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A Ligand for CD5 Is CD5 - The Journal of Immunology
A Ligand for CD5 Is CD5 - The Journal of Immunology

... Two receptors expressed primarily on T cells, CD5 and CD6, are linked genetically and are structurally similar, both containing three scavenger receptor cysteine-rich domains in their extracellular regions. A specific cell surface interaction for CD5 has been difficult to define at the molecular lev ...
Paracoccidioides brasiliensis Strain IVIC Pb9
Paracoccidioides brasiliensis Strain IVIC Pb9

... Electron micrographs (Fig. 5 ) showed fibrils shorter than those described by Carbonell, Kanetsuna & Gil (1970) for the chitin and P-1,3-glucan of the parental strain IVIC ~ b 9 . Fraction 2 . Both strains formed about the same amount of this fraction. However, their compositions differed (Table 2). ...
View Full Page PDF
View Full Page PDF

... mutational analysis of the mscL gene identified structural domains critical for function (39, 41, 277, 391, 477). Several models of MscL mechanosensitivity, based on structure-function relations, have been proposed (37, 168). The crystal structure of MscL from M. tuberculosis (Tb-MscL), at 3.5Å reso ...
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor

... Is there a link between IL-6 and vascular leakage during sepsis? In a visionary paper published in 1997, Ciliberto and coworkers showed that vascular endothelial cells express gp130 but not IL-6R and respond to trans-signaling by IL6/ sIL-6R (Romano and others 1997). In sepsis, considerable amounts ...
PDF
PDF

... short stumpy, SS). Only the SS form is capable of differentiating efficiently to the PF that can resume proliferation in the fly. Interestingly, a form of quorum sensing pathway controls differentiation to the SS form. As parasitemia increases during the proliferation of slender LS, a parasite deriv ...
The power cell
The power cell

... which organisms obtain energy from food. The students, on the other hand, give definitions that don't mention food or energy at all! It might be that the confusion shown by students in their definitions of respiration simply reflects ambiguity in the meaning of the word. After all, the definitions g ...
Enhancement of Na Uptake Currents, Time
Enhancement of Na Uptake Currents, Time

... mm KCl) and found IK⫹in in 91% of the protoplasts (Fig. 1A) and IK⫹out in only 45% (n ⫽ 101 total protoplasts). Patch-clamp experiments in which the extracellular K⫹ concentration was shifted from 100 to 30 mm followed by current reversal (“tail”) analyses showed that IK⫹in were carried by K⫹ (data ...
Functional Role of the Fast Transient Outward K Current IA in
Functional Role of the Fast Transient Outward K Current IA in

... Outward K ⴙ currents in rat visual cortical pyramidal neurons In the experiments here, cortical neurons were isolated from the primary visual cortices of P4 –P7 rats, plated on glial monolayers, and maintained in vitro. Large, pyramidal-shaped neurons were selected for recordings (Desai et al., 1999 ...
The use of mutants to probe models of gravitropism
The use of mutants to probe models of gravitropism

... A broad conceptual model can encompass several more specific models. The specific conceptual models offer more opportunities for experimental challenge than the broad conceptual models hence are of greater value. Sensitivity to a auxin changes as part of the tropistic mechanism (model 2.1): The failu ...
ii. pyaemic lung abscesses
ii. pyaemic lung abscesses

... • Rarely, infections below the diaphragm, such as the subdiaphragmatic or liver abscess, may extend by continuity through the diaphragm ...
Polyunsaturated fatty acids modulate NOX 4 anion superoxide
Polyunsaturated fatty acids modulate NOX 4 anion superoxide

... anion. In order to demonstrate the production of superoxide by fibroblasts triggered by fatty acids, we performed LC/MS analysis of E OH+ on different samples including culture media and cells. As a positive control for superoxide anion production, we used a xanthine–XO assay for which typical chrom ...
Class III: Natural Detoxification
Class III: Natural Detoxification

... ◦ IV delivery enhances the extracellular stores and is used in all IV detox protocols but can only be delivered during IV. Thermosomal glutathione delivery  Can be used throughout the day maintaining blood levels at home.  Delivers Glutathione to the intracellular component, not reached by extrace ...
Proprioceptive Coupling within Motor Neurons Drives C. elegans
Proprioceptive Coupling within Motor Neurons Drives C. elegans

