Interconnections Between RNA-Processing Pathways Revealed by
... chromatin remodeling enzymes such as the SWI/SNF complex (Patrick et al. 2015), suggesting ...
... chromatin remodeling enzymes such as the SWI/SNF complex (Patrick et al. 2015), suggesting ...
A Receptor-Like Kinase Mediates Ammonium
... Ling Bai,1 Xiaonan Ma,1 Guozeng Zhang,1 Shufei Song, Yun Zhou, Lijie Gao, Yuchen Miao, and Chun-Peng Song2 Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, Department of Biology, Henan University, Kaifeng 475001, China ...
... Ling Bai,1 Xiaonan Ma,1 Guozeng Zhang,1 Shufei Song, Yun Zhou, Lijie Gao, Yuchen Miao, and Chun-Peng Song2 Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, Department of Biology, Henan University, Kaifeng 475001, China ...
Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type
... (DNMTs) and sirtuin-1 (SIRT-1), which leads to DNA hypermethylation of nuclear genes [59]. This would lead to downregulation of these genes. In yeast, low functioning mitochondria can signal the transcription factors, retrograde signaling proteins 1–3 (RTG 1–3), which translocate to the nucleus and ...
... (DNMTs) and sirtuin-1 (SIRT-1), which leads to DNA hypermethylation of nuclear genes [59]. This would lead to downregulation of these genes. In yeast, low functioning mitochondria can signal the transcription factors, retrograde signaling proteins 1–3 (RTG 1–3), which translocate to the nucleus and ...
S1 File.
... restriction enzymes. Note that a KpnI site was introduced into the vector through the reverse ...
... restriction enzymes. Note that a KpnI site was introduced into the vector through the reverse ...
Meclofenamic acid selectively inhibits FTO demethylation of m A
... (METTL3–METTL14–WTAP) further highlights the biological significance of m6 A methylation (4,5). The physiological relevance of this modification remains unclear, however. Two recent RNA ‘methylome’ studies have provided a map of m6 A-modified mRNAs (6,7). Both found that the ubiquitous m6 A modifica ...
... (METTL3–METTL14–WTAP) further highlights the biological significance of m6 A methylation (4,5). The physiological relevance of this modification remains unclear, however. Two recent RNA ‘methylome’ studies have provided a map of m6 A-modified mRNAs (6,7). Both found that the ubiquitous m6 A modifica ...
Intracellular control of developmental and regenerative axon growth
... heavily studied as extracellular factors that stimulate axon growth. Downstream of receptor tyrosine kinases, recent studies have suggested that phosphatidylinositol-3 kinase (PI3K) regulates local assembly of axonal cytoskeleton, especially microtubules, via glycogen synthase kinase 3b (GSK-3b) and ...
... heavily studied as extracellular factors that stimulate axon growth. Downstream of receptor tyrosine kinases, recent studies have suggested that phosphatidylinositol-3 kinase (PI3K) regulates local assembly of axonal cytoskeleton, especially microtubules, via glycogen synthase kinase 3b (GSK-3b) and ...
Achilles` heel of Grapevine Downy Mildew
... These limitations show that new strategies are required for the control of Downy Mildew. P. viticola has a vulnerable side at his motile life cycle stage, the zoospores. Merely surrounded by one membrane, they swim on the surface of grapevines for a short time. This side was analysed in this study. ...
... These limitations show that new strategies are required for the control of Downy Mildew. P. viticola has a vulnerable side at his motile life cycle stage, the zoospores. Merely surrounded by one membrane, they swim on the surface of grapevines for a short time. This side was analysed in this study. ...
Cornell University, 1989 M.S. Environmental Engineering Stanford University, 1990
... I am indebted to my other comn-ittee members, Phil Gschwend, Jim McCarthy, and Rob Olson for their patience and devotion to my work over these many years. Through them, I have been able to gain many different insights into the world of oceanography, and science in general. Over my final year, I have ...
... I am indebted to my other comn-ittee members, Phil Gschwend, Jim McCarthy, and Rob Olson for their patience and devotion to my work over these many years. Through them, I have been able to gain many different insights into the world of oceanography, and science in general. Over my final year, I have ...
Platelets Served with - The Journal of Immunology
... http://www.jimmunol.org/content/194/12/5579.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription ...
... http://www.jimmunol.org/content/194/12/5579.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription ...
