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Mitochondrial behaviour throughout the lytic cycle of Toxoplasma
Mitochondrial behaviour throughout the lytic cycle of Toxoplasma

... novel observations pave the way for future research to identify molecular mechanisms involved in mitochondrial distribution in Toxoplasma and the consequences of these mitochondrion changes on parasite physiology. The various functions of mitochondria are governed in part by positioning of the organ ...
Use of Phenylboronic Acids to Investigate Boron
Use of Phenylboronic Acids to Investigate Boron

... the same concentration of 3-methoxyphenylboronic acid (3-MBA; Fig. 1, E and F; pKa 8.6) or phenylboronic acid (PBA; not shown; pKa 8.8) for 2 h remain in a transition state where most cytoplasmic strands disappear but the nucleus remains centered (termed here as partially disrupted). PBA-treated cel ...
Effects of Sulphur Dioxide on Biochemical Activity and
Effects of Sulphur Dioxide on Biochemical Activity and

... Saunders and Wood (1973) have reported that even though gaseous SO2 can penetrate into plants, its absorption into the water film and formation of H2S03 between individual cells and on cell walls are prerequisite for any activity relating to metabolic disturbance or physical damage. Our present work ...
crayfish dissection
crayfish dissection

... the abdomen. The cephalothorax consists of the cephalic (or head) region and the thoracic region. The part of the exoskeleton that covers the cephalothorax is called the carapace. The abdomen is located behind the cephalothorax and consists of six clearly divided segments. The cephalothorax consists ...
Amyloplasts and Vacuolar Membrane Dynamics in
Amyloplasts and Vacuolar Membrane Dynamics in

... Higher plants cannot escape from the place where they germinate and settle, even if the environmental conditions drastically change. Plants have developed many mechanisms during the course of evolution to survive in such circumstances by changing growth direction or architecture of their body shape. ...
as a PDF
as a PDF

... Higher plants cannot escape from the place where they germinate and settle, even if the environmental conditions drastically change. Plants have developed many mechanisms during the course of evolution to survive in such circumstances by changing growth direction or architecture of their body shape. ...
Neural bHLH Genes Control the Neuronal versus Glial Fate
Neural bHLH Genes Control the Neuronal versus Glial Fate

... excessive generation of astrocytic precursors. An analysis of wild-type and mutant cortical progenitors in culture showed that a large fraction of Ngn2; Mash1 double-mutant progenitors failed to adopt a neuronal fate, instead remaining pluripotent or entering an astrocytic differentiation pathway. T ...
Mutations in the non-helical linker segment L1
Mutations in the non-helical linker segment L1

... differentiation. Each IF is composed of ~20,000-30,000 polypeptides that, in vitro, assemble into complex 10 nm structures in the absence of any apparent auxiliary proteins or factors (reviewed by Conway and Parry, 1988; Albers and Fuchs, 1992). Approximately 32 polypeptides constitute the diameter ...
Therapeutic approaches to Lysosomal Storage Disorders
Therapeutic approaches to Lysosomal Storage Disorders

... nucleases, proteases, polysaccharidases, oligosaccharidases and lipases) responsible for all of the degradative processes of lysosomes. These enzymes are not only limited to the degradation of specific substrates, but are also involved in many lysosomemediated cellular processes such as bone remodel ...
Fungi
Fungi

...  The most common body structures are multicellular filaments and single cells (such as yeast).  Multicellular:  Constructed out of tiny filaments called hyphae  Cells that are long and thread-like and are connected end to end.  Hyphae produce sporocarp which creates the mushroom structure ...
Cardioprotective Effects of Erythropoietin in Rats Subjected to
Cardioprotective Effects of Erythropoietin in Rats Subjected to

... function in the infarction region and, overall, could improve prognosis. Although erythropoietin (EPO) was developed as a hematopoietic growth factor, stimulating the production and release of red blood cells, EPO has recently been shown to protect ischemic neural and myocardial tissue (7–9). The he ...
Respiratory System notes
Respiratory System notes

