Regulation of Nerve Growth Factor Receptor Gene Expression by
... Figure 1. Expression of the NGF receptor, tyrosine hydroxylase, and neuropeptide Y mRNAs in the postnatal day 12 SCG with and without NGF treatment. Northern blot analysis of (a) NGF receptor, (b) tyrosine hydroxylase, and (c) neuropeptide Y mRNAs in equal amounts of total RNA from the SCG of an an ...
... Figure 1. Expression of the NGF receptor, tyrosine hydroxylase, and neuropeptide Y mRNAs in the postnatal day 12 SCG with and without NGF treatment. Northern blot analysis of (a) NGF receptor, (b) tyrosine hydroxylase, and (c) neuropeptide Y mRNAs in equal amounts of total RNA from the SCG of an an ...
Response to Bacteria Excess Production of IL-12 and IL
... inflammation by using an IL-10-deficient (IL-10ⴚ/ⴚ) mouse colitis model. GM-CSF-induced bone marrow-derived M (GM-M) and M-CSF-induced bone marrow-derived M (M-M) were generated from bone marrow CD11bⴙ cells. M-M from IL-10ⴚ/ⴚ mice produced abnormally large amounts of IL-12 and IL-23 upon stimu ...
... inflammation by using an IL-10-deficient (IL-10ⴚ/ⴚ) mouse colitis model. GM-CSF-induced bone marrow-derived M (GM-M) and M-CSF-induced bone marrow-derived M (M-M) were generated from bone marrow CD11bⴙ cells. M-M from IL-10ⴚ/ⴚ mice produced abnormally large amounts of IL-12 and IL-23 upon stimu ...
Further analysis on lidocaine-induced increase in intracellular Zn2+
... Both lidocaine and tetracaine are well known as representative local anesthetics. In our previous studies, lidocaine augmented FluoZin-3 fluorescence of rat thymocytes (Nishimura and Oyama, 2009) whereas tetracaine attenuated it (Kimura et al., 2011). These results suggested that lidocaine increased ...
... Both lidocaine and tetracaine are well known as representative local anesthetics. In our previous studies, lidocaine augmented FluoZin-3 fluorescence of rat thymocytes (Nishimura and Oyama, 2009) whereas tetracaine attenuated it (Kimura et al., 2011). These results suggested that lidocaine increased ...
Transfer RNA is highly unstable during early
... these and other studies support a general view of dynamic control of both the production, modification, aminoacylation, and degradation of tRNAs, which serves to align the supply of aminoacylated tRNAs with the changing demands posed by the transcriptome characteristic of different cellular states o ...
... these and other studies support a general view of dynamic control of both the production, modification, aminoacylation, and degradation of tRNAs, which serves to align the supply of aminoacylated tRNAs with the changing demands posed by the transcriptome characteristic of different cellular states o ...
CE - University of Pittsburgh
... cholesterol is excreted as bile salts or repackaged in VLDL for distribution to tissues. • Cholesterol synthesis in the liver is regulated by the cholesterol arriving through HDL (and dietary cholesterol returned by chylomicrons remnants). • Cholesterol (CE) in HDL is referred to as “good cholestero ...
... cholesterol is excreted as bile salts or repackaged in VLDL for distribution to tissues. • Cholesterol synthesis in the liver is regulated by the cholesterol arriving through HDL (and dietary cholesterol returned by chylomicrons remnants). • Cholesterol (CE) in HDL is referred to as “good cholestero ...
Dramatic increase in lymph node dendritic cell
... detected, which corresponded to the extinction of the immune response against MMTV(SW), occurring during the second week after virus injection.7 Interestingly, the comparison of the increase in the absolute number of CD8⫺ versus CD8⫹ DCs revealed that during the first week the increase was higher fo ...
... detected, which corresponded to the extinction of the immune response against MMTV(SW), occurring during the second week after virus injection.7 Interestingly, the comparison of the increase in the absolute number of CD8⫺ versus CD8⫹ DCs revealed that during the first week the increase was higher fo ...
Differential Auxin-Transporting Activities of PIN
... Auxin flows from young aerial parts all the way down to the root tip columella in which an auxin maximum is formed for root stem cell maintenance and moves up toward the root differentiation zone through root epidermal cells, where a part of it travels back to the root tip via cortical cells (Blilou ...
... Auxin flows from young aerial parts all the way down to the root tip columella in which an auxin maximum is formed for root stem cell maintenance and moves up toward the root differentiation zone through root epidermal cells, where a part of it travels back to the root tip via cortical cells (Blilou ...
REVIEWS - Unisciel
... M-protein (~165 kDa) and myomesin (~185 kDa). Myomesin might directly bind to Ig domains in the M-line part of titin, and therefore might interact with both myosin and titin components of thick filaments within the M-line25. The A-band contains the largest part of the molecule (~2.1 MDa) and the seq ...
... M-protein (~165 kDa) and myomesin (~185 kDa). Myomesin might directly bind to Ig domains in the M-line part of titin, and therefore might interact with both myosin and titin components of thick filaments within the M-line25. The A-band contains the largest part of the molecule (~2.1 MDa) and the seq ...