LEFT-HANDED Z-DNA: STRUCTURE AND FUNCTION
... until the torsional strain stabilizing the Z-DNA is relieved by topoisomerases. This mechanism might ensure spatial separation between successive polymerases. As a consequence, processing of an RNA would then be physically and temporally removed from that of subsequent transcripts, perhaps minimizin ...
... until the torsional strain stabilizing the Z-DNA is relieved by topoisomerases. This mechanism might ensure spatial separation between successive polymerases. As a consequence, processing of an RNA would then be physically and temporally removed from that of subsequent transcripts, perhaps minimizin ...
Toxoplasma gondii Chitinase Induces Macrophage Activation
... enzyme implicated, or its origin, whether derived from the parasite or host cell. NAGase activity has also been detected in T. cruzi epimastigotes [30], but its biological role is unknown. Otherwise, chitinases from Leishmania spp. [12] and Plasmodium spp. [13] were reported to play important roles ...
... enzyme implicated, or its origin, whether derived from the parasite or host cell. NAGase activity has also been detected in T. cruzi epimastigotes [30], but its biological role is unknown. Otherwise, chitinases from Leishmania spp. [12] and Plasmodium spp. [13] were reported to play important roles ...
DEVELOPMENT AND DISEASE Tbx5 is required for forelimb bud
... Additional chick Groucho genes were cloned by degenerate PCR from chick limb cDNA prepared from HH stages 20-23. The degenerate PCR primers lie in the highly conserved Q domain and WD40 domains of Drosophila, mouse and human Groucho genes: 5′-AARACIGARATGCARMGICAY-3′, 5′-IGCYTCICCICCIACDATIAR3′. PCR ...
... Additional chick Groucho genes were cloned by degenerate PCR from chick limb cDNA prepared from HH stages 20-23. The degenerate PCR primers lie in the highly conserved Q domain and WD40 domains of Drosophila, mouse and human Groucho genes: 5′-AARACIGARATGCARMGICAY-3′, 5′-IGCYTCICCICCIACDATIAR3′. PCR ...
October 9, 2009 - Northwestern University
... these sequences in vitro (for purity, see Fig. S3), they were able to induce significant amounts of IFN-␣ in human monocytes (Fig. 2E). The levels were comparable with those induced by ss2.2s IVT RNA or an optimized IVT hairpin artificially designed by fusion of the sense and antisense strand of the ...
... these sequences in vitro (for purity, see Fig. S3), they were able to induce significant amounts of IFN-␣ in human monocytes (Fig. 2E). The levels were comparable with those induced by ss2.2s IVT RNA or an optimized IVT hairpin artificially designed by fusion of the sense and antisense strand of the ...
estrogen receptor by cyclin D1 Ligand
... ER and cyclin D1 share a coactivator binding motif To study how cyclin D1 activates ER, cyclin D1 deletion mutants were tested for their effect on ER transactivation. Cos-7 cells were transfected with cyclin D1 mutants, together with ER and a luciferase reporter gene construct driven by a minimal TA ...
... ER and cyclin D1 share a coactivator binding motif To study how cyclin D1 activates ER, cyclin D1 deletion mutants were tested for their effect on ER transactivation. Cos-7 cells were transfected with cyclin D1 mutants, together with ER and a luciferase reporter gene construct driven by a minimal TA ...
Analysis of exocyst subunit EXO70 family reveals
... clathrin-mediated endocytosis. Both NtEXO70A1a and NtEXO70B1 colocalized to a different degree with markers for anionic signaling phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidic acid. In contrast, members of EXO70 C-class, which are specifically expressed in tip growing cells, e ...
... clathrin-mediated endocytosis. Both NtEXO70A1a and NtEXO70B1 colocalized to a different degree with markers for anionic signaling phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidic acid. In contrast, members of EXO70 C-class, which are specifically expressed in tip growing cells, e ...
The secreted cell signal Folded Gastrulation regulates glial
... against glial and neuronal markers. We found that most of the prominent (high-level) fog-expressing cells in the CNS also ...
... against glial and neuronal markers. We found that most of the prominent (high-level) fog-expressing cells in the CNS also ...
Ascorbic acid: metabolism and functions of a multi
... in pea seedling embryonic axes after their ascorbate content has been increased by feeding with ascorbate [26’]. ...
