Mitotic Block Induced in HeLa Cells by Low Concentrations of
... bules potently stabilizes microtubule dynamics (12). Together these results have suggested that mitotic block in HeLa cells by low con centrations of paclitaxel results from a potent kinetic stabilization of mitotic spindle microtubule dynamics (3, 12). However, it has gen erally been considered tha ...
... bules potently stabilizes microtubule dynamics (12). Together these results have suggested that mitotic block in HeLa cells by low con centrations of paclitaxel results from a potent kinetic stabilization of mitotic spindle microtubule dynamics (3, 12). However, it has gen erally been considered tha ...
Gibberellins accumulate in the elongating endodermal cells of
... regulators called plant hormones (1). Plants regulate hormone response pathways at multiple levels including hormone biosynthesis, metabolism, perception, and signaling. In the case of auxin, elegant studies have shown that the regulation of auxin distribution through the action of specific transport ...
... regulators called plant hormones (1). Plants regulate hormone response pathways at multiple levels including hormone biosynthesis, metabolism, perception, and signaling. In the case of auxin, elegant studies have shown that the regulation of auxin distribution through the action of specific transport ...
Culm strenth of a rice brittle mutant
... In rice, at least six brittle culm mutants (bc1 to bc6) have been reported. These brittle mutants have been genetically identified in rice and mapped onto genetic map as follows: bc1 on chromosome 3, bc2 on chromosome5, bc3 and bc5 on chromosome 2, bc4 on chromosome 6 (Nagato and Yoshimura, 1998), ...
... In rice, at least six brittle culm mutants (bc1 to bc6) have been reported. These brittle mutants have been genetically identified in rice and mapped onto genetic map as follows: bc1 on chromosome 3, bc2 on chromosome5, bc3 and bc5 on chromosome 2, bc4 on chromosome 6 (Nagato and Yoshimura, 1998), ...
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... complement of intracellular organelles. However, as lens fiber cells mature they must destroy their organelles, including nuclei, in a process that has remained enigmatic for over a century, but which is crucial for the formation of the organelle-free zone in the center of the lens that assures clar ...
... complement of intracellular organelles. However, as lens fiber cells mature they must destroy their organelles, including nuclei, in a process that has remained enigmatic for over a century, but which is crucial for the formation of the organelle-free zone in the center of the lens that assures clar ...
Figure 1 - Journal of The Royal Society Interface
... zone develop into bark, while inner cells differentiate into wood, with a layer of cambial cells remaining between the two. Over a period of about three weeks as the cells differentiate, they change shape and form the secondary cell wall; once secondary wall formation is complete, the cell dies. The ...
... zone develop into bark, while inner cells differentiate into wood, with a layer of cambial cells remaining between the two. Over a period of about three weeks as the cells differentiate, they change shape and form the secondary cell wall; once secondary wall formation is complete, the cell dies. The ...
chapter 9 telomeres and telomerase in adult stem cells and
... role of telomerase in human aging and life span, has come from the study of human diseases associated with mutations in telomerase components. As discussed above, mutations in the telomerase core components, Tert and Terc, are present in patients that suffer from aplastic anemia, idiopathic pulmonar ...
... role of telomerase in human aging and life span, has come from the study of human diseases associated with mutations in telomerase components. As discussed above, mutations in the telomerase core components, Tert and Terc, are present in patients that suffer from aplastic anemia, idiopathic pulmonar ...
Dynamin as a mover and pincher during cell migration and invasion
... This capacity for rapid assembly and constriction while interacting with adaptor, signaling and cytoskeletal molecules that leads to the deformation and scission of cellular membranes makes dynamin unique. We can thus view it as a contractile polymeric scaffold (Thompson and McNiven, 2001) that coul ...
... This capacity for rapid assembly and constriction while interacting with adaptor, signaling and cytoskeletal molecules that leads to the deformation and scission of cellular membranes makes dynamin unique. We can thus view it as a contractile polymeric scaffold (Thompson and McNiven, 2001) that coul ...
Database Machine
... Success of SAN caches is built upon predictive analytics They work well, if a small percentage of disk accessed most often - The emphasis is on disk; not data Most database systems - Are way bigger than caches - Need to get the data to the memory to process --> I/O at the disk level is still h ...