... does not contain motifs that might be easily interpreted as local CPG elements that could spontaneously generate oscillatory activity (e.g., oscillators driven by mutual inhibition between two neuronal classes that can be found in larger animals) (Figure 1B). The synaptic connectivity does contain a ...
Occasional Paper No. 113 THE POWER CELL
Occasional Paper No. 113 THE POWER CELL

... which organisms obtain energy from food. The students, on the other hand, give definitions that don't mention food or energy at all! It might be that the confusion shown by students in their definitions of respiration simply reflects ambiguity in the meaning of the word. After all, the definitions g ...
CLASS 5 - Mother-Teresa
CLASS 5 - Mother-Teresa

... 2. Blood vessels present at the junction of an artery and vein – Capillaries. 3. Chambers present in human heart – Four. 4. Red blood cells are also known as – Erythrocytes. 5. The part of the heart that receives impure blood – Right auricle. G. Answer the following questions: 1. Give three function ...
Biology Olympiad (NSEB ) 2012
Biology Olympiad (NSEB ) 2012

... Cells were cultured in a medium containing heavy isotope of phosphorous till the entire DNA complement had only this isotope. Subsequently some cells were transferred to a medium with the normal isotope of phosphorous. After a certain period some cells were harvested and analyzed for heavy phosphoro ...
PDZ proteins retain and regulate membrane transporters in
PDZ proteins retain and regulate membrane transporters in

... renal proximal tubule cells (66, 77). The human ortholog of NHERF-1 is also known as EBP50 (ezrin-radixin-moesinbinding phosphoprotein-50) (62). NHERF-2, also known as E3KARP, is a structurally and functionally related isoform (81). In mouse proximal tubule cells, NHERF-1 is strongly expressed in mi ...
Expression of and Cytokine Activation by Eschevichia coli Curi
Expression of and Cytokine Activation by Eschevichia coli Curi

... age of LPSs in patients with sepsis [7– 9], suggesting that other components of gram-negative bacteria may play a role in the induction and pathology of septic shock. Curli are a novel class of bacterial surface structures, expressed in both Escherichia coli and Salmonella, that are characterized by ...
Endocytic membrane fusion and buckling
Endocytic membrane fusion and buckling

... reflect the progressive stages of abscission ...
Monoclonal Antibody Characterization of Two Distant Sites
Monoclonal Antibody Characterization of Two Distant Sites

... these questions is the development of specific mAbs that can inhibit fibronectin function . If they can be mapped to different points along the molecule, a series of inhibitory and noninhibitory mAbs can provide insights into which sites are important for function in the form of an independent test ...
WJEC s13-biology1
WJEC s13-biology1

... conferences were held shortly after the papers were taken so that reference could be made to the full range of candidates' responses, with photocopied scripts forming the basis of discussion. The aim of the conferences was to ensure that the marking schemes were interpreted and applied in the same w ...
How to protect red wounds
How to protect red wounds

... - Resultant tissue filling is referred To as granulation tissue - process of wound contraction begins ...
Epiblast and primitive-streak origins of the endoderm in
Epiblast and primitive-streak origins of the endoderm in

... For injections of the parastreak epiblast, embryos at stages 3a/b and 3c (n=15) were cultured dorsal side upwards in Spratt culture (Spratt, 1947), modified as described by Schoenwolf (Schoenwolf, 1988). The epiblast was injected lateral to the rostral end of the primitive streak (Fig. 1) at a site ...
An evaluation of switching criteria for ferroelectrics under stress and
An evaluation of switching criteria for ferroelectrics under stress and

... There exists a lack of comprehensive experimental data in combined electro-mechanical loading, against which models can be validated. In the following sections, measured multi-axial responses of BaTiO3 and of the hard PZT material PZT-4D to stress and electric field loading are reported. In order to ...
Signaling networks that regulate muscle development: Lessons from
Signaling networks that regulate muscle development: Lessons from

... to convergence extension movements. (c) Slow muscle precursors are specified by signaling from the notochord. Magenta indicates the location of adaxial cells, precursors of muscle pioneer and other slow muscle cells. Green indicates the location of fast muscle precursors. Upper panel shows the dorsa ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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