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Contributions by members of the TGFbeta superfamily to lens
Contributions by members of the TGFbeta superfamily to lens

... 2000). Germ line deletion of at least two ligands, BMP4 and BMP7, showed that they participate in lens induction and later eye development (Furuta and Hogan 1998, Jena et al., 1997, Luo et al., 1995, Solursh et al., 1996, Wawersik et al., 1999). There is also evidence that BMPs and TGFβs contribute ...
Quasistatic Deformation and Failure Modes of Composite Square Honeycombs
Quasistatic Deformation and Failure Modes of Composite Square Honeycombs

... Carbon fibre epoxy matrix composite honeycombs have been fabricated by slotting, assembling and adhesively bonding composite laminate sheets with various fibre architectures. Their out-of-plane compressive and in-plane shear responses were measured as a function of relative density, ratio of the cel ...
Some unanswered questions in radiation biology
Some unanswered questions in radiation biology

... University of Oxford 1. Gray Institute for Radiation Oncology & Biology 2. 21 Century School Particle Therapy Cancer Research Institute, Oxford Physics. ...
Maurizio Gentile Role of mTOR in the Activation of Prof. Andrea Cerutti
Maurizio Gentile Role of mTOR in the Activation of Prof. Andrea Cerutti

... The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from blood-borne viruses and bacteria. These antigens activate MZ B cells by engaging somatically recombined B cell receptors (BCRs) and germlin ...
Xyloglucan and its Interactions with Other Components of the
Xyloglucan and its Interactions with Other Components of the

... to conformation because arabinose removal reduced the molecular mass by only 11%. The polymer with less substitution assumed a more compact conformation; self-aggregation of the backbone may have contributed to the smaller size. In the case of xyloglucans, conformation may vary with the degree of su ...
Implications for Cancer Biology
Implications for Cancer Biology

... In this review, we discuss how 4EBP1 and S6K1 are effectors for a growth factor- and nutrient-regulated signaling network containing the signaling proteins phosphatidylinositol-3-kinase (PI3K) and target of rapamycin (TOR). We discuss how dysregulation of either the growth factor signal or the nutri ...


... 1985; Winter, Robinson & Heldt 1993, 1994). Surprisingly, in their only quantitative example, Siddiqi & Glass use ‘cytosolic’ values from one such study (in fact, these values are reported merely as ‘detection limits’ by personal communication in Winter et al. 1994), even after having stated that th ...
video slide
video slide

... Peroxisomes: Oxidation • Specialized metabolic compartments bounded by a single membrane ...
Mutations Defining Functional Regions of the Superantigen
Mutations Defining Functional Regions of the Superantigen

... of the fusion protein was cleaved in vivo from the majority of the SEB or the ATG introduced between LacZ and SEB was for some reason a more efficient translation initiation site than that of LacZ. In the course of these studies, this construct was modified to introduce silent base changes which pro ...
Bacterial toxins modifying the actin cytoskeleton
Bacterial toxins modifying the actin cytoskeleton

The Lyn kinase C-lobe mediates Golgi export of Lyn through
The Lyn kinase C-lobe mediates Golgi export of Lyn through

... N- and C-terminal lobes (N- and C-lobes) of the kinase domain, the alanine mutations of Asp346, Glu353, Asp498 and Asp499 (A in red) in the C-lobe, the negative-regulatory tyrosine residue (Y), and the HA and GST tags are indicated. (B)Triton X-100 lysates prepared from HeLa cells were used for pul ...
Ontology_for_Develop.. - Buffalo Ontology Site
Ontology_for_Develop.. - Buffalo Ontology Site

... some special natural, social, or institutional set of circumstances in which the bearer does not have to be ...
Ch 23 Respiratory Notes
Ch 23 Respiratory Notes

... pulmonary artery (from the heart) ...
Intracellular trafficking of GO
Intracellular trafficking of GO

... Figure 1. Structure of CD33. Scheme depicting the domain structure of CD33 as well as individual amino acids that have been implicated in phosphorylation or ubiquitylation events or have been identified as residues of relatively frequent non-synonymous single nucleotide polymorphisms (SNPs). Abbrevi ...
Regulated trafficking of neurotransmitter transporters: common notes
Regulated trafficking of neurotransmitter transporters: common notes

... and Zahniser 2001). Finally, it is possible to separate intracellular vesicles from the plasma membrane using differential centrifugation. The amount of immunoreactivity in each fraction is then evaluated by western blot. This strategy has been used with both Xenopus oocytes and with cell cultures ( ...
CML cells actively evade host immune surveillance
CML cells actively evade host immune surveillance

Bradykinin stimulates IL-6 and IL-8 production by human lung
Bradykinin stimulates IL-6 and IL-8 production by human lung

... generated from kininogens by the action of plasma and tissue kallikreins. It has been postulated that the kallikreinkinin system is important in the pathophysiology of acute lung injury, acute (adult) respiratory distress syndrome (ARDS) and multiple organ failure. Experimental endotoxin shock, bact ...
LIU-THESIS - eCommons@USASK
LIU-THESIS - eCommons@USASK

... temperatures increasing more than day temperatures (Easterling and Horton, 1997; IPCC, 2007). According to Gu et al. (2008) and as reviewed in Storey and Tanino (2012), injury due to low temperature stress will become even more important under global warming, not less. Since temperature also influen ...
Pre-operative HBO treatment led to enhanced expression of
Pre-operative HBO treatment led to enhanced expression of

... around the nuclei could have important implications. Namely, if GM3 molecules are more intensively expressed, their precursors ceramide and sphingosine would be present in a smaller amount. Therefore, the apoptosis during liver regeneration would be less intense, resulting in more rapid liver regene ...
Soluble factors from human endometrium promote angiogenesis
Soluble factors from human endometrium promote angiogenesis

Relationship of Net Chloride Flow across the Human Erythrocyte
Relationship of Net Chloride Flow across the Human Erythrocyte

... Blood was obtained from apparently healthy adults with heparin as an anticoagulant. The cells were washed three times in 160 mM NaCl and 5 mM HEPES at room temperature and the white cells were removed by aspiration . ...
Functional Anatomy of the Respiratory System
Functional Anatomy of the Respiratory System

... • Serosa covers the outer surface of the lungs – Pulmonary (visceral) pleura covers the lung surface – Parietal pleura lines the walls of the thoracic cavity ...
Gram`s staining - Micro-Rao
Gram`s staining - Micro-Rao

... Propionibacterium have cell walls particularly sensitive to breakage during cell division, resulting in Gram-negative staining of these cells. In cultures of Bacillus, and Clostridium a decrease in peptidoglycan thickness during cell growth may cause some of them to appear Gram negative. Certain gro ...
(a) H
(a) H

...  It is driven by differences in pressure potential, not solute potential  It occurs in hollow dead cells, not across the membranes of living cells  It moves the entire solution, not just water or solutes  It is much faster ...
Analysis of the Golgi Apparatus in Arabidopsis Seed
Analysis of the Golgi Apparatus in Arabidopsis Seed

... had a large central vacuole, a nucleus typically located at the basolateral side of the cell, and amyloplasts (containing starch granules) that were either basal or apical (Figure 1A). Golgi stacks were seen in the narrow cytosolic region surrounding the vacuole. Cisternae were long and relatively t ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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