Roles of Long Non-coding RNAs in X
... Strauss 2005; Memili et al. 2001). Consistent with its classification as a ncRNA, Xist lacks conserved open reading frames, but does contain up to six regions of tandemly arrayed repetitive sequence that may be responsible for aspects of its function (Brockdorff et al. 1992; Brown et al. 1992; Neste ...
... Strauss 2005; Memili et al. 2001). Consistent with its classification as a ncRNA, Xist lacks conserved open reading frames, but does contain up to six regions of tandemly arrayed repetitive sequence that may be responsible for aspects of its function (Brockdorff et al. 1992; Brown et al. 1992; Neste ...
Tetrazine−trans-cyclooctene Mediated Conjugation of Antibodies to
... TIRF microscopy. (B) TIRF images of Ab−MTs (red) transporting fluorescent protein analyte (green) at 0.1, 1, and 10 pM concentrations. Scale bar: 5 μm. (C) Plotting the increase in the fluorescence intensity of the analyte per unit length of Ab−MTs as a function of analyte concentration demonstrates t ...
... TIRF microscopy. (B) TIRF images of Ab−MTs (red) transporting fluorescent protein analyte (green) at 0.1, 1, and 10 pM concentrations. Scale bar: 5 μm. (C) Plotting the increase in the fluorescence intensity of the analyte per unit length of Ab−MTs as a function of analyte concentration demonstrates t ...
TETRASPORE is required for male meiotic
... 2648 M. Spielman and others walls (Worrall et al., 1992; Peirson et al., 1996). In these, membranes or non-callosic walls separate the microspores, while in tes no intersporal membranes or walls are observed in the absence of callose. Secondly, TES is also unlikely to encode a product required for ...
... 2648 M. Spielman and others walls (Worrall et al., 1992; Peirson et al., 1996). In these, membranes or non-callosic walls separate the microspores, while in tes no intersporal membranes or walls are observed in the absence of callose. Secondly, TES is also unlikely to encode a product required for ...
TETRASPORE is required for male meiotic
... 2648 M. Spielman and others walls (Worrall et al., 1992; Peirson et al., 1996). In these, membranes or non-callosic walls separate the microspores, while in tes no intersporal membranes or walls are observed in the absence of callose. Secondly, TES is also unlikely to encode a product required for ...
... 2648 M. Spielman and others walls (Worrall et al., 1992; Peirson et al., 1996). In these, membranes or non-callosic walls separate the microspores, while in tes no intersporal membranes or walls are observed in the absence of callose. Secondly, TES is also unlikely to encode a product required for ...
Collagen in the Human Lung
... Methods have been developed to examine human fetal and adult lung collagen with respect to its composition and synthesis. The second trimester fetal lung has a large number of cells per unit lung mass (36.6±2.7 lsg DNA/mg dry wt) and relatively small amounts of collagen (17.0±5.3 Ag collagen/mg dry ...
... Methods have been developed to examine human fetal and adult lung collagen with respect to its composition and synthesis. The second trimester fetal lung has a large number of cells per unit lung mass (36.6±2.7 lsg DNA/mg dry wt) and relatively small amounts of collagen (17.0±5.3 Ag collagen/mg dry ...
Foxp3-positive macrophages display immunosuppressive properties
... Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineagespecific transcription factor Foxp3, and their main function is to suppress T cells. While evaluating T reg cells, we identified a population of Foxp3-positive cells that were CD11b+F4/80+CD68+, indicating ma ...
... Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineagespecific transcription factor Foxp3, and their main function is to suppress T cells. While evaluating T reg cells, we identified a population of Foxp3-positive cells that were CD11b+F4/80+CD68+, indicating ma ...
HIV-1 Replication by Distinct Mechanisms Monocyte
... either classical (M1) or alternatively activated (M2a) MDM is associated with a reduced capacity to support productive CCR5dependent (R5) HIV-1 infection. M1 polarization was associated with a significant down-regulation of CD4 receptors, increased secretion of CCR5-binding chemokines (CCL3, CCL4, a ...
... either classical (M1) or alternatively activated (M2a) MDM is associated with a reduced capacity to support productive CCR5dependent (R5) HIV-1 infection. M1 polarization was associated with a significant down-regulation of CD4 receptors, increased secretion of CCR5-binding chemokines (CCL3, CCL4, a ...
Relationship of Net Chloride Flow across the Human Erythrocyte
... et al ., 1977). Under the conditions of these experiments, DIDS binds very selectively to band 3 (Ship et al ., 1977), which suggests that the band 3 protein is involved in both net and exchange anion flow. Further evidence for this is provided by the finding that vesicles from which almost all of t ...
... et al ., 1977). Under the conditions of these experiments, DIDS binds very selectively to band 3 (Ship et al ., 1977), which suggests that the band 3 protein is involved in both net and exchange anion flow. Further evidence for this is provided by the finding that vesicles from which almost all of t ...
The endosperm-specific ZHOUPI gene of
... endosperm than do wild-type seeds at maturity, suggesting that ZOU also controls endosperm breakdown. We identify several target genes whose expression in the ESR is regulated by ZOU. These include ABNORMAL LEAF SHAPE1, which encodes a subtilisinlike protease previously shown to have a similar role ...
