Melanotransferrin stimulates t-PA
... survival [33]. Functional interactions have been described between plasminogen/plasmin and MMP systems, suggesting that both systems cooperate in tissue remodeling [34]. Moreover, MMPs such as pro-MMP-1 [29] and pro-MMP-3 [35] can be activated by plasmin [21,29]. The adhesive glycoprotein fibronecti ...
... survival [33]. Functional interactions have been described between plasminogen/plasmin and MMP systems, suggesting that both systems cooperate in tissue remodeling [34]. Moreover, MMPs such as pro-MMP-1 [29] and pro-MMP-3 [35] can be activated by plasmin [21,29]. The adhesive glycoprotein fibronecti ...
High-throughput screens for fluorescent dye discovery
... mark an antigen has become one of the most common staining techniques for fluorescence microscopy because of its versatility: fairly specific antibodies can be developed for most proteins. If enough is known about a biological pathway, an investigator can readily create antibodies to proteins known ...
... mark an antigen has become one of the most common staining techniques for fluorescence microscopy because of its versatility: fairly specific antibodies can be developed for most proteins. If enough is known about a biological pathway, an investigator can readily create antibodies to proteins known ...
Synovial fibroblasts: key players in rheumatoid
... This notion has mainly been derived from studies in the severe combined immunodeficient mouse (SCID) co-implantation model [10, 11]. This animal model for RA was developed to investigate several aspects of an affected human joint under controlled conditions in vivo. Briefly, human RASF and fresh human ...
... This notion has mainly been derived from studies in the severe combined immunodeficient mouse (SCID) co-implantation model [10, 11]. This animal model for RA was developed to investigate several aspects of an affected human joint under controlled conditions in vivo. Briefly, human RASF and fresh human ...
Apoptotic cell removal
... recognition receptors [11–13,47,48]. In the absence of phosphatidylserine expression, uptake is minimal and deliberate replenishment of outer leaflet phosphatidylserine restores uptake [48]. The selectivity and stereospecificity of this restoration system strongly implicates the newly cloned phospha ...
... recognition receptors [11–13,47,48]. In the absence of phosphatidylserine expression, uptake is minimal and deliberate replenishment of outer leaflet phosphatidylserine restores uptake [48]. The selectivity and stereospecificity of this restoration system strongly implicates the newly cloned phospha ...
Human Cardiac-Derived Adherent Proliferating Cells Reduce
... progressive course, indicating a need for alternative therapeutic strategies to improve long-term outcomes. Experimental [5,6] and clinical studies [7,8] have consistently supported the application of cellular transplantation as a strategy to improve myocardial function [6,9]. Whereas experimental s ...
... progressive course, indicating a need for alternative therapeutic strategies to improve long-term outcomes. Experimental [5,6] and clinical studies [7,8] have consistently supported the application of cellular transplantation as a strategy to improve myocardial function [6,9]. Whereas experimental s ...
Copyright Information of the Article Published Online TITLE Dynamic
... not completely understood. Understanding the implications of therapeutic approaches for the transdifferentiation of fibroblasts into MFs at different stages of carcinogenesis will facilitate in developing a treatment plan. ...
... not completely understood. Understanding the implications of therapeutic approaches for the transdifferentiation of fibroblasts into MFs at different stages of carcinogenesis will facilitate in developing a treatment plan. ...
division plane orientation in plant cells
... transversely while others divide longitudinally. 2.1.4 A role for extracellular signals Some cells do not abide by the geometrical rules that predict the division planes of most plant cells. Divisions that occur in response to wounding are a clear example. Upon injury, cells close to the wound are i ...
... transversely while others divide longitudinally. 2.1.4 A role for extracellular signals Some cells do not abide by the geometrical rules that predict the division planes of most plant cells. Divisions that occur in response to wounding are a clear example. Upon injury, cells close to the wound are i ...
MUC1 is a novel costimulatory molecule of human T cells and
... through phosphorylation of transcription factors [18]. In the original studies [8], it was demonstrated that MUC1 was only expressed on a fraction of activated T cells at a given time. Once matured with mitogens, MUC1 was determined to have coinhibitory capabilities in highly purified T-cell cultures ...
... through phosphorylation of transcription factors [18]. In the original studies [8], it was demonstrated that MUC1 was only expressed on a fraction of activated T cells at a given time. Once matured with mitogens, MUC1 was determined to have coinhibitory capabilities in highly purified T-cell cultures ...
