ...
... 2015).The inability to restore muscle strength and contractile properties may be attributed to altered splice isoforms of TNNT3. FHL1 over-expression does not affect the pathogenic pathway involving FRG1/Suv-20h/Eid3. FRG1 might affect muscle physiology independent of FHL1 expression explaining inab ...
Biochemical characterization of the initial steps of the Kennedy
... DNA using Pfu DNA polymerase and the forward and reverse primers 5 -ATAAGTAAGCGGCCGCCCGCCTAAGTTAGAAGTTGCGCT-3 and 5 -ATAAGTAAGCGGCCGCTCCAATAGCTCCAGGGAAGGAAAGGGACG-3 for TbC/EK1; and 5 -ATAAGTAAGCGGCCGCAAGTGCGTTGTGCAGGTCGGCGACGGT-3 and 5 -ATAAGTAAGCGGCCGCCGTTGGAAGGAGGAAAACGGCCGAGG-3 for TbC/E ...
... DNA using Pfu DNA polymerase and the forward and reverse primers 5 -ATAAGTAAGCGGCCGCCCGCCTAAGTTAGAAGTTGCGCT-3 and 5 -ATAAGTAAGCGGCCGCTCCAATAGCTCCAGGGAAGGAAAGGGACG-3 for TbC/EK1; and 5 -ATAAGTAAGCGGCCGCAAGTGCGTTGTGCAGGTCGGCGACGGT-3 and 5 -ATAAGTAAGCGGCCGCCGTTGGAAGGAGGAAAACGGCCGAGG-3 for TbC/E ...
The Role of Carnitine System in Maintaining Muscle Homeostasis
... Carnitine system physiology in the skeletal muscle is at the basis of a metabolic phenotype in which type I muscle fibers predominate. Contractile properties of the fatigue resistant, slow-twitch oxidative type I fiber is molecularly distinguished by the myosin heavy chain (MHC) I isoform. This impa ...
... Carnitine system physiology in the skeletal muscle is at the basis of a metabolic phenotype in which type I muscle fibers predominate. Contractile properties of the fatigue resistant, slow-twitch oxidative type I fiber is molecularly distinguished by the myosin heavy chain (MHC) I isoform. This impa ...
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic
... important to determine which Ca2+ signaling processes control the development of cardiac hypertrophy. Persistent activation of the β-adrenergic and renin-angiotensin-aldosterone systems (RAS) is a hallmark of cardiac hypertrophy and subsequent heart failure, in which norepinephrine (NE) and angioten ...
... important to determine which Ca2+ signaling processes control the development of cardiac hypertrophy. Persistent activation of the β-adrenergic and renin-angiotensin-aldosterone systems (RAS) is a hallmark of cardiac hypertrophy and subsequent heart failure, in which norepinephrine (NE) and angioten ...
Zinc transporters that regulate vacuolar zinc storage in
... which belong to the ZIP family of metal transporters. Under zinc limitation, ZRT1 and ZRT2 transcription is induced by the Zap1p transcriptional activator. We describe here a new component of zinc homeostasis, vacuolar zinc storage, that is also regulated by Zap1p. Zinc-replete cells accumulate zinc ...
... which belong to the ZIP family of metal transporters. Under zinc limitation, ZRT1 and ZRT2 transcription is induced by the Zap1p transcriptional activator. We describe here a new component of zinc homeostasis, vacuolar zinc storage, that is also regulated by Zap1p. Zinc-replete cells accumulate zinc ...
Lecture 14
... The Gustatory System • Transduction ⇐ Salty: diffusion through ion channels Neuron Na+ Na+ ...
... The Gustatory System • Transduction ⇐ Salty: diffusion through ion channels Neuron Na+ Na+ ...
Identification of a Nuclear Export Signal in the Catalytic Subunit of
... (http://creativecommons.org/licenses/by-nc-sa/3.0). ...
... (http://creativecommons.org/licenses/by-nc-sa/3.0). ...
Human Cardiac Troponin Complex. Structure and Functions
... on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was shown that the region limited by residues 138-145 does not possess a stable secondary structure. In the work by Takeda et al. [67], they were not able to crystallize the i ...
... on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was shown that the region limited by residues 138-145 does not possess a stable secondary structure. In the work by Takeda et al. [67], they were not able to crystallize the i ...
www.drmichaellevin.org
... Although this model (including activin as a factor thought to be upstream of Shh) fits the chick data, it is unclear to what extent the postulated pathway upstream of nodal applies to other species. No asymmetric expression of Shh has been observed in mice [Collignon et al., 1996]. Likewise, null mu ...
... Although this model (including activin as a factor thought to be upstream of Shh) fits the chick data, it is unclear to what extent the postulated pathway upstream of nodal applies to other species. No asymmetric expression of Shh has been observed in mice [Collignon et al., 1996]. Likewise, null mu ...
Microbiology
... The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by screening a transposon mutagenized library of two Edw. ictaluri strains for phageresistant mutants. ...
... The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by screening a transposon mutagenized library of two Edw. ictaluri strains for phageresistant mutants. ...