... • Helps keep alveoli open by reducing surface tension • Lack of surfactant triggers respiratory distress syndrome © 2013 Pearson Education, Inc. ...
Molecular organization of the cell wall of Candida albicans and its
Molecular organization of the cell wall of Candida albicans and its

... Invasive fungal infections are important causes of morbidity and mortality, mainly in immunodepressed and hospitalized patients. Among these, the infectious processes caused by Candida albicans have acquired an increasing importance. Different virulence factors are involved in C. albicans pathogenic ...
Developmental stage‐specific expression of Rbm suggests its
Developmental stage‐specific expression of Rbm suggests its

... microdeletions in infertile men reveal that phenotypes associated with AZFb deletions are variable, ranging from Sertoli cell-only syndrome to spermatogenic arrest (Foresta et al., 2001). One explanation for these observations could be that Rbm is involved in multiple functions during spermatogenesi ...
Structural Studies of Human 5’-Nucleotidases Karin Walldén
Structural Studies of Human 5’-Nucleotidases Karin Walldén

... By removing the α-phosphate group from a nucleotide, the 5’NTs release the nucleoside to pass the plasma membrane by facilitated diffusion. Depending on the cellular need for nucleotides, the nucleosides can either exit the cell for reuse elsewhere or be imported and subsequently phosphorylated by n ...
The Respiratory System
The Respiratory System

... • Lack of surfactant triggers respiratory distress syndrome © 2013 Pearson Education, Inc. ...
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of

... and basophils, indicating the involvement of these proteins in leukocyte degranulation. It has been well-established that leukocyte degranulation requires a higher chemoattractant concentration than chemotaxis, which may reflect the need for activation of multiple signaling pathways for degranulatio ...
Chapter_020
Chapter_020

... Lymph from rest of the body empties into the thoracic duct, which then drains into left subclavian vein; thoracic duct originates as the cisterna chyli (chyle cistern) Mosby items and derived items © 2007, 2003 by Mosby, Inc. ...
Serial killers: ordering caspase activation events in apoptosis
Serial killers: ordering caspase activation events in apoptosis

... threat of damage to proteins other than their intended targets. For this reason, the potentially destructive forces of proteases are typically muzzled within the cell until their services are required. This is usually achieved in two basic ways: (1) many proteases are synthesized as inactive pro-enz ...
Lesson Overview
Lesson Overview

... Lesson Overview 34.4 Fertilization and Development ...
Robust circadian clocks from coupled protein
Robust circadian clocks from coupled protein

... but also a hypothetical system in which the two parts are coupled as in textbook models of coupled phase oscillators. Our analysis thus predicts that both cycles are required to generate robust circadian rhythms over the full range of growth conditions. Kai ∣ oscillations ...
Did trypanosomatid parasites have photosynthetic
Did trypanosomatid parasites have photosynthetic

... Figure 1. An illustration of euglenozoan relationships, emphasizing the diverse modes of nutrition present in the group. This general framework reflects the current state of knowledge about euglenozoan phylogeny. It is a synthetic hypothesis based primarily on comparative morphology (cladistic analy ...
A cellular backline: specialization of host membranes for defence
A cellular backline: specialization of host membranes for defence

... pathogen threat via pathogen-associated molecular patterns (PAMPs) are anchored in the membrane and trigger signalling cascades that alter both the intracellular and extracellular environment, in some contexts by the transfer of signals and/or molecules across the lipid bilayer. Host membranes polar ...
SLC_ABCs_2013 - Jianhai Du Lab @ West Virginia University
SLC_ABCs_2013 - Jianhai Du Lab @ West Virginia University

... membrane localization, hydrophobic nature, and relatively low abundance, although physiological data for a variety of transporters have been reported extensively. It has now been over two decades since the expression cloning approach for transporters was developed (Hediger et al., 1987; Romero et al ...
Vesicle trafficking dynamics and visualization of zones of exocytosis
Vesicle trafficking dynamics and visualization of zones of exocytosis

... Imaging). The regions measured are defined as follows. The apical dome region extended from the tip to the location where the semihemispherical dome joined the cylindrical body of the tube, which averaged 3 lm distal to the apex. The adjacent region spanned the area from 3 lm to 10 lm distal to the ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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