Pre-operative HBO treatment led to enhanced expression of
... GM3(Neu5Ac), GM3(Neu5Gc), nLc4Cer, GM2(Neu5Ac), and anti-GalNAc-GM1b, with or without permeabilization. Results: All antibodies were capable of labelling of regenerated hepatocytes, predominantly at the cell surface level. The strongest reactivity was observed for GM3(Neu5Gc), equally in all groups ...
... GM3(Neu5Ac), GM3(Neu5Gc), nLc4Cer, GM2(Neu5Ac), and anti-GalNAc-GM1b, with or without permeabilization. Results: All antibodies were capable of labelling of regenerated hepatocytes, predominantly at the cell surface level. The strongest reactivity was observed for GM3(Neu5Gc), equally in all groups ...
Plant grafting: Insights into tissue regeneration
... 2009). In the last century, grafting has expanded beyond woody plants so a wide variety of plants are grafted. Over 1 billion vegetable plants in Japan and Korea are grafted, primarily from the Solanaceae (i.e., tomatoes, eggplants, peppers) and melon families (Lee et al., 2010). Over 70 woody peren ...
... 2009). In the last century, grafting has expanded beyond woody plants so a wide variety of plants are grafted. Over 1 billion vegetable plants in Japan and Korea are grafted, primarily from the Solanaceae (i.e., tomatoes, eggplants, peppers) and melon families (Lee et al., 2010). Over 70 woody peren ...
Localised axial progenitor cell populations in the avian tail bud are
... mouse tail bud. Using heterotopic transplantations, we show that the fate of CNH cells depends on their environment within the tail bud. Furthermore, we show that the anteroposterior identity of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gastrula-st ...
... mouse tail bud. Using heterotopic transplantations, we show that the fate of CNH cells depends on their environment within the tail bud. Furthermore, we show that the anteroposterior identity of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gastrula-st ...
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... mouse tail bud. Using heterotopic transplantations, we show that the fate of CNH cells depends on their environment within the tail bud. Furthermore, we show that the anteroposterior identity of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gastrula-st ...
... mouse tail bud. Using heterotopic transplantations, we show that the fate of CNH cells depends on their environment within the tail bud. Furthermore, we show that the anteroposterior identity of tail bud progenitor cells can be reset by heterochronic transplantation to the node region of gastrula-st ...
Presence of exposed phospholipids in the outer membrane of Vibrio
... Atypical permeability features of the outer membrane V . cholerae cells were found to be highly sensitive to a wide variety of compounds (Table 1). Since the MIC values may vary with the experimental conditions, the sensitivity of E. coli strain C-600 (chemotype Ra) was determined under identical co ...
... Atypical permeability features of the outer membrane V . cholerae cells were found to be highly sensitive to a wide variety of compounds (Table 1). Since the MIC values may vary with the experimental conditions, the sensitivity of E. coli strain C-600 (chemotype Ra) was determined under identical co ...
Exposure to UV light causes increased biotinylation of histones in
... purchased from American Type Culture Collection (Manassas, VA). Cells were cultured in humidified atmosphere (5% CO2) at 37°C. Culture medium consisted of 90% RPMI 1640 (Hyclone, Logan, UT) and 10% fetal bovine serum (Hyclone), containing 100 IU/ml penicillin and 100 g/ml streptomycin. Unless other ...
... purchased from American Type Culture Collection (Manassas, VA). Cells were cultured in humidified atmosphere (5% CO2) at 37°C. Culture medium consisted of 90% RPMI 1640 (Hyclone, Logan, UT) and 10% fetal bovine serum (Hyclone), containing 100 IU/ml penicillin and 100 g/ml streptomycin. Unless other ...
Possible Occurrence of DNA Double-strand Breaks during Repair of
... their inability to repair enzymatically induced dsb rather than to their lack of repair of dimers . Also, the minor importance of the RAD52-controlled pathway for u .v . ...
... their inability to repair enzymatically induced dsb rather than to their lack of repair of dimers . Also, the minor importance of the RAD52-controlled pathway for u .v . ...
Receptor-Mediated Entry by Equine Infectious Anemia Virus Utilizes
... or ammonium chloride. In contrast, no significant reduction in early RT levels was produced by the presence of either chloroquine or sucrose during virus infection of the same target cells. Specifically, a 97% reduction in early RT products relative to untreated cell infections resulted from treatme ...