... endosperm than do wild-type seeds at maturity, suggesting that ZOU also controls endosperm breakdown. We identify several target genes whose expression in the ESR is regulated by ZOU. These include ABNORMAL LEAF SHAPE1, which encodes a subtilisinlike protease previously shown to have a similar role ...
Slide 1
... Mutant B-catenin translocated into nucleus (w/out need of TGF-B1) Mutant B-catenin induced profileration of MSCs and inhibited osteogenic differentiation Supports direct correlation between activation of Smad3/B-cateninmediated TGF-B1 signaling pathway and its unique biological responses in MSCs ...
... Mutant B-catenin translocated into nucleus (w/out need of TGF-B1) Mutant B-catenin induced profileration of MSCs and inhibited osteogenic differentiation Supports direct correlation between activation of Smad3/B-cateninmediated TGF-B1 signaling pathway and its unique biological responses in MSCs ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
... leading to an increase in interstitial fibrosis and a decrease in ventricular function. Metabolic changes have emerged as key mechanisms involved in the development and progression of pathological remodelling. As the myocardium is a highly oxidative tissue, mitochondria play a central role in mainta ...
... leading to an increase in interstitial fibrosis and a decrease in ventricular function. Metabolic changes have emerged as key mechanisms involved in the development and progression of pathological remodelling. As the myocardium is a highly oxidative tissue, mitochondria play a central role in mainta ...
Mitochondrial dysfunction in Parkinson`s disease
... complexity, primary mesencephalic cultures from NDUFS4 knockout mice did not show an increased rate of cell death. Moreover, they were not protected from cell death induced by MPP+ and rotenone [85]. These findings are surprising as they do not support the link between complex I deficiency, ATP deplet ...
... complexity, primary mesencephalic cultures from NDUFS4 knockout mice did not show an increased rate of cell death. Moreover, they were not protected from cell death induced by MPP+ and rotenone [85]. These findings are surprising as they do not support the link between complex I deficiency, ATP deplet ...
Targets hidden by fibrin networks still need to find their place in the
... Fibrin networks provide sites for crosslinking of additional matrix proteins, such as fibronectin (Figure 2 & 3) [18, 20]. The resulting multimolecular scaffold greatly enhances opportunities for cell attachment. It also offers binding sites for growth factors. Notably, vascular endothelium growth f ...
... Fibrin networks provide sites for crosslinking of additional matrix proteins, such as fibronectin (Figure 2 & 3) [18, 20]. The resulting multimolecular scaffold greatly enhances opportunities for cell attachment. It also offers binding sites for growth factors. Notably, vascular endothelium growth f ...
A single-headed fission yeast myosin V transports actin in a
... Dimerization of most myosins occurs through a region of the tail called the rod, a domain that typically forms an α-helical coiled coil. The propensity to form an α-helical coiled coil is based on the strength of the heptad repeat, a seven–amino acid motif in which the first and fourth positions, wh ...
... Dimerization of most myosins occurs through a region of the tail called the rod, a domain that typically forms an α-helical coiled coil. The propensity to form an α-helical coiled coil is based on the strength of the heptad repeat, a seven–amino acid motif in which the first and fourth positions, wh ...
Encapsulation of Plasmid DNA in Stabilized Plasmid – Lipid
... plasmid DNA can be entrapped in "stabilized plasmid-lipid particles" (SPLP) using low levels (5- 10 mol%) of cationic lipid, the fusogenic lipid dioleoylphosphatidylethanolamine (DOPE), and a polyethyleneglycol (PEG) coating for stabilization. The PEG moieties are attached to a ceramide anchor conta ...
... plasmid DNA can be entrapped in "stabilized plasmid-lipid particles" (SPLP) using low levels (5- 10 mol%) of cationic lipid, the fusogenic lipid dioleoylphosphatidylethanolamine (DOPE), and a polyethyleneglycol (PEG) coating for stabilization. The PEG moieties are attached to a ceramide anchor conta ...
regionally specific induction by the spemann
... from posteriorizing factors23, prevent ectopic organizer formation26 or promote anterior positional identity27. As the organizer was for decades considered to be the source of a powerful instructive agent, it initially came as a surprise, but is now widely accepted, that its main molecular function ...
... from posteriorizing factors23, prevent ectopic organizer formation26 or promote anterior positional identity27. As the organizer was for decades considered to be the source of a powerful instructive agent, it initially came as a surprise, but is now widely accepted, that its main molecular function ...
PDF
... To study the function of Mgl during Drosophila development, we first examined its tissue distribution. Mgl is expressed throughout the cuticle-secreting ectoderm, both during embyrogenesis and in the imaginal discs (see Fig. S1 in the supplementary material) (Khaliullina et al., 2009). In embryos, M ...
... To study the function of Mgl during Drosophila development, we first examined its tissue distribution. Mgl is expressed throughout the cuticle-secreting ectoderm, both during embyrogenesis and in the imaginal discs (see Fig. S1 in the supplementary material) (Khaliullina et al., 2009). In embryos, M ...