The influence of age and type 2 diabetes on
... bedside regarding the susceptibility to myocardial infarction with old age and diabetes. In laboratories all over the world, strategies have been developed to protect the myocardium from this insult, including the use of ischaemic conditioning (short periods of ischaemia and reperfusion prior to or ...
... bedside regarding the susceptibility to myocardial infarction with old age and diabetes. In laboratories all over the world, strategies have been developed to protect the myocardium from this insult, including the use of ischaemic conditioning (short periods of ischaemia and reperfusion prior to or ...
Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, and Bassell GJ. Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling. Molecular Cell 42: 673-688 (June 2011).
... (Kocerha et al., 2009; Kosik, 2006; Lee et al., 2008). A subset of miRNAs are localized to dendrites (Kye et al., 2007; Schratt et al., 2006; Siegel et al., 2009), where local translation may affect dendritic spine morphology (Schratt, 2009b; Schratt et al., 2006). A critical gap is understanding ho ...
... (Kocerha et al., 2009; Kosik, 2006; Lee et al., 2008). A subset of miRNAs are localized to dendrites (Kye et al., 2007; Schratt et al., 2006; Siegel et al., 2009), where local translation may affect dendritic spine morphology (Schratt, 2009b; Schratt et al., 2006). A critical gap is understanding ho ...
Boundless Study Slides
... • adenosine triphosphate a multifunctional nucleoside triphosphate used in cells as a coenzyme, often called the "molecular unit of energy currency" in intracellular energy transfer • adenosine triphosphate a multifunctional nucleoside triphosphate used in cells as a coenzyme, often called the "mole ...
... • adenosine triphosphate a multifunctional nucleoside triphosphate used in cells as a coenzyme, often called the "molecular unit of energy currency" in intracellular energy transfer • adenosine triphosphate a multifunctional nucleoside triphosphate used in cells as a coenzyme, often called the "mole ...
REDESIGN OF CARNITINE ACETYLTRANSFERASE SPECIFICITY BY PROTEIN ENGINEERING UNIVERSIDAD DE BARCELONA
... A novel compound, the fatty acid synthase (FAS) inhibitor C75, has been proposed to pharmacologically regulate CPT I activity (Price, 2001). Structurally, C75 is a cell-permeable α-methylene-γ-butyrolactone designed to be less reactive and potentially safer than cerulenin, a natural product obtained ...
... A novel compound, the fatty acid synthase (FAS) inhibitor C75, has been proposed to pharmacologically regulate CPT I activity (Price, 2001). Structurally, C75 is a cell-permeable α-methylene-γ-butyrolactone designed to be less reactive and potentially safer than cerulenin, a natural product obtained ...
SCARFACE Encodes an ARF-GAP That Is Required for Normal
... controls PIN1 localization. In addition, the complex cell biology of vesicle trafficking suggests that many additional components required for PIN trafficking remain to be identified. GN/EMB30 performs its role in PIN1 cycling through regulation of an ADP ribosylation factor (ARF). ARFs are small GT ...
... controls PIN1 localization. In addition, the complex cell biology of vesicle trafficking suggests that many additional components required for PIN trafficking remain to be identified. GN/EMB30 performs its role in PIN1 cycling through regulation of an ADP ribosylation factor (ARF). ARFs are small GT ...
Par3/Baz levels control epithelial folding at actomyosin
... PSBs) first enrich actomyosin at gastrulation, during germ-band extension (Tetley et al., 2016). Wingless signaling on one side of the compartmental boundary maintains these enrichments at germband extended stage, where they act as mechanical barriers to keep dividing cells in their compartment of o ...
... PSBs) first enrich actomyosin at gastrulation, during germ-band extension (Tetley et al., 2016). Wingless signaling on one side of the compartmental boundary maintains these enrichments at germband extended stage, where they act as mechanical barriers to keep dividing cells in their compartment of o ...
patterning mechanisms controlling vertebrate limb development
... genes in the chick embryo has revealed that specific combinations of Hox gene expression in the embryonic trunk and LPM associate well, both with the levels at which the limbs are going to develop, and with the type of limb that develops (Cohn et al. 1997). Third, the absence of forelimbs in some sn ...
... genes in the chick embryo has revealed that specific combinations of Hox gene expression in the embryonic trunk and LPM associate well, both with the levels at which the limbs are going to develop, and with the type of limb that develops (Cohn et al. 1997). Third, the absence of forelimbs in some sn ...
Nicotinamide adenine dinucleotide, a metabolic regulator of
... loci. Clock/BMAL1 and NPAS2/BMAL1 are heterodimeric transcription factors that regulate the expression of genes controlling the circadian clock. These factors are regulated by the redox state of NAD(H) and NADP(H) [20]. This transcriptional feedback system, whose activity fluctuates as a function o ...
... loci. Clock/BMAL1 and NPAS2/BMAL1 are heterodimeric transcription factors that regulate the expression of genes controlling the circadian clock. These factors are regulated by the redox state of NAD(H) and NADP(H) [20]. This transcriptional feedback system, whose activity fluctuates as a function o ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.