... in pea seedling embryonic axes after their ascorbate content has been increased by feeding with ascorbate [26’]. ...
Myocardial gene reprogramming associated with a
... LPS preconditioning, and seems to involve de novo protein synthesis (24, 26, 31). It is likely that resistance to LPS and resistance to ischemia are two components of LPS-induced cardiac cross-resistance. However, it is unclear whether LPS-induced cardiac resistance to LPS is sustained and whether t ...
... LPS preconditioning, and seems to involve de novo protein synthesis (24, 26, 31). It is likely that resistance to LPS and resistance to ischemia are two components of LPS-induced cardiac cross-resistance. However, it is unclear whether LPS-induced cardiac resistance to LPS is sustained and whether t ...
Characterization of Vincristine Transport by the Mr 190,000
... ated transport of leukotriene <'.,. together they act as relatively potent competitive inhibitors. Overall, our data demonstrate that MRP can actively cotransport GSH and unmodified vincristine and that these com pounds probably interact, either with the leukotriene ( ', binding site(s) on the prote ...
... ated transport of leukotriene <'.,. together they act as relatively potent competitive inhibitors. Overall, our data demonstrate that MRP can actively cotransport GSH and unmodified vincristine and that these com pounds probably interact, either with the leukotriene ( ', binding site(s) on the prote ...
Evasion of the Immune Response by Trypanosoma cruzi during
... affects nearly 8 million people, accounting for the loss of 662,000 disability-adjusted life years (1–3) (WHO).1 This parasite alternates between invertebrate hematophagous insects from the Reduviidae family and a broad range of mammalian hosts (4). Although the estimated period for T. cruzi speciat ...
... affects nearly 8 million people, accounting for the loss of 662,000 disability-adjusted life years (1–3) (WHO).1 This parasite alternates between invertebrate hematophagous insects from the Reduviidae family and a broad range of mammalian hosts (4). Although the estimated period for T. cruzi speciat ...
Jelena Raspopovic Molecular basis for digit patterning in the vertebrate limb
... This thesis focuses on the identification of the Turing network that underlies digit patterning in the mouse limb. Traditionally, digit specification has been explained by positional information models based on the temporal-spatial gradient of Sonic Hedge Hog (Shh). However embryonic and genetic man ...
... This thesis focuses on the identification of the Turing network that underlies digit patterning in the mouse limb. Traditionally, digit specification has been explained by positional information models based on the temporal-spatial gradient of Sonic Hedge Hog (Shh). However embryonic and genetic man ...
Human Cardiac Troponin Complex. Structure and Functions
... as to impede the actomyosin complex formation [76, 77]. A few variants of the inhibitory domain structure are presented in the literature. In the work of Brown et al. [74] on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was ...
... as to impede the actomyosin complex formation [76, 77]. A few variants of the inhibitory domain structure are presented in the literature. In the work of Brown et al. [74] on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was ...
SCARFACE Encodes an ARF-GAP That Is Required for Normal
... mutants produce phenotypes resembling pin1 (Bennett et al., 1995), and PIN1 localizes to incorrect cellular positions in pid mutants and in plants overexpressing PID (Friml et al., 2004). However, we do not know the targets of PID kinase nor how it controls PIN1 localization. In addition, the comple ...
... mutants produce phenotypes resembling pin1 (Bennett et al., 1995), and PIN1 localizes to incorrect cellular positions in pid mutants and in plants overexpressing PID (Friml et al., 2004). However, we do not know the targets of PID kinase nor how it controls PIN1 localization. In addition, the comple ...
Selective and differential interactions of BNN27
... Fig. 1. BNN27 specifically binds to TrkA receptor. (A) Competition binding assays of [3H]-DHEA in the presence of increasing concentrations of BNN27 using membranes isolated from HEK293 cells transfected with cDNAs of TrkA or TrkB or TrkC receptors. Ki represents the mean ± SEM, n ¼ 6 experiments. Ri ...
... Fig. 1. BNN27 specifically binds to TrkA receptor. (A) Competition binding assays of [3H]-DHEA in the presence of increasing concentrations of BNN27 using membranes isolated from HEK293 cells transfected with cDNAs of TrkA or TrkB or TrkC receptors. Ki represents the mean ± SEM, n ¼ 6 experiments. Ri ...