... Success of SAN caches is built upon predictive analytics They work well, if a small percentage of disk accessed most often - The emphasis is on disk; not data Most database systems - Are way bigger than caches - Need to get the data to the memory to process --> I/O at the disk level is still h ...
Surface CD81 Via Microparticles Release and Intercellular Transfer
... To examine CD81 transcription upon T cell activation, RNase protection analysis was performed in Jurkat T cells. Using a fulllength antisense CD81-specific riboprobe, we observed a reduction of CD81 mRNA at 9 h after activation (Fig. 2B). This time point coincided with the late phase of activation-i ...
... To examine CD81 transcription upon T cell activation, RNase protection analysis was performed in Jurkat T cells. Using a fulllength antisense CD81-specific riboprobe, we observed a reduction of CD81 mRNA at 9 h after activation (Fig. 2B). This time point coincided with the late phase of activation-i ...
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... Figure 1. Schematic illustration of different pathways of glucose metabolism in cancer cells. Glucose enters the cell via glucose transporter proteins (GLUT). Metabolic flux rates in different pathways are determined by the regulation of rate-limiting enzymes as described in the text, as well as by ...
... Figure 1. Schematic illustration of different pathways of glucose metabolism in cancer cells. Glucose enters the cell via glucose transporter proteins (GLUT). Metabolic flux rates in different pathways are determined by the regulation of rate-limiting enzymes as described in the text, as well as by ...
The Cell Membrane
... The nucleus contains DNA, the genetic instructions within chromosomes. The instructions tell how to synthesize the proteins that determine cell structure and function. Chromosomes also contain various proteins that control expression of the genetic information. ...
... The nucleus contains DNA, the genetic instructions within chromosomes. The instructions tell how to synthesize the proteins that determine cell structure and function. Chromosomes also contain various proteins that control expression of the genetic information. ...
... indicated that, M. xanthus PCO2 released an extracellular substance that dissolved the cyanobacteria cell wall at the point of contact. It was therefore, speculated based on the Burnham studies (1981) that, there is a possibility of release of exoenzymes during the physical contact between bacteria ...
Cnidarians: An evolutionarily conserved model system for
... They can regenerate any amputated head or foot, and when dissociated into single cells, even intact animals will regenerate from reaggregates. This extensive regeneration capacity is mediated by epithelial stem cells, and it is based on the restoration of a signaling center, i.e., an organizer. Orga ...
... They can regenerate any amputated head or foot, and when dissociated into single cells, even intact animals will regenerate from reaggregates. This extensive regeneration capacity is mediated by epithelial stem cells, and it is based on the restoration of a signaling center, i.e., an organizer. Orga ...
The Cortical Microtubule Array: From Dynamics to
... recent studies have revealed that CMT arrays consist of microtubules with mixed plus-end orientations (Dhonukshe and Gadella, 2003; Shaw et al., 2003; Tian et al., 2004; Vos et al., 2004). Therefore, CMT array organization does not require a uniform orientation of the microtubule plusends (Figure 1B ...
... recent studies have revealed that CMT arrays consist of microtubules with mixed plus-end orientations (Dhonukshe and Gadella, 2003; Shaw et al., 2003; Tian et al., 2004; Vos et al., 2004). Therefore, CMT array organization does not require a uniform orientation of the microtubule plusends (Figure 1B ...
Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2
... Objective—Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. Approach and Results—Here, we show that laminar flow exposure r ...
... Objective—Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. Approach and Results—Here, we show that laminar flow exposure r ...
Gene expression profiling of Escherichia coli growth transitions: an
... major subunits of RNA polymerase, ribosomal proteins, and transcription and translation factors. These genes generally show a rapid decrease in mRNA levels at the onset of transient growth arrest and again upon entry into stationary phase. This point is clearly illustrated by averaging the expressio ...
... major subunits of RNA polymerase, ribosomal proteins, and transcription and translation factors. These genes generally show a rapid decrease in mRNA levels at the onset of transient growth arrest and again upon entry into stationary phase. This point is clearly illustrated by averaging the expressio ...
Centrosome misorientation mediates slowing of the cell cycle under
... we previously reported to have stereotypically oriented centrosomes (Yamashita et al., 2003), sometimes have a high frequency of misoriented centrosomes. While investigating the cause, we realized that this high frequency of centrosome misorientation was associated with an overcrowded culture, leadi ...
... we previously reported to have stereotypically oriented centrosomes (Yamashita et al., 2003), sometimes have a high frequency of misoriented centrosomes. While investigating the cause, we realized that this high frequency of centrosome misorientation was associated with an overcrowded culture, leadi ...
Mineralogy - Carleton College
... • A lattice point occurs where the corners of four cells meet, and therefore, 1/4 point per corner lies in a give cell (1/4 * 4=1) C ...
... • A lattice point occurs where the corners of four cells meet, and therefore, 1/4 point per corner lies in a give cell (1/4 * 4=1) C ...
Comparison of an immortalized human corneal epithelial cell line
... Susceptibility of HCE to HSV-1 and its suitability for the isolation of HSV-1 The HCE was found to be suceptible to HSV-1 as determined by both the shell vial and tube cultures. Cytopathic effect (CPE) (fig. 2) was seen in the tube cultures at 48 h (>50% of the cells were refractile, showed rounding ...
... Susceptibility of HCE to HSV-1 and its suitability for the isolation of HSV-1 The HCE was found to be suceptible to HSV-1 as determined by both the shell vial and tube cultures. Cytopathic effect (CPE) (fig. 2) was seen in the tube cultures at 48 h (>50% of the cells were refractile, showed rounding ...
transcriptome analyses reveal differential gene - ePIC
... and can also serve to take up material from the extracellular space for trophic purposes (i.e., phagotrophy). Especially in protists, phagotrophy plays a key role, as it provided (and still provides) a prerequisite for heterotrophic feeding and the evolution of photoautotrophy in eukaryotes (Raven 1 ...
... and can also serve to take up material from the extracellular space for trophic purposes (i.e., phagotrophy). Especially in protists, phagotrophy plays a key role, as it provided (and still provides) a prerequisite for heterotrophic feeding and the evolution of photoautotrophy in eukaryotes (Raven 1 ...
Cytostatic factor: an activity that puts the cell cycle on hold
... CSF and the cell cycle Emi1: a mitotic APC/C inhibitor Upon entry into mitosis, cells must activate Cdk1 to induce processes such as nuclear envelope breakdown, chromosome condensation and bipolar spindle assembly. However, rising Cdk1 activity also promotes the activation of the APC/C by inducing t ...
... CSF and the cell cycle Emi1: a mitotic APC/C inhibitor Upon entry into mitosis, cells must activate Cdk1 to induce processes such as nuclear envelope breakdown, chromosome condensation and bipolar spindle assembly. However, rising Cdk1 activity also promotes the activation of the APC/C by inducing t ...
Centrosome Maturation and Mitotic Spindle Assembly in C. elegans
... associates with centrioles and is required for their duplication in early embryonic cells, but is not required for centrosome growth and maturation (O’Connell et al., 2001). In mammals, cell division kinases (CDKs) regulate the initiation of centriole duplication, providing coordination with the cel ...
... associates with centrioles and is required for their duplication in early embryonic cells, but is not required for centrosome growth and maturation (O’Connell et al., 2001). In mammals, cell division kinases (CDKs) regulate the initiation of centriole duplication, providing coordination with the cel ...
Development of differentiation assay in neuroblastoma to elucidate
... Poorly differentiated cancers present an aggressive phenotype – they grow quickly, have higher metastatic potential and are correlated with unfavourable outcome. The idea of differentiation therapy is therefore well understood. However, there’s no standard method to assess differentiation in neurobl ...
... Poorly differentiated cancers present an aggressive phenotype – they grow quickly, have higher metastatic potential and are correlated with unfavourable outcome. The idea of differentiation therapy is therefore well understood. However, there’s no standard method to assess differentiation in neurobl ...
Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells. In prokaryotes which lack a cell nucleus, the cell cycle occurs via a process termed binary fission. In cells with a nucleus, as in eukaryotes, the cell cycle can be divided into three periods: interphase, the mitotic (M) phase, and cytokinesis. During interphase, the cell grows, accumulating nutrients needed for mitosis, preparing it for cell division and duplicating its DNA. During the mitotic phase, the cell splits itself into two distinct daughter cells. During the final stage, cytokinesis, the new cell is completely divided. To ensure the proper division of the cell, there are control mechanisms known as cell cycle checkpoints.The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and some internal organs are renewed. After cell division, each of the daughter cells begin the interphase of a new cycle. Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell division.