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Lab 02 Cell Diversity Bio160 RevA
Lab 02 Cell Diversity Bio160 RevA

... The light microscope revolutionized how the world viewed and understood the nature of living things. Take a look in the mirror, or at any other living thing, for example. Without a microscope what would you say it is made of? Prior to the invention of the microscope in the 1600s, no one knew that li ...
Cytoskeletal Architecture and Cell Morphogenesis
Cytoskeletal Architecture and Cell Morphogenesis

... Our team explores how the cytoskeleton is organized, how it controls the establishment of functional membrane domains devoted to polarized cell growth or cell division, and how it is remodeled at mitotic entry for the assembly of the mitotic spindle and contractile ring, two complex molecular machin ...
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Chapter 3: From Cells to Systems
Chapter 3: From Cells to Systems

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Bridging the gap
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Simultaneous Analysis of Secreted Il-2 and Jurkat Cells
Simultaneous Analysis of Secreted Il-2 and Jurkat Cells

... this time with phorbol 12-myristate 13-acetate (PMA) co-stimulation. The highest doses of PHA used in this experiment also caused cell death that was dose dependent, even while the IL-2 production peaked. For example, the amount of IL-2 produced per cell increased even as the number of live cells su ...
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Cell Shape and Arrangement

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Circulatory and Respiratory Vocab

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... promotion of proliferation to apoptosis. Apoptosis is a type of programmed cell death, which is necessary in development and homeostatic maintenance of the multicellular organisms. Apoptosis is said to occur when the cellular redox potential reaches its oxidative range and it is believed that the de ...
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Cell wall structure and biogenesis

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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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