... or ammonium chloride. In contrast, no significant reduction in early RT levels was produced by the presence of either chloroquine or sucrose during virus infection of the same target cells. Specifically, a 97% reduction in early RT products relative to untreated cell infections resulted from treatme ...
Evaluation of flow cytometry as replacement for plating in in vitro
... The history of antibiotics can be said to start at several points in time, as humans have traditionally utilized plants, roots, molds and other natural compounds for medical purposes since millennia1. Antibiotics in the modern meaning are a more recent phenomenon. The scientific characterization and ...
... The history of antibiotics can be said to start at several points in time, as humans have traditionally utilized plants, roots, molds and other natural compounds for medical purposes since millennia1. Antibiotics in the modern meaning are a more recent phenomenon. The scientific characterization and ...
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... has been proposed to mediate subtype interconversion in pH shift experiments on cultured cells (Al-Awqati, 1996) and in vivo (Schwartz et al., 2002; Gao et al., 2010) but the transcriptional mechanisms underlying its activities are still unclear. Moreover, little is known about when ICs acquire subt ...
... has been proposed to mediate subtype interconversion in pH shift experiments on cultured cells (Al-Awqati, 1996) and in vivo (Schwartz et al., 2002; Gao et al., 2010) but the transcriptional mechanisms underlying its activities are still unclear. Moreover, little is known about when ICs acquire subt ...
CD4 CD25 Foxp3 Regulatory T Cells Protect the Proinflammatory
... the mechanisms of it. Methods and Results—ECs play a major role in atherogenic initiation, changing their quiescence into activated phenotypes to support every phase of the inflammatory process. HUVECs were incubated alone, with Tregs or CD4⫹CD25⫺ T cells in the presence of anti–CD3 monoclonal antib ...
... the mechanisms of it. Methods and Results—ECs play a major role in atherogenic initiation, changing their quiescence into activated phenotypes to support every phase of the inflammatory process. HUVECs were incubated alone, with Tregs or CD4⫹CD25⫺ T cells in the presence of anti–CD3 monoclonal antib ...
Apical constriction: A cell shape change that can
... Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving proc ...
... Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving proc ...
Physcomitrella Cyclin-Dependent Kinase A Links
... The results from flow cytometry and microphotometry consistently imply that gametophore blade cells are arrested in G2. However, unexpectedly, in cells induced to reprogram, but before cytokinesis, we found that 5-ethynyl-29-deoxyuridine (EdU) was incorporated in leaf cell nuclei (Figures 1H to 1L). ...
... The results from flow cytometry and microphotometry consistently imply that gametophore blade cells are arrested in G2. However, unexpectedly, in cells induced to reprogram, but before cytokinesis, we found that 5-ethynyl-29-deoxyuridine (EdU) was incorporated in leaf cell nuclei (Figures 1H to 1L). ...
- Wiley Online Library
... on their in vivo substrate using an amoeboid or bleb-dependent mechanism rather than using lamellipodia [15]. In addition, we also showed that the ability of satellite cells to form blebs and migrate was dependent on nitric oxide (NO), a potent signaling molecule that regulates cell movement in nume ...
... on their in vivo substrate using an amoeboid or bleb-dependent mechanism rather than using lamellipodia [15]. In addition, we also showed that the ability of satellite cells to form blebs and migrate was dependent on nitric oxide (NO), a potent signaling molecule that regulates cell movement in nume ...
Commentary on “Research on Mitotic Mechanisms”
... Mitosis is the process by which eukaryotic cells segregate their already duplicated chromosomes and move them to opposite ends of the cell in preparation for cell division. Its biological importance is seen in the facts that accurate chromosome segregation is essential for successful cell division a ...
... Mitosis is the process by which eukaryotic cells segregate their already duplicated chromosomes and move them to opposite ends of the cell in preparation for cell division. Its biological importance is seen in the facts that accurate chromosome segregation is essential for successful cell division a ...
Change of Extracellular Polymeric Substances Composition of
... divalent cations such as Ca2+ or Mg2+. In the ferrosphere and in case of biofilms of acidophilic leaching bacteria on metal sulfides Fe2+ and Fe3+ have an important function [6,18]. Due to the complex nature of EPS, there is no universal method for its chemical characterization. The latter also requ ...
... divalent cations such as Ca2+ or Mg2+. In the ferrosphere and in case of biofilms of acidophilic leaching bacteria on metal sulfides Fe2+ and Fe3+ have an important function [6,18]. Due to the complex nature of EPS, there is no universal method for its chemical characterization. The latter